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Protein

Ras-related protein Rab-21

Gene

RAB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34GTP9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi132 – 135GTP4
Nucleotide bindingi162 – 164GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • anterograde axonal transport Source: Ensembl
  • positive regulation of dendrite morphogenesis Source: Ensembl
  • positive regulation of early endosome to late endosome transport Source: UniProtKB
  • positive regulation of receptor-mediated endocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of axon extension Source: Ensembl
  • regulation of exocytosis Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.2 2681
ReactomeiR-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Gene namesi
Name:RAB21
Synonyms:KIAA0118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000080371.5
HGNCiHGNC:18263 RAB21
MIMi612398 gene
neXtProtiNX_Q9UL25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33T → N: Defects in GTP-binding. 1 Publication1
Mutagenesisi78Q → L: Defects in GTP hydrolysis. 1 Publication1

Organism-specific databases

DisGeNETi23011
OpenTargetsiENSG00000080371
PharmGKBiPA34111

Polymorphism and mutation databases

BioMutaiRAB21
DMDMi13633613

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001212052 – 222Ras-related protein Rab-21Add BLAST221
PropeptideiPRO_0000370768223 – 225Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Lipidationi221S-geranylgeranyl cysteineBy similarity1
Modified residuei222Cysteine methyl esterSequence analysis1
Lipidationi222S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ9UL25
MaxQBiQ9UL25
PaxDbiQ9UL25
PeptideAtlasiQ9UL25
PRIDEiQ9UL25

PTM databases

CarbonylDBiQ9UL25
iPTMnetiQ9UL25
PhosphoSitePlusiQ9UL25
SwissPalmiQ9UL25

Expressioni

Tissue specificityi

Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.1 Publication

Gene expression databases

BgeeiENSG00000080371
CleanExiHS_RAB21
ExpressionAtlasiQ9UL25 baseline and differential
GenevisibleiQ9UL25 HS

Organism-specific databases

HPAiCAB037048
HPA016988

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG110EBI-1056039,EBI-741243

Protein-protein interaction databases

BioGridi116653, 29 interactors
DIPiDIP-29349N
IntActiQ9UL25, 9 interactors
MINTiQ9UL25
STRINGi9606.ENSP00000261263

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 25Combined sources8
Helixi28 – 30Combined sources3
Helixi32 – 41Combined sources10
Beta strandi46 – 48Combined sources3
Beta strandi55 – 65Combined sources11
Beta strandi67 – 74Combined sources8
Helixi79 – 83Combined sources5
Helixi85 – 89Combined sources5
Beta strandi93 – 100Combined sources8
Helixi104 – 121Combined sources18
Helixi122 – 124Combined sources3
Beta strandi125 – 132Combined sources8
Helixi134 – 139Combined sources6
Helixi144 – 153Combined sources10
Beta strandi157 – 162Combined sources6
Turni163 – 166Combined sources4
Helixi169 – 181Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZTX-ray2.05A/B16-183[»]
1YZUX-ray2.50A/B16-183[»]
1Z08X-ray1.80A/B/C/D16-183[»]
1Z0IX-ray2.33A16-183[»]
2OT3X-ray2.10B16-183[»]
ProteinModelPortaliQ9UL25
SMRiQ9UL25
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UL25

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 56Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0088 Eukaryota
ENOG410XQT5 LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9UL25
KOiK07890
OMAiTDQDSFQ
OrthoDBiEOG091G0HKN
PhylomeDBiQ9UL25
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT
60 70 80 90 100
TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD
110 120 130 140 150
ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY
160 170 180 190 200
AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT
210 220
ARRGVQIIDD EPQAQTSGGG CCSSG
Length:225
Mass (Da):24,348
Last modified:January 23, 2007 - v3
Checksum:i73CA2C127F0CBFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091035 mRNA Translation: AAF00048.1
BC021901 mRNA Translation: AAH21901.1
BC092475 mRNA Translation: AAH92475.1
D42087 mRNA Translation: BAA07682.1
CCDSiCCDS9003.1
RefSeqiNP_055814.1, NM_014999.3
UniGeneiHs.524590

Genome annotation databases

EnsembliENST00000261263; ENSP00000261263; ENSG00000080371
GeneIDi23011
KEGGihsa:23011
UCSCiuc001swt.4 human

Similar proteinsi

Entry informationi

Entry nameiRAB21_HUMAN
AccessioniPrimary (citable) accession number: Q9UL25
Secondary accession number(s): Q14466, Q569H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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