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Protein

Sarcosine dehydrogenase, mitochondrial

Gene

SARDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarityNote: Binds 1 FAD covalently per monomer.By similarity

Pathwayi

GO - Molecular functioni

  1. sarcosine dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:HS04663-MONOMER.
UniPathwayiUPA00292; UER00398.

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcosine dehydrogenase, mitochondrial (EC:1.5.8.3)
Short name:
SarDH
Alternative name(s):
BPR-2
Gene namesi
Name:SARDH
Synonyms:DMGDHL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10536. SARDH.

Subcellular locationi

  1. Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Sarcosinemia (SARCOS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA metabolic disorder characterized by an increased concentration of sarcosine in plasma and an increased excretion of sarcosine in urine. Sarcosinemia is most probably a benign condition without significant clinical problems. Some reports have associated sarcosinemia with mental retardation and neurologic problems.

See also OMIM:268900
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711V → F in SARCOS. 1 Publication
VAR_069272
Natural varianti287 – 2871P → L in SARCOS. 1 Publication
Corresponds to variant rs149481147 [ dbSNP | Ensembl ].
VAR_069273

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi268900. phenotype.
Orphaneti3129. Sarcosinemia.
PharmGKBiPA34944.

Polymorphism and mutation databases

BioMutaiSARDH.
DMDMi52000845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 918896Sarcosine dehydrogenase, mitochondrialPRO_0000010770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-succinyllysineBy similarity
Modified residuei108 – 1081Tele-8alpha-FAD histidineBy similarity
Modified residuei173 – 1731N6-acetyllysine; alternateBy similarity
Modified residuei173 – 1731N6-succinyllysine; alternateBy similarity
Modified residuei377 – 3771N6-succinyllysineBy similarity
Modified residuei391 – 3911N6-succinyllysineBy similarity
Modified residuei559 – 5591N6-acetyllysineBy similarity
Modified residuei775 – 7751N6-acetyllysineBy similarity
Modified residuei777 – 7771Phosphotyrosine1 Publication
Modified residuei802 – 8021N6-acetyllysine; alternateBy similarity
Modified residuei802 – 8021N6-succinyllysine; alternateBy similarity
Modified residuei884 – 8841N6-acetyllysine; alternateBy similarity
Modified residuei884 – 8841N6-succinyllysine; alternateBy similarity
Modified residuei904 – 9041N6-acetyllysine; alternateBy similarity
Modified residuei904 – 9041N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9UL12.
PaxDbiQ9UL12.
PRIDEiQ9UL12.

PTM databases

PhosphoSiteiQ9UL12.

Expressioni

Gene expression databases

BgeeiQ9UL12.
CleanExiHS_SARDH.
ExpressionAtlasiQ9UL12. baseline and differential.
GenevestigatoriQ9UL12.

Organism-specific databases

HPAiHPA057267.
HPA058086.

Interactioni

Protein-protein interaction databases

BioGridi108097. 2 interactions.
STRINGi9606.ENSP00000360938.

Structurei

3D structure databases

ProteinModelPortaliQ9UL12.
SMRiQ9UL12. Positions 66-916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0665.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG002326.
InParanoidiQ9UL12.
KOiK00314.
OMAiRADFGFT.
OrthoDBiEOG7W1533.
PhylomeDBiQ9UL12.
TreeFamiTF314735.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSRALRV AAAHPRQSPT RGMGPCNLSS AAGPTAEKSV PYQRTLKEGQ
60 70 80 90 100
GTSVVAQGPS RPLPSTANVV VIGGGSLGCQ TLYHLAKLGM SGAVLLERER
110 120 130 140 150
LTSGTTWHTA GLLWQLRPSD VEVELLAHTR RVVSRELEEE TGLHTGWIQN
160 170 180 190 200
GGLFIASNRQ RLDEYKRLMS LGKAYGVESH VLSPAETKTL YPLMNVDDLY
210 220 230 240 250
GTLYVPHDGT MDPAGTCTTL ARAASARGAQ VIENCPVTGI RVWTDDFGVR
260 270 280 290 300
RVAGVETQHG SIQTPCVVNC AGVWASAVGR MAGVKVPLVA MHHAYVVTER
310 320 330 340 350
IEGIQNMPNV RDHDASVYLR LQGDALSVGG YEANPIFWEE VSDKFAFGLF
360 370 380 390 400
DLDWEVFTQH IEGAINRVPV LEKTGIKSTV CGPESFTPDH KPLMGEAPEL
410 420 430 440 450
RGFFLGCGFN SAGMMLGGGC GQELAHWIIH GRPEKDMHGY DIRRFHHSLT
460 470 480 490 500
DHPRWIRERS HESYAKNYSV VFPHDEPLAG RNMRRDPLHE ELLGQGCVFQ
510 520 530 540 550
ERHGWERPGW FHPRGPAPVL EYDYYGAYGS RAHEDYAYRR LLADEYTFAF
560 570 580 590 600
PPHHDTIKKE CLACRGAAAV FDMSYFGKFY LVGLDARKAA DWLFSADVSR
610 620 630 640 650
PPGSTVYTCM LNHRGGTESD LTVSRLAPSH QASPLAPAFE GDGYYLAMGG
660 670 680 690 700
AVAQHNWSHI TTVLQDQKSQ CQLIDSSEDL GMISIQGPAS RAILQEVLDA
710 720 730 740 750
DLSNEAFPFS THKLLRAAGH LVRAMRLSFV GELGWELHIP KASCVPVYRA
760 770 780 790 800
VMAAGAKHGL INAGYRAIDS LSIEKGYRHW HADLRPDDSP LEAGLAFTCK
810 820 830 840 850
LKSPVPFLGR EALEQQRAAG LRRRLVCFTM EDKVPMFGLE AIWRNGQVVG
860 870 880 890 900
HVRRADFGFA IDKTIAYGYI HDPSGGPVSL DFVKSGDYAL ERMGVTYGAQ
910
AHLKSPFDPN NKRVKGIY
Length:918
Mass (Da):101,037
Last modified:May 1, 2000 - v1
Checksum:i4ADA132D5F44B37A
GO
Isoform 2 (identifier: Q9UL12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Note: No experimental confirmation available.

Show »
Length:750
Mass (Da):82,962
Checksum:i80F4539F88849319
GO

Sequence cautioni

The sequence AAD33412.1 differs from that shown. Reason: Frameshift at position 867. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221G → C.
Corresponds to variant rs35559818 [ dbSNP | Ensembl ].
VAR_039077
Natural varianti71 – 711V → F in SARCOS. 1 Publication
VAR_069272
Natural varianti287 – 2871P → L in SARCOS. 1 Publication
Corresponds to variant rs149481147 [ dbSNP | Ensembl ].
VAR_069273
Natural varianti372 – 3721E → D.
Corresponds to variant rs35218200 [ dbSNP | Ensembl ].
VAR_039078
Natural varianti614 – 6141R → H.2 Publications
Corresponds to variant rs2073817 [ dbSNP | Ensembl ].
VAR_019687
Natural varianti648 – 6481M → V.1 Publication
Corresponds to variant rs886016 [ dbSNP | Ensembl ].
VAR_019688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 168168Missing in isoform 2. 1 PublicationVSP_056309Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095735 mRNA. Translation: AAD53398.2.
AF162428 mRNA. Translation: AAD43585.1.
AF140745
, AF140726, AF140727, AF140728, AF140729, AF140730, AF140731, AF140732, AF140733, AF140734, AF140735, AF140736, AF140737, AF140738, AF140739, AF140740, AF140741, AF140742, AF140743, AF140744 Genomic DNA. Translation: AAD32214.1.
AK298348 mRNA. Translation: BAG60594.1.
AK316494 mRNA. Translation: BAH14865.1.
AL590710, AL365494 Genomic DNA. Translation: CAI12276.1.
AL365494, AL590710 Genomic DNA. Translation: CAI13356.1.
CH471090 Genomic DNA. Translation: EAW88103.1.
BC136363 mRNA. Translation: AAI36364.1.
BC136364 mRNA. Translation: AAI36365.1.
BC144035 mRNA. Translation: AAI44036.1.
AF129265 mRNA. Translation: AAD33412.1. Frameshift.
CCDSiCCDS6978.1. [Q9UL12-1]
RefSeqiNP_001128179.1. NM_001134707.1. [Q9UL12-1]
NP_009032.2. NM_007101.3. [Q9UL12-1]
XP_006717053.1. XM_006716990.2. [Q9UL12-1]
UniGeneiHs.198003.

Genome annotation databases

EnsembliENST00000371872; ENSP00000360938; ENSG00000123453. [Q9UL12-1]
ENST00000439388; ENSP00000403084; ENSG00000123453. [Q9UL12-1]
GeneIDi1757.
KEGGihsa:1757.
UCSCiuc004ceo.3. human. [Q9UL12-1]

Polymorphism and mutation databases

BioMutaiSARDH.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095735 mRNA. Translation: AAD53398.2.
AF162428 mRNA. Translation: AAD43585.1.
AF140745
, AF140726, AF140727, AF140728, AF140729, AF140730, AF140731, AF140732, AF140733, AF140734, AF140735, AF140736, AF140737, AF140738, AF140739, AF140740, AF140741, AF140742, AF140743, AF140744 Genomic DNA. Translation: AAD32214.1.
AK298348 mRNA. Translation: BAG60594.1.
AK316494 mRNA. Translation: BAH14865.1.
AL590710, AL365494 Genomic DNA. Translation: CAI12276.1.
AL365494, AL590710 Genomic DNA. Translation: CAI13356.1.
CH471090 Genomic DNA. Translation: EAW88103.1.
BC136363 mRNA. Translation: AAI36364.1.
BC136364 mRNA. Translation: AAI36365.1.
BC144035 mRNA. Translation: AAI44036.1.
AF129265 mRNA. Translation: AAD33412.1. Frameshift.
CCDSiCCDS6978.1. [Q9UL12-1]
RefSeqiNP_001128179.1. NM_001134707.1. [Q9UL12-1]
NP_009032.2. NM_007101.3. [Q9UL12-1]
XP_006717053.1. XM_006716990.2. [Q9UL12-1]
UniGeneiHs.198003.

3D structure databases

ProteinModelPortaliQ9UL12.
SMRiQ9UL12. Positions 66-916.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108097. 2 interactions.
STRINGi9606.ENSP00000360938.

PTM databases

PhosphoSiteiQ9UL12.

Polymorphism and mutation databases

BioMutaiSARDH.
DMDMi52000845.

Proteomic databases

MaxQBiQ9UL12.
PaxDbiQ9UL12.
PRIDEiQ9UL12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371872; ENSP00000360938; ENSG00000123453. [Q9UL12-1]
ENST00000439388; ENSP00000403084; ENSG00000123453. [Q9UL12-1]
GeneIDi1757.
KEGGihsa:1757.
UCSCiuc004ceo.3. human. [Q9UL12-1]

Organism-specific databases

CTDi1757.
GeneCardsiGC09M136528.
H-InvDBHIX0079029.
HGNCiHGNC:10536. SARDH.
HPAiHPA057267.
HPA058086.
MIMi268900. phenotype.
604455. gene.
neXtProtiNX_Q9UL12.
Orphaneti3129. Sarcosinemia.
PharmGKBiPA34944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0665.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG002326.
InParanoidiQ9UL12.
KOiK00314.
OMAiRADFGFT.
OrthoDBiEOG7W1533.
PhylomeDBiQ9UL12.
TreeFamiTF314735.

Enzyme and pathway databases

UniPathwayiUPA00292; UER00398.
BioCyciMetaCyc:HS04663-MONOMER.

Miscellaneous databases

ChiTaRSiSARDH. human.
GeneWikiiSARDH.
GenomeRNAii1757.
NextBioi35473878.
PROiQ9UL12.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UL12.
CleanExiHS_SARDH.
ExpressionAtlasiQ9UL12. baseline and differential.
GenevestigatoriQ9UL12.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia."
    Eschenbrenner M., Jorns M.S.
    Genomics 59:300-308(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POTENTIAL TRANSIT PEPTIDE, INVOLVEMENT IN SARCOS.
    Tissue: Liver.
  2. "Characterization and cloning of human sarcosine dehydrogenase genomic and cDNA."
    Hoard H.M., Binzak B.A., Vockley J.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-614.
  7. "Physical and cDNA mapping in the DBH region of human chromosome 9q34."
    Gilbert J.R., Kumar A., Newey S., Rao N., Ioannou P., Qiu H., Lin D., Xu P., Pettenati M.J., Pericak-Vance M.A.
    Hum. Hered. 50:151-157(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 239-882, VARIANTS HIS-614 AND VAL-648.
    Tissue: Brain.
  8. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
    Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
    Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. Cited for: VARIANTS SARCOS PHE-71 AND LEU-287.

Entry informationi

Entry nameiSARDH_HUMAN
AccessioniPrimary (citable) accession number: Q9UL12
Secondary accession number(s): B2RMR5
, B4DPI2, B7ZLT6, Q5SYV0, Q9Y280, Q9Y2Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.