Q9UL01 (DSE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dermatan-sulfate epimerase
Short name=DS epimerase
EC=5.1.3.19

Alternative name(s):
Chondroitin-glucuronate 5-epimerase
Squamous cell carcinoma antigen recognized by T-cells 2
Short name=SART-2

Gene names

Name:	DSE
Synonyms:	SART2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	958 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Ref.4
Catalytic activity	Chondroitin D-glucuronate = dermatan L-iduronate.
Pathway	Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level). Ref.1
Sequence similarities	Belongs to the dermatan-sulfate isomerase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Isomerase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome chondroitin sulfate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway chondroitin sulfate metabolic process Traceable author statement. Source: Reactome dermatan sulfate biosynthetic process Inferred from direct assay Ref.4. Source: UniProtKB heparan sulfate proteoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome endoplasmic reticulum Inferred from direct assay Ref.1. Source: HGNC integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chondroitin-glucuronate 5-epimerase activity Inferred from direct assay Ref.4. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 958	936	Dermatan-sulfate epimerase		PRO_0000223311
Regions
	Transmembrane	903 – 923	21	Helical; Potential
	Transmembrane	934 – 954	21	Helical; Potential
Amino acid modifications
	Glycosylation	642	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	25	1	T → I. Corresponds to variant rs10485183 [ dbSNP | Ensembl ].		VAR_034481
	Natural variant	34	1	P → L. Corresponds to variant rs35548455 [ dbSNP | Ensembl ].		VAR_053833
	Natural variant	282	1	I → V. Corresponds to variant rs34994230 [ dbSNP | Ensembl ].		VAR_053834

Sequences

	Sequence		Length	Mass (Da)
	Q9UL01 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A3D05C6194B4D2F9	FASTA	958	109,773
	10 20 30 40 50 60 MRTHTRGAPS VFFIYLLCFV SAYITDENPE VMIPFTNANY DSHPMLYFSR AEVAELQLRA 70 80 90 100 110 120 ASSHEHIAAR LTEAVHTMLS SPLEYLPPWD PKDYSARWNE IFGNNLGALA MFCVLYPENI 130 140 150 160 170 180 EARDMAKDYM ERMAAQPSWL VKDAPWDEVP LAHSLVGFAT AYDFLYNYLS KTQQEKFLEV 190 200 210 220 230 240 IANASGYMYE TSYRRGWGFQ YLHNHQPTNC MALLTGSLVL MNQGYLQEAY LWTKQVLTIM 250 260 270 280 290 300 EKSLVLLREV TDGSLYEGVA YGSYTTRSLF QYMFLVQRHF NINHFGHPWL KQHFAFMYRT 310 320 330 340 350 360 ILPGFQRTVA IADSNYNWFY GPESQLVFLD KFVMRNGSGN WLADQIRRNR VVEGPGTPSK 370 380 390 400 410 420 GQRWCTLHTE FLWYDGSLKS VPPPDFGTPT LHYFEDWGVV TYGSALPAEI NRSFLSFKSG 430 440 450 460 470 480 KLGGRAIYDI VHRNKYKDWI KGWRNFNAGH EHPDQNSFTF APNGVPFITE ALYGPKYTFF 490 500 510 520 530 540 NNVLMFSPAV SKSCFSPWVG QVTEDCSSKW SKYKHDLAAS CQGRVVAAEE KNGVVFIRGE 550 560 570 580 590 600 GVGAYNPQLN LKNVQRNLIL LHPQLLLLVD QIHLGEESPL ETAASFFHNV DVPFEETVVD 610 620 630 640 650 660 GVHGAFIRQR DGLYKMYWMD DTGYSEKATF ASVTYPRGYP YNGTNYVNVT MHLRSPITRA 670 680 690 700 710 720 AYLFIGPSID VQSFTVHGDS QQLDVFIATS KHAYATYLWT GEATGQSAFA QVIADRHKIL 730 740 750 760 770 780 FDRNSAIKSS IVPEVKDYAA IVEQNLQHFK PVFQLLEKQI LSRVRNTASF RKTAERLLRF 790 800 810 820 830 840 SDKRQTEEAI DRIFAISQQQ QQQSKSKKNR RAGKRYKFVD AVPDIFAQIE VNEKKIRQKA 850 860 870 880 890 900 QILAQKELPI DEDEEMKDLL DFADVTYEKH KNGGLIKGRF GQARMVTTTH SRAPSLSASY 910 920 930 940 950 TRLFLILNIA IFFVMLAMQL TYFQRAQSLH GQRCLYAVLL IDSCILLWLY SSCSQSQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL." Nakao M., Shichijo S., Imaizumi T., Inoue Y., Matsunaga K., Yamada A., Kikuchi M., Tsuda N., Ohta K., Takamori S., Yamana H., Fujita H., Itoh K. J. Immunol. 164:2565-2574(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2." Maccarana M., Olander B., Malmstroem J., Tiedemann K., Aebersold R., Lindahl U., Li J.-P., Malmstroem A. J. Biol. Chem. 281:11560-11568(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098066 mRNA. Translation: AAF00087.1. Z84488 Genomic DNA. Translation: CAI23407.1. Z84488 Genomic DNA. Translation: CAI23408.1. BC039245 mRNA. Translation: AAH39245.1.
IPI	IPI01013307.
RefSeq	NP_001074445.1. NM_001080976.1. NP_037484.1. NM_013352.2.
UniGene	Hs.744135.
3D structure databases
ProteinModelPortal	Q9UL01.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UL01. 2 interactions.
STRING	9606.ENSP00000332151.
PTM databases
PhosphoSite	Q9UL01.
Polymorphism databases
DMDM	74762778.
Proteomic databases
PaxDb	Q9UL01.
PRIDE	Q9UL01.
Protocols and materials databases
DNASU	29940.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331677; ENSP00000332151; ENSG00000111817. ENST00000359564; ENSP00000352567; ENSG00000111817. ENST00000430252; ENSP00000397597; ENSG00000111817. ENST00000452085; ENSP00000404049; ENSG00000111817.
GeneID	29940.
KEGG	hsa:29940.
UCSC	uc003pws.3. human.
Organism-specific databases
CTD	29940.
GeneCards	GC06P116582.
HGNC	HGNC:21144. DSE.
HPA	HPA014764.
MIM	605942. gene.
neXtProt	NX_Q9UL01.
PharmGKB	PA162384080.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG19607.
HOVERGEN	HBG057715.
InParanoid	Q9UL01.
KO	K01794.
OrthoDB	EOG4FXR6S.
PhylomeDB	Q9UL01.
Enzyme and pathway databases
BioCyc	MetaCyc:HS03472-MONOMER.
Reactome	REACT_111217. Metabolism. REACT_116125. Disease.
UniPathway	UPA00755. UPA00756.
Gene expression databases
ArrayExpress	Q9UL01.
Bgee	Q9UL01.
CleanEx	HS_DSE.
Genevestigator	Q9UL01.
GermOnline	ENSG00000111817. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	DSE. human.
GenomeRNAi	29940.
NextBio	52587.
SOURCE	Search...

Entry information

Entry name

DSE_HUMAN

Accession

Primary (citable) accession number: Q9UL01
Secondary accession number(s): Q5R3K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.