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Protein

T-box transcription factor TBX21

Gene

TBX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 326186T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to organic substance Source: Ensembl
  • lymphocyte migration Source: UniProtKB
  • multicellular organismal development Source: UniProtKB
  • positive regulation of isotype switching to IgG isotypes Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • response to virus Source: UniProtKB
  • T cell differentiation Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX21
Short name:
T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene namesi
Name:TBX21
Synonyms:TBET, TBLYM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11599. TBX21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Asthma, with nasal polyps and aspirin intolerance (ANPAI)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.

See also OMIM:208550

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi208550. phenotype.
PharmGKBiPA36362.

Polymorphism and mutation databases

BioMutaiTBX21.
DMDMi12230772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535T-box transcription factor TBX21PRO_0000184453Add
BLAST

Proteomic databases

MaxQBiQ9UL17.
PaxDbiQ9UL17.
PRIDEiQ9UL17.

PTM databases

PhosphoSiteiQ9UL17.

Expressioni

Tissue specificityi

T-cell specific.

Gene expression databases

BgeeiQ9UL17.
CleanExiHS_TBX21.
GenevestigatoriQ9UL17.

Organism-specific databases

HPAiCAB009524.
CAB030043.

Interactioni

Protein-protein interaction databases

BioGridi119027. 9 interactions.
DIPiDIP-61303N.
IntActiQ9UL17. 1 interaction.
STRINGi9606.ENSP00000177694.

Structurei

3D structure databases

ProteinModelPortaliQ9UL17.
SMRiQ9UL17. Positions 137-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254024.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9UL17.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9UL17.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UL17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG
60 70 80 90 100
GGSLGSPYPG GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE
110 120 130 140 150
GYQPGEGYAA PDPRAGLYPG PREDYALPAG LEVSGKLRVA LNNHLLWSKF
160 170 180 190 200
NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT SHYRMFVDVV LVDQHHWRYQ
210 220 230 240 250
SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG KLKLTNNKGA
260 270 280 290 300
SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI
310 320 330 340 350
AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL
360 370 380 390 400
GGDHYSPLLP NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR
410 420 430 440 450
AVSMKPAFLP SAPGPTMSYY RGQEVLAPGA GWPVAPQYPP KMGPASWFRP
460 470 480 490 500
MRTLPMEPGP GGSEGRGPED QGPPLVWTEI APIRPESSDS GLGEGDSKRR
510 520 530
RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN
Length:535
Mass (Da):58,328
Last modified:May 1, 2000 - v1
Checksum:i51F351335598CEF2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331H → Q.1 Publication
Corresponds to variant rs2240017 [ dbSNP | Ensembl ].
VAR_020252
Natural varianti339 – 3391I → V.
Corresponds to variant rs12721471 [ dbSNP | Ensembl ].
VAR_029275

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093098 mRNA. Translation: AAF00055.1.
AF241243 mRNA. Translation: AAF61243.1.
BC039739 mRNA. Translation: AAH39739.1.
CCDSiCCDS11514.1.
RefSeqiNP_037483.1. NM_013351.1.
UniGeneiHs.272409.

Genome annotation databases

EnsembliENST00000177694; ENSP00000177694; ENSG00000073861.
GeneIDi30009.
KEGGihsa:30009.
UCSCiuc002ilv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093098 mRNA. Translation: AAF00055.1.
AF241243 mRNA. Translation: AAF61243.1.
BC039739 mRNA. Translation: AAH39739.1.
CCDSiCCDS11514.1.
RefSeqiNP_037483.1. NM_013351.1.
UniGeneiHs.272409.

3D structure databases

ProteinModelPortaliQ9UL17.
SMRiQ9UL17. Positions 137-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119027. 9 interactions.
DIPiDIP-61303N.
IntActiQ9UL17. 1 interaction.
STRINGi9606.ENSP00000177694.

PTM databases

PhosphoSiteiQ9UL17.

Polymorphism and mutation databases

BioMutaiTBX21.
DMDMi12230772.

Proteomic databases

MaxQBiQ9UL17.
PaxDbiQ9UL17.
PRIDEiQ9UL17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000177694; ENSP00000177694; ENSG00000073861.
GeneIDi30009.
KEGGihsa:30009.
UCSCiuc002ilv.1. human.

Organism-specific databases

CTDi30009.
GeneCardsiGC17P045810.
HGNCiHGNC:11599. TBX21.
HPAiCAB009524.
CAB030043.
MIMi208550. phenotype.
604895. gene.
neXtProtiNX_Q9UL17.
PharmGKBiPA36362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254024.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9UL17.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9UL17.
TreeFamiTF106341.

Miscellaneous databases

GeneWikiiTBX21.
GenomeRNAii30009.
NextBioi52824.
PROiQ9UL17.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UL17.
CleanExiHS_TBX21.
GenevestigatoriQ9UL17.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new member of T-box gene family."
    Yang S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel transcription factor, T-bet, directs Th1 lineage commitment."
    Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
    Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASPIRIN-INDUCED ASTHMA, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA AND NASAL POLYPS, VARIANT GLN-33.

Entry informationi

Entry nameiTBX21_HUMAN
AccessioniPrimary (citable) accession number: Q9UL17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.