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Protein

Myosin-2

Gene

MYH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction. Required for cytoskeleton organization (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 186ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: UniProtKB

GO - Biological processi

  • Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  • muscle contraction Source: UniProtKB
  • muscle filament sliding Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125414-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
SIGNORiQ9UKX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-2
Alternative name(s):
Myosin heavy chain 2
Myosin heavy chain 2a
Short name:
MyHC-2a
Myosin heavy chain IIa
Short name:
MyHC-IIa
Myosin heavy chain, skeletal muscle, adult 2
Gene namesi
Name:MYH2
Synonyms:MYHSA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7572. MYH2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • muscle myosin complex Source: UniProtKB
  • myofibril Source: BHF-UCL
  • myosin filament Source: UniProtKB-KW
  • protein complex Source: LIFEdb
  • sarcomere Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Involvement in diseasei

Myopathy, proximal, and ophthalmoplegia (MYPOP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.
See also OMIM:605637
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032630706E → K in MYPOP. 1 PublicationCorresponds to variant rs121434589dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4620.
MalaCardsiMYH2.
MIMi605637. phenotype.
OpenTargetsiENSG00000125414.
Orphaneti363677. Childhood-onset autosomal recessive myopathy with external ophthalmoplegia.
79091. Hereditary inclusion body myopathy - joint contractures - ophthalmoplegia.
PharmGKBiPA31369.

Polymorphism and mutation databases

BioMutaiMYH2.
DMDMi13431716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233931 – 1941Myosin-2Add BLAST1941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei759Pros-methylhistidineBy similarity1
Modified residuei1094PhosphoserineBy similarity1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1164PhosphoserineBy similarity1
Modified residuei1239PhosphoserineBy similarity1
Modified residuei1243PhosphothreonineBy similarity1
Modified residuei1245PhosphoserineBy similarity1
Modified residuei1257PhosphothreonineBy similarity1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1288PhosphothreonineBy similarity1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1308PhosphoserineBy similarity1
Modified residuei1469PhosphothreonineBy similarity1
Modified residuei1476PhosphoserineBy similarity1
Modified residuei1494PhosphotyrosineBy similarity1
Modified residuei1497PhosphoserineBy similarity1
Modified residuei1503PhosphothreonineBy similarity1
Modified residuei1516PhosphoserineBy similarity1
Modified residuei1519PhosphothreonineBy similarity1
Modified residuei1556PhosphoserineBy similarity1
Modified residuei1576PhosphoserineBy similarity1
Modified residuei1602PhosphoserineBy similarity1
Modified residuei1605PhosphoserineBy similarity1
Modified residuei1716PhosphoserineBy similarity1
Modified residuei1728PhosphoserineBy similarity1
Modified residuei1732PhosphothreonineBy similarity1
Modified residuei1738PhosphothreonineBy similarity1
Modified residuei1741PhosphoserineBy similarity1
Cross-linki1815Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKX2.
PaxDbiQ9UKX2.
PeptideAtlasiQ9UKX2.
PRIDEiQ9UKX2.

2D gel databases

UCD-2DPAGEQ9UKX2.

PTM databases

iPTMnetiQ9UKX2.
PhosphoSitePlusiQ9UKX2.

Expressioni

Gene expression databases

BgeeiENSG00000125414.
CleanExiHS_MYH2.
ExpressionAtlasiQ9UKX2. baseline and differential.
GenevisibleiQ9UKX2. HS.

Organism-specific databases

HPAiCAB010760.
HPA001349.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.1 Publication

Protein-protein interaction databases

BioGridi110705. 16 interactors.
IntActiQ9UKX2. 6 interactors.
MINTiMINT-2821903.
STRINGi9606.ENSP00000245503.

Structurei

3D structure databases

ProteinModelPortaliQ9UKX2.
SMRiQ9UKX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 784Myosin motorAdd BLAST699
Domaini787 – 816IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 683Actin-bindingBy similarityAdd BLAST23
Regioni763 – 777Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili845 – 1941Sequence analysisAdd BLAST1097

