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Protein

Integrin alpha-11

Gene

ITGA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-11/beta-1 is a receptor for collagen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi488 – 496Sequence analysis9
Calcium bindingi551 – 559Sequence analysis9
Calcium bindingi613 – 621Sequence analysis9

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • collagen receptor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell adhesion mediated by integrin Source: UniProtKB
  • cell-matrix adhesion Source: UniProtKB
  • collagen-activated signaling pathway Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB
  • muscle organ development Source: ProtInc
  • osteoblast differentiation Source: UniProtKB
  • substrate-dependent cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137809-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
SignaLinkiQ9UKX5.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-11
Gene namesi
Name:ITGA11
ORF Names:MSTP018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:6136. ITGA11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 1141ExtracellularSequence analysisAdd BLAST1119
Transmembranei1142 – 1164HelicalSequence analysisAdd BLAST23
Topological domaini1165 – 1188CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • integrin alpha11-beta1 complex Source: UniProtKB
  • integrin complex Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1170R → A: No effect on RAB21-binding. 1 Publication1

Organism-specific databases

DisGeNETi22801.
OpenTargetsiENSG00000137809.
PharmGKBiPA29937.

Chemistry databases

ChEMBLiCHEMBL5883.

Polymorphism and mutation databases

BioMutaiITGA11.
DMDMi313104119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001631823 – 1188Integrin alpha-11Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 83By similarity
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 139Sequence analysis
Disulfide bondi129 ↔ 159Sequence analysis
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)1 Publication1
Glycosylationi358N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi462N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi642N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi659 ↔ 668By similarity
Disulfide bondi674 ↔ 729By similarity
Glycosylationi694N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi781 ↔ 787By similarity
Glycosylationi857N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi881 ↔ 893By similarity
Glycosylationi894N-linked (GlcNAc...)Sequence analysis1
Glycosylationi973N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1031N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1039N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1059N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKX5.
PeptideAtlasiQ9UKX5.
PRIDEiQ9UKX5.

PTM databases

iPTMnetiQ9UKX5.
PhosphoSitePlusiQ9UKX5.

Expressioni

Tissue specificityi

According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.1 Publication

Developmental stagei

Strongly up-regulated in differentiating fetal muscle cells (in vitro).

Gene expression databases

BgeeiENSG00000137809.
CleanExiHS_ITGA11.
GenevisibleiQ9UKX5. HS.

Organism-specific databases

HPAiHPA051813.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB

Protein-protein interaction databases

BioGridi116481. 1 interactor.
IntActiQ9UKX5. 3 interactors.
STRINGi9606.ENSP00000327290.

Structurei

3D structure databases

ProteinModelPortaliQ9UKX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati91 – 151FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
Domaini164 – 345VWFAPROSITE-ProRule annotationAdd BLAST182
Repeati355 – 406FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati411 – 461FG-GAP 4PROSITE-ProRule annotationAdd BLAST51
Repeati462 – 527FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati528 – 586FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati590 – 650FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1153 – 1161Poly-Leu9
Compositional biasi1173 – 1176Poly-Arg4

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB8. Eukaryota.
ENOG410YTFZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ9UKX5.
KOiK06587.
OMAiYQNARFG.
OrthoDBiEOG091G00QA.
PhylomeDBiQ9UKX5.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI
60 70 80 90 100
SGNKWLVVGA PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK
110 120 130 140 150
DNMRLGLSLA TNPKDNSFLA CSPLWSHECG SSYYTTGMCS RVNSNFRFSK
160 170 180 190 200
TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE VQHFLINILK KFYIGPGQIQ
210 220 230 240 250
VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET RTAFGIEFAR
260 270 280 290 300
SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL
310 320 330 340 350
GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF
360 370 380 390 400
SLEGTNKNET SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA
410 420 430 440 450
GKVIPLRESY LKEFPEELKN HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH
460 470 480 490 500
TGKVILFTMH NNRSLTIHQA MRGQQIGSYF GSEITSVDID GDGVTDVLLV
510 520 530 540 550
GAPMYFNEGR ERGKVYVYEL RQNLFVYNGT LKDSHSYQNA RFGSSIASVR
560 570 580 590 600
DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG
610 620 630 640 650
LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS
660 670 680 690 700
KINIFHRDCK RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER
710 720 730 740 750
RYTPRAHLDE GGDRFTNRAV LLSSGQELCE RINFHVLDTA DYVKPVTFSV
760 770 780 790 800
EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG CNEDEHCVPD LVLDARSDLP
810 820 830 840 850
TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV EATLENRGEN
860 870 880 890 900
AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF
910 920 930 940 950
RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH
960 970 980 990 1000
LKYEADVLFT RSSSLSHYEV KPNSSLERYD GIGPPFSCIF RIQNLGLFPI
1010 1020 1030 1040 1050
HGMMMKITIP IATRSGNRLL KLRDFLTDEA NTSCNIWGNS TEYRPTPVEE
1060 1070 1080 1090 1100
DLRRAPQLNH SNSDVVSINC NIRLVPNQEI NFHLLGNLWL RSLKALKYKS
1110 1120 1130 1140 1150
MKIMVNAALQ RQFHSPFIFR EEDPSRQIVF EISKQEDWQV PIWIIVGSTL
1160 1170 1180
GGLLLLALLV LALWKLGFFR SARRRREPGL DPTPKVLE
Length:1,188
Mass (Da):133,470
Last modified:November 30, 2010 - v2
Checksum:iBFD95E57ED5D5849
GO
Isoform 2 (identifier: Q9UKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1029-1029: E → EV

Show »
Length:1,189
Mass (Da):133,569
Checksum:i8EDBBE2EF6191164
GO

Sequence cautioni

The sequence AAL39001 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009889433V → M.Corresponds to variant rs2306022dbSNPEnsembl.1
Natural variantiVAR_020038471M → L.Corresponds to variant rs2306024dbSNPEnsembl.1
Natural variantiVAR_009890524L → R.3 PublicationsCorresponds to variant rs7168069dbSNPEnsembl.1
Natural variantiVAR_020039891Q → K.Corresponds to variant rs2271725dbSNPEnsembl.1
Natural variantiVAR_009891972P → L.3 PublicationsCorresponds to variant rs4777035dbSNPEnsembl.1
Natural variantiVAR_0098921003M → I.1 Publication1
Natural variantiVAR_0098941093L → V.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0534161029E → EV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109681 mRNA. Translation: AAF01258.1.
AF137378 mRNA. Translation: AAD51919.2.
AC021553 Genomic DNA. No translation available.
AC100825 Genomic DNA. No translation available.
AF111799 mRNA. Translation: AAL39001.1. Different initiation.
AL359064 mRNA. Translation: CAB94392.1.
CCDSiCCDS45291.1. [Q9UKX5-1]
RefSeqiNP_001004439.1. NM_001004439.1. [Q9UKX5-1]
UniGeneiHs.436416.
Hs.458733.

Genome annotation databases

EnsembliENST00000315757; ENSP00000327290; ENSG00000137809. [Q9UKX5-1]
ENST00000423218; ENSP00000403392; ENSG00000137809. [Q9UKX5-2]
GeneIDi22801.
KEGGihsa:22801.
UCSCiuc002ari.4. human. [Q9UKX5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109681 mRNA. Translation: AAF01258.1.
AF137378 mRNA. Translation: AAD51919.2.
AC021553 Genomic DNA. No translation available.
AC100825 Genomic DNA. No translation available.
AF111799 mRNA. Translation: AAL39001.1. Different initiation.
AL359064 mRNA. Translation: CAB94392.1.
CCDSiCCDS45291.1. [Q9UKX5-1]
RefSeqiNP_001004439.1. NM_001004439.1. [Q9UKX5-1]
UniGeneiHs.436416.
Hs.458733.

3D structure databases

ProteinModelPortaliQ9UKX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116481. 1 interactor.
IntActiQ9UKX5. 3 interactors.
STRINGi9606.ENSP00000327290.

Chemistry databases

ChEMBLiCHEMBL5883.

PTM databases

iPTMnetiQ9UKX5.
PhosphoSitePlusiQ9UKX5.

Polymorphism and mutation databases

BioMutaiITGA11.
DMDMi313104119.

Proteomic databases

PaxDbiQ9UKX5.
PeptideAtlasiQ9UKX5.
PRIDEiQ9UKX5.

Protocols and materials databases

DNASUi22801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315757; ENSP00000327290; ENSG00000137809. [Q9UKX5-1]
ENST00000423218; ENSP00000403392; ENSG00000137809. [Q9UKX5-2]
GeneIDi22801.
KEGGihsa:22801.
UCSCiuc002ari.4. human. [Q9UKX5-1]

Organism-specific databases

CTDi22801.
DisGeNETi22801.
GeneCardsiITGA11.
H-InvDBHIX0012380.
HGNCiHGNC:6136. ITGA11.
HPAiHPA051813.
MIMi604789. gene.
neXtProtiNX_Q9UKX5.
OpenTargetsiENSG00000137809.
PharmGKBiPA29937.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPB8. Eukaryota.
ENOG410YTFZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ9UKX5.
KOiK06587.
OMAiYQNARFG.
OrthoDBiEOG091G00QA.
PhylomeDBiQ9UKX5.
TreeFamiTF105391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137809-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
SignaLinkiQ9UKX5.

Miscellaneous databases

ChiTaRSiITGA11. human.
GenomeRNAii22801.
PROiQ9UKX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137809.
CleanExiHS_ITGA11.
GenevisibleiQ9UKX5. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA11_HUMAN
AccessioniPrimary (citable) accession number: Q9UKX5
Secondary accession number(s): J3KQM2, Q8WYI8, Q9UKQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.