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Protein

Zinc finger protein 236

Gene

ZNF236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 236
Gene namesi
Name:ZNF236
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:13028. ZNF236.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7776.
OpenTargetsiENSG00000130856.
PharmGKBiPA37606.

Polymorphism and mutation databases

BioMutaiZNF236.
DMDMi296453040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474761 – 1845Zinc finger protein 236Add BLAST1845

Proteomic databases

EPDiQ9UL36.
PaxDbiQ9UL36.
PeptideAtlasiQ9UL36.
PRIDEiQ9UL36.

PTM databases

iPTMnetiQ9UL36.
PhosphoSitePlusiQ9UL36.

Expressioni

Tissue specificityi

Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.

Gene expression databases

BgeeiENSG00000130856.
CleanExiHS_ZNF236.
ExpressionAtlasiQ9UL36. baseline and differential.
GenevisibleiQ9UL36. HS.

Organism-specific databases

HPAiHPA008600.

Interactioni

Protein-protein interaction databases

BioGridi113558. 1 interactor.
STRINGi9606.ENSP00000253159.

Structurei

3D structure databases

ProteinModelPortaliQ9UL36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 30 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129863.
HOGENOMiHOG000168751.
HOVERGENiHBG079380.
InParanoidiQ9UL36.
PhylomeDBiQ9UL36.
TreeFamiTF350781.

Family and domain databases

Gene3Di3.30.160.60. 27 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 30 hits.
PS50157. ZINC_FINGER_C2H2_2. 30 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q9UL36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLCGLLERC WLHHDPDGVL TLNAENTNYA YQVPNFHKCE ICLLSFPKES
60 70 80 90 100
QFQRHMRDHE RNDKPHRCDQ CPQTFNVEFN LTLHKCTHSG EDPTCPVCNK
110 120 130 140 150
KFSRVASLKA HIMLHEKEEN LICSECGDEF TLQSQLAVHM EEHRQELAGT
160 170 180 190 200
RQHACKACKK EFETSSELKE HMKTHYKIRV SSTRSYNRNI DRSGFTYSCP
210 220 230 240 250
HCGKTFQKPS QLTRHIRIHT GERPFKCSEC GKAFNQKGAL QTHMIKHTGE
260 270 280 290 300
KPHACAFCPA AFSQKGNLQS HVQRVHSEVK NGPTYNCTEC SCVFKSLGSL
310 320 330 340 350
NTHISKMHMG GPQNSTSSTE TAHVLTATLF QTLPLQQTEA QATSASSQPS
360 370 380 390 400
SQAVSDVIQQ LLELSEPAPV ESGQSPQPGQ QLSITVGINQ DILQQALENS
410 420 430 440 450
GLSSIPAAAH PNDSCHAKTS APHAQNPDVS SVSNEQTDPT DAEQEKEQES
460 470 480 490 500
PEKLDKKEKK MIKKKSPFLP GSIREENGVR WHVCPYCAKE FRKPSDLVRH
510 520 530 540 550
IRIHTHEKPF KCPQCFRAFA VKSTLTAHIK THTGIKAFKC QYCMKSFSTS
560 570 580 590 600
GSLKVHIRLH TGVRPFACPH CDKKFRTSGH RKTHIASHFK HTELRKMRHQ
610 620 630 640 650
RKPAKVRVGK TNIPVPDIPL QEPILITDLG LIQPIPKNQF FQSYFNNNFV
660 670 680 690 700
NEADRPYKCF YCHRAYKKSC HLKQHIRSHT GEKPFKCSQC GRGFVSAGVL
710 720 730 740 750
KAHIRTHTGL KSFKCLICNG AFTTGGSLRR HMGIHNDLRP YMCPYCQKTF
760 770 780 790 800
KTSLNCKKHM KTHRYELAQQ LQQHQQAASI DDSTVDQQSM QASTQMQVEI
810 820 830 840 850
ESDELPQTAE VVAANPEAML DLEPQHVVGT EEAGLGQQLA DQPLEADEDG
860 870 880 890 900
FVAPQDPLRG HVDQFEEQSP AQQSFEPAGL PQGFTVTDTY HQQPQFPPVQ
910 920 930 940 950
QLQDSSTLES QALSTSFHQQ SLLQAPSSDG MNVTTRLIQE SSQEELDLQA
960 970 980 990 1000
QGSQFLEDNE DQSRRSYRCD YCNKGFKKSS HLKQHVRSHT GEKPYKCKLC
1010 1020 1030 1040 1050
GRGFVSSGVL KSHEKTHTGV KAFSCSVCNA SFTTNGSLTR HMATHMSMKP
1060 1070 1080 1090 1100
YKCPFCEEGF RTTVHCKKHM KRHQTVPSAV SATGETEGGD ICMEEEEEHS
1110 1120 1130 1140 1150
DRNASRKSRP EVITFTEEET AQLAKIRPQE SATVSEKVLV QSAAEKDRIS
1160 1170 1180 1190 1200
ELRDKQAELQ DEPKHANCCT YCPKSFKKPS DLVRHVRIHT GEKPYKCDEC
1210 1220 1230 1240 1250
GKSFTVKSTL DCHVKTHTGQ KLFSCHVCSN AFSTKGSLKV HMRLHTGAKP
1260 1270 1280 1290 1300
FKCPHCELRF RTSGRRKTHM QFHYKPDPKK ARKPMTRSSS EGLQPVNLLN
1310 1320 1330 1340 1350
SSSTDPNVFI MNNSVLTGQF DQNLLQPGLV GQAILPASVS AGGDLTVSLT
1360 1370 1380 1390 1400
DGSLATLEGI QLQLAANLVG PNVQISGIDA ASINNITLQI DPSILQQTLQ
1410 1420 1430 1440 1450
QGNLLAQQLT GEPGLAPQNS SLQTSDSTVP ASVVIQPISG LSLQPTVTSA
1460 1470 1480 1490 1500
NLTIGPLSEQ DSVLTTNSSG TQDLTQVMTS QGLVSPSGGP HEITLTINNS
1510 1520 1530 1540 1550
SLSQVLAQAA GPTATSSSGS PQEITLTISE LNTTSGSLPS TTPMSPSAIS
1560 1570 1580 1590 1600
TQNLVMSSSG VGGDASVTLT LADTQGMLSG GLDTVTLNIT SQGQQFPALL
1610 1620 1630 1640 1650
TDPSLSGQGG AGSPQVILVS HTPQSASAAC EEIAYQVAGV SGNLAPGNQP
1660 1670 1680 1690 1700
EKEGRAHQCL ECDRAFSSAA VLMHHSKEVH GRERIHGCPV CRKAFKRATH
1710 1720 1730 1740 1750
LKEHMQTHQA GPSLSSQKPR VFKCDTCEKA FAKPSQLERH SRIHTGERPF
1760 1770 1780 1790 1800
HCTLCEKAFN QKSALQVHMK KHTGERPYKC AYCVMGFTQK SNMKLHMKRA
1810 1820 1830 1840
HSYAGALQES AGHPEQDGEE LSRTLHLEEV VQEAAGEWQA LTHVF
Length:1,845
Mass (Da):203,704
Last modified:May 18, 2010 - v2
Checksum:iDEC98655EEC0DB09
GO
Isoform A (identifier: Q9UL36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1530-1558: ELNTTSGSLPSTTPMSPSAISTQNLVMSS → GSRSVQHSVGPQECGSVEALYLENSSDKT
     1559-1845: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,558
Mass (Da):172,707
Checksum:i03A7F013E023EF14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1544M → T in AAD55329 (PubMed:10458916).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057410166S → L.Corresponds to variant rs2276211dbSNPEnsembl.1
Natural variantiVAR_065094613I → V.3 PublicationsCorresponds to variant rs608433dbSNPEnsembl.1
Natural variantiVAR_057411614P → S.Corresponds to variant rs8093707dbSNPEnsembl.1
Natural variantiVAR_057412643S → G.Corresponds to variant rs3794873dbSNPEnsembl.1
Natural variantiVAR_057413818A → T.Corresponds to variant rs3752078dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069071530 – 1558ELNTT…LVMSS → GSRSVQHSVGPQECGSVEAL YLENSSDKT in isoform A. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0069081559 – 1845Missing in isoform A. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085244 mRNA. Translation: AAD55329.1.
AF085243 mRNA. Translation: AAD55328.1.
AC027575 Genomic DNA. No translation available.
AC093330 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66587.1.
BC140859 mRNA. Translation: AAI40860.1.
CCDSiCCDS42447.1. [Q9UL36-1]
RefSeqiNP_001293018.1. NM_001306089.1.
NP_031371.3. NM_007345.3. [Q9UL36-1]
XP_011524467.1. XM_011526165.2. [Q9UL36-1]
UniGeneiHs.719137.

Genome annotation databases

EnsembliENST00000253159; ENSP00000253159; ENSG00000130856. [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856. [Q9UL36-2]
GeneIDi7776.
KEGGihsa:7776.
UCSCiuc002lmi.4. human. [Q9UL36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085244 mRNA. Translation: AAD55329.1.
AF085243 mRNA. Translation: AAD55328.1.
AC027575 Genomic DNA. No translation available.
AC093330 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66587.1.
BC140859 mRNA. Translation: AAI40860.1.
CCDSiCCDS42447.1. [Q9UL36-1]
RefSeqiNP_001293018.1. NM_001306089.1.
NP_031371.3. NM_007345.3. [Q9UL36-1]
XP_011524467.1. XM_011526165.2. [Q9UL36-1]
UniGeneiHs.719137.

3D structure databases

ProteinModelPortaliQ9UL36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113558. 1 interactor.
STRINGi9606.ENSP00000253159.

PTM databases

iPTMnetiQ9UL36.
PhosphoSitePlusiQ9UL36.

Polymorphism and mutation databases

BioMutaiZNF236.
DMDMi296453040.

Proteomic databases

EPDiQ9UL36.
PaxDbiQ9UL36.
PeptideAtlasiQ9UL36.
PRIDEiQ9UL36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253159; ENSP00000253159; ENSG00000130856. [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856. [Q9UL36-2]
GeneIDi7776.
KEGGihsa:7776.
UCSCiuc002lmi.4. human. [Q9UL36-1]

Organism-specific databases

CTDi7776.
DisGeNETi7776.
GeneCardsiZNF236.
HGNCiHGNC:13028. ZNF236.
HPAiHPA008600.
MIMi604760. gene.
neXtProtiNX_Q9UL36.
OpenTargetsiENSG00000130856.
PharmGKBiPA37606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129863.
HOGENOMiHOG000168751.
HOVERGENiHBG079380.
InParanoidiQ9UL36.
PhylomeDBiQ9UL36.
TreeFamiTF350781.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130856-MONOMER.

Miscellaneous databases

ChiTaRSiZNF236. human.
GenomeRNAii7776.
PROiQ9UL36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130856.
CleanExiHS_ZNF236.
ExpressionAtlasiQ9UL36. baseline and differential.
GenevisibleiQ9UL36. HS.

Family and domain databases

Gene3Di3.30.160.60. 27 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 30 hits.
PS50157. ZINC_FINGER_C2H2_2. 30 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN236_HUMAN
AccessioniPrimary (citable) accession number: Q9UL36
Secondary accession number(s): B2RTX9, Q9UL37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.