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Q9UL12

- SARDH_HUMAN

UniProt

Q9UL12 - SARDH_HUMAN

Protein

Sarcosine dehydrogenase, mitochondrial

Gene

SARDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.

    Cofactori

    Binds 1 FAD covalently per monomer.By similarity

    Pathwayi

    GO - Molecular functioni

    1. aminomethyltransferase activity Source: InterPro
    2. sarcosine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciMetaCyc:HS04663-MONOMER.
    UniPathwayiUPA00292; UER00398.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcosine dehydrogenase, mitochondrial (EC:1.5.8.3)
    Short name:
    SarDH
    Alternative name(s):
    BPR-2
    Gene namesi
    Name:SARDH
    Synonyms:DMGDHL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10536. SARDH.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Sarcosinemia (SARCOS) [MIM:268900]: A metabolic disorder characterized by an increased concentration of sarcosine in plasma and an increased excretion of sarcosine in urine. Sarcosinemia is most probably a benign condition without significant clinical problems. Some reports have associated sarcosinemia with mental retardation and neurologic problems.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711V → F in SARCOS. 1 Publication
    VAR_069272
    Natural varianti287 – 2871P → L in SARCOS. 1 Publication
    Corresponds to variant rs149481147 [ dbSNP | Ensembl ].
    VAR_069273

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi268900. phenotype.
    Orphaneti3129. Sarcosinemia.
    PharmGKBiPA34944.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 918896Sarcosine dehydrogenase, mitochondrialPRO_0000010770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-succinyllysineBy similarity
    Modified residuei108 – 1081Tele-8alpha-FAD histidineBy similarity
    Modified residuei173 – 1731N6-acetyllysine; alternateBy similarity
    Modified residuei173 – 1731N6-succinyllysine; alternateBy similarity
    Modified residuei377 – 3771N6-succinyllysineBy similarity
    Modified residuei391 – 3911N6-succinyllysineBy similarity
    Modified residuei559 – 5591N6-acetyllysineBy similarity
    Modified residuei775 – 7751N6-acetyllysineBy similarity
    Modified residuei777 – 7771Phosphotyrosine1 Publication
    Modified residuei802 – 8021N6-acetyllysine; alternateBy similarity
    Modified residuei802 – 8021N6-succinyllysine; alternateBy similarity
    Modified residuei884 – 8841N6-acetyllysine; alternateBy similarity
    Modified residuei884 – 8841N6-succinyllysine; alternateBy similarity
    Modified residuei904 – 9041N6-acetyllysine; alternateBy similarity
    Modified residuei904 – 9041N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UL12.
    PaxDbiQ9UL12.
    PRIDEiQ9UL12.

    PTM databases

    PhosphoSiteiQ9UL12.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UL12.
    BgeeiQ9UL12.
    CleanExiHS_SARDH.
    GenevestigatoriQ9UL12.

    Organism-specific databases

    HPAiHPA057267.
    HPA058086.

    Interactioni

    Protein-protein interaction databases

    BioGridi108097. 2 interactions.
    STRINGi9606.ENSP00000360938.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UL12.
    SMRiQ9UL12. Positions 66-445, 478-852.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvT family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0665.
    HOGENOMiHOG000251716.
    HOVERGENiHBG002326.
    InParanoidiQ9UL12.
    KOiK00314.
    OMAiAIWRNGQ.
    OrthoDBiEOG7W1533.
    PhylomeDBiQ9UL12.
    TreeFamiTF314735.

    Family and domain databases

    Gene3Di2.40.30.110. 1 hit.
    3.30.1360.120. 3 hits.
    InterProiIPR006076. FAD-dep_OxRdtase.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF101790. SSF101790. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UL12-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLSRALRV AAAHPRQSPT RGMGPCNLSS AAGPTAEKSV PYQRTLKEGQ    50
    GTSVVAQGPS RPLPSTANVV VIGGGSLGCQ TLYHLAKLGM SGAVLLERER 100
    LTSGTTWHTA GLLWQLRPSD VEVELLAHTR RVVSRELEEE TGLHTGWIQN 150
    GGLFIASNRQ RLDEYKRLMS LGKAYGVESH VLSPAETKTL YPLMNVDDLY 200
    GTLYVPHDGT MDPAGTCTTL ARAASARGAQ VIENCPVTGI RVWTDDFGVR 250
    RVAGVETQHG SIQTPCVVNC AGVWASAVGR MAGVKVPLVA MHHAYVVTER 300
    IEGIQNMPNV RDHDASVYLR LQGDALSVGG YEANPIFWEE VSDKFAFGLF 350
    DLDWEVFTQH IEGAINRVPV LEKTGIKSTV CGPESFTPDH KPLMGEAPEL 400
    RGFFLGCGFN SAGMMLGGGC GQELAHWIIH GRPEKDMHGY DIRRFHHSLT 450
    DHPRWIRERS HESYAKNYSV VFPHDEPLAG RNMRRDPLHE ELLGQGCVFQ 500
    ERHGWERPGW FHPRGPAPVL EYDYYGAYGS RAHEDYAYRR LLADEYTFAF 550
    PPHHDTIKKE CLACRGAAAV FDMSYFGKFY LVGLDARKAA DWLFSADVSR 600
    PPGSTVYTCM LNHRGGTESD LTVSRLAPSH QASPLAPAFE GDGYYLAMGG 650
    AVAQHNWSHI TTVLQDQKSQ CQLIDSSEDL GMISIQGPAS RAILQEVLDA 700
    DLSNEAFPFS THKLLRAAGH LVRAMRLSFV GELGWELHIP KASCVPVYRA 750
    VMAAGAKHGL INAGYRAIDS LSIEKGYRHW HADLRPDDSP LEAGLAFTCK 800
    LKSPVPFLGR EALEQQRAAG LRRRLVCFTM EDKVPMFGLE AIWRNGQVVG 850
    HVRRADFGFA IDKTIAYGYI HDPSGGPVSL DFVKSGDYAL ERMGVTYGAQ 900
    AHLKSPFDPN NKRVKGIY 918
    Length:918
    Mass (Da):101,037
    Last modified:May 1, 2000 - v1
    Checksum:i4ADA132D5F44B37A
    GO
    Isoform 2 (identifier: Q9UL12-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-168: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:750
    Mass (Da):82,962
    Checksum:i80F4539F88849319
    GO

    Sequence cautioni

    The sequence AAD33412.1 differs from that shown. Reason: Frameshift at position 867.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221G → C.
    Corresponds to variant rs35559818 [ dbSNP | Ensembl ].
    VAR_039077
    Natural varianti71 – 711V → F in SARCOS. 1 Publication
    VAR_069272
    Natural varianti287 – 2871P → L in SARCOS. 1 Publication
    Corresponds to variant rs149481147 [ dbSNP | Ensembl ].
    VAR_069273
    Natural varianti372 – 3721E → D.
    Corresponds to variant rs35218200 [ dbSNP | Ensembl ].
    VAR_039078
    Natural varianti614 – 6141R → H.2 Publications
    Corresponds to variant rs2073817 [ dbSNP | Ensembl ].
    VAR_019687
    Natural varianti648 – 6481M → V.1 Publication
    Corresponds to variant rs886016 [ dbSNP | Ensembl ].
    VAR_019688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 168168Missing in isoform 2. 1 PublicationVSP_056309Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095735 mRNA. Translation: AAD53398.2.
    AF162428 mRNA. Translation: AAD43585.1.
    AF140745
    , AF140726, AF140727, AF140728, AF140729, AF140730, AF140731, AF140732, AF140733, AF140734, AF140735, AF140736, AF140737, AF140738, AF140739, AF140740, AF140741, AF140742, AF140743, AF140744 Genomic DNA. Translation: AAD32214.1.
    AK298348 mRNA. Translation: BAG60594.1.
    AK316494 mRNA. Translation: BAH14865.1.
    AL590710, AL365494 Genomic DNA. Translation: CAI12276.1.
    AL365494, AL590710 Genomic DNA. Translation: CAI13356.1.
    CH471090 Genomic DNA. Translation: EAW88103.1.
    BC136363 mRNA. Translation: AAI36364.1.
    BC136364 mRNA. Translation: AAI36365.1.
    BC144035 mRNA. Translation: AAI44036.1.
    AF129265 mRNA. Translation: AAD33412.1. Frameshift.
    CCDSiCCDS6978.1.
    RefSeqiNP_001128179.1. NM_001134707.1.
    NP_009032.2. NM_007101.3.
    XP_005272227.1. XM_005272170.1.
    XP_006717053.1. XM_006716990.1.
    XP_006717054.1. XM_006716991.1.
    UniGeneiHs.198003.

    Genome annotation databases

    EnsembliENST00000371872; ENSP00000360938; ENSG00000123453.
    ENST00000422262; ENSP00000415537; ENSG00000123453.
    ENST00000439388; ENSP00000403084; ENSG00000123453.
    GeneIDi1757.
    KEGGihsa:1757.
    UCSCiuc004ceo.3. human.

    Polymorphism databases

    DMDMi52000845.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095735 mRNA. Translation: AAD53398.2 .
    AF162428 mRNA. Translation: AAD43585.1 .
    AF140745
    , AF140726 , AF140727 , AF140728 , AF140729 , AF140730 , AF140731 , AF140732 , AF140733 , AF140734 , AF140735 , AF140736 , AF140737 , AF140738 , AF140739 , AF140740 , AF140741 , AF140742 , AF140743 , AF140744 Genomic DNA. Translation: AAD32214.1 .
    AK298348 mRNA. Translation: BAG60594.1 .
    AK316494 mRNA. Translation: BAH14865.1 .
    AL590710 , AL365494 Genomic DNA. Translation: CAI12276.1 .
    AL365494 , AL590710 Genomic DNA. Translation: CAI13356.1 .
    CH471090 Genomic DNA. Translation: EAW88103.1 .
    BC136363 mRNA. Translation: AAI36364.1 .
    BC136364 mRNA. Translation: AAI36365.1 .
    BC144035 mRNA. Translation: AAI44036.1 .
    AF129265 mRNA. Translation: AAD33412.1 . Frameshift.
    CCDSi CCDS6978.1.
    RefSeqi NP_001128179.1. NM_001134707.1.
    NP_009032.2. NM_007101.3.
    XP_005272227.1. XM_005272170.1.
    XP_006717053.1. XM_006716990.1.
    XP_006717054.1. XM_006716991.1.
    UniGenei Hs.198003.

    3D structure databases

    ProteinModelPortali Q9UL12.
    SMRi Q9UL12. Positions 66-445, 478-852.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108097. 2 interactions.
    STRINGi 9606.ENSP00000360938.

    PTM databases

    PhosphoSitei Q9UL12.

    Polymorphism databases

    DMDMi 52000845.

    Proteomic databases

    MaxQBi Q9UL12.
    PaxDbi Q9UL12.
    PRIDEi Q9UL12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371872 ; ENSP00000360938 ; ENSG00000123453 .
    ENST00000422262 ; ENSP00000415537 ; ENSG00000123453 .
    ENST00000439388 ; ENSP00000403084 ; ENSG00000123453 .
    GeneIDi 1757.
    KEGGi hsa:1757.
    UCSCi uc004ceo.3. human.

    Organism-specific databases

    CTDi 1757.
    GeneCardsi GC09M136528.
    H-InvDB HIX0079029.
    HGNCi HGNC:10536. SARDH.
    HPAi HPA057267.
    HPA058086.
    MIMi 268900. phenotype.
    604455. gene.
    neXtProti NX_Q9UL12.
    Orphaneti 3129. Sarcosinemia.
    PharmGKBi PA34944.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0665.
    HOGENOMi HOG000251716.
    HOVERGENi HBG002326.
    InParanoidi Q9UL12.
    KOi K00314.
    OMAi AIWRNGQ.
    OrthoDBi EOG7W1533.
    PhylomeDBi Q9UL12.
    TreeFami TF314735.

    Enzyme and pathway databases

    UniPathwayi UPA00292 ; UER00398 .
    BioCyci MetaCyc:HS04663-MONOMER.

    Miscellaneous databases

    GeneWikii SARDH.
    GenomeRNAii 1757.
    NextBioi 7153.
    PROi Q9UL12.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UL12.
    Bgeei Q9UL12.
    CleanExi HS_SARDH.
    Genevestigatori Q9UL12.

    Family and domain databases

    Gene3Di 2.40.30.110. 1 hit.
    3.30.1360.120. 3 hits.
    InterProi IPR006076. FAD-dep_OxRdtase.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101790. SSF101790. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia."
      Eschenbrenner M., Jorns M.S.
      Genomics 59:300-308(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POTENTIAL TRANSIT PEPTIDE, INVOLVEMENT IN SARCOS.
      Tissue: Liver.
    2. "Characterization and cloning of human sarcosine dehydrogenase genomic and cDNA."
      Hoard H.M., Binzak B.A., Vockley J.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-614.
    7. "Physical and cDNA mapping in the DBH region of human chromosome 9q34."
      Gilbert J.R., Kumar A., Newey S., Rao N., Ioannou P., Qiu H., Lin D., Xu P., Pettenati M.J., Pericak-Vance M.A.
      Hum. Hered. 50:151-157(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 239-882, VARIANTS HIS-614 AND VAL-648.
      Tissue: Brain.
    8. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
      Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
      Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    9. Cited for: VARIANTS SARCOS PHE-71 AND LEU-287.

    Entry informationi

    Entry nameiSARDH_HUMAN
    AccessioniPrimary (citable) accession number: Q9UL12
    Secondary accession number(s): B2RMR5
    , B4DPI2, B7ZLT6, Q5SYV0, Q9Y280, Q9Y2Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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