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Q9UL17 (TBX21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX21

Short name=T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene names
Name:TBX21
Synonyms:TBET, TBLYM
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Subcellular location

Nucleus.

Tissue specificity

T-cell specific.

Involvement in disease

Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities

Contains 1 T-box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535T-box transcription factor TBX21
PRO_0000184453

Regions

DNA binding141 – 326186T-box

Natural variations

Natural variant331H → Q. Ref.4
Corresponds to variant rs2240017 [ dbSNP | Ensembl ].
VAR_020252
Natural variant3391I → V.
Corresponds to variant rs12721471 [ dbSNP | Ensembl ].
VAR_029275

Sequences

Sequence LengthMass (Da)Tools
Q9UL17 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 51F351335598CEF2

FASTA53558,328
        10         20         30         40         50         60 
MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG GGSLGSPYPG 

        70         80         90        100        110        120 
GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE GYQPGEGYAA PDPRAGLYPG 

       130        140        150        160        170        180 
PREDYALPAG LEVSGKLRVA LNNHLLWSKF NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT 

       190        200        210        220        230        240 
SHYRMFVDVV LVDQHHWRYQ SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG 

       250        260        270        280        290        300 
KLKLTNNKGA SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI 

       310        320        330        340        350        360 
AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL GGDHYSPLLP 

       370        380        390        400        410        420 
NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR AVSMKPAFLP SAPGPTMSYY 

       430        440        450        460        470        480 
RGQEVLAPGA GWPVAPQYPP KMGPASWFRP MRTLPMEPGP GGSEGRGPED QGPPLVWTEI 

       490        500        510        520        530 
APIRPESSDS GLGEGDSKRR RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a new member of T-box gene family."
Yang S.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel transcription factor, T-bet, directs Th1 lineage commitment."
Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma."
Akahoshi M., Obara K., Hirota T., Matsuda A., Hasegawa K., Takahashi N., Shimizu M., Nakashima K., Cheng L., Doi S., Fujiwara H., Miyatake A., Fujita K., Higashi N., Taniguchi M., Enomoto T., Mao X.-Q., Nakashima H. expand/collapse author list , Adra C.N., Nakamura Y., Tamari M., Shirakawa T.
Hum. Genet. 117:16-26(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASPIRIN-INDUCED ASTHMA, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA AND NASAL POLYPS, VARIANT GLN-33.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF093098 mRNA. Translation: AAF00055.1.
AF241243 mRNA. Translation: AAF61243.1.
BC039739 mRNA. Translation: AAH39739.1.
CCDSCCDS11514.1.
RefSeqNP_037483.1. NM_013351.1.
UniGeneHs.272409.

3D structure databases

ProteinModelPortalQ9UL17.
SMRQ9UL17. Positions 137-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119027. 7 interactions.
IntActQ9UL17. 1 interaction.
STRING9606.ENSP00000177694.

PTM databases

PhosphoSiteQ9UL17.

Polymorphism databases

DMDM12230772.

Proteomic databases

MaxQBQ9UL17.
PaxDbQ9UL17.
PRIDEQ9UL17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000177694; ENSP00000177694; ENSG00000073861.
GeneID30009.
KEGGhsa:30009.
UCSCuc002ilv.1. human.

Organism-specific databases

CTD30009.
GeneCardsGC17P045810.
HGNCHGNC:11599. TBX21.
HPACAB009524.
CAB030043.
MIM208550. phenotype.
604895. gene.
neXtProtNX_Q9UL17.
PharmGKBPA36362.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254024.
HOGENOMHOG000218633.
HOVERGENHBG000578.
InParanoidQ9UL17.
KOK10166.
OMAAPPGRFL.
OrthoDBEOG7C2R14.
PhylomeDBQ9UL17.
TreeFamTF106341.

Gene expression databases

BgeeQ9UL17.
CleanExHS_TBX21.
GenevestigatorQ9UL17.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTBX21.
GenomeRNAi30009.
NextBio52824.
PROQ9UL17.
SOURCESearch...

Entry information

Entry nameTBX21_HUMAN
AccessionPrimary (citable) accession number: Q9UL17
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM