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Protein

Prion-like protein doppel

Gene

PRND

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171864-MONOMER.

Protein family/group databases

TCDBi1.C.48.1.4. the prion peptide (prp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Prion-like protein doppel
Alternative name(s):
PrPLP
Prion protein 2
Gene namesi
Name:PRND
Synonyms:DPL
ORF Names:UNQ1830/PRO3443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15748. PRND.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23627.
OpenTargetsiENSG00000171864.
PharmGKBiPA33795.

Polymorphism and mutation databases

BioMutaiPRND.
DMDMi68067934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002574527 – 152Prion-like protein doppelAdd BLAST126
PropeptideiPRO_0000025746153 – 176Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 1451 Publication
Glycosylationi98N-linked (GlcNAc...)Curated1
Disulfide bondi108 ↔ 1401 Publication
Glycosylationi110N-linked (GlcNAc...)Curated1
Lipidationi152GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9UKY0.
PeptideAtlasiQ9UKY0.
PRIDEiQ9UKY0.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiENSG00000171864.
CleanExiHS_PRND.
GenevisibleiQ9UKY0. HS.

Organism-specific databases

HPAiHPA043373.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306900.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi72 – 81Combined sources10
Helixi82 – 84Combined sources3
Helixi101 – 115Combined sources15
Turni117 – 121Combined sources5
Helixi126 – 141Combined sources16
Beta strandi146 – 148Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LG4NMR-A24-152[»]
ProteinModelPortaliQ9UKY0.
SMRiQ9UKY0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKY0.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 50Flexible tailAdd BLAST24
Regioni51 – 152GlobularAdd BLAST102

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9UKY0.
OMAiYYEANYW.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9UKY0.
TreeFamiTF337532.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ
60 70 80 90 100
VAENRPGAFI KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT
110 120 130 140 150
KEAFVTGCIN ATQAANQGEF QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE
160 170
RGAGLRVTMH QPVLLCLLAL IWLTVK
Length:176
Mass (Da):20,293
Last modified:June 21, 2005 - v2
Checksum:iA0F41EB0DFEED236
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → E in AAG43448 (Ref. 2) Curated1
Sequence conflicti143K → E in AAG43449 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0137696S → I.1 Publication1
Natural variantiVAR_01377022S → P.1 Publication1
Natural variantiVAR_01376526T → P.1 Publication1
Natural variantiVAR_01377131H → R.1 Publication1
Natural variantiVAR_01376656P → L.1 PublicationCorresponds to variant rs35453518dbSNPEnsembl.1
Natural variantiVAR_01377270F → L.1 Publication1
Natural variantiVAR_013773149L → S.1 Publication1
Natural variantiVAR_013767174T → M Common polymorphism. 6 PublicationsCorresponds to variant rs2245220dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA. Translation: AAF02424.1.
AF187843 mRNA. Translation: AAG43448.1.
AF187844 mRNA. Translation: AAG43449.1.
EU009729 Genomic DNA. Translation: ABU40603.1.
AY358985 mRNA. Translation: AAQ89344.1.
AL133396 Genomic DNA. Translation: CAB75502.1.
BC043644 mRNA. Translation: AAH43644.1.
CCDSiCCDS13081.1.
RefSeqiNP_036541.2. NM_012409.3.
UniGeneiHs.406696.

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864.
GeneIDi23627.
KEGGihsa:23627.
UCSCiuc002wkz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA. Translation: AAF02424.1.
AF187843 mRNA. Translation: AAG43448.1.
AF187844 mRNA. Translation: AAG43449.1.
EU009729 Genomic DNA. Translation: ABU40603.1.
AY358985 mRNA. Translation: AAQ89344.1.
AL133396 Genomic DNA. Translation: CAB75502.1.
BC043644 mRNA. Translation: AAH43644.1.
CCDSiCCDS13081.1.
RefSeqiNP_036541.2. NM_012409.3.
UniGeneiHs.406696.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LG4NMR-A24-152[»]
ProteinModelPortaliQ9UKY0.
SMRiQ9UKY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306900.

Protein family/group databases

TCDBi1.C.48.1.4. the prion peptide (prp) family.

Polymorphism and mutation databases

BioMutaiPRND.
DMDMi68067934.

Proteomic databases

PaxDbiQ9UKY0.
PeptideAtlasiQ9UKY0.
PRIDEiQ9UKY0.

Protocols and materials databases

DNASUi23627.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864.
GeneIDi23627.
KEGGihsa:23627.
UCSCiuc002wkz.5. human.

Organism-specific databases

CTDi23627.
DisGeNETi23627.
GeneCardsiPRND.
H-InvDBHIX0027662.
HGNCiHGNC:15748. PRND.
HPAiHPA043373.
MIMi604263. gene.
neXtProtiNX_Q9UKY0.
OpenTargetsiENSG00000171864.
PharmGKBiPA33795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9UKY0.
OMAiYYEANYW.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9UKY0.
TreeFamiTF337532.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171864-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UKY0.
GeneWikiiPRND.
GenomeRNAii23627.
PROiQ9UKY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171864.
CleanExiHS_PRND.
GenevisibleiQ9UKY0. HS.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRND_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY0
Secondary accession number(s): A7U7M5
, Q9H311, Q9H312, Q9NTM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.