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Protein

CCR4-NOT transcription complex subunit 11

Gene

CNOT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 11
Gene namesi
Name:CNOT11
Synonyms:C2orf29
ORF Names:C40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000158435.7
HGNCiHGNC:25217 CNOT11
neXtProtiNX_Q9UKZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158435
PharmGKBiPA134899354

Polymorphism and mutation databases

BioMutaiCNOT11
DMDMi71152358

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893571 – 510CCR4-NOT transcription complex subunit 11Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9UKZ1
MaxQBiQ9UKZ1
PaxDbiQ9UKZ1
PeptideAtlasiQ9UKZ1
PRIDEiQ9UKZ1

PTM databases

iPTMnetiQ9UKZ1
PhosphoSitePlusiQ9UKZ1

Expressioni

Gene expression databases

BgeeiENSG00000158435
CleanExiHS_C2orf29
ExpressionAtlasiQ9UKZ1 baseline and differential
GenevisibleiQ9UKZ1 HS

Organism-specific databases

HPAiHPA069823

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120724, 46 interactors
CORUMiQ9UKZ1
IntActiQ9UKZ1, 20 interactors
STRINGi9606.ENSP00000289382

Structurei

3D structure databases

ProteinModelPortaliQ9UKZ1
SMRiQ9UKZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 59Gly-richAdd BLAST57
Compositional biasi155 – 180Pro-richAdd BLAST26
Compositional biasi287 – 290Poly-Pro4

Sequence similaritiesi

Belongs to the CNOT11 family.Curated

Phylogenomic databases

eggNOGiKOG4508 Eukaryota
ENOG410XPKT LUCA
GeneTreeiENSGT00390000006356
HOGENOMiHOG000264251
HOVERGENiHBG080995
InParanoidiQ9UKZ1
OMAiLMDVGNM
OrthoDBiEOG091G0P4K
PhylomeDBiQ9UKZ1
TreeFamiTF323711

Family and domain databases

InterProiView protein in InterPro
IPR019312 CNOT11
PANTHERiPTHR15975 PTHR15975, 1 hit
PfamiView protein in Pfam
PF10155 DUF2363, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG
60 70 80 90 100
SGGPGGPAGR MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD
110 120 130 140 150
HFRLGSVLVM LLQQPDLLPS AAQRLTALYL LWEMYRTEPL AANPFAASFA
160 170 180 190 200
HLLNPAPPAR GGQEPDRPPL SGFLPPITPP EKFFLSQLML APPRELFKKT
210 220 230 240 250
PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF PSILSDPDPD
260 270 280 290 300
SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW
310 320 330 340 350
LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL
360 370 380 390 400
EKDPKLVYHI GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN
410 420 430 440 450
MDMSLHSMEV VNRLTTAVDL PPEFIHLYIS NCISTCEQIK DKYMQNRLVR
460 470 480 490 500
LVCVFLQSLI RNKIINVQDL FIEVQAFCIE FSRIREAAGL FRLLKTLDTG
510
ETPSETKMSK
Length:510
Mass (Da):55,215
Last modified:May 1, 2000 - v1
Checksum:iE733DA59F1D0F280
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti507K → E in AAH64421 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103798 mRNA Translation: AAF02418.1
AC013722 Genomic DNA Translation: AAY15088.1
BC018664 mRNA Translation: AAH18664.2
BC064421 mRNA Translation: AAH64421.1
CCDSiCCDS2050.1
RefSeqiNP_060016.3, NM_017546.4
UniGeneiHs.744080

Genome annotation databases

EnsembliENST00000289382; ENSP00000289382; ENSG00000158435
GeneIDi55571
KEGGihsa:55571
UCSCiuc002taw.5 human

Similar proteinsi

Entry informationi

Entry nameiCNO11_HUMAN
AccessioniPrimary (citable) accession number: Q9UKZ1
Secondary accession number(s): Q6P2M9, Q8N681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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