Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-21

Gene

RAB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34GTP9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi132 – 135GTP4
Nucleotide bindingi162 – 164GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • anterograde axonal transport Source: Ensembl
  • positive regulation of dendrite morphogenesis Source: Ensembl
  • positive regulation of early endosome to late endosome transport Source: UniProtKB
  • positive regulation of receptor-mediated endocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of axon extension Source: Ensembl
  • regulation of exocytosis Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080371-MONOMER.
BRENDAi3.6.5.2. 2681.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Gene namesi
Name:RAB21
Synonyms:KIAA0118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18263. RAB21.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • cleavage furrow Source: UniProtKB-SubCell
  • cytoplasmic side of early endosome membrane Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome Source: LIFEdb
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
  • vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33T → N: Defects in GTP-binding. 1 Publication1
Mutagenesisi78Q → L: Defects in GTP hydrolysis. 1 Publication1

Organism-specific databases

DisGeNETi23011.
OpenTargetsiENSG00000080371.
PharmGKBiPA34111.

Polymorphism and mutation databases

BioMutaiRAB21.
DMDMi13633613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001212052 – 222Ras-related protein Rab-21Add BLAST221
PropeptideiPRO_0000370768223 – 225Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Lipidationi221S-geranylgeranyl cysteineBy similarity1
Modified residuei222Cysteine methyl esterSequence analysis1
Lipidationi222S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ9UL25.
MaxQBiQ9UL25.
PaxDbiQ9UL25.
PeptideAtlasiQ9UL25.
PRIDEiQ9UL25.

PTM databases

iPTMnetiQ9UL25.
PhosphoSitePlusiQ9UL25.
SwissPalmiQ9UL25.

Expressioni

Tissue specificityi

Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.1 Publication

Gene expression databases

BgeeiENSG00000080371.
CleanExiHS_RAB21.
ExpressionAtlasiQ9UL25. baseline and differential.
GenevisibleiQ9UL25. HS.

Organism-specific databases

HPAiCAB037048.
HPA016988.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG110EBI-1056039,EBI-741243

Protein-protein interaction databases

BioGridi116653. 18 interactors.
DIPiDIP-29349N.
IntActiQ9UL25. 5 interactors.
MINTiMINT-3081967.
STRINGi9606.ENSP00000261263.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 25Combined sources8
Helixi28 – 30Combined sources3
Helixi32 – 41Combined sources10
Beta strandi46 – 48Combined sources3
Beta strandi55 – 65Combined sources11
Beta strandi67 – 74Combined sources8
Helixi79 – 83Combined sources5
Helixi85 – 89Combined sources5
Beta strandi93 – 100Combined sources8
Helixi104 – 121Combined sources18
Helixi122 – 124Combined sources3
Beta strandi125 – 132Combined sources8
Helixi134 – 139Combined sources6
Helixi144 – 153Combined sources10
Beta strandi157 – 162Combined sources6
Turni163 – 166Combined sources4
Helixi169 – 181Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZTX-ray2.05A/B16-183[»]
1YZUX-ray2.50A/B16-183[»]
1Z08X-ray1.80A/B/C/D16-183[»]
1Z0IX-ray2.33A16-183[»]
2OT3X-ray2.10B16-183[»]
ProteinModelPortaliQ9UL25.
SMRiQ9UL25.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UL25.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 56Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0088. Eukaryota.
ENOG410XQT5. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9UL25.
KOiK07890.
OMAiMDARMRE.
OrthoDBiEOG091G0HKN.
PhylomeDBiQ9UL25.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT
60 70 80 90 100
TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD
110 120 130 140 150
ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY
160 170 180 190 200
AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT
210 220
ARRGVQIIDD EPQAQTSGGG CCSSG
Length:225
Mass (Da):24,348
Last modified:January 23, 2007 - v3
Checksum:i73CA2C127F0CBFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091035 mRNA. Translation: AAF00048.1.
BC021901 mRNA. Translation: AAH21901.1.
BC092475 mRNA. Translation: AAH92475.1.
D42087 mRNA. Translation: BAA07682.1.
CCDSiCCDS9003.1.
RefSeqiNP_055814.1. NM_014999.3.
UniGeneiHs.524590.

Genome annotation databases

EnsembliENST00000261263; ENSP00000261263; ENSG00000080371.
GeneIDi23011.
KEGGihsa:23011.
UCSCiuc001swt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091035 mRNA. Translation: AAF00048.1.
BC021901 mRNA. Translation: AAH21901.1.
BC092475 mRNA. Translation: AAH92475.1.
D42087 mRNA. Translation: BAA07682.1.
CCDSiCCDS9003.1.
RefSeqiNP_055814.1. NM_014999.3.
UniGeneiHs.524590.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZTX-ray2.05A/B16-183[»]
1YZUX-ray2.50A/B16-183[»]
1Z08X-ray1.80A/B/C/D16-183[»]
1Z0IX-ray2.33A16-183[»]
2OT3X-ray2.10B16-183[»]
ProteinModelPortaliQ9UL25.
SMRiQ9UL25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116653. 18 interactors.
DIPiDIP-29349N.
IntActiQ9UL25. 5 interactors.
MINTiMINT-3081967.
STRINGi9606.ENSP00000261263.

PTM databases

iPTMnetiQ9UL25.
PhosphoSitePlusiQ9UL25.
SwissPalmiQ9UL25.

Polymorphism and mutation databases

BioMutaiRAB21.
DMDMi13633613.

Proteomic databases

EPDiQ9UL25.
MaxQBiQ9UL25.
PaxDbiQ9UL25.
PeptideAtlasiQ9UL25.
PRIDEiQ9UL25.

Protocols and materials databases

DNASUi23011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261263; ENSP00000261263; ENSG00000080371.
GeneIDi23011.
KEGGihsa:23011.
UCSCiuc001swt.4. human.

Organism-specific databases

CTDi23011.
DisGeNETi23011.
GeneCardsiRAB21.
HGNCiHGNC:18263. RAB21.
HPAiCAB037048.
HPA016988.
MIMi612398. gene.
neXtProtiNX_Q9UL25.
OpenTargetsiENSG00000080371.
PharmGKBiPA34111.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0088. Eukaryota.
ENOG410XQT5. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9UL25.
KOiK07890.
OMAiMDARMRE.
OrthoDBiEOG091G0HKN.
PhylomeDBiQ9UL25.
TreeFamiTF300199.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080371-MONOMER.
BRENDAi3.6.5.2. 2681.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiRAB21. human.
EvolutionaryTraceiQ9UL25.
GeneWikiiRAB21.
GenomeRNAii23011.
PROiQ9UL25.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080371.
CleanExiHS_RAB21.
ExpressionAtlasiQ9UL25. baseline and differential.
GenevisibleiQ9UL25. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB21_HUMAN
AccessioniPrimary (citable) accession number: Q9UL25
Secondary accession number(s): Q14466, Q569H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.