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ9UKX2.
KOiK10352.
OMAiQITSNRK.
OrthoDBiEOG091G07UM.
PhylomeDBiQ9UKX2.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDSELAVF GEAAPFLRKS ERERIEAQNR PFDAKTSVFV AEPKESFVKG
60 70 80 90 100
TIQSREGGKV TVKTEGGATL TVKDDQVFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYKPEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEI TSGKIQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVVFQL KAERSYHIFY QITSNKKPEL
310 320 330 340 350
IEMLLITTNP YDYPFVSQGE ISVASIDDQE ELMATDSAID ILGFTNEEKV
360 370 380 390 400
SIYKLTGAVM HYGNLKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV EQVSNAVGAL AKAVYEKMFL WMVARINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYDQHL GKSANFQKPK VVKGKAEAHF ALIHYAGVVD YNITGWLEKN
610 620 630 640 650
KDPLNETVVG LYQKSAMKTL AQLFSGAQTA EGEGAGGGAK KGGKKKGSSF
660 670 680 690 700
QTVSALFREN LNKLMTNLRS THPHFVRCII PNETKTPGAM EHELVLHQLR
710 720 730 740 750
CNGVLEGIRI CRKGFPSRIL YADFKQRYKV LNASAIPEGQ FIDSKKASEK
760 770 780 790 800
LLASIDIDHT QYKFGHTKVF FKAGLLGLLE EMRDDKLAQL ITRTQARCRG
810 820 830 840 850
FLARVEYQRM VERREAIFCI QYNIRSFMNV KHWPWMKLFF KIKPLLKSAE
860 870 880 890 900
TEKEMATMKE EFQKIKDELA KSEAKRKELE EKMVTLLKEK NDLQLQVQAE
910 920 930 940 950
AEGLADAEER CDQLIKTKIQ LEAKIKEVTE RAEDEEEINA ELTAKKRKLE
960 970 980 990 1000
DECSELKKDI DDLELTLAKV EKEKHATENK VKNLTEEMAG LDETIAKLTK
1010 1020 1030 1040 1050
EKKALQEAHQ QTLDDLQAEE DKVNTLTKAK IKLEQQVDDL EGSLEQEKKL
1060 1070 1080 1090 1100
RMDLERAKRK LEGDLKLAQE SIMDIENEKQ QLDEKLKKKE FEISNLQSKI
1110 1120 1130 1140 1150
EDEQALGIQL QKKIKELQAR IEELEEEIEA ERASRAKAEK QRSDLSRELE
1160 1170 1180 1190 1200
EISERLEEAG GATSAQIEMN KKREAEFQKM RRDLEEATLQ HEATAATLRK
1210 1220 1230 1240 1250
KHADSVAELG EQIDNLQRVK QKLEKEKSEM KMEIDDLASN VETVSKAKGN
1260 1270 1280 1290 1300
LEKMCRTLED QLSELKSKEE EQQRLINDLT AQRGRLQTES GEFSRQLDEK
1310 1320 1330 1340 1350
EALVSQLSRG KQAFTQQIEE LKRQLEEEIK AKNALAHALQ SSRHDCDLLR
1360 1370 1380 1390 1400
EQYEEEQESK AELQRALSKA NTEVAQWRTK YETDAIQRTE ELEEAKKKLA
1410 1420 1430 1440 1450
QRLQAAEEHV EAVNAKCASL EKTKQRLQNE VEDLMLDVER TNAACAALDK
1460 1470 1480 1490 1500
KQRNFDKILA EWKQKCEETH AELEASQKEA RSLGTELFKI KNAYEESLDQ
1510 1520 1530 1540 1550
LETLKRENKN LQQEISDLTE QIAEGGKRIH ELEKIKKQVE QEKCELQAAL
1560 1570 1580 1590 1600
EEAEASLEHE EGKILRIQLE LNQVKSEVDR KIAEKDEEID QLKRNHIRIV
1610 1620 1630 1640 1650
ESMQSTLDAE IRSRNDAIRL KKKMEGDLNE MEIQLNHANR MAAEALRNYR
1660 1670 1680 1690 1700
NTQGILKDTQ IHLDDALRSQ EDLKEQLAMV ERRANLLQAE IEELRATLEQ
1710 1720 1730 1740 1750
TERSRKIAEQ ELLDASERVQ LLHTQNTSLI NTKKKLETDI SQMQGEMEDI
1760 1770 1780 1790 1800
LQEARNAEEK AKKAITDAAM MAEELKKEQD TSAHLERMKK NMEQTVKDLQ
1810 1820 1830 1840 1850
LRLDEAEQLA LKGGKKQIQK LEARVRELEG EVESEQKRNA EAVKGLRKHE
1860 1870 1880 1890 1900
RRVKELTYQT EEDRKNILRL QDLVDKLQAK VKSYKRQAEE AEEQSNTNLA
1910 1920 1930 1940
KFRKLQHELE EAEERADIAE SQVNKLRVKS REVHTKVISE E
Length:1,941
Mass (Da):223,044
Last modified:May 1, 2000 - v1
Checksum:i681E866F83AEA83F
GO
Isoform 2 (identifier: Q9UKX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-1891: Missing.

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):79,880
Checksum:i44FD901775553881
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150E → G in CAD91136 (PubMed:17974005).Curated1
Sequence conflicti1844K → R in CAA83687 (PubMed:7751403).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032630706E → K in MYPOP. 1 PublicationCorresponds to variant rs121434589dbSNPEnsembl.1
Natural variantiVAR_032631970V → I in one patient with familial myopathy; unknown pathological significance. 1 PublicationCorresponds to variant rs143872329dbSNPEnsembl.1
Natural variantiVAR_0326321061L → V.1 PublicationCorresponds to variant rs142586585dbSNPEnsembl.1
Natural variantiVAR_0326331927R → Q.Corresponds to variant rs34161789dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056291659 – 1891Missing in isoform 2. 1 PublicationAdd BLAST1233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111784 mRNA. Translation: AAD29950.1.
BX510904 mRNA. Translation: CAD91136.1.
AC005323 Genomic DNA. No translation available.
BC093082 mRNA. Translation: AAH93082.1.
BC126409 mRNA. Translation: AAI26410.1.
S73840 mRNA. Translation: AAC13916.1.
Z32858 mRNA. Translation: CAA83687.1.
CCDSiCCDS11156.1. [Q9UKX2-1]
PIRiI51912.