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Protein

Trafficking protein particle complex subunit 2-like protein

Gene

TRAPPC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 2-like protein
Gene namesi
ORF Names:HSPC126
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30887. TRAPPC2L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147879.

Polymorphism and mutation databases

BioMutaiTRAPPC2L.
DMDMi74721024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Trafficking protein particle complex subunit 2-like proteinPRO_0000294451Add
BLAST

Proteomic databases

EPDiQ9UL33.
MaxQBiQ9UL33.
PaxDbiQ9UL33.
PRIDEiQ9UL33.

PTM databases

iPTMnetiQ9UL33.
PhosphoSiteiQ9UL33.

Expressioni

Tissue specificityi

Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.1 Publication

Gene expression databases

BgeeiQ9UL33.
CleanExiHS_TRAPPC2L.
ExpressionAtlasiQ9UL33. baseline and differential.
GenevisibleiQ9UL33. HS.

Organism-specific databases

HPAiHPA041714.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A. Interacts with TRAPPC6A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BLZF1Q9H2G93EBI-747601,EBI-2548012
CEP57L1Q8IYX8-23EBI-747601,EBI-10181988
RELQ048643EBI-747601,EBI-307352
REPS1Q96D71-23EBI-747601,EBI-10284498
REPS1Q96D71-33EBI-747601,EBI-10284512
TCF4P158843EBI-747601,EBI-533224
TRAPPC3O436176EBI-747601,EBI-743566
TRIP6Q156543EBI-747601,EBI-742327

Protein-protein interaction databases

BioGridi119681. 30 interactions.
IntActiQ9UL33. 17 interactions.
MINTiMINT-4541589.
STRINGi9606.ENSP00000301021.

Structurei

3D structure databases

ProteinModelPortaliQ9UL33.
SMRiQ9UL33. Positions 29-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3444. Eukaryota.
ENOG4111IEZ. LUCA.
GeneTreeiENSGT00510000047505.
HOGENOMiHOG000230646.
HOVERGENiHBG056603.
PhylomeDBiQ9UL33.
TreeFamiTF323920.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PANTHERiPTHR12403. PTHR12403. 1 hit.
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVCIAVIAK ENYPLYIRST PTENELKFHY MVHTSLDVVD EKISAMGKAL
60 70 80 90 100
VDQRELYLGL LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF
110 120 130 140
RKLHNSYTDV MCNPFYNPGD RIQSSRAFDN MVTSMMIQVC
Length:140
Mass (Da):16,146
Last modified:May 1, 2000 - v1
Checksum:i4549BCA7CE9566DC
GO
Isoform 2 (identifier: Q9UL33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: Missing.

Show »
Length:139
Mass (Da):16,059
Checksum:i027C66E8D9B96662
GO

Sequence cautioni

The sequence BAC86686.1 differs from that shown.Intron retention.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 1251Missing in isoform 2. 2 PublicationsVSP_026641

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089106 mRNA. Translation: AAF00568.1.
AF161524 mRNA. Translation: AAF29139.1.
AK126779 mRNA. Translation: BAC86686.1. Sequence problems.
AK311885 mRNA. Translation: BAG34826.1.
AC092384 Genomic DNA. No translation available.
BC011369 mRNA. Translation: AAH11369.1.
BC018024 mRNA. Translation: AAH18024.1.
BC105809 mRNA. Translation: AAI05810.1.
CCDSiCCDS10971.1. [Q9UL33-1]
RefSeqiNP_001305453.1. NM_001318524.1.
NP_001305454.1. NM_001318525.1. [Q9UL33-2]
NP_001305455.1. NM_001318526.1.
NP_001305456.1. NM_001318527.1.
NP_001305457.1. NM_001318528.1.
NP_001305458.1. NM_001318529.1.
NP_001305459.1. NM_001318530.1.
NP_001305461.1. NM_001318532.1.
NP_057293.1. NM_016209.4. [Q9UL33-1]
UniGeneiHs.461722.
Hs.732161.

Genome annotation databases

EnsembliENST00000301021; ENSP00000301021; ENSG00000167515. [Q9UL33-1]
GeneIDi51693.
KEGGihsa:51693.
UCSCiuc002fmg.4. human. [Q9UL33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089106 mRNA. Translation: AAF00568.1.
AF161524 mRNA. Translation: AAF29139.1.
AK126779 mRNA. Translation: BAC86686.1. Sequence problems.
AK311885 mRNA. Translation: BAG34826.1.
AC092384 Genomic DNA. No translation available.
BC011369 mRNA. Translation: AAH11369.1.
BC018024 mRNA. Translation: AAH18024.1.
BC105809 mRNA. Translation: AAI05810.1.
CCDSiCCDS10971.1. [Q9UL33-1]
RefSeqiNP_001305453.1. NM_001318524.1.
NP_001305454.1. NM_001318525.1. [Q9UL33-2]
NP_001305455.1. NM_001318526.1.
NP_001305456.1. NM_001318527.1.
NP_001305457.1. NM_001318528.1.
NP_001305458.1. NM_001318529.1.
NP_001305459.1. NM_001318530.1.
NP_001305461.1. NM_001318532.1.
NP_057293.1. NM_016209.4. [Q9UL33-1]
UniGeneiHs.461722.
Hs.732161.

3D structure databases

ProteinModelPortaliQ9UL33.
SMRiQ9UL33. Positions 29-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119681. 30 interactions.
IntActiQ9UL33. 17 interactions.
MINTiMINT-4541589.
STRINGi9606.ENSP00000301021.

PTM databases

iPTMnetiQ9UL33.
PhosphoSiteiQ9UL33.

Polymorphism and mutation databases

BioMutaiTRAPPC2L.
DMDMi74721024.

Proteomic databases

EPDiQ9UL33.
MaxQBiQ9UL33.
PaxDbiQ9UL33.
PRIDEiQ9UL33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301021; ENSP00000301021; ENSG00000167515. [Q9UL33-1]
GeneIDi51693.
KEGGihsa:51693.
UCSCiuc002fmg.4. human. [Q9UL33-1]

Organism-specific databases

CTDi51693.
GeneCardsiTRAPPC2L.
H-InvDBHIX0019527.
HGNCiHGNC:30887. TRAPPC2L.
HPAiHPA041714.
MIMi610970. gene.
neXtProtiNX_Q9UL33.
PharmGKBiPA145147879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3444. Eukaryota.
ENOG4111IEZ. LUCA.
GeneTreeiENSGT00510000047505.
HOGENOMiHOG000230646.
HOVERGENiHBG056603.
PhylomeDBiQ9UL33.
TreeFamiTF323920.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

GenomeRNAii51693.
NextBioi55706.
PROiQ9UL33.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UL33.
CleanExiHS_TRAPPC2L.
ExpressionAtlasiQ9UL33. baseline and differential.
GenevisibleiQ9UL33. HS.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PANTHERiPTHR12403. PTHR12403. 1 hit.
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cDNA complete cds with product weakly homologous to yeast P38334 hypothetical 19.7 KD protein."
    Zhu X., Qu Z.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum and Pericardium.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Eye.
  6. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
    Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
    Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2; TRAPPC3; TRAPPC4 AND TRAPPC6A, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.

Entry informationi

Entry nameiTPC2L_HUMAN
AccessioniPrimary (citable) accession number: Q9UL33
Secondary accession number(s): B2R4M9, Q6ZTA7, Q9NZZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 2000
Last modified: April 13, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.