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Protein

Protein CDV3 homolog

Gene

CDV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CDV3 homolog
Gene namesi
Name:CDV3
Synonyms:H41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000091527.15
HGNCiHGNC:26928 CDV3
neXtProtiNX_Q9UKY7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55573
OpenTargetsiENSG00000091527
PharmGKBiPA142672138

Polymorphism and mutation databases

BioMutaiCDV3
DMDMi74721018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002995602 – 258Protein CDV3 homologAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei95PhosphotyrosineBy similarity1
Modified residuei106PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei190PhosphotyrosineBy similarity1
Modified residuei244PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKY7
PaxDbiQ9UKY7
PeptideAtlasiQ9UKY7
PRIDEiQ9UKY7
TopDownProteomicsiQ9UKY7-1 [Q9UKY7-1]
Q9UKY7-2 [Q9UKY7-2]
Q9UKY7-3 [Q9UKY7-3]

PTM databases

iPTMnetiQ9UKY7
PhosphoSitePlusiQ9UKY7

Expressioni

Tissue specificityi

Expression levels correlate with those of HER-2/neu in breast cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000091527
CleanExiHS_CDV3
ExpressionAtlasiQ9UKY7 baseline and differential
GenevisibleiQ9UKY7 HS

Organism-specific databases

HPAiHPA029761
HPA029762
HPA029763

Interactioni

Protein-protein interaction databases

BioGridi120726, 46 interactors
IntActiQ9UKY7, 1 interactor
STRINGi9606.ENSP00000264993

Structurei

3D structure databases

ProteinModelPortaliQ9UKY7
SMRiQ9UKY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 22Poly-Lys5
Compositional biasi28 – 77Ala-richAdd BLAST50
Compositional biasi127 – 133Poly-Gly7

Sequence similaritiesi

Belongs to the CDV3 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ3A Eukaryota
ENOG410XY8Z LUCA
GeneTreeiENSGT00390000000805
HOGENOMiHOG000007697
HOVERGENiHBG063147
InParanoidiQ9UKY7
OMAiYSGLRIQ
OrthoDBiEOG091G0SXV
PhylomeDBiQ9UKY7
TreeFamiTF315891

Family and domain databases

InterProiView protein in InterPro
IPR026806 CDV3
PANTHERiPTHR16284 PTHR16284, 1 hit
PfamiView protein in Pfam
PF15359 CDV3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG
60 70 80 90 100
GAGAGTRPGD GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV
110 120 130 140 150
QAMQISSEKE EDDNEKRQDP GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP
160 170 180 190 200
PAPVIVTETP EPAMTSGVYR PPGARLTTTR KTPQGPPEIY SDTQFPSLQS
210 220 230 240 250
TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL DNQYAVLENQ

KSSHSQYN
Length:258
Mass (Da):27,335
Last modified:May 1, 2000 - v1
Checksum:i4BE95D0C217EE346
GO
Isoform 2 (identifier: Q9UKY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-213: KDKEM → NRYLK
     214-258: Missing.

Show »
Length:213
Mass (Da):22,079
Checksum:iA3A2759CFBA4ED51
GO
Isoform 3 (identifier: Q9UKY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     210-212: DKE → YLK
     213-258: Missing.

Show »
Length:110
Mass (Da):11,911
Checksum:iDDB0671438DDBBA1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413571 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_027760209 – 213KDKEM → NRYLK in isoform 2. 1 Publication5
Alternative sequenceiVSP_041358210 – 212DKE → YLK in isoform 3. 1 Publication3
Alternative sequenceiVSP_041359213 – 258Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_027761214 – 258Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103803 mRNA Translation: AAF02423.1
AK096865 mRNA Translation: BAG53384.1
AC016255 Genomic DNA No translation available.
BC007338 mRNA Translation: AAH07338.1
CCDSiCCDS3079.1 [Q9UKY7-1]
CCDS46917.1 [Q9UKY7-2]
CCDS46918.1 [Q9UKY7-3]
RefSeqiNP_001127894.1, NM_001134422.1 [Q9UKY7-2]
NP_001127895.1, NM_001134423.2 [Q9UKY7-3]
NP_001269691.1, NM_001282762.1
NP_001269692.1, NM_001282763.1
NP_001269693.1, NM_001282764.1
NP_001269694.1, NM_001282765.1
NP_060018.1, NM_017548.4 [Q9UKY7-1]
UniGeneiHs.518265

Genome annotation databases

EnsembliENST00000264993; ENSP00000264993; ENSG00000091527 [Q9UKY7-1]
ENST00000420115; ENSP00000413272; ENSG00000091527 [Q9UKY7-3]
ENST00000431519; ENSP00000391955; ENSG00000091527 [Q9UKY7-2]
GeneIDi55573
KEGGihsa:55573
UCSCiuc003epp.5 human [Q9UKY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDV3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY7
Secondary accession number(s): B3KUC2, Q96IP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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