Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 346

Gene

ZNF346

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1By similarity1
Metal bindingi78Zinc 1By similarity1
Metal bindingi91Zinc 1; via tele nitrogenBy similarity1
Metal bindingi97Zinc 1; via pros nitrogenBy similarity1
Metal bindingi136Zinc 2By similarity1
Metal bindingi139Zinc 2By similarity1
Metal bindingi152Zinc 2; via tele nitrogenBy similarity1
Metal bindingi158Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • p53 binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113761-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:ZNF346
Synonyms:JAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16403. ZNF346.

Subcellular locationi

  • Nucleusnucleolus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113761.
PharmGKBiPA134898181.

Polymorphism and mutation databases

BioMutaiZNF346.
DMDMi74735051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918091 – 294Zinc finger protein 346Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UL40.
PaxDbiQ9UL40.
PeptideAtlasiQ9UL40.
PRIDEiQ9UL40.

PTM databases

iPTMnetiQ9UL40.
PhosphoSitePlusiQ9UL40.

Expressioni

Gene expression databases

BgeeiENSG00000113761.
CleanExiHS_ZNF346.
ExpressionAtlasiQ9UL40. baseline and differential.
GenevisibleiQ9UL40. HS.

Organism-specific databases

HPAiHPA018485.

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2AK2P195252EBI-2462313,EBI-640775
TARBP2Q156333EBI-2462313,EBI-978581

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • p53 binding Source: GO_Central

Protein-protein interaction databases

BioGridi117109. 38 interactors.
IntActiQ9UL40. 18 interactors.
STRINGi9606.ENSP00000350869.

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni176 – 178Combined sources3
Beta strandi185 – 187Combined sources3
Turni188 – 191Combined sources4
Beta strandi192 – 194Combined sources3
Helixi197 – 203Combined sources7
Helixi207 – 222Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKDNMR-A168-227[»]
2MKNNMR-A168-227[»]
ProteinModelPortaliQ9UL40.
SMRiQ9UL40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.By similarity

Sequence similaritiesi

Contains 4 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4K. Eukaryota.
ENOG4111JFP. LUCA.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9UL40.
OMAiQIPMQRQ.
OrthoDBiEOG091G0GWT.
PhylomeDBiQ9UL40.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG
60 70 80 90 100
AQPVGREEVE HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK
110 120 130 140 150
VKRYLAIHGM ETLKGETKKL DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ
160 170 180 190 200
SHYLGKTHAK NLKLKQQSTK VEALHQNREM IDPDKFCSLC HATFNDPVMA
210 220 230 240 250
QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP CKTCKIVLNS
260 270 280 290
IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED
Length:294
Mass (Da):32,933
Last modified:May 1, 2000 - v1
Checksum:i095F02E19FBCFBE0
GO
Isoform 2 (identifier: Q9UL40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: E → EAQFFPHSRTVIPILVLSETYSLCHP

Note: No experimental confirmation available.
Show »
Length:319
Mass (Da):35,771
Checksum:i42E18B795453AEB0
GO
Isoform 3 (identifier: Q9UL40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-125: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,267
Checksum:i5EAB16A18CAE634C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152H → Y in CAH18475 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01597158E → EAQFFPHSRTVIPILVLSET YSLCHP in isoform 2. 1 Publication1
Alternative sequenceiVSP_05509894 – 125Missing in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083340 mRNA. Translation: AAD52018.1.
AK131469 mRNA. Translation: BAD18614.1.
AK295549 mRNA. Translation: BAH12103.1.
CR749692 mRNA. Translation: CAH18475.1.
AC027314 Genomic DNA. No translation available.
AC027317 Genomic DNA. No translation available.
BC007775 mRNA. Translation: AAH07775.1.
CCDSiCCDS4409.1. [Q9UL40-1]
CCDS78094.1. [Q9UL40-2]
CCDS83052.1. [Q9UL40-3]
RefSeqiNP_001295142.1. NM_001308213.1. [Q9UL40-2]
NP_001295143.1. NM_001308214.1. [Q9UL40-3]
NP_001295148.1. NM_001308219.1.
NP_001295152.1. NM_001308223.1.
NP_036411.1. NM_012279.3. [Q9UL40-1]
XP_016864784.1. XM_017009295.1. [Q9UL40-1]
XP_016864785.1. XM_017009296.1. [Q9UL40-1]
UniGeneiHs.484259.
Hs.671568.

Genome annotation databases

EnsembliENST00000358149; ENSP00000350869; ENSG00000113761. [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761. [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761. [Q9UL40-3]
GeneIDi23567.
KEGGihsa:23567.
UCSCiuc003mfi.4. human. [Q9UL40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083340 mRNA. Translation: AAD52018.1.
AK131469 mRNA. Translation: BAD18614.1.
AK295549 mRNA. Translation: BAH12103.1.
CR749692 mRNA. Translation: CAH18475.1.
AC027314 Genomic DNA. No translation available.
AC027317 Genomic DNA. No translation available.
BC007775 mRNA. Translation: AAH07775.1.
CCDSiCCDS4409.1. [Q9UL40-1]
CCDS78094.1. [Q9UL40-2]
CCDS83052.1. [Q9UL40-3]
RefSeqiNP_001295142.1. NM_001308213.1. [Q9UL40-2]
NP_001295143.1. NM_001308214.1. [Q9UL40-3]
NP_001295148.1. NM_001308219.1.
NP_001295152.1. NM_001308223.1.
NP_036411.1. NM_012279.3. [Q9UL40-1]
XP_016864784.1. XM_017009295.1. [Q9UL40-1]
XP_016864785.1. XM_017009296.1. [Q9UL40-1]
UniGeneiHs.484259.
Hs.671568.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKDNMR-A168-227[»]
2MKNNMR-A168-227[»]
ProteinModelPortaliQ9UL40.
SMRiQ9UL40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117109. 38 interactors.
IntActiQ9UL40. 18 interactors.
STRINGi9606.ENSP00000350869.

PTM databases

iPTMnetiQ9UL40.
PhosphoSitePlusiQ9UL40.

Polymorphism and mutation databases

BioMutaiZNF346.
DMDMi74735051.

Proteomic databases

EPDiQ9UL40.
PaxDbiQ9UL40.
PeptideAtlasiQ9UL40.
PRIDEiQ9UL40.

Protocols and materials databases

DNASUi23567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358149; ENSP00000350869; ENSG00000113761. [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761. [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761. [Q9UL40-3]
GeneIDi23567.
KEGGihsa:23567.
UCSCiuc003mfi.4. human. [Q9UL40-1]

Organism-specific databases

CTDi23567.
GeneCardsiZNF346.
HGNCiHGNC:16403. ZNF346.
HPAiHPA018485.
MIMi605308. gene.
neXtProtiNX_Q9UL40.
OpenTargetsiENSG00000113761.
PharmGKBiPA134898181.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ4K. Eukaryota.
ENOG4111JFP. LUCA.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9UL40.
OMAiQIPMQRQ.
OrthoDBiEOG091G0GWT.
PhylomeDBiQ9UL40.
TreeFamiTF350019.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113761-MONOMER.

Miscellaneous databases

ChiTaRSiZNF346. human.
GeneWikiiZNF346.
GenomeRNAii23567.
PROiQ9UL40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113761.
CleanExiHS_ZNF346.
ExpressionAtlasiQ9UL40. baseline and differential.
GenevisibleiQ9UL40. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_HUMAN
AccessioniPrimary (citable) accession number: Q9UL40
Secondary accession number(s): B7Z367, Q68CV9, Q6ZMW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.