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Q9UKY1

- ZHX1_HUMAN

UniProt

Q9UKY1 - ZHX1_HUMAN

Protein

Zinc fingers and homeoboxes protein 1

Gene

ZHX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 9324C2H2-type 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri102 – 12524C2H2-type 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi284 – 34663Homeobox 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi464 – 52663Homeobox 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi569 – 63062Homeobox 3CuratedPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi660 – 72263Homeobox 4CuratedPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi777 – 83256Homeobox 5CuratedPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc fingers and homeoboxes protein 1
    Gene namesi
    Name:ZHX1
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:12871. ZHX1.

    Subcellular locationi

    Nucleus 2 PublicationsPROSITE-ProRule annotation
    Note: Colocalized in the nucleus with DNMT3B.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Zinc fingers and homeoboxes protein 1PRO_0000049388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Phosphoserine1 Publication
    Modified residuei47 – 471Phosphoserine2 Publications
    Modified residuei48 – 481Phosphoserine2 Publications
    Modified residuei648 – 6481Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UKY1.
    PaxDbiQ9UKY1.
    PRIDEiQ9UKY1.

    PTM databases

    PhosphoSiteiQ9UKY1.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Expressed in podocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ9UKY1.
    BgeeiQ9UKY1.
    CleanExiHS_ZHX1.
    GenevestigatoriQ9UKY1.

    Organism-specific databases

    HPAiHPA051900.
    HPA055357.

    Interactioni

    Subunit structurei

    Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain).4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN1P542535EBI-347767,EBI-930964
    DNMT3BQ9UBC3-14EBI-347767,EBI-6083193

    Protein-protein interaction databases

    BioGridi116406. 55 interactions.
    IntActiQ9UKY1. 56 interactions.
    MINTiMINT-1424551.
    STRINGi9606.ENSP00000297857.

    Structurei

    Secondary structure

    1
    873
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni60 – 623
    Beta strandi68 – 714
    Beta strandi78 – 803
    Helixi82 – 9211
    Beta strandi102 – 1043
    Turni105 – 1084
    Beta strandi109 – 1135
    Helixi115 – 1184
    Helixi120 – 1234
    Beta strandi131 – 1355
    Beta strandi144 – 1507
    Helixi473 – 48513
    Helixi491 – 50111
    Helixi505 – 51814
    Turni519 – 5235
    Helixi577 – 58913
    Helixi595 – 60410
    Helixi609 – 62416
    Beta strandi664 – 6674
    Helixi669 – 68113
    Helixi687 – 69711
    Helixi701 – 71515
    Turni716 – 7183
    Helixi721 – 73010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ECBNMR-A565-640[»]
    2GHFNMR-A60-153[»]
    2LY9NMR-A462-532[»]
    3NARX-ray2.60A/B655-731[»]
    ProteinModelPortaliQ9UKY1.
    SMRiQ9UKY1. Positions 60-153, 297-339, 462-532, 565-637, 662-731.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UKY1.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni272 – 564293Required for interaction with NFYAAdd
    BLAST
    Regioni272 – 432161Required for dimerizationAdd
    BLAST
    Regioni734 – 76835Required for nuclear localizationAdd
    BLAST
    Regioni831 – 87343Required for repressor activityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ZHX family.Curated
    Contains 2 C2H2-type zinc fingers.CuratedPROSITE-ProRule annotation
    Contains 5 homeobox DNA-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 9324C2H2-type 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri102 – 12524C2H2-type 2CuratedPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Homeobox, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG39488.
    HOGENOMiHOG000013231.
    HOVERGENiHBG007920.
    InParanoidiQ9UKY1.
    OMAiSHMGYEQ.
    OrthoDBiEOG76HQ0T.
    PhylomeDBiQ9UKY1.
    TreeFamiTF333363.

    Family and domain databases

    Gene3Di1.10.10.60. 5 hits.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 4 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 5 hits.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 5 hits.
    PROSITEiPS50071. HOMEOBOX_2. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKY1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRRKSTTP CMVLASEQDP DLELISDLDE GPPVLTPVEN TRAESISSDE    50
    EVHESVDSDN QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS 100
    SYVCVECNFL TKRYDALSEH NLKYHPGEEN FKLTMVKRNN QTIFEQTIND 150
    LTFDGSFVKE ENAEQAESTE VSSSGISISK TPIMKMMKNK VENKRIAVHH 200
    NSVEDVPEEK ENEIKPDREE IVENPSSSAS ESNTSTSIVN RIHPSTASTV 250
    VTPAAVLPGL AQVITAVSAQ QNSNLIPKVL IPVNSIPTYN AALDNNPLLL 300
    NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE 350
    ARRKQFNGTV HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ 400
    VAGTNTLPVT APIALTVAGV PSQNNIQKSQ VPAAQPTAET KPATAAVPTS 450
    QSVKHETALV NPDSFGIRAK KTKEQLAELK VSYLKNQFPH DSEIIRLMKI 500
    TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSTTIII DSSDETTESP 550
    TVGTAQPKQS WNPFPDFTPQ KFKEKTAEQL RVLQASFLNS SVLTDEELNR 600
    LRAQTKLTRR EIDAWFTEKK KSKALKEEKM EIDESNAGSS KEEAGETSPA 650
    DESGAPKSGS TGKICKKTPE QLHMLKSAFV RTQWPSPEEY DKLAKESGLA 700
    RTDIVSWFGD TRYAWKNGNL KWYYYYQSAN SSSMNGLSSL RKRGRGRPKG 750
    RGRGRPRGRP RGSKRINNWD RGPSLIKFKT GTAILKDYYL KHKFLNEQDL 800
    DELVNKSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE VIDDQEEDEE 850
    ETDDSDTWEP PRHVKRKLSK SDD 873
    Length:873
    Mass (Da):98,098
    Last modified:May 1, 2000 - v1
    Checksum:i66CF1CEC5EF824E5
    GO
    Isoform 2 (identifier: Q96EF9-1) [UniParc]FASTAAdd to Basket

    Also known as: ZHX1-C8orf76

    The sequence of this isoform can be found in the external entry Q96EF9.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein. No experimental confirmation available.

    Length:292
    Mass (Da):33,285
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631V → M in AAH40481. (PubMed:15489334)Curated
    Sequence conflicti792 – 7921H → R in AAH40481. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106862 mRNA. Translation: AAD50624.1.
    AF195766 mRNA. Translation: AAF35183.1.
    BC040481 mRNA. Translation: AAH40481.1.
    CCDSiCCDS6342.1. [Q9UKY1-1]
    PIRiJC7079.
    RefSeqiNP_001017926.1. NM_001017926.2. [Q9UKY1-1]
    NP_009153.3. NM_007222.4. [Q9UKY1-1]
    UniGeneiHs.521800.

    Genome annotation databases

    EnsembliENST00000297857; ENSP00000297857; ENSG00000165156. [Q9UKY1-1]
    ENST00000395571; ENSP00000378938; ENSG00000165156. [Q9UKY1-1]
    ENST00000522655; ENSP00000428821; ENSG00000165156. [Q9UKY1-1]
    GeneIDi11244.
    KEGGihsa:11244.
    UCSCiuc003yqe.3. human. [Q9UKY1-1]

    Polymorphism databases

    DMDMi44888551.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106862 mRNA. Translation: AAD50624.1 .
    AF195766 mRNA. Translation: AAF35183.1 .
    BC040481 mRNA. Translation: AAH40481.1 .
    CCDSi CCDS6342.1. [Q9UKY1-1 ]
    PIRi JC7079.
    RefSeqi NP_001017926.1. NM_001017926.2. [Q9UKY1-1 ]
    NP_009153.3. NM_007222.4. [Q9UKY1-1 ]
    UniGenei Hs.521800.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ECB NMR - A 565-640 [» ]
    2GHF NMR - A 60-153 [» ]
    2LY9 NMR - A 462-532 [» ]
    3NAR X-ray 2.60 A/B 655-731 [» ]
    ProteinModelPortali Q9UKY1.
    SMRi Q9UKY1. Positions 60-153, 297-339, 462-532, 565-637, 662-731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116406. 55 interactions.
    IntActi Q9UKY1. 56 interactions.
    MINTi MINT-1424551.
    STRINGi 9606.ENSP00000297857.

    PTM databases

    PhosphoSitei Q9UKY1.

    Polymorphism databases

    DMDMi 44888551.

    Proteomic databases

    MaxQBi Q9UKY1.
    PaxDbi Q9UKY1.
    PRIDEi Q9UKY1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297857 ; ENSP00000297857 ; ENSG00000165156 . [Q9UKY1-1 ]
    ENST00000395571 ; ENSP00000378938 ; ENSG00000165156 . [Q9UKY1-1 ]
    ENST00000522655 ; ENSP00000428821 ; ENSG00000165156 . [Q9UKY1-1 ]
    GeneIDi 11244.
    KEGGi hsa:11244.
    UCSCi uc003yqe.3. human. [Q9UKY1-1 ]

    Organism-specific databases

    CTDi 11244.
    GeneCardsi GC08M124260.
    HGNCi HGNC:12871. ZHX1.
    HPAi HPA051900.
    HPA055357.
    MIMi 604764. gene.
    neXtProti NX_Q9UKY1.
    PharmGKBi PA37460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39488.
    HOGENOMi HOG000013231.
    HOVERGENi HBG007920.
    InParanoidi Q9UKY1.
    OMAi SHMGYEQ.
    OrthoDBi EOG76HQ0T.
    PhylomeDBi Q9UKY1.
    TreeFami TF333363.

    Miscellaneous databases

    EvolutionaryTracei Q9UKY1.
    GeneWikii ZHX1.
    GenomeRNAii 11244.
    NextBioi 42786.
    PROi Q9UKY1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKY1.
    Bgeei Q9UKY1.
    CleanExi HS_ZHX1.
    Genevestigatori Q9UKY1.

    Family and domain databases

    Gene3Di 1.10.10.60. 5 hits.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 4 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 5 hits.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 5 hits.
    PROSITEi PS50071. HOMEOBOX_2. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y."
      Yamada K., Printz R.L., Osawa H., Granner D.K.
      Biochem. Biophys. Res. Commun. 261:614-621(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH NFYA.
      Tissue: Liver1 Publication.
    2. "Identification and cloning of the human ZHX1 gene."
      Mueller R., Ziegler B.L.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: TestisImported.
    4. "Identification of proteins that interact with NF-YA."
      Yamada K., Osawa H., Granner D.K.
      FEBS Lett. 460:41-45(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NFYA.
    5. Cited for: FUNCTION, HOMODIMERIZATION, SUBCELLULAR LOCATION.
    6. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."
      Yamada K., Kawata H., Shou Z., Hirano S., Mizutani T., Yazawa T., Sekiguchi T., Yoshino M., Kajitani T., Miyamoto K.
      Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: HETERODIMERIZATION WITH ZHX3, INTERACTION WITH ATF7IP.
    7. "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor."
      Kawata H., Yamada K., Shou Z., Mizutani T., Yazawa T., Yoshino M., Sekiguchi T., Kajitani T., Miyamoto K.
      Biochem. J. 373:747-757(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: HETERODIMERIZATION WITH ZHX2.
    8. "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome."
      Liu G., Clement L.C., Kanwar Y.S., Avila-Casado C., Chugh S.S.
      J. Biol. Chem. 281:39681-39692(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression."
      Kim S.H., Park J., Choi M.C., Kim H.P., Park J.H., Jung Y., Lee J.H., Oh D.Y., Im S.A., Bang Y.J., Kim T.Y.
      Biochem. Biophys. Res. Commun. 355:318-323(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNMT3B.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-47 AND SER-48, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-48 AND SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Solution structure of the zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)."
      Structural proteomics in Europe (SPINE)
      Submitted (APR-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 60-153.
    15. "The solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 565-640.
    16. "The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension."
      Wienk H., Lammers I., Hotze A., Wu J., Wechselberger R.W., Owens R., Stammers D.K., Stuart D., Kaptein R., Folkers G.E.
      Biochemistry 48:4431-4439(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 60-153.
    17. "Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains."
      Bird L.E., Ren J., Nettleship J.E., Folkers G.E., Owens R.J., Stammers D.K.
      BMC Struct. Biol. 10:13-13(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 655-731.

    Entry informationi

    Entry nameiZHX1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKY1
    Secondary accession number(s): Q8IWD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3