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Protein

Integrator complex subunit 6

Gene

INTS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).1 Publication3 Publications

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription from RNA polymerase II promoter Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 6
Short name:
Int6
Alternative name(s):
DBI-1
Protein DDX26
Protein deleted in cancer 1
Short name:
DICE1
Gene namesi
Name:INTS6
Synonyms:DBI1, DDX26, DDX26A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:14879. INTS6.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • integrator complex Source: HGNC
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26512.
OpenTargetsiENSG00000102786.
PharmGKBiPA27212.

Polymorphism and mutation databases

BioMutaiINTS6.
DMDMi74753376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595431 – 887Integrator complex subunit 6Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei804PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UL03.
PaxDbiQ9UL03.
PeptideAtlasiQ9UL03.
PRIDEiQ9UL03.
TopDownProteomicsiQ9UL03-2. [Q9UL03-2]

PTM databases

iPTMnetiQ9UL03.
PhosphoSitePlusiQ9UL03.

Expressioni

Tissue specificityi

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Inductioni

Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear.1 Publication

Gene expression databases

BgeeiENSG00000102786.
CleanExiHS_INTS6.
ExpressionAtlasiQ9UL03. baseline and differential.
GenevisibleiQ9UL03. HS.

Organism-specific databases

HPAiHPA001552.
HPA001846.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCM7P3399310EBI-1381827,EBI-355924

Protein-protein interaction databases

BioGridi117717. 62 interactors.
DIPiDIP-38627N.
IntActiQ9UL03. 19 interactors.
MINTiMINT-4541530.
STRINGi9606.ENSP00000310260.

Structurei

3D structure databases

ProteinModelPortaliQ9UL03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 227VWFAPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the Integrator subunit 6 family.Curated

Phylogenomic databases

eggNOGiKOG3768. Eukaryota.
ENOG410XRER. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000015308.
HOVERGENiHBG081468.
InParanoidiQ9UL03.
KOiK13143.
OMAiKEQCPEE.
OrthoDBiEOG091G03YA.
PhylomeDBiQ9UL03.
TreeFamiTF323386.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR029307. INT_SG_DDX_CT_C.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF15300. INT_SG_DDX_CT_C. 1 hit.
PF13519. VWA_2. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiView protein in PROSITE
PS50234. VWFA. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPILLFLIDT SASMNQRSHL GTTYLDTAKG AVETFMKLRA RDPASRGDRY
60 70 80 90 100
MLVTFEEPPY AIKAGWKENH ATFMNELKNL QAEGLTTLGQ SLRTAFDLLN
110 120 130 140 150
LNRLVTGIDN YGQGRNPFFL EPAIIITITD GSKLTTTSGV QDELHLPLNS
160 170 180 190 200
PLPGSELTKE PFRWDQRLFA LVLRLPGTMS VESEQLTGVP LDDSAITPMC
210 220 230 240 250
EVTGGRSYSV CSPRMLNQCL ESLVQKVQSG VVINFEKAGP DPSPVEDGQP
260 270 280 290 300
DISRPFGSQP WHSCHKLIYV RPNPKTGVPI GHWPVPESFW PDQNSPTLPP
310 320 330 340 350
RTSHPVVKFS CTDCEPMVID KLPFDKYELE PSPLTQFILE RKSPQTCWQV
360 370 380 390 400
YVSNSAKYSE LGHPFGYLKA STALNCVNLF VMPYNYPVLL PLLDDLFKVH
410 420 430 440 450
KAKPTLKWRQ SFESYLKTMP PYYLGPLKKA VRMMGAPNLI ADSMEYGLSY
460 470 480 490 500
SVISYLKKLS QQAKIESDRV IGSVGKKVVQ ETGIKVRSRS HGLSMAYRKD
510 520 530 540 550
FQQLLQGISE DVPHRLLDLN MKEYTGFQVA LLNKDLKPQT FRNAYDIPRR
560 570 580 590 600
NLLDHLTRMR SNLLKSTRRF LKGQDEDQVH SVPIAQMGNY QEYLKQVPSP
610 620 630 640 650
LRELDPDQPR RLHTFGNPFK LDKKGMMIDE ADEFVAGPQN KHKRPGEPNM
660 670 680 690 700
QGIPKRRRCM SPLLRGRQQN PVVNNHIGGK GPPAPTTQAQ PDLIKPLPLH
710 720 730 740 750
KISETTNDSI IHDVVENHVA DQLSSDITPN AMDTEFSASS PASLLERPTN
760 770 780 790 800
HMEALGHDHL GTNDLTVGGF LENHEEPRDK EQCAEENIPA SSLNKGKKLM
810 820 830 840 850
HCRSHEEVNT ELKAQIMKEI RKPGRKYERI FTLLKHVQGS LQTRLIFLQN
860 870 880
VIKEASRFKK RMLIEQLENF LDEIHRRANQ INHINSN
Length:887
Mass (Da):100,390
Last modified:May 1, 2000 - v1
Checksum:iFCD3FD61B7767E03
GO
Isoform 2 (identifier: Q9UL03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: GR → VG
     116-887: Missing.

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):12,854
Checksum:i89C3CC2495007B4A
GO
Isoform 3 (identifier: Q9UL03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:874
Mass (Da):98,987
Checksum:iC1F5FA55ADA2C443
GO

Sequence cautioni

The sequence AAH13358 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AL833524 differs from that shown. Reason: Erroneous termination at position 796. Translated as Gly.Curated
The sequence CAB56020 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273N → R in AAD39481 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413561 – 13Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_021457114 – 115GR → VG in isoform 2. 1 Publication2
Alternative sequenceiVSP_021458116 – 887Missing in isoform 2. 1 PublicationAdd BLAST772

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097645 mRNA. Translation: AAF03046.1.
AL833524 mRNA. No translation available.
AL354820, AL137780 Genomic DNA. Translation: CAI15586.1.
AL137780, AL354820 Genomic DNA. Translation: CAI12905.1.
BC013358 mRNA. Translation: AAH13358.1. Sequence problems.
BC018725 mRNA. Translation: AAH18725.1.
BC032386 mRNA. Translation: AAH32386.1.
BC039829 mRNA. Translation: AAH39829.1.
AF141326 mRNA. Translation: AAD39481.1.
AL117626 mRNA. Translation: CAB56020.1. Different initiation.
BK005730 mRNA. Translation: DAA05730.1.
CCDSiCCDS41890.1. [Q9UL03-3]
CCDS45048.1. [Q9UL03-2]
CCDS9428.1. [Q9UL03-1]
PIRiT17330.
RefSeqiNP_001035026.1. NM_001039937.1. [Q9UL03-3]
NP_001035027.1. NM_001039938.1. [Q9UL03-2]
NP_001293020.1. NM_001306091.1.
NP_036273.1. NM_012141.2. [Q9UL03-1]
XP_011533342.1. XM_011535040.2. [Q9UL03-1]
UniGeneiHs.439440.

Genome annotation databases

EnsembliENST00000311234; ENSP00000310260; ENSG00000102786. [Q9UL03-1]
ENST00000398119; ENSP00000381187; ENSG00000102786. [Q9UL03-3]
ENST00000442263; ENSP00000411245; ENSG00000102786. [Q9UL03-2]
GeneIDi26512.
KEGGihsa:26512.
UCSCiuc001vfj.4. human. [Q9UL03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiINT6_HUMAN
AccessioniPrimary (citable) accession number: Q9UL03
Secondary accession number(s): Q0P664
, Q6PJP4, Q9UFK0, Q9Y5M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families