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Q9UKX3 (MYH13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-13
Alternative name(s):
Myosin heavy chain 13
Myosin heavy chain, skeletal muscle, extraocular
Short name=MyHC-EO
Myosin heavy chain, skeletal muscle, laryngeal
Short name=MyHC-IIL
Superfast myosin
Gene names
Name:MYH13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1938 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. Ref.6

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Tissue specificity

Specifically expressed in extraocular and laryngeal muscles. Ref.5

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

The head-like domain S1 exhibits a much faster ATP-induced detachment from actin, and ADP affinity is more than 3-fold weaker than other myosins.

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19381938Myosin-13
PRO_0000123430

Regions

Domain1 – 784784Myosin head-like
Domain785 – 81430IQ
Nucleotide binding179 – 1868ATP Potential
Region659 – 68123Actin-binding By similarity
Region761 – 77515Actin-binding By similarity
Coiled coil843 – 19381096 Potential

Amino acid modifications

Modified residue1301N6,N6,N6-trimethyllysine Potential

Natural variations

Natural variant7011G → R.
Corresponds to variant rs2190729 [ dbSNP | Ensembl ].
VAR_030231
Natural variant10711M → V.
Corresponds to variant rs2074877 [ dbSNP | Ensembl ].
VAR_024543
Natural variant10761D → E. Ref.1
Corresponds to variant rs2074876 [ dbSNP | Ensembl ].
VAR_030232
Natural variant12941R → Q.
Corresponds to variant rs17690195 [ dbSNP | Ensembl ].
VAR_030233
Natural variant18621H → R. Ref.1
Corresponds to variant rs3744550 [ dbSNP | Ensembl ].
VAR_030234

Experimental info

Sequence conflict10971K → R in AAD29948. Ref.1
Sequence conflict13761R → K in AAD29948. Ref.1
Sequence conflict14071N → K in AAD29948. Ref.1
Sequence conflict16451K → R in AAD29948. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UKX3 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: 66DD43A84F5D38DA

FASTA1,938223,605
        10         20         30         40         50         60 
MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFV ADNKEMYVKG MIQTRENDKV 

        70         80         90        100        110        120 
IVKTLDDRML TLNNDQVFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 

       130        140        150        160        170        180 
LFCVTVNPYK WLPVYKPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR DNQSILITGE 

       190        200        210        220        230        240 
SGAGKTVNTK RVIQYFATIA VTGDKKKETQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN 

       250        260        270        280        290        300 
DNSSRFGKFI RIHFGATGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI 

       310        320        330        340        350        360 
DLLLISTNPF DFPFVSQGEV TVASIDDSEE LLATDNAIDI LGFSSEEKVG IYKLTGAVMH 

       370        380        390        400        410        420 
YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG LCCPRVKVGN EYVTKGQNVQ 

       430        440        450        460        470        480 
QVTNSVGALA KAVYEKMFLW MVTRINQQLD TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI 

       490        500        510        520        530        540 
NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC 

       550        560        570        580        590        600 
MFPKATDTSF KNKLYDQHLG KSNNFQKPKP AKGKAEAHFS LVHYAGTVDY NIAGWLDKNK 

       610        620        630        640        650        660 
DPLNETVVGL YQKSSLKLLS FLFSNYAGAE TGDSGGSKKG GKKKGSSFQT VSAVFRENLN 

       670        680        690        700        710        720 
KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH YLVMHQLRCN GVLEGIRICR KGFPSRILYA 

       730        740        750        760        770        780 
DFKQRYRILN ASAIPEGQFI DSKNASEKLL NSIDVDREQF RFGNTKVFFK AGLLGLLEEM 

       790        800        810        820        830        840 
RDEKLVTLMT STQAVCRGYL MRVEFKKMME RRDSIFCIQY NIRSFMNVKH WPWMNLFFKI 

       850        860        870        880        890        900 
KPLLKSAEAE KEMATMKEDF ERTKEELARS EARRKELEEK MVSLLQEKND LQLQVQSETE 

       910        920        930        940        950        960 
NLMDAEERCE GLIKSKILLE AKVKELTERL EEEEEMNSEL VAKKRNLEDK CSSLKRDIDD 

       970        980        990       1000       1010       1020 
LELTLTKVEK EKHATENKVK NLSEEMTALE ENISKLTKEK KSLQEAHQQT LDDLQVEEDK 

      1030       1040       1050       1060       1070       1080 
VNGLIKINAK LEQQTDDLEG SLEQEKKLRA DLERAKRKLE GDLKMSQESI MDLENDKQQI 

      1090       1100       1110       1120       1130       1140 
EEKLKKKEFE LSQLQAKIDD EQVHSLQFQK KIKELQARIE ELEEEIEAEH TLRAKIEKQR 

      1150       1160       1170       1180       1190       1200 
SDLARELEEI SERLEEASGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKQ 

      1210       1220       1230       1240       1250       1260 
ADSVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDMASNIE ALSKSKSNIE RTCRTVEDQF 

      1270       1280       1290       1300       1310       1320 
SEIKAKDEQQ TQLIHDLNMQ KARLQTQNGE LSHRVEEKES LISQLTKSKQ ALTQQLEELK 

      1330       1340       1350       1360       1370       1380 
RQMEEETKAK NAMAHALQSS RHDCDLLREQ YEEEQEAKAE LQRALSKANS EVAQWRTKYE 

      1390       1400       1410       1420       1430       1440 
TDAIQRTEEL EEAKKKLAQR LQEAEENTET ANSKCASLEK TKQRLQGEVE DLMRDLERSH 

      1450       1460       1470       1480       1490       1500 
TACATLDKKQ RNFDKVLAEW KQKLDESQAE LEAAQKESRS LSTELFKMRN AYEEVVDQLE 

      1510       1520       1530       1540       1550       1560 
TLRRENKNLQ EEISDLTEQI AETGKNLQEA EKTKKLVEQE KSDLQVALEE VEGSLEHEES 

      1570       1580       1590       1600       1610       1620 
KILRVQLELS QVKSELDRKV IEKDEEIEQL KRNSQRAAEA LQSVLDAEIR SRNDALRLKK 

      1630       1640       1650       1660       1670       1680 
KMEGDLNEME IQLGHSNRQM AETQKHLRTV QGQLKDSQLH LDDALRSNED LKEQLAIVER 

      1690       1700       1710       1720       1730       1740 
RNGLLLEELE EMKVALEQTE RTRRLSEQEL LDASDRVQLL HSQNTSLINT KKKLEADIAQ 

      1750       1760       1770       1780       1790       1800 
CQAEVENSIQ ESRNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR 

      1810       1820       1830       1840       1850       1860 
LDEAEQLALK GGKKQIQKLE NRVRELENEL DVEQKRGAEA LKGAHKYERK VKEMTYQAEE 

      1870       1880       1890       1900       1910       1920 
DHKNILRLQD LVDKLQAKVK SYKRQAEEAE EQANTQLSRC RRVQHELEEA AERADIAESQ 

      1930 
VNKLRAKSRD VGSQKMEE 

« Hide

References

« Hide 'large scale' references
[1]"Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity."
Weiss A., Schiaffino S., Leinwand L.A.
J. Mol. Biol. 290:61-75(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLU-1076 AND ARG-1862.
Tissue: Extraocular muscle.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Human skeletal myosin heavy chain genes are tightly linked in the order embryonic-IIa-IId/x-ILb-perinatal-extraocular."
Shrager J.B., Desjardins P.R., Burkman J.M., Konig S.K., Stewart S.K., Su L., Shah M.C., Bricklin E., Tewari M., Hoffman R., Rickels M.R., Jullian E.H., Rubinstein N.A., Stedman H.H.
J. Muscle Res. Cell Motil. 21:345-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1656-1822.
[4]"The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17."
Winters L.M., Briggs M.M., Schachat F.
Genomics 54:188-189(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1917-1938.
Tissue: Extraocular muscle.
[5]"Phylogenetic implications of the superfast myosin in extraocular muscles."
Schachat F., Briggs M.M.
J. Exp. Biol. 205:2189-2201(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms."
Bloemink M.J., Deacon J.C., Resnicow D.I., Leinwand L.A., Geeves M.A.
J. Biol. Chem. 288:27469-27479(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF111782 mRNA. Translation: AAD29948.1.
AC005291 Genomic DNA. No translation available.
AH009397 Genomic DNA. Translation: AAF73155.1.
AF075248 Genomic DNA. Translation: AAC83241.1.
RefSeqNP_003793.2. NM_003802.2.
UniGeneHs.711142.

3D structure databases

ProteinModelPortalQ9UKX3.
SMRQ9UKX3. Positions 4-965.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114272. 2 interactions.
IntActQ9UKX3. 3 interactions.
MINTMINT-2821927.
STRING9606.ENSP00000252172.

PTM databases

PhosphoSiteQ9UKX3.

Polymorphism databases

DMDM322510049.

Proteomic databases

PaxDbQ9UKX3.
PeptideAtlasQ9UKX3.
PRIDEQ9UKX3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252172; ENSP00000252172; ENSG00000006788.
ENST00000418404; ENSP00000404570; ENSG00000006788.
GeneID8735.
KEGGhsa:8735.
UCSCuc002gmk.1. human.

Organism-specific databases

CTD8735.
GeneCardsGC17M010201.
H-InvDBHIX0039060.
HGNCHGNC:7571. MYH13.
HPACAB000140.
MIM603487. gene.
neXtProtNX_Q9UKX3.
PharmGKBPA31368.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000173959.
HOVERGENHBG004704.
InParanoidQ9UKX3.
KOK10352.
OMAGCLEQEK.
OrthoDBEOG7RBZ7G.
PhylomeDBQ9UKX3.
TreeFamTF314375.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressQ9UKX3.
BgeeQ9UKX3.
CleanExHS_MYH13.
GenevestigatorQ9UKX3.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR015650. Myosin_1/23/4/6/7/8/13/15.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR13140:SF22. PTHR13140:SF22. 1 hit.
PfamPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYH13. human.
GeneWikiMYH13.
GenomeRNAi8735.
NextBio32765.
PROQ9UKX3.
SOURCESearch...

Entry information

Entry nameMYH13_HUMAN
AccessionPrimary (citable) accession number: Q9UKX3
Secondary accession number(s): O95252, Q9P0U8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM