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Protein

Protein CDV3 homolog

Gene

CDV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CDV3 homolog
Gene namesi
Name:CDV3
Synonyms:H41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26928. CDV3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672138.

Polymorphism and mutation databases

BioMutaiCDV3.
DMDMi74721018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 258257Protein CDV3 homologPRO_0000299560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei4 – 41PhosphothreonineCombined sources
Modified residuei8 – 81PhosphoserineCombined sources
Modified residuei95 – 951PhosphotyrosineBy similarity
Modified residuei106 – 1061PhosphoserineCombined sources
Modified residuei107 – 1071PhosphoserineCombined sources
Modified residuei182 – 1821PhosphothreonineCombined sources
Modified residuei190 – 1901PhosphotyrosineBy similarity
Modified residuei244 – 2441PhosphotyrosineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKY7.
MaxQBiQ9UKY7.
PaxDbiQ9UKY7.
PeptideAtlasiQ9UKY7.
PRIDEiQ9UKY7.
TopDownProteomicsiQ9UKY7-1. [Q9UKY7-1]
Q9UKY7-2. [Q9UKY7-2]
Q9UKY7-3. [Q9UKY7-3]

PTM databases

iPTMnetiQ9UKY7.
PhosphoSiteiQ9UKY7.

Expressioni

Tissue specificityi

Expression levels correlate with those of HER-2/neu in breast cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000091527.
CleanExiHS_CDV3.
ExpressionAtlasiQ9UKY7. baseline and differential.
GenevisibleiQ9UKY7. HS.

Organism-specific databases

HPAiHPA029761.
HPA029762.
HPA029763.

Interactioni

Protein-protein interaction databases

BioGridi120726. 44 interactions.
IntActiQ9UKY7. 1 interaction.
STRINGi9606.ENSP00000264993.

Structurei

3D structure databases

ProteinModelPortaliQ9UKY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 225Poly-Lys
Compositional biasi28 – 7750Ala-richAdd
BLAST
Compositional biasi127 – 1337Poly-Gly

Sequence similaritiesi

Belongs to the CDV3 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ3A. Eukaryota.
ENOG410XY8Z. LUCA.
GeneTreeiENSGT00390000000805.
HOGENOMiHOG000007697.
HOVERGENiHBG063147.
InParanoidiQ9UKY7.
OMAiVMQIPVP.
OrthoDBiEOG091G0SXV.
PhylomeDBiQ9UKY7.
TreeFamiTF315891.

Family and domain databases

InterProiIPR026806. CDV3.
[Graphical view]
PANTHERiPTHR16284. PTHR16284. 1 hit.
PfamiPF15359. CDV3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG
60 70 80 90 100
GAGAGTRPGD GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV
110 120 130 140 150
QAMQISSEKE EDDNEKRQDP GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP
160 170 180 190 200
PAPVIVTETP EPAMTSGVYR PPGARLTTTR KTPQGPPEIY SDTQFPSLQS
210 220 230 240 250
TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL DNQYAVLENQ

KSSHSQYN
Length:258
Mass (Da):27,335
Last modified:May 1, 2000 - v1
Checksum:i4BE95D0C217EE346
GO
Isoform 2 (identifier: Q9UKY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-213: KDKEM → NRYLK
     214-258: Missing.

Show »
Length:213
Mass (Da):22,079
Checksum:iA3A2759CFBA4ED51
GO
Isoform 3 (identifier: Q9UKY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     210-212: DKE → YLK
     213-258: Missing.

Show »
Length:110
Mass (Da):11,911
Checksum:iDDB0671438DDBBA1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_041357Add
BLAST
Alternative sequencei209 – 2135KDKEM → NRYLK in isoform 2. 1 PublicationVSP_027760
Alternative sequencei210 – 2123DKE → YLK in isoform 3. 1 PublicationVSP_041358
Alternative sequencei213 – 25846Missing in isoform 3. 1 PublicationVSP_041359Add
BLAST
Alternative sequencei214 – 25845Missing in isoform 2. 1 PublicationVSP_027761Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103803 mRNA. Translation: AAF02423.1.
AK096865 mRNA. Translation: BAG53384.1.
AC016255 Genomic DNA. No translation available.
BC007338 mRNA. Translation: AAH07338.1.
CCDSiCCDS3079.1. [Q9UKY7-1]
CCDS46917.1. [Q9UKY7-2]
CCDS46918.1. [Q9UKY7-3]
RefSeqiNP_001127894.1. NM_001134422.1. [Q9UKY7-2]
NP_001127895.1. NM_001134423.2. [Q9UKY7-3]
NP_001269691.1. NM_001282762.1.
NP_001269692.1. NM_001282763.1.
NP_001269693.1. NM_001282764.1.
NP_001269694.1. NM_001282765.1.
NP_060018.1. NM_017548.4. [Q9UKY7-1]
UniGeneiHs.518265.

Genome annotation databases

EnsembliENST00000264993; ENSP00000264993; ENSG00000091527. [Q9UKY7-1]
ENST00000420115; ENSP00000413272; ENSG00000091527. [Q9UKY7-3]
ENST00000431519; ENSP00000391955; ENSG00000091527. [Q9UKY7-2]
GeneIDi55573.
KEGGihsa:55573.
UCSCiuc003epp.5. human. [Q9UKY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103803 mRNA. Translation: AAF02423.1.
AK096865 mRNA. Translation: BAG53384.1.
AC016255 Genomic DNA. No translation available.
BC007338 mRNA. Translation: AAH07338.1.
CCDSiCCDS3079.1. [Q9UKY7-1]
CCDS46917.1. [Q9UKY7-2]
CCDS46918.1. [Q9UKY7-3]
RefSeqiNP_001127894.1. NM_001134422.1. [Q9UKY7-2]
NP_001127895.1. NM_001134423.2. [Q9UKY7-3]
NP_001269691.1. NM_001282762.1.
NP_001269692.1. NM_001282763.1.
NP_001269693.1. NM_001282764.1.
NP_001269694.1. NM_001282765.1.
NP_060018.1. NM_017548.4. [Q9UKY7-1]
UniGeneiHs.518265.

3D structure databases

ProteinModelPortaliQ9UKY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120726. 44 interactions.
IntActiQ9UKY7. 1 interaction.
STRINGi9606.ENSP00000264993.

PTM databases

iPTMnetiQ9UKY7.
PhosphoSiteiQ9UKY7.

Polymorphism and mutation databases

BioMutaiCDV3.
DMDMi74721018.

Proteomic databases

EPDiQ9UKY7.
MaxQBiQ9UKY7.
PaxDbiQ9UKY7.
PeptideAtlasiQ9UKY7.
PRIDEiQ9UKY7.
TopDownProteomicsiQ9UKY7-1. [Q9UKY7-1]
Q9UKY7-2. [Q9UKY7-2]
Q9UKY7-3. [Q9UKY7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264993; ENSP00000264993; ENSG00000091527. [Q9UKY7-1]
ENST00000420115; ENSP00000413272; ENSG00000091527. [Q9UKY7-3]
ENST00000431519; ENSP00000391955; ENSG00000091527. [Q9UKY7-2]
GeneIDi55573.
KEGGihsa:55573.
UCSCiuc003epp.5. human. [Q9UKY7-1]

Organism-specific databases

CTDi55573.
GeneCardsiCDV3.
HGNCiHGNC:26928. CDV3.
HPAiHPA029761.
HPA029762.
HPA029763.
neXtProtiNX_Q9UKY7.
PharmGKBiPA142672138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3A. Eukaryota.
ENOG410XY8Z. LUCA.
GeneTreeiENSGT00390000000805.
HOGENOMiHOG000007697.
HOVERGENiHBG063147.
InParanoidiQ9UKY7.
OMAiVMQIPVP.
OrthoDBiEOG091G0SXV.
PhylomeDBiQ9UKY7.
TreeFamiTF315891.

Miscellaneous databases

ChiTaRSiCDV3. human.
GenomeRNAii55573.
PROiQ9UKY7.

Gene expression databases

BgeeiENSG00000091527.
CleanExiHS_CDV3.
ExpressionAtlasiQ9UKY7. baseline and differential.
GenevisibleiQ9UKY7. HS.

Family and domain databases

InterProiIPR026806. CDV3.
[Graphical view]
PANTHERiPTHR16284. PTHR16284. 1 hit.
PfamiPF15359. CDV3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDV3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY7
Secondary accession number(s): B3KUC2, Q96IP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.