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Protein

Paraneoplastic antigen Ma2

Gene

PNMA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.

GO - Biological processi

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma2
Alternative name(s):
40 kDa neuronal protein
Onconeuronal antigen Ma2
Paraneoplastic neuronal antigen MM2
Gene namesi
Name:PNMA2
Synonyms:KIAA0883, MA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000240694.8.
HGNCiHGNC:9159. PNMA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10687.
OpenTargetsiENSG00000240694.
PharmGKBiPA33482.

Polymorphism and mutation databases

BioMutaiPNMA2.
DMDMi37999812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001552022 – 364Paraneoplastic antigen Ma2Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UL42.
MaxQBiQ9UL42.
PaxDbiQ9UL42.
PeptideAtlasiQ9UL42.
PRIDEiQ9UL42.

PTM databases

iPTMnetiQ9UL42.
PhosphoSitePlusiQ9UL42.

Expressioni

Tissue specificityi

Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.2 Publications

Gene expression databases

BgeeiENSG00000240694.
CleanExiHS_PNMA2.
GenevisibleiQ9UL42. HS.

Organism-specific databases

HPAiHPA001936.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115926. 50 interactors.
IntActiQ9UL42. 41 interactors.
MINTiMINT-7242062.
STRINGi9606.ENSP00000429344.

Structurei

3D structure databases

ProteinModelPortaliQ9UL42.
SMRiQ9UL42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi333 – 338Poly-Glu6

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410J6QQ. Eukaryota.
ENOG410Y05Y. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9UL42.
OMAiFKTPNQD.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ9UL42.
TreeFamiTF335054.

Family and domain databases

InterProiView protein in InterPro
IPR026523. PNMA.
IPR026525. PNMA2.
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF16. PTHR23095:SF16. 1 hit.
PfamiView protein in Pfam
PF14893. PNMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR
60 70 80 90 100
LLGKIFRKQE NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT
110 120 130 140 150
EFLERLNLFL EKEGQTVSGM FRALGQEGVS PATVPCISPE LLAHLLGQAM
160 170 180 190 200
AHAPQPLLPM RYRKLRVFSG SAVPAPEEES FEVWLEQATE IVKEWPVTEA
210 220 230 240 250
EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV FGSLESRRTA
260 270 280 290 300
QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA
310 320 330 340 350
GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE
360
ERDGYGRWNH EGDD
Length:364
Mass (Da):41,509
Last modified:October 24, 2003 - v2
Checksum:i6E417AD96E3F0E93
GO

Sequence cautioni

The sequence BAA74906 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128 – 129GV → AL in AAD02098 (PubMed:10362822).Curated2
Sequence conflicti141L → I in AAD02098 (PubMed:10362822).Curated1
Sequence conflicti257T → P in AAF05625 (PubMed:10362822).Curated1
Sequence conflicti278R → K in AAF05626 (PubMed:10362822).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053597186E → K. Corresponds to variant dbSNP:rs2233701Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037365 mRNA. Translation: AAD02098.1.
AF083114 mRNA. Translation: AAF05625.1.
AF083115 mRNA. Translation: AAF05626.1.
AF286487 mRNA. Translation: AAG28165.1.
AB020690 mRNA. Translation: BAA74906.2. Different initiation.
AK055325 mRNA. Translation: BAG51501.1.
CH471080 Genomic DNA. Translation: EAW63575.1.
BC047515 mRNA. Translation: AAH47515.1.
BC062301 mRNA. Translation: AAH62301.1.
CCDSiCCDS34868.1.
RefSeqiNP_009188.1. NM_007257.5.
XP_011542667.1. XM_011544365.2.
UniGeneiHs.591838.

Genome annotation databases

EnsembliENST00000522362; ENSP00000429344; ENSG00000240694.
GeneIDi10687.
KEGGihsa:10687.
UCSCiuc003xez.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPNMA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UL42
Secondary accession number(s): B3KNY9
, O94959, O95145, Q49A18, Q9UL43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: October 25, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families