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Protein

Paraneoplastic antigen Ma3

Gene

PNMA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Antibodies against PNMA3 are present in sera from patients suffering of paraneoplastic neurological disorders.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 429CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTumor antigen
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma3
Gene namesi
Name:PNMA3
Synonyms:MA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000183837.9
HGNCiHGNC:18742 PNMA3
MIMi300675 gene
neXtProtiNX_Q9UL41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183837
PharmGKBiPA38667

Polymorphism and mutation databases

DMDMi296452862

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802151 – 463Paraneoplastic antigen Ma3Add BLAST463

Proteomic databases

EPDiQ9UL41
PaxDbiQ9UL41
PeptideAtlasiQ9UL41
PRIDEiQ9UL41

PTM databases

iPTMnetiQ9UL41
PhosphoSitePlusiQ9UL41

Expressioni

Tissue specificityi

Expressed at high levels in the brain and testis. Expressed at lower levels in the heart, trachea and kidney.3 Publications

Gene expression databases

BgeeiENSG00000183837
CleanExiHS_PNMA3
GenevisibleiQ9UL41 HS

Organism-specific databases

HPAiHPA047920

Interactioni

Protein-protein interaction databases

BioGridi118981, 6 interactors
IntActiQ9UL41, 17 interactors
STRINGi9606.ENSP00000359286

Structurei

3D structure databases

ProteinModelPortaliQ9UL41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 337Poly-Glu6
Compositional biasi384 – 410Arg-richAdd BLAST27

Sequence similaritiesi

Belongs to the PNMA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 429CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J6QQ Eukaryota
ENOG410Y05Y LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ9UL41
OrthoDBiEOG091G0BG9
PhylomeDBiQ9UL41
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL41-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLTLLQDWC RGEHLNTRRC MLILGIPEDC GEDEFEETLQ EACRHLGRYR
60 70 80 90 100
VIGRMFRREE NAQAILLELA QDIDYALLPR EIPGKGGPWE VIVKPRNSDG
110 120 130 140 150
EFLNRLNRFL EEERRTVSDM NRVLGSDTNC SAPRVTISPE FWTWAQTLGA
160 170 180 190 200
AVQPLLEQML YRELRVFSGN TISIPGALAF DAWLEHTTEM LQMWQVPEGE
210 220 230 240 250
KRRRLMECLR GPALQVVSGL RASNASITVE ECLAALQQVF GPVESHKIAQ
260 270 280 290 300
VKLCKAYQEA GEKVSSFVLR LEPLLQRAVE NNVVSRRNVN QTRLKRVLSG
310 320 330 340 350
ATLPDKLRDK LKLMKQRRKP PGFLALVKLL REEEEWEATL GPDRESLEGL
360 370 380 390 400
EVAPRPPARI TGVGAVPLPA SGNSFDARPS QGYRRRRGRG QHRRGGVARA
410 420 430 440 450
GSRGSRKRKR HTFCYSCGED GHIRVQCINP SNLLLVKQKK QAAVESGNGN
460
WAWDKSHPKS KAK
Length:463
Mass (Da):52,376
Last modified:March 28, 2018 - v3
Checksum:i0843EF6601D8557C
GO
Isoform 2 (identifier: Q9UL41-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-463: VKQKKQAAVESGNGNWAWDKSHPKSKAK → AKETKEILEGGEREAQTNSR

Show »
Length:455
Mass (Da):51,514
Checksum:i9AC8CC06685A8956
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377A → V in EAW72888 (Ref. 4) 1
Sequence conflicti377A → V in EAW72889 (Ref. 4) 1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057701382G → S. Corresponds to variant dbSNP:rs36042591Ensembl.1
Natural variantiVAR_057702386R → Q. Corresponds to variant dbSNP:rs35603712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023571436 – 463VKQKK…KSKAK → AKETKEILEGGEREAQTNSR in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083116 mRNA Translation: AAF05627.1
AL136878 mRNA Translation: CAB66812.1
AC243428 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72888.1
CH471172 Genomic DNA Translation: EAW72889.1
BC105096 mRNA Translation: AAI05097.1
BC105098 mRNA Translation: AAI05099.1
CCDSiCCDS35435.2 [Q9UL41-1]
CCDS65344.1 [Q9UL41-2]
RefSeqiNP_001269464.1, NM_001282535.1 [Q9UL41-2]
NP_037496.4, NM_013364.5 [Q9UL41-1]
UniGeneiHs.449627
Hs.744496

Genome annotation databases

EnsembliENST00000424805; ENSP00000390576; ENSG00000183837 [Q9UL41-1]
ENST00000593810; ENSP00000469445; ENSG00000183837 [Q9UL41-1]
ENST00000619635; ENSP00000480719; ENSG00000183837 [Q9UL41-2]
GeneIDi29944
KEGGihsa:29944
UCSCiuc033faq.1 human [Q9UL41-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPNMA3_HUMAN
AccessioniPrimary (citable) accession number: Q9UL41
Secondary accession number(s): D3DWT7, Q9H0A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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