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Reviewed, UniProtKB/Swiss-Prot Q9UKX5 (ITA11_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Integrin alpha-11
Gene names
Name: ITGA11
ORF Names: MSTP018
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Integrin alpha-11/beta-1 is a receptor for collagen.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21. Ref.5

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

According Ref.2 highest levels in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to Ref.1 also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver. Ref.2

Developmental stage

Strongly up-regulated in differentiating fetal muscle cells (in vitro).

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

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Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
   LigandCalcium
Magnesium
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processcell-matrix adhesion Ref.2

Traceable author statement. Source: ProtInc

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

muscle organ development Ref.2

Traceable author statement. Source: ProtInc

   Cellular componentintegrin complex Ref.1

Traceable author statement. Source: ProtInc

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

collagen binding Ref.2

Traceable author statement. Source: ProtInc

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 11891167Integrin alpha-11
PRO_0000016318

Regions

Topological domain23 – 11421120Extracellular Potential
Transmembrane1143 – 116523 Potential
Topological domain1166 – 118924Cytoplasmic Potential
Repeat38 – 9457FG-GAP 1
Repeat102 – 16362FG-GAP 2
Domain164 – 345182VWFA
Repeat359 – 42062FG-GAP 3
Repeat422 – 47554FG-GAP 4
Repeat477 – 53761FG-GAP 5
Repeat539 – 59860FG-GAP 6
Repeat601 – 65353FG-GAP 7
Calcium binding488 – 4969 Potential
Calcium binding551 – 5599 Potential
Calcium binding613 – 6219 Potential
Compositional bias1154 – 11629Poly-Leu
Compositional bias1174 – 11774Poly-Arg

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...)
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation6421N-linked (GlcNAc...) Potential
Glycosylation6941N-linked (GlcNAc...) Potential
Glycosylation8571N-linked (GlcNAc...) Potential
Glycosylation8941N-linked (GlcNAc...) Potential
Glycosylation9731N-linked (GlcNAc...) Potential
Glycosylation10321N-linked (GlcNAc...) Potential
Glycosylation10401N-linked (GlcNAc...) Potential
Glycosylation10601N-linked (GlcNAc...) Potential
Disulfide bond76 ↔ 83 By similarity
Disulfide bond121 ↔ 139 Potential
Disulfide bond129 ↔ 159 Potential
Disulfide bond659 ↔ 668 By similarity
Disulfide bond674 ↔ 729 By similarity
Disulfide bond781 ↔ 787 By similarity
Disulfide bond881 ↔ 893 By similarity

Natural variations

Natural variant4331V → M: dbSNP rs2306022.
VAR_009889
Natural variant4711M → L: dbSNP rs2306024.
VAR_020038
Natural variant5241R → L
VAR_009890
Natural variant8911Q → K: dbSNP rs2271725.
VAR_020039
Natural variant9721L → P
VAR_009891
Natural variant10031I → M
VAR_009892
Natural variant10301Missing
VAR_009893
Natural variant10941L → V
VAR_009894

Experimental info

Mutagenesis11711R → A: No effect on RAB21-binding. Ref.5

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Sequences

Sequence LengthMass (Da)Tools
Q9UKX5-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 60303C08A4A4CD52

FASTA1,189133,610
        10         20         30         40         50         60 
MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI SGNKWLVVGA 

        70         80         90        100        110        120 
PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK DNMRLGLSLA TNPKDNSFLA 

       130        140        150        160        170        180 
CSPLWSHECG SSYYTTGMCS RVNSNFRFSK TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE 

       190        200        210        220        230        240 
VQHFLINILK KFYIGPGQIQ VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET 

       250        260        270        280        290        300 
RTAFGIEFAR SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL 

       310        320        330        340        350        360 
GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF SLEGTNKNET 

       370        380        390        400        410        420 
SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA GKVIPLRESY LKEFPEELKN 

       430        440        450        460        470        480 
HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH TGKVILFTMH NNRSLTIHQA MRGQQIGSYF 

       490        500        510        520        530        540 
GSEITSVDID GDGVTDVLLV GAPMYFNEGR ERGKVYVYEL RQNRFVYNGT LKDSHSYQNA 

       550        560        570        580        590        600 
RFGSSIASVR DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG 

       610        620        630        640        650        660 
LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS KINIFHRDCK 

       670        680        690        700        710        720 
RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER RYTPRAHLDE GGDRFTNRAV 

       730        740        750        760        770        780 
LLSSGQELCE RINFHVLDTA DYVKPVTFSV EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG 

       790        800        810        820        830        840 
CNEDEHCVPD LVLDARSDLP TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV 

       850        860        870        880        890        900 
EATLENRGEN AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF 

       910        920        930        940        950        960 
RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH LKYEADVLFT 

       970        980        990       1000       1010       1020 
RSSSLSHYEV KLNSSLERYD GIGPPFSCIF RIQNLGLFPI HGIMMKITIP IATRSGNRLL 

      1030       1040       1050       1060       1070       1080 
KLRDFLTDEV ANTSCNIWGN STEYRPTPVE EDLRRAPQLN HSNSDVVSIN CNIRLVPNQE 

      1090       1100       1110       1120       1130       1140 
INFHLLGNLW LRSLKALKYK SMKIMVNAAL QRQFHSPFIF REEDPSRQIV FEISKQEDWQ 

      1150       1160       1170       1180 
VPIWIIVGST LGGLLLLALL VLALWKLGFF RSARRRREPG LDPTPKVLE

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References

« Hide 'large scale' references
[1]"Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)."
Lehnert K., Ni J., Leung E., Gough S.M., Weaver A., Yao W.P., Liu D., Wang S.-X., Morris C.M., Krissansen G.W.
Genomics 60:179-187(1999) [PubMed: 10486209] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal heart and Osteoblast.
[2]"cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues."
Velling T., Kusche-Gullberg M., Sejersen T., Gullberg D.
J. Biol. Chem. 274:25735-25742(1999) [PubMed: 10464311] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal muscle and Uterus.
[3]Xu Y.Y., Sun L.Z., Wu Q.Y., Liu Y.Q., Liu B., Zhao B., Wang X.Y., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Sun Y.H., Jiang Y.X., Zhao X.W., Liu S. expand/collapse author list , Liu L.S., Ding J.F., Gao R.L., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 317-1189.
Tissue: Aorta.
[4]The European IMAGE consortium
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 954-1189.
Tissue: Fibroblast.
[5]"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
J. Cell Biol. 173:767-780(2006) [PubMed: 16754960] [Abstract]
Cited for: INTERACTION WITH RAB21, MUTAGENESIS OF ARG-1171.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-331, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF109681 mRNA. Translation: AAF01258.1.
AF137378 mRNA. Translation: AAD51919.2.
AF111799 mRNA. Translation: AAL39001.1. Different initiation.
AL359064 mRNA. Translation: CAB94392.1.
IPIIPI00215613.
RefSeqNP_001004439.1.
UniGeneHs.436416

3D structure databases

HSSPHSSP built from PDB template 1MHP based on UniProtKB P18614.
ModBaseSearch...

PTM databases

PhosphoSiteQ9UKX5.

Proteomic databases

PRIDEQ9UKX5.

Genome annotation databases

EnsemblENSG00000137809. Homo sapiens. [Contig view]
GeneID22801.
KEGGhsa:22801.

Organism-specific databases

GeneCardsGC15M066381.
H-InvDBHIX0012380.
HGNCHGNC:6136. ITGA11.
MIM604789. gene.
PharmGKBPA29937.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9UKX5.
HOVERGENQ9UKX5.

Enzyme and pathway databases

ReactomeREACT_13552. Integrin cell surface interactions.

Gene expression databases

ArrayExpressQ9UKX5.
BgeeQ9UKX5.
CleanExHS_ITGA11.
GermOnlineENSG00000137809. Homo sapiens.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS00242. INTEGRIN_ALPHA. False negative.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00775. Tirofiban.
NextBio43152.
SOURCESearch...

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Entry information

Entry nameITA11_HUMAN
AccessionPrimary (citable) accession number: Q9UKX5
Secondary accession number(s): Q8WYI8, Q9UKQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents