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Protein

Paraneoplastic antigen Ma2

Gene

PNMA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma2
Alternative name(s):
40 kDa neuronal protein
Onconeuronal antigen Ma2
Paraneoplastic neuronal antigen MM2
Gene namesi
Name:PNMA2
Synonyms:KIAA0883, MA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9159. PNMA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33482.

Polymorphism and mutation databases

BioMutaiPNMA2.
DMDMi37999812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 364363Paraneoplastic antigen Ma2PRO_0000155202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UL42.
MaxQBiQ9UL42.
PaxDbiQ9UL42.
PRIDEiQ9UL42.

PTM databases

iPTMnetiQ9UL42.
PhosphoSiteiQ9UL42.

Expressioni

Tissue specificityi

Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.2 Publications

Gene expression databases

BgeeiQ9UL42.
CleanExiHS_PNMA2.
GenevisibleiQ9UL42. HS.

Organism-specific databases

HPAiHPA001936.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138953EBI-302355,EBI-358049
CBX8Q9HC523EBI-302355,EBI-712912
ENKD1Q9H0I24EBI-302355,EBI-744099
FAM161AQ3B8203EBI-302355,EBI-719941
LRR1Q96L503EBI-302355,EBI-2510106
MORF4L2Q150143EBI-302355,EBI-399257
NCK1P163332EBI-302355,EBI-389883
PPIGQ134273EBI-302355,EBI-396072
PRPF31F1T0A53EBI-302355,EBI-10177194
PSMA1P257863EBI-302355,EBI-359352
RNF8O760644EBI-302355,EBI-373337
RPL9P329693EBI-302355,EBI-358122
RTP5Q14D333EBI-302355,EBI-10217913
SCNM1Q9BWG63EBI-302355,EBI-748391
SDCBPO005603EBI-302355,EBI-727004
TOP3BO959853EBI-302355,EBI-373403
TTLL10Q6ZVT03EBI-302355,EBI-7844656
ZNF417Q8TAU34EBI-302355,EBI-740727
ZNF587Q96SQ53EBI-302355,EBI-6427977

Protein-protein interaction databases

BioGridi115926. 43 interactions.
IntActiQ9UL42. 30 interactions.
MINTiMINT-7242062.
STRINGi9606.ENSP00000429344.

Structurei

3D structure databases

ProteinModelPortaliQ9UL42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi333 – 3386Poly-Glu

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410J6QQ. Eukaryota.
ENOG410Y05Y. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9UL42.
OMAiFKTPNQD.
OrthoDBiEOG708VZW.
PhylomeDBiQ9UL42.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026525. PNMA2.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF16. PTHR23095:SF16. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR
60 70 80 90 100
LLGKIFRKQE NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT
110 120 130 140 150
EFLERLNLFL EKEGQTVSGM FRALGQEGVS PATVPCISPE LLAHLLGQAM
160 170 180 190 200
AHAPQPLLPM RYRKLRVFSG SAVPAPEEES FEVWLEQATE IVKEWPVTEA
210 220 230 240 250
EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV FGSLESRRTA
260 270 280 290 300
QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA
310 320 330 340 350
GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE
360
ERDGYGRWNH EGDD
Length:364
Mass (Da):41,509
Last modified:October 24, 2003 - v2
Checksum:i6E417AD96E3F0E93
GO

Sequence cautioni

The sequence BAA74906.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1292GV → AL in AAD02098 (PubMed:10362822).Curated
Sequence conflicti141 – 1411L → I in AAD02098 (PubMed:10362822).Curated
Sequence conflicti257 – 2571T → P in AAF05625 (PubMed:10362822).Curated
Sequence conflicti278 – 2781R → K in AAF05626 (PubMed:10362822).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861E → K.
Corresponds to variant rs2233701 [ dbSNP | Ensembl ].
VAR_053597

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037365 mRNA. Translation: AAD02098.1.
AF083114 mRNA. Translation: AAF05625.1.
AF083115 mRNA. Translation: AAF05626.1.
AF286487 mRNA. Translation: AAG28165.1.
AB020690 mRNA. Translation: BAA74906.2. Different initiation.
AK055325 mRNA. Translation: BAG51501.1.
CH471080 Genomic DNA. Translation: EAW63575.1.
BC047515 mRNA. Translation: AAH47515.1.
BC062301 mRNA. Translation: AAH62301.1.
CCDSiCCDS34868.1.
RefSeqiNP_009188.1. NM_007257.5.
XP_011542667.1. XM_011544365.1.
UniGeneiHs.591838.

Genome annotation databases

EnsembliENST00000522362; ENSP00000429344; ENSG00000240694.
GeneIDi10687.
KEGGihsa:10687.
UCSCiuc003xez.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037365 mRNA. Translation: AAD02098.1.
AF083114 mRNA. Translation: AAF05625.1.
AF083115 mRNA. Translation: AAF05626.1.
AF286487 mRNA. Translation: AAG28165.1.
AB020690 mRNA. Translation: BAA74906.2. Different initiation.
AK055325 mRNA. Translation: BAG51501.1.
CH471080 Genomic DNA. Translation: EAW63575.1.
BC047515 mRNA. Translation: AAH47515.1.
BC062301 mRNA. Translation: AAH62301.1.
CCDSiCCDS34868.1.
RefSeqiNP_009188.1. NM_007257.5.
XP_011542667.1. XM_011544365.1.
UniGeneiHs.591838.

3D structure databases

ProteinModelPortaliQ9UL42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115926. 43 interactions.
IntActiQ9UL42. 30 interactions.
MINTiMINT-7242062.
STRINGi9606.ENSP00000429344.

PTM databases

iPTMnetiQ9UL42.
PhosphoSiteiQ9UL42.

Polymorphism and mutation databases

BioMutaiPNMA2.
DMDMi37999812.

Proteomic databases

EPDiQ9UL42.
MaxQBiQ9UL42.
PaxDbiQ9UL42.
PRIDEiQ9UL42.

Protocols and materials databases

DNASUi10687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522362; ENSP00000429344; ENSG00000240694.
GeneIDi10687.
KEGGihsa:10687.
UCSCiuc003xez.3. human.

Organism-specific databases

CTDi10687.
GeneCardsiPNMA2.
HGNCiHGNC:9159. PNMA2.
HPAiHPA001936.
MIMi603970. gene.
neXtProtiNX_Q9UL42.
PharmGKBiPA33482.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6QQ. Eukaryota.
ENOG410Y05Y. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9UL42.
OMAiFKTPNQD.
OrthoDBiEOG708VZW.
PhylomeDBiQ9UL42.
TreeFamiTF335054.

Miscellaneous databases

ChiTaRSiPNMA2. human.
GeneWikiiPNMA2.
GenomeRNAii10687.
NextBioi40625.
PROiQ9UL42.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UL42.
CleanExiHS_PNMA2.
GenevisibleiQ9UL42. HS.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026525. PNMA2.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF16. PTHR23095:SF16. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer."
    Voltz R., Gultekin S.H., Rosenfeld M.R., Gerstner E., Eichen J., Posner J.B., Dalmau J.
    N. Engl. J. Med. 340:1788-1795(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. "Molecular and clinical diversity in paraneoplastic immunity to Ma proteins."
    Rosenfeld M.R., Eichen J.G., Wade D.F., Posner J.B., Dalmau J.
    Ann. Neurol. 50:339-348(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain stem.
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  7. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 20-44; 58-85; 95-122 AND 239-247, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  8. "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders."
    Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.
    Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
  9. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
    Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
    Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPNMA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UL42
Secondary accession number(s): B3KNY9
, O94959, O95145, Q49A18, Q9UL43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: May 11, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.