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Protein

CCR4-NOT transcription complex subunit 11

Gene

CNOT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 11
Gene namesi
Name:CNOT11
Synonyms:C2orf29
ORF Names:C40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25217. CNOT11.

Subcellular locationi

GO - Cellular componenti

  • CCR4-NOT complex Source: UniProtKB
  • cytosol Source: Reactome
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899354.

Polymorphism and mutation databases

BioMutaiCNOT11.
DMDMi71152358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510CCR4-NOT transcription complex subunit 11PRO_0000089357Add
BLAST

Proteomic databases

EPDiQ9UKZ1.
MaxQBiQ9UKZ1.
PaxDbiQ9UKZ1.
PeptideAtlasiQ9UKZ1.
PRIDEiQ9UKZ1.

PTM databases

iPTMnetiQ9UKZ1.
PhosphoSiteiQ9UKZ1.

Expressioni

Gene expression databases

BgeeiENSG00000158435.
CleanExiHS_C2orf29.
ExpressionAtlasiQ9UKZ1. baseline and differential.
GenevisibleiQ9UKZ1. HS.

Organism-specific databases

HPAiHPA069823.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT1A5YKK64EBI-2562014,EBI-1222758
CNOT10Q9H9A54EBI-2562014,EBI-1054261
Cnot7Q608093EBI-2562014,EBI-2104739From a different organism.

Protein-protein interaction databases

BioGridi120724. 38 interactions.
IntActiQ9UKZ1. 15 interactions.
STRINGi9606.ENSP00000289382.

Structurei

3D structure databases

ProteinModelPortaliQ9UKZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 5957Gly-richAdd
BLAST
Compositional biasi155 – 18026Pro-richAdd
BLAST
Compositional biasi287 – 2904Poly-Pro

Sequence similaritiesi

Belongs to the CNOT11 family.Curated

Phylogenomic databases

eggNOGiKOG4508. Eukaryota.
ENOG410XPKT. LUCA.
GeneTreeiENSGT00390000006356.
HOGENOMiHOG000264251.
HOVERGENiHBG080995.
InParanoidiQ9UKZ1.
OMAiQWDRSMC.
OrthoDBiEOG091G0P4K.
PhylomeDBiQ9UKZ1.
TreeFamiTF323711.

Family and domain databases

InterProiIPR019312. DUF2363.
[Graphical view]
PANTHERiPTHR15975. PTHR15975. 1 hit.
PfamiPF10155. DUF2363. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG
60 70 80 90 100
SGGPGGPAGR MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD
110 120 130 140 150
HFRLGSVLVM LLQQPDLLPS AAQRLTALYL LWEMYRTEPL AANPFAASFA
160 170 180 190 200
HLLNPAPPAR GGQEPDRPPL SGFLPPITPP EKFFLSQLML APPRELFKKT
210 220 230 240 250
PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF PSILSDPDPD
260 270 280 290 300
SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW
310 320 330 340 350
LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL
360 370 380 390 400
EKDPKLVYHI GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN
410 420 430 440 450
MDMSLHSMEV VNRLTTAVDL PPEFIHLYIS NCISTCEQIK DKYMQNRLVR
460 470 480 490 500
LVCVFLQSLI RNKIINVQDL FIEVQAFCIE FSRIREAAGL FRLLKTLDTG
510
ETPSETKMSK
Length:510
Mass (Da):55,215
Last modified:May 1, 2000 - v1
Checksum:iE733DA59F1D0F280
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti507 – 5071K → E in AAH64421 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103798 mRNA. Translation: AAF02418.1.
AC013722 Genomic DNA. Translation: AAY15088.1.
BC018664 mRNA. Translation: AAH18664.2.
BC064421 mRNA. Translation: AAH64421.1.
CCDSiCCDS2050.1.
RefSeqiNP_060016.3. NM_017546.4.
UniGeneiHs.744080.

Genome annotation databases

EnsembliENST00000289382; ENSP00000289382; ENSG00000158435.
GeneIDi55571.
KEGGihsa:55571.
UCSCiuc002taw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103798 mRNA. Translation: AAF02418.1.
AC013722 Genomic DNA. Translation: AAY15088.1.
BC018664 mRNA. Translation: AAH18664.2.
BC064421 mRNA. Translation: AAH64421.1.
CCDSiCCDS2050.1.
RefSeqiNP_060016.3. NM_017546.4.
UniGeneiHs.744080.

3D structure databases

ProteinModelPortaliQ9UKZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120724. 38 interactions.
IntActiQ9UKZ1. 15 interactions.
STRINGi9606.ENSP00000289382.

PTM databases

iPTMnetiQ9UKZ1.
PhosphoSiteiQ9UKZ1.

Polymorphism and mutation databases

BioMutaiCNOT11.
DMDMi71152358.

Proteomic databases

EPDiQ9UKZ1.
MaxQBiQ9UKZ1.
PaxDbiQ9UKZ1.
PeptideAtlasiQ9UKZ1.
PRIDEiQ9UKZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289382; ENSP00000289382; ENSG00000158435.
GeneIDi55571.
KEGGihsa:55571.
UCSCiuc002taw.5. human.

Organism-specific databases

CTDi55571.
GeneCardsiCNOT11.
H-InvDBHIX0002326.
HGNCiHGNC:25217. CNOT11.
HPAiHPA069823.
neXtProtiNX_Q9UKZ1.
PharmGKBiPA134899354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4508. Eukaryota.
ENOG410XPKT. LUCA.
GeneTreeiENSGT00390000006356.
HOGENOMiHOG000264251.
HOVERGENiHBG080995.
InParanoidiQ9UKZ1.
OMAiQWDRSMC.
OrthoDBiEOG091G0P4K.
PhylomeDBiQ9UKZ1.
TreeFamiTF323711.

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

GenomeRNAii55571.
PROiQ9UKZ1.

Gene expression databases

BgeeiENSG00000158435.
CleanExiHS_C2orf29.
ExpressionAtlasiQ9UKZ1. baseline and differential.
GenevisibleiQ9UKZ1. HS.

Family and domain databases

InterProiIPR019312. DUF2363.
[Graphical view]
PANTHERiPTHR15975. PTHR15975. 1 hit.
PfamiPF10155. DUF2363. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNO11_HUMAN
AccessioniPrimary (citable) accession number: Q9UKZ1
Secondary accession number(s): Q6P2M9, Q8N681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.