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Q9UL40 (ZN346_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene names
Name:ZNF346
Synonyms:JAZ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. Ref.10

Subunit structure

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner. Ref.6

Subcellular location

Nucleusnucleolus. Cytoplasm. Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5. Ref.6

Domain

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization By similarity.

Sequence similarities

Contains 4 matrin-type zinc fingers.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EIF2AK2P195252EBI-2462313,EBI-640775

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UL40-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UL40-2)

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: E → EAQFFPHSRTVIPILVLSETYSLCHP
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UL40-3)

The sequence of this isoform differs from the canonical sequence as follows:
     94-125: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Zinc finger protein 346
PRO_0000191809

Regions

Zinc finger70 – 10435Matrin-type 1
Zinc finger131 – 16535Matrin-type 2
Zinc finger182 – 21635Matrin-type 3
Zinc finger236 – 27035Matrin-type 4

Sites

Metal binding751Zinc 1 By similarity
Metal binding781Zinc 1 By similarity
Metal binding911Zinc 1; via tele nitrogen By similarity
Metal binding971Zinc 1; via pros nitrogen By similarity
Metal binding1361Zinc 2 By similarity
Metal binding1391Zinc 2 By similarity
Metal binding1521Zinc 2; via tele nitrogen By similarity
Metal binding1581Zinc 2; via pros nitrogen By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7 Ref.9

Natural variations

Alternative sequence581E → EAQFFPHSRTVIPILVLSET YSLCHP in isoform 2.
VSP_015971
Alternative sequence94 – 12532Missing in isoform 3.
VSP_055098

Experimental info

Sequence conflict1521H → Y in CAH18475. Ref.3

Secondary structure

........... 294
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 095F02E19FBCFBE0

FASTA29432,933
        10         20         30         40         50         60 
MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG AQPVGREEVE 

        70         80         90        100        110        120 
HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK VKRYLAIHGM ETLKGETKKL 

       130        140        150        160        170        180 
DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ SHYLGKTHAK NLKLKQQSTK VEALHQNREM 

       190        200        210        220        230        240 
IDPDKFCSLC HATFNDPVMA QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP 

       250        260        270        280        290 
CKTCKIVLNS IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED 

« Hide

Isoform 2 [UniParc].

Checksum: 42E18B795453AEB0
Show »

FASTA31935,771
Isoform 3 [UniParc].

Checksum: 5EAB16A18CAE634C
Show »

FASTA26229,267

References

« Hide 'large scale' references
[1]"JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization."
Yang M., May W.S., Ito T.
J. Biol. Chem. 274:27399-27406(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Hippocampus and Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[6]"Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5."
Chen T., Brownawell A.M., Macara I.G.
Mol. Cell. Biol. 24:6608-6619(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN; ILF3 AND DOUBLE-STRANDED RNA, SUBCELLULAR LOCATION, INTERACTION WITH XPO5 AND ILF3.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids."
Burge R.G., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
Biochemistry 53:1495-1510(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 168-227, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF083340 mRNA. Translation: AAD52018.1.
AK131469 mRNA. Translation: BAD18614.1.
AK295549 mRNA. Translation: BAH12103.1.
CR749692 mRNA. Translation: CAH18475.1.
AC027314 Genomic DNA. No translation available.
AC027317 Genomic DNA. No translation available.
BC007775 mRNA. Translation: AAH07775.1.
CCDSCCDS4409.1. [Q9UL40-1]
RefSeqNP_036411.1. NM_012279.2. [Q9UL40-1]
XP_006714900.1. XM_006714837.1. [Q9UL40-2]
UniGeneHs.484259.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2MKDNMR-A168-227[»]
2MKNNMR-A181-224[»]
ProteinModelPortalQ9UL40.
SMRQ9UL40. Positions 53-227, 240-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117109. 9 interactions.
IntActQ9UL40. 6 interactions.
STRING9606.ENSP00000350869.

Polymorphism databases

DMDM74735051.

Proteomic databases

MaxQBQ9UL40.
PaxDbQ9UL40.
PRIDEQ9UL40.

Protocols and materials databases

DNASU23567.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261948; ENSP00000261948; ENSG00000113761. [Q9UL40-2]
ENST00000358149; ENSP00000350869; ENSG00000113761. [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761. [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761.
GeneID23567.
KEGGhsa:23567.
UCSCuc003mfi.3. human. [Q9UL40-1]
uc003mfk.1. human. [Q9UL40-2]

Organism-specific databases

CTD23567.
GeneCardsGC05P176382.
HGNCHGNC:16403. ZNF346.
HPAHPA018485.
MIM605308. gene.
neXtProtNX_Q9UL40.
PharmGKBPA134898181.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85918.
HOGENOMHOG000008682.
HOVERGENHBG061007.
OMAEVEHMIQ.
PhylomeDBQ9UL40.
TreeFamTF350019.

Gene expression databases

ArrayExpressQ9UL40.
BgeeQ9UL40.
CleanExHS_ZNF346.
GenevestigatorQ9UL40.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF346. human.
GeneWikiZNF346.
GenomeRNAi23567.
NextBio46164.
PROQ9UL40.
SOURCESearch...

Entry information

Entry nameZN346_HUMAN
AccessionPrimary (citable) accession number: Q9UL40
Secondary accession number(s): B7Z367, Q68CV9, Q6ZMW1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM