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Q9UL40

- ZN346_HUMAN

UniProt

Q9UL40 - ZN346_HUMAN

Protein

Zinc finger protein 346

Gene

ZNF346

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Zinc 1By similarity
    Metal bindingi78 – 781Zinc 1By similarity
    Metal bindingi91 – 911Zinc 1; via tele nitrogenBy similarity
    Metal bindingi97 – 971Zinc 1; via pros nitrogenBy similarity
    Metal bindingi136 – 1361Zinc 2By similarity
    Metal bindingi139 – 1391Zinc 2By similarity
    Metal bindingi152 – 1521Zinc 2; via tele nitrogenBy similarity
    Metal bindingi158 – 1581Zinc 2; via pros nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10435Matrin-type 1Add
    BLAST
    Zinc fingeri131 – 16535Matrin-type 2Add
    BLAST
    Zinc fingeri182 – 21635Matrin-type 3Add
    BLAST
    Zinc fingeri236 – 27035Matrin-type 4Add
    BLAST

    GO - Molecular functioni

    1. double-stranded RNA binding Source: UniProtKB
    2. enzyme binding Source: UniProt
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of apoptotic process Source: Ensembl

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 346
    Alternative name(s):
    Just another zinc finger protein
    Gene namesi
    Name:ZNF346
    Synonyms:JAZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:16403. ZNF346.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Cytoplasm 1 Publication
    Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134898181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Zinc finger protein 346PRO_0000191809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9UL40.
    PaxDbiQ9UL40.
    PRIDEiQ9UL40.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UL40.
    BgeeiQ9UL40.
    CleanExiHS_ZNF346.
    GenevestigatoriQ9UL40.

    Organism-specific databases

    HPAiHPA018485.

    Interactioni

    Subunit structurei

    Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF2AK2P195252EBI-2462313,EBI-640775

    Protein-protein interaction databases

    BioGridi117109. 27 interactions.
    IntActiQ9UL40. 6 interactions.
    STRINGi9606.ENSP00000350869.

    Structurei

    Secondary structure

    1
    294
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni176 – 1783
    Beta strandi185 – 1873
    Turni188 – 1914
    Beta strandi192 – 1943
    Helixi197 – 2037
    Helixi207 – 22216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MKDNMR-A168-227[»]
    2MKNNMR-A181-224[»]
    ProteinModelPortaliQ9UL40.
    SMRiQ9UL40. Positions 53-227, 240-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.By similarity

    Sequence similaritiesi

    Contains 4 matrin-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10435Matrin-type 1Add
    BLAST
    Zinc fingeri131 – 16535Matrin-type 2Add
    BLAST
    Zinc fingeri182 – 21635Matrin-type 3Add
    BLAST
    Zinc fingeri236 – 27035Matrin-type 4Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG85918.
    HOGENOMiHOG000008682.
    HOVERGENiHBG061007.
    OMAiEVEHMIQ.
    PhylomeDBiQ9UL40.
    TreeFamiTF350019.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UL40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG    50
    AQPVGREEVE HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK 100
    VKRYLAIHGM ETLKGETKKL DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ 150
    SHYLGKTHAK NLKLKQQSTK VEALHQNREM IDPDKFCSLC HATFNDPVMA 200
    QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP CKTCKIVLNS 250
    IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED 294
    Length:294
    Mass (Da):32,933
    Last modified:May 1, 2000 - v1
    Checksum:i095F02E19FBCFBE0
    GO
    Isoform 2 (identifier: Q9UL40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-58: E → EAQFFPHSRTVIPILVLSETYSLCHP

    Note: No experimental confirmation available.

    Show »
    Length:319
    Mass (Da):35,771
    Checksum:i42E18B795453AEB0
    GO
    Isoform 3 (identifier: Q9UL40-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-125: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:262
    Mass (Da):29,267
    Checksum:i5EAB16A18CAE634C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521H → Y in CAH18475. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei58 – 581E → EAQFFPHSRTVIPILVLSET YSLCHP in isoform 2. 1 PublicationVSP_015971
    Alternative sequencei94 – 12532Missing in isoform 3. 1 PublicationVSP_055098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083340 mRNA. Translation: AAD52018.1.
    AK131469 mRNA. Translation: BAD18614.1.
    AK295549 mRNA. Translation: BAH12103.1.
    CR749692 mRNA. Translation: CAH18475.1.
    AC027314 Genomic DNA. No translation available.
    AC027317 Genomic DNA. No translation available.
    BC007775 mRNA. Translation: AAH07775.1.
    CCDSiCCDS4409.1. [Q9UL40-1]
    RefSeqiNP_036411.1. NM_012279.2. [Q9UL40-1]
    XP_006714900.1. XM_006714837.1. [Q9UL40-2]
    UniGeneiHs.484259.

    Genome annotation databases

    EnsembliENST00000358149; ENSP00000350869; ENSG00000113761. [Q9UL40-1]
    ENST00000503039; ENSP00000424495; ENSG00000113761. [Q9UL40-2]
    ENST00000503425; ENSP00000421212; ENSG00000113761. [Q9UL40-3]
    GeneIDi23567.
    KEGGihsa:23567.
    UCSCiuc003mfi.3. human. [Q9UL40-1]
    uc003mfk.1. human. [Q9UL40-2]

    Polymorphism databases

    DMDMi74735051.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083340 mRNA. Translation: AAD52018.1 .
    AK131469 mRNA. Translation: BAD18614.1 .
    AK295549 mRNA. Translation: BAH12103.1 .
    CR749692 mRNA. Translation: CAH18475.1 .
    AC027314 Genomic DNA. No translation available.
    AC027317 Genomic DNA. No translation available.
    BC007775 mRNA. Translation: AAH07775.1 .
    CCDSi CCDS4409.1. [Q9UL40-1 ]
    RefSeqi NP_036411.1. NM_012279.2. [Q9UL40-1 ]
    XP_006714900.1. XM_006714837.1. [Q9UL40-2 ]
    UniGenei Hs.484259.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MKD NMR - A 168-227 [» ]
    2MKN NMR - A 181-224 [» ]
    ProteinModelPortali Q9UL40.
    SMRi Q9UL40. Positions 53-227, 240-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117109. 27 interactions.
    IntActi Q9UL40. 6 interactions.
    STRINGi 9606.ENSP00000350869.

    Polymorphism databases

    DMDMi 74735051.

    Proteomic databases

    MaxQBi Q9UL40.
    PaxDbi Q9UL40.
    PRIDEi Q9UL40.

    Protocols and materials databases

    DNASUi 23567.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358149 ; ENSP00000350869 ; ENSG00000113761 . [Q9UL40-1 ]
    ENST00000503039 ; ENSP00000424495 ; ENSG00000113761 . [Q9UL40-2 ]
    ENST00000503425 ; ENSP00000421212 ; ENSG00000113761 . [Q9UL40-3 ]
    GeneIDi 23567.
    KEGGi hsa:23567.
    UCSCi uc003mfi.3. human. [Q9UL40-1 ]
    uc003mfk.1. human. [Q9UL40-2 ]

    Organism-specific databases

    CTDi 23567.
    GeneCardsi GC05P176382.
    HGNCi HGNC:16403. ZNF346.
    HPAi HPA018485.
    MIMi 605308. gene.
    neXtProti NX_Q9UL40.
    PharmGKBi PA134898181.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85918.
    HOGENOMi HOG000008682.
    HOVERGENi HBG061007.
    OMAi EVEHMIQ.
    PhylomeDBi Q9UL40.
    TreeFami TF350019.

    Miscellaneous databases

    ChiTaRSi ZNF346. human.
    GeneWikii ZNF346.
    GenomeRNAii 23567.
    NextBioi 35479161.
    PROi Q9UL40.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UL40.
    Bgeei Q9UL40.
    CleanExi HS_ZNF346.
    Genevestigatori Q9UL40.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization."
      Yang M., May W.S., Ito T.
      J. Biol. Chem. 274:27399-27406(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Hippocampus and Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    6. "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5."
      Chen T., Brownawell A.M., Macara I.G.
      Mol. Cell. Biol. 24:6608-6619(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN; ILF3 AND DOUBLE-STRANDED RNA, SUBCELLULAR LOCATION, INTERACTION WITH XPO5 AND ILF3.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids."
      Burge R.G., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
      Biochemistry 53:1495-1510(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 168-227, FUNCTION.

    Entry informationi

    Entry nameiZN346_HUMAN
    AccessioniPrimary (citable) accession number: Q9UL40
    Secondary accession number(s): B7Z367, Q68CV9, Q6ZMW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3