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Q9UL17

- TBX21_HUMAN

UniProt

Q9UL17 - TBX21_HUMAN

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Protein
T-box transcription factor TBX21
Gene
TBX21, TBET, TBLYM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 326186T-box
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  2. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. T cell differentiation Source: Ensembl
  2. lymphocyte migration Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB
  4. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB
  7. response to virus Source: UniProtKB
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX21
Short name:
T-box protein 21
Alternative name(s):
T-cell-specific T-box transcription factor T-bet
Transcription factor TBLYM
Gene namesi
Name:TBX21
Synonyms:TBET, TBLYM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11599. TBX21.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi208550. phenotype.
PharmGKBiPA36362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535T-box transcription factor TBX21
PRO_0000184453Add
BLAST

Proteomic databases

MaxQBiQ9UL17.
PaxDbiQ9UL17.
PRIDEiQ9UL17.

PTM databases

PhosphoSiteiQ9UL17.

Expressioni

Tissue specificityi

T-cell specific.

Gene expression databases

BgeeiQ9UL17.
CleanExiHS_TBX21.
GenevestigatoriQ9UL17.

Organism-specific databases

HPAiCAB009524.
CAB030043.

Interactioni

Protein-protein interaction databases

BioGridi119027. 7 interactions.
IntActiQ9UL17. 1 interaction.
STRINGi9606.ENSP00000177694.

Structurei

3D structure databases

ProteinModelPortaliQ9UL17.
SMRiQ9UL17. Positions 137-325.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG254024.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ9UL17.
KOiK10166.
OMAiAPPGRFL.
OrthoDBiEOG7C2R14.
PhylomeDBiQ9UL17.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UL17-1 [UniParc]FASTAAdd to Basket

« Hide

MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG    50
GGSLGSPYPG GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE 100
GYQPGEGYAA PDPRAGLYPG PREDYALPAG LEVSGKLRVA LNNHLLWSKF 150
NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT SHYRMFVDVV LVDQHHWRYQ 200
SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG KLKLTNNKGA 250
SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI 300
AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL 350
GGDHYSPLLP NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR 400
AVSMKPAFLP SAPGPTMSYY RGQEVLAPGA GWPVAPQYPP KMGPASWFRP 450
MRTLPMEPGP GGSEGRGPED QGPPLVWTEI APIRPESSDS GLGEGDSKRR 500
RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN 535
Length:535
Mass (Da):58,328
Last modified:May 1, 2000 - v1
Checksum:i51F351335598CEF2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331H → Q.1 Publication
Corresponds to variant rs2240017 [ dbSNP | Ensembl ].
VAR_020252
Natural varianti339 – 3391I → V.
Corresponds to variant rs12721471 [ dbSNP | Ensembl ].
VAR_029275

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093098 mRNA. Translation: AAF00055.1.
AF241243 mRNA. Translation: AAF61243.1.
BC039739 mRNA. Translation: AAH39739.1.
CCDSiCCDS11514.1.
RefSeqiNP_037483.1. NM_013351.1.
UniGeneiHs.272409.

Genome annotation databases

EnsembliENST00000177694; ENSP00000177694; ENSG00000073861.
GeneIDi30009.
KEGGihsa:30009.
UCSCiuc002ilv.1. human.

Polymorphism databases

DMDMi12230772.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093098 mRNA. Translation: AAF00055.1 .
AF241243 mRNA. Translation: AAF61243.1 .
BC039739 mRNA. Translation: AAH39739.1 .
CCDSi CCDS11514.1.
RefSeqi NP_037483.1. NM_013351.1.
UniGenei Hs.272409.

3D structure databases

ProteinModelPortali Q9UL17.
SMRi Q9UL17. Positions 137-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119027. 7 interactions.
IntActi Q9UL17. 1 interaction.
STRINGi 9606.ENSP00000177694.

PTM databases

PhosphoSitei Q9UL17.

Polymorphism databases

DMDMi 12230772.

Proteomic databases

MaxQBi Q9UL17.
PaxDbi Q9UL17.
PRIDEi Q9UL17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000177694 ; ENSP00000177694 ; ENSG00000073861 .
GeneIDi 30009.
KEGGi hsa:30009.
UCSCi uc002ilv.1. human.

Organism-specific databases

CTDi 30009.
GeneCardsi GC17P045810.
HGNCi HGNC:11599. TBX21.
HPAi CAB009524.
CAB030043.
MIMi 208550. phenotype.
604895. gene.
neXtProti NX_Q9UL17.
PharmGKBi PA36362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254024.
HOGENOMi HOG000218633.
HOVERGENi HBG000578.
InParanoidi Q9UL17.
KOi K10166.
OMAi APPGRFL.
OrthoDBi EOG7C2R14.
PhylomeDBi Q9UL17.
TreeFami TF106341.

Miscellaneous databases

GeneWikii TBX21.
GenomeRNAii 30009.
NextBioi 52824.
PROi Q9UL17.
SOURCEi Search...

Gene expression databases

Bgeei Q9UL17.
CleanExi HS_TBX21.
Genevestigatori Q9UL17.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new member of T-box gene family."
    Yang S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel transcription factor, T-bet, directs Th1 lineage commitment."
    Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H.
    Cell 100:655-669(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASPIRIN-INDUCED ASTHMA, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA AND NASAL POLYPS, VARIANT GLN-33.

Entry informationi

Entry nameiTBX21_HUMAN
AccessioniPrimary (citable) accession number: Q9UL17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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