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Q9UL40

- ZN346_HUMAN

UniProt

Q9UL40 - ZN346_HUMAN

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Protein

Zinc finger protein 346

Gene
ZNF346, JAZ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Zinc 1 By similarity
Metal bindingi78 – 781Zinc 1 By similarity
Metal bindingi91 – 911Zinc 1; via tele nitrogen By similarity
Metal bindingi97 – 971Zinc 1; via pros nitrogen By similarity
Metal bindingi136 – 1361Zinc 2 By similarity
Metal bindingi139 – 1391Zinc 2 By similarity
Metal bindingi152 – 1521Zinc 2; via tele nitrogen By similarity
Metal bindingi158 – 1581Zinc 2; via pros nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 10435Matrin-type 1Add
BLAST
Zinc fingeri131 – 16535Matrin-type 2Add
BLAST
Zinc fingeri182 – 21635Matrin-type 3Add
BLAST
Zinc fingeri236 – 27035Matrin-type 4Add
BLAST

GO - Molecular functioni

  1. double-stranded RNA binding Source: UniProtKB
  2. enzyme binding Source: UniProt
  3. nucleic acid binding Source: InterPro
  4. poly(A) RNA binding Source: UniProtKB
  5. protein binding Source: IntAct
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:ZNF346
Synonyms:JAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:16403. ZNF346.

Subcellular locationi

Nucleusnucleolus. Cytoplasm
Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Zinc finger protein 346PRO_0000191809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UL40.
PaxDbiQ9UL40.
PRIDEiQ9UL40.

Expressioni

Gene expression databases

ArrayExpressiQ9UL40.
BgeeiQ9UL40.
CleanExiHS_ZNF346.
GenevestigatoriQ9UL40.

Organism-specific databases

HPAiHPA018485.

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2AK2P195252EBI-2462313,EBI-640775

Protein-protein interaction databases

BioGridi117109. 27 interactions.
IntActiQ9UL40. 6 interactions.
STRINGi9606.ENSP00000350869.

Structurei

Secondary structure

1
294
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni176 – 1783
Beta strandi185 – 1873
Turni188 – 1914
Beta strandi192 – 1943
Helixi197 – 2037
Helixi207 – 22216

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MKDNMR-A168-227[»]
2MKNNMR-A181-224[»]
ProteinModelPortaliQ9UL40.
SMRiQ9UL40. Positions 53-227, 240-268.

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG85918.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
OMAiEVEHMIQ.
PhylomeDBiQ9UL40.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UL40-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG    50
AQPVGREEVE HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK 100
VKRYLAIHGM ETLKGETKKL DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ 150
SHYLGKTHAK NLKLKQQSTK VEALHQNREM IDPDKFCSLC HATFNDPVMA 200
QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP CKTCKIVLNS 250
IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED 294
Length:294
Mass (Da):32,933
Last modified:May 1, 2000 - v1
Checksum:i095F02E19FBCFBE0
GO
Isoform 2 (identifier: Q9UL40-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: E → EAQFFPHSRTVIPILVLSETYSLCHP

Note: No experimental confirmation available.

Show »
Length:319
Mass (Da):35,771
Checksum:i42E18B795453AEB0
GO
Isoform 3 (identifier: Q9UL40-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-125: Missing.

Note: No experimental confirmation available.

Show »
Length:262
Mass (Da):29,267
Checksum:i5EAB16A18CAE634C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 581E → EAQFFPHSRTVIPILVLSET YSLCHP in isoform 2. VSP_015971
Alternative sequencei94 – 12532Missing in isoform 3. VSP_055098Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521H → Y in CAH18475. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083340 mRNA. Translation: AAD52018.1.
AK131469 mRNA. Translation: BAD18614.1.
AK295549 mRNA. Translation: BAH12103.1.
CR749692 mRNA. Translation: CAH18475.1.
AC027314 Genomic DNA. No translation available.
AC027317 Genomic DNA. No translation available.
BC007775 mRNA. Translation: AAH07775.1.
CCDSiCCDS4409.1. [Q9UL40-1]
RefSeqiNP_036411.1. NM_012279.2. [Q9UL40-1]
XP_006714900.1. XM_006714837.1. [Q9UL40-2]
UniGeneiHs.484259.

Genome annotation databases

EnsembliENST00000261948; ENSP00000261948; ENSG00000113761. [Q9UL40-2]
ENST00000358149; ENSP00000350869; ENSG00000113761. [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761. [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761.
GeneIDi23567.
KEGGihsa:23567.
UCSCiuc003mfi.3. human. [Q9UL40-1]
uc003mfk.1. human. [Q9UL40-2]

Polymorphism databases

DMDMi74735051.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083340 mRNA. Translation: AAD52018.1 .
AK131469 mRNA. Translation: BAD18614.1 .
AK295549 mRNA. Translation: BAH12103.1 .
CR749692 mRNA. Translation: CAH18475.1 .
AC027314 Genomic DNA. No translation available.
AC027317 Genomic DNA. No translation available.
BC007775 mRNA. Translation: AAH07775.1 .
CCDSi CCDS4409.1. [Q9UL40-1 ]
RefSeqi NP_036411.1. NM_012279.2. [Q9UL40-1 ]
XP_006714900.1. XM_006714837.1. [Q9UL40-2 ]
UniGenei Hs.484259.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MKD NMR - A 168-227 [» ]
2MKN NMR - A 181-224 [» ]
ProteinModelPortali Q9UL40.
SMRi Q9UL40. Positions 53-227, 240-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117109. 27 interactions.
IntActi Q9UL40. 6 interactions.
STRINGi 9606.ENSP00000350869.

Polymorphism databases

DMDMi 74735051.

Proteomic databases

MaxQBi Q9UL40.
PaxDbi Q9UL40.
PRIDEi Q9UL40.

Protocols and materials databases

DNASUi 23567.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261948 ; ENSP00000261948 ; ENSG00000113761 . [Q9UL40-2 ]
ENST00000358149 ; ENSP00000350869 ; ENSG00000113761 . [Q9UL40-1 ]
ENST00000503039 ; ENSP00000424495 ; ENSG00000113761 . [Q9UL40-2 ]
ENST00000503425 ; ENSP00000421212 ; ENSG00000113761 .
GeneIDi 23567.
KEGGi hsa:23567.
UCSCi uc003mfi.3. human. [Q9UL40-1 ]
uc003mfk.1. human. [Q9UL40-2 ]

Organism-specific databases

CTDi 23567.
GeneCardsi GC05P176382.
HGNCi HGNC:16403. ZNF346.
HPAi HPA018485.
MIMi 605308. gene.
neXtProti NX_Q9UL40.
PharmGKBi PA134898181.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85918.
HOGENOMi HOG000008682.
HOVERGENi HBG061007.
OMAi EVEHMIQ.
PhylomeDBi Q9UL40.
TreeFami TF350019.

Miscellaneous databases

ChiTaRSi ZNF346. human.
GeneWikii ZNF346.
GenomeRNAii 23567.
NextBioi 35479161.
PROi Q9UL40.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UL40.
Bgeei Q9UL40.
CleanExi HS_ZNF346.
Genevestigatori Q9UL40.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization."
    Yang M., May W.S., Ito T.
    J. Biol. Chem. 274:27399-27406(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Hippocampus and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5."
    Chen T., Brownawell A.M., Macara I.G.
    Mol. Cell. Biol. 24:6608-6619(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN; ILF3 AND DOUBLE-STRANDED RNA, SUBCELLULAR LOCATION, INTERACTION WITH XPO5 AND ILF3.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids."
    Burge R.G., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    Biochemistry 53:1495-1510(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 168-227, FUNCTION.

Entry informationi

Entry nameiZN346_HUMAN
AccessioniPrimary (citable) accession number: Q9UL40
Secondary accession number(s): B7Z367, Q68CV9, Q6ZMW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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