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Protein

Putative inactive carboxylesterase 4

Gene

CES1P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Has no esterase activity.Curated

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: ProtInc

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiS09.986.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive carboxylesterase 4
Alternative name(s):
Inactive carboxylesterase 1 pseudogene 1
Placental carboxylesterase 3
Short name:
PCE-3
Gene namesi
Name:CES1P1
Synonyms:CES4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18546. CES1P1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi215273984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 287269Putative inactive carboxylesterase 4PRO_0000308588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UKY3.
PeptideAtlasiQ9UKY3.
PRIDEiQ9UKY3.

Expressioni

Tissue specificityi

Expressed in placenta.1 Publication

Gene expression databases

CleanExiHS_CES4.

Structurei

3D structure databases

ProteinModelPortaliQ9UKY3.
SMRiQ9UKY3. Positions 22-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107856.
InParanoidiQ9UKY3.
PhylomeDBiQ9UKY3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLPALVLAT LAASAAWAGH LSSPPLVDTL HGKVLGKFVS LEGFAQPVAV
60 70 80 90 100
FLGIPFAKPP LGPLRFTLPQ PAEPWNFVKN ATSYPPMFTQ DPKAGQLISE
110 120 130 140 150
LFTNRKENIP LKLSEDCLYL NIYTPADLTK KNRLPVMVWI HGGGLMVGAA
160 170 180 190 200
STYDGLALAA HENVVVVTIQ YRLGIWGFFS TGDEHSPGNW GHLDQLAALH
210 220 230 240 250
WVQDNIASFG GNPGSVTIFG GSVGGESVSV LVLSPLAKNL FHRAISESGV
260 270 280
ALTSVLVKKG DVKPLAEVGL RLVRLRLDTP TSLALCS
Length:287
Mass (Da):30,679
Last modified:November 25, 2008 - v2
Checksum:i2CB2AAECEE2C81BD
GO
Isoform 2 (identifier: Q9UKY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):15,802
Checksum:i9A8278A8A3F70D3C
GO

Sequence cautioni

The sequence AAF14185.1 differs from that shown. Reason: Frameshift at positions 92 and 95. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191G → V in AAF14185 (PubMed:10452915).Curated
Sequence conflicti21 – 211L → P in AAF14185 (PubMed:10452915).Curated
Sequence conflicti26 – 261L → V in AAF14185 (PubMed:10452915).Curated
Sequence conflicti30 – 301L → V in AAF14185 (PubMed:10452915).Curated
Sequence conflicti39 – 391V → I in AAF14185 (PubMed:10452915).Curated
Sequence conflicti68 – 681L → P in AAF14185 (PubMed:10452915).Curated
Sequence conflicti76 – 761N → S in AAF14185 (PubMed:10452915).Curated
Sequence conflicti83 – 831S → L in AAF14185 (PubMed:10452915).Curated
Sequence conflicti190 – 1901W → C in BC131699 (PubMed:15489334).Curated
Sequence conflicti223 – 2231V → A in AAF14185 (PubMed:10452915).Curated
Sequence conflicti223 – 2231V → A in BC131699 (PubMed:15489334).Curated
Sequence conflicti276 – 2761R → W in AAF14185 (PubMed:10452915).Curated
Sequence conflicti276 – 2761R → W in BC131699 (PubMed:15489334).Curated
Sequence conflicti280 – 2801P → H in AAF14185 (PubMed:10452915).Curated
Sequence conflicti280 – 2801P → H in BC131699 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 2. 1 PublicationVSP_029004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106005 mRNA. Translation: AAF14185.1. Frameshift.
AC136621 Genomic DNA. No translation available.
BC131699 mRNA. No translation available.
UniGeneiHs.721645.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106005 mRNA. Translation: AAF14185.1. Frameshift.
AC136621 Genomic DNA. No translation available.
BC131699 mRNA. No translation available.
UniGeneiHs.721645.

3D structure databases

ProteinModelPortaliQ9UKY3.
SMRiQ9UKY3. Positions 22-267.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.986.

Polymorphism and mutation databases

DMDMi215273984.

Proteomic databases

EPDiQ9UKY3.
PeptideAtlasiQ9UKY3.
PRIDEiQ9UKY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiCES1P1.
HGNCiHGNC:18546. CES1P1.
neXtProtiNX_Q9UKY3.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG107856.
InParanoidiQ9UKY3.
PhylomeDBiQ9UKY3.

Miscellaneous databases

PROiQ9UKY3.

Gene expression databases

CleanExiHS_CES4.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms."
    Yan B., Matoney L., Yang D.
    Placenta 20:599-607(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiCES1P_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY3
Secondary accession number(s): A2RRL8, B9ZVS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to other members of the family, it is shorter and lacks the C-terminal part that contains the conserved Glu and His active sites.Curated
Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.