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Protein

Ras-related protein Rab-22A

Gene

RAB22A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20GTPBy similarity9
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4
Nucleotide bindingi148 – 150GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosome organization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of vesicle size Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-22A
Short name:
Rab-22
Gene namesi
Name:RAB22A
Synonyms:RAB22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9764. RAB22A.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: Ensembl
  • early endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • late endosome Source: UniProtKB-SubCell
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19S → L: Loss of GTPase activity. 1 Publication1
Mutagenesisi64Q → L: Constitutive GTPase activity. Impairs normal protein trafficking through early endosomes. 2 Publications1

Organism-specific databases

DisGeNETi57403.
OpenTargetsiENSG00000124209.
PharmGKBiPA34112.

Polymorphism and mutation databases

BioMutaiRAB22A.
DMDMi13633614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212091 – 194Ras-related protein Rab-22AAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ9UL26.
MaxQBiQ9UL26.
PaxDbiQ9UL26.
PeptideAtlasiQ9UL26.
PRIDEiQ9UL26.

PTM databases

iPTMnetiQ9UL26.
PhosphoSitePlusiQ9UL26.

Expressioni

Gene expression databases

BgeeiENSG00000124209.
CleanExiHS_RAB22A.
GenevisibleiQ9UL26. HS.

Organism-specific databases

HPAiHPA058894.
HPA066920.

Interactioni

Subunit structurei

Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1. Interacts (in its GTP-bound form) with RINL.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL2Q8NEU86EBI-399456,EBI-741261
EEA1Q150753EBI-399456,EBI-298113

Protein-protein interaction databases

BioGridi121505. 11 interactors.
IntActiQ9UL26. 4 interactors.
MINTiMINT-5003659.
STRINGi9606.ENSP00000244040.

Structurei

3D structure databases

ProteinModelPortaliQ9UL26.
SMRiQ9UL26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9UL26.
KOiK07891.
OMAiKCDLSDA.
OrthoDBiEOG091G0HKN.
PhylomeDBiQ9UL26.
TreeFamiTF331262.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UL26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ
60 70 80 90 100
NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV
110 120 130 140 150
KELRQHGPPN IVVAIAGNKC DLIDVREVME RDAKDYADSI HAIFVETSAK
160 170 180 190
NAININELFI EISRRIPSTD ANLPSGGKGF KLRRQPSEPK RSCC
Length:194
Mass (Da):21,855
Last modified:March 1, 2001 - v2
Checksum:iEBC84711DA3F839B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184R → K in CAC10538 (Ref. 3) Curated1
Sequence conflicti192 – 193SC → TA in AAL75941 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125104 mRNA. Translation: AAL75941.1.
AF091034 mRNA. Translation: AAF00047.2.
AJ276210 mRNA. Translation: CAC10538.1.
BT007046 mRNA. Translation: AAP35695.1.
AK091180 mRNA. Translation: BAG52298.1.
AL035455 Genomic DNA. Translation: CAC15020.1.
CH471077 Genomic DNA. Translation: EAW75496.1.
CH471077 Genomic DNA. Translation: EAW75497.1.
BC015710 mRNA. Translation: AAH15710.1.
BC063457 mRNA. Translation: AAH63457.1.
CCDSiCCDS33497.1.
RefSeqiNP_065724.1. NM_020673.2.
UniGeneiHs.529044.

Genome annotation databases

EnsembliENST00000244040; ENSP00000244040; ENSG00000124209.
GeneIDi57403.
KEGGihsa:57403.
UCSCiuc002xyz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125104 mRNA. Translation: AAL75941.1.
AF091034 mRNA. Translation: AAF00047.2.
AJ276210 mRNA. Translation: CAC10538.1.
BT007046 mRNA. Translation: AAP35695.1.
AK091180 mRNA. Translation: BAG52298.1.
AL035455 Genomic DNA. Translation: CAC15020.1.
CH471077 Genomic DNA. Translation: EAW75496.1.
CH471077 Genomic DNA. Translation: EAW75497.1.
BC015710 mRNA. Translation: AAH15710.1.
BC063457 mRNA. Translation: AAH63457.1.
CCDSiCCDS33497.1.
RefSeqiNP_065724.1. NM_020673.2.
UniGeneiHs.529044.

3D structure databases

ProteinModelPortaliQ9UL26.
SMRiQ9UL26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121505. 11 interactors.
IntActiQ9UL26. 4 interactors.
MINTiMINT-5003659.
STRINGi9606.ENSP00000244040.

PTM databases

iPTMnetiQ9UL26.
PhosphoSitePlusiQ9UL26.

Polymorphism and mutation databases

BioMutaiRAB22A.
DMDMi13633614.

Proteomic databases

EPDiQ9UL26.
MaxQBiQ9UL26.
PaxDbiQ9UL26.
PeptideAtlasiQ9UL26.
PRIDEiQ9UL26.

Protocols and materials databases

DNASUi57403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244040; ENSP00000244040; ENSG00000124209.
GeneIDi57403.
KEGGihsa:57403.
UCSCiuc002xyz.4. human.

Organism-specific databases

CTDi57403.
DisGeNETi57403.
GeneCardsiRAB22A.
HGNCiHGNC:9764. RAB22A.
HPAiHPA058894.
HPA066920.
MIMi612966. gene.
neXtProtiNX_Q9UL26.
OpenTargetsiENSG00000124209.
PharmGKBiPA34112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9UL26.
KOiK07891.
OMAiKCDLSDA.
OrthoDBiEOG091G0HKN.
PhylomeDBiQ9UL26.
TreeFamiTF331262.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124209-MONOMER.

Miscellaneous databases

ChiTaRSiRAB22A. human.
GeneWikiiRAB22A.
GenomeRNAii57403.
PROiQ9UL26.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124209.
CleanExiHS_RAB22A.
GenevisibleiQ9UL26. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB22A_HUMAN
AccessioniPrimary (citable) accession number: Q9UL26
Secondary accession number(s): B3KR86
, E1P605, Q8TF12, Q9H4E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.