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Protein

Paraneoplastic antigen Ma3

Gene

PNMA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 429CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31476-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma3
Gene namesi
Name:PNMA3
Synonyms:MA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18742. PNMA3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38667.

Polymorphism and mutation databases

DMDMi296452862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802151 – 463Paraneoplastic antigen Ma3Add BLAST463

Proteomic databases

EPDiQ9UL41.
PaxDbiQ9UL41.
PeptideAtlasiQ9UL41.
PRIDEiQ9UL41.

PTM databases

iPTMnetiQ9UL41.
PhosphoSitePlusiQ9UL41.

Expressioni

Tissue specificityi

Expressed at high levels in the brain and testis. Expressed at lower levels in the heart, trachea and kidney.3 Publications

Gene expression databases

BgeeiENSG00000183837.
CleanExiHS_PNMA3.
GenevisibleiQ9UL41. HS.

Organism-specific databases

HPAiHPA047920.

Interactioni

Protein-protein interaction databases

BioGridi118981. 6 interactors.
IntActiQ9UL41. 11 interactors.
STRINGi9606.ENSP00000359286.

Structurei

3D structure databases

ProteinModelPortaliQ9UL41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 337Poly-Glu6
Compositional biasi384 – 410Arg-richAdd BLAST27

Sequence similaritiesi

Belongs to the PNMA family.Curated
Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 429CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J6QQ. Eukaryota.
ENOG410Y05Y. LUCA.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9UL41.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ9UL41.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026529. PNMA3.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF22. PTHR23095:SF22. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL41-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLTLLQDWC RGEHLNTRRC MLILGIPEDC GEDEFEETLQ EACRHLGRYR
60 70 80 90 100
VIGRMFRREE NAQAILLELA QDIDYALLPR EIPGKGGPWE VIVKPRNSDG
110 120 130 140 150
EFLNRLNRFL EEERRTVSDM NRVLGSDTNC SAPRVTISPE FWTWAQTLGA
160 170 180 190 200
AVQPLLEQML YRELRVFSGN TISIPGALAF DAWLEHTTEM LQMWQVPEGE
210 220 230 240 250
KRRRLMECLR GPALQVVSGL RASNASITVE ECLAALQQVF GPVESHKIAQ
260 270 280 290 300
VKLCKAYQEA GEKVSSFVLR LEPLLQRAVE NNVVSRRNVN QTRLKRVLSG
310 320 330 340 350
ATLPDKLRDK LKLMKQRRKP PGFLALVKLL REEEEWEATL GPDRESLEGL
360 370 380 390 400
EVAPRPPARI TGVGAVPLPA SGNSFDVRPS QGYRRRRGRG QHRRGGVARA
410 420 430 440 450
GSRGSRKRKR HTFCYSCGED GHIRVQCINP SNLLLVKQKK QAAVESGNGN
460
WAWDKSHPKS KAK
Length:463
Mass (Da):52,404
Last modified:May 18, 2010 - v2
Checksum:i8E32887066D84DD3
GO
Isoform 2 (identifier: Q9UL41-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-463: VKQKKQAAVESGNGNWAWDKSHPKSKAK → AKETKEILEGGEREAQTNSR

Show »
Length:455
Mass (Da):51,542
Checksum:i4D8063E1385A9BCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377V → A in AAF05627 (PubMed:11558790).Curated1
Sequence conflicti377V → A in CAB66812 (PubMed:11230166).Curated1
Sequence conflicti377V → A in AAI05097 (PubMed:15489334).Curated1
Sequence conflicti377V → A in AAI05099 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057701382G → S.Corresponds to variant rs36042591dbSNPEnsembl.1
Natural variantiVAR_057702386R → Q.Corresponds to variant rs35603712dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023571436 – 463VKQKK…KSKAK → AKETKEILEGGEREAQTNSR in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083116 mRNA. Translation: AAF05627.1.
AL136878 mRNA. Translation: CAB66812.1.
AC152006 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72888.1.
CH471172 Genomic DNA. Translation: EAW72889.1.
BC105096 mRNA. Translation: AAI05097.1.
BC105098 mRNA. Translation: AAI05099.1.
CCDSiCCDS35435.2. [Q9UL41-1]
CCDS65344.1. [Q9UL41-2]
RefSeqiNP_001269464.1. NM_001282535.1.
NP_037496.4. NM_013364.5.
UniGeneiHs.449627.
Hs.744496.

Genome annotation databases

EnsembliENST00000424805; ENSP00000390576; ENSG00000183837.
ENST00000593810; ENSP00000469445; ENSG00000183837.
ENST00000619635; ENSP00000480719; ENSG00000183837.
GeneIDi29944.
KEGGihsa:29944.
UCSCiuc033faq.1. human. [Q9UL41-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083116 mRNA. Translation: AAF05627.1.
AL136878 mRNA. Translation: CAB66812.1.
AC152006 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72888.1.
CH471172 Genomic DNA. Translation: EAW72889.1.
BC105096 mRNA. Translation: AAI05097.1.
BC105098 mRNA. Translation: AAI05099.1.
CCDSiCCDS35435.2. [Q9UL41-1]
CCDS65344.1. [Q9UL41-2]
RefSeqiNP_001269464.1. NM_001282535.1.
NP_037496.4. NM_013364.5.
UniGeneiHs.449627.
Hs.744496.

3D structure databases

ProteinModelPortaliQ9UL41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118981. 6 interactors.
IntActiQ9UL41. 11 interactors.
STRINGi9606.ENSP00000359286.

PTM databases

iPTMnetiQ9UL41.
PhosphoSitePlusiQ9UL41.

Polymorphism and mutation databases

DMDMi296452862.

Proteomic databases

EPDiQ9UL41.
PaxDbiQ9UL41.
PeptideAtlasiQ9UL41.
PRIDEiQ9UL41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424805; ENSP00000390576; ENSG00000183837.
ENST00000593810; ENSP00000469445; ENSG00000183837.
ENST00000619635; ENSP00000480719; ENSG00000183837.
GeneIDi29944.
KEGGihsa:29944.
UCSCiuc033faq.1. human. [Q9UL41-1]

Organism-specific databases

CTDi29944.
GeneCardsiPNMA3.
H-InvDBHIX0023487.
HGNCiHGNC:18742. PNMA3.
HPAiHPA047920.
MIMi300675. gene.
neXtProtiNX_Q9UL41.
PharmGKBiPA38667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6QQ. Eukaryota.
ENOG410Y05Y. LUCA.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9UL41.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ9UL41.
TreeFamiTF335054.

Enzyme and pathway databases

BioCyciZFISH:G66-31476-MONOMER.

Miscellaneous databases

GenomeRNAii29944.
PROiQ9UL41.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183837.
CleanExiHS_PNMA3.
GenevisibleiQ9UL41. HS.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026529. PNMA3.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF22. PTHR23095:SF22. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNMA3_HUMAN
AccessioniPrimary (citable) accession number: Q9UL41
Secondary accession number(s): D3DWT7, Q9H0A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against PNMA3 are present in sera from patients suffering of paraneoplastic neurological disorders.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.