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Protein

Prion-like protein doppel

Gene

PRND

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prion

Names & Taxonomyi

Protein namesi
Recommended name:
Prion-like protein doppel
Alternative name(s):
PrPLP
Prion protein 2
Gene namesi
Name:PRND
Synonyms:DPL
ORF Names:UNQ1830/PRO3443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15748. PRND.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33795.

Polymorphism and mutation databases

BioMutaiPRND.
DMDMi68067934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 152126Prion-like protein doppelPRO_0000025745Add
BLAST
Propeptidei153 – 17624Removed in mature formBy similarityPRO_0000025746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 1451 Publication
Glycosylationi98 – 981N-linked (GlcNAc...)Curated
Disulfide bondi108 ↔ 1401 Publication
Glycosylationi110 – 1101N-linked (GlcNAc...)Curated
Lipidationi152 – 1521GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9UKY0.
PeptideAtlasiQ9UKY0.
PRIDEiQ9UKY0.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiQ9UKY0.
CleanExiHS_PRND.
GenevisibleiQ9UKY0. HS.

Organism-specific databases

HPAiHPA043373.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306900.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi72 – 8110Combined sources
Helixi82 – 843Combined sources
Helixi101 – 11515Combined sources
Turni117 – 1215Combined sources
Helixi126 – 14116Combined sources
Beta strandi146 – 1483Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LG4NMR-A24-152[»]
ProteinModelPortaliQ9UKY0.
SMRiQ9UKY0. Positions 1-30, 52-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKY0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 5024Flexible tailAdd
BLAST
Regioni51 – 152102GlobularAdd
BLAST

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9UKY0.
OMAiYYEANYW.
OrthoDBiEOG712TXK.
PhylomeDBiQ9UKY0.
TreeFamiTF337532.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ
60 70 80 90 100
VAENRPGAFI KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT
110 120 130 140 150
KEAFVTGCIN ATQAANQGEF QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE
160 170
RGAGLRVTMH QPVLLCLLAL IWLTVK
Length:176
Mass (Da):20,293
Last modified:June 21, 2005 - v2
Checksum:iA0F41EB0DFEED236
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431K → E in AAG43448 (Ref. 2) Curated
Sequence conflicti143 – 1431K → E in AAG43449 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61S → I.1 Publication
VAR_013769
Natural varianti22 – 221S → P.1 Publication
VAR_013770
Natural varianti26 – 261T → P.1 Publication
VAR_013765
Natural varianti31 – 311H → R.1 Publication
VAR_013771
Natural varianti56 – 561P → L.1 Publication
Corresponds to variant rs35453518 [ dbSNP | Ensembl ].
VAR_013766
Natural varianti70 – 701F → L.1 Publication
VAR_013772
Natural varianti149 – 1491L → S.1 Publication
VAR_013773
Natural varianti174 – 1741T → M Common polymorphism. 6 Publications
Corresponds to variant rs2245220 [ dbSNP | Ensembl ].
VAR_013767

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA. Translation: AAF02424.1.
AF187843 mRNA. Translation: AAG43448.1.
AF187844 mRNA. Translation: AAG43449.1.
EU009729 Genomic DNA. Translation: ABU40603.1.
AY358985 mRNA. Translation: AAQ89344.1.
AL133396 Genomic DNA. Translation: CAB75502.1.
BC043644 mRNA. Translation: AAH43644.1.
CCDSiCCDS13081.1.
RefSeqiNP_036541.2. NM_012409.3.
UniGeneiHs.406696.

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864.
GeneIDi23627.
KEGGihsa:23627.
UCSCiuc002wkz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA. Translation: AAF02424.1.
AF187843 mRNA. Translation: AAG43448.1.
AF187844 mRNA. Translation: AAG43449.1.
EU009729 Genomic DNA. Translation: ABU40603.1.
AY358985 mRNA. Translation: AAQ89344.1.
AL133396 Genomic DNA. Translation: CAB75502.1.
BC043644 mRNA. Translation: AAH43644.1.
CCDSiCCDS13081.1.
RefSeqiNP_036541.2. NM_012409.3.
UniGeneiHs.406696.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LG4NMR-A24-152[»]
ProteinModelPortaliQ9UKY0.
SMRiQ9UKY0. Positions 1-30, 52-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306900.

Polymorphism and mutation databases

BioMutaiPRND.
DMDMi68067934.

Proteomic databases

PaxDbiQ9UKY0.
PeptideAtlasiQ9UKY0.
PRIDEiQ9UKY0.

Protocols and materials databases

DNASUi23627.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864.
GeneIDi23627.
KEGGihsa:23627.
UCSCiuc002wkz.5. human.

Organism-specific databases

CTDi23627.
GeneCardsiPRND.
H-InvDBHIX0027662.
HGNCiHGNC:15748. PRND.
HPAiHPA043373.
MIMi604263. gene.
neXtProtiNX_Q9UKY0.
PharmGKBiPA33795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9UKY0.
OMAiYYEANYW.
OrthoDBiEOG712TXK.
PhylomeDBiQ9UKY0.
TreeFamiTF337532.

Miscellaneous databases

EvolutionaryTraceiQ9UKY0.
GeneWikiiPRND.
GenomeRNAii23627.
PROiQ9UKY0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKY0.
CleanExiHS_PRND.
GenevisibleiQ9UKY0. HS.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-174.
  2. "Human mRNA sequence for a novel Prion-like gene, prnd."
    Lee I.Y., Wang K., Westaway D., Hood L.E.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-174.
    Tissue: Brain cortex and Testis.
  3. Chen H.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-174.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-174.
    Tissue: Testis.
  7. "Expression and structural characterization of the recombinant human doppel protein."
    Lu K., Wang W., Xie Z., Wong B.-S., Li R., Petersen R.B., Sy M.-S., Chen S.G.
    Biochemistry 39:13575-13583(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: STRUCTURE BY NMR.
  9. "First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases."
    Peoc'h K., Guerin C., Brandel J.-P., Launay J.-M., Laplanche J.-L.
    Neurosci. Lett. 286:144-148(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-26; LEU-56 AND MET-174.
  10. "Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders."
    Schroeder B., Franz B., Hempfling P., Selbert M., Juergens T., Kretzschmar H.A., Bodemer M., Poser S., Zerr I.
    Hum. Genet. 109:319-325(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ILE-6; PRO-22; ARG-31; LEU-70; SER-149 AND MET-174.

Entry informationi

Entry nameiPRND_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY0
Secondary accession number(s): A7U7M5
, Q9H311, Q9H312, Q9NTM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 21, 2005
Last modified: July 6, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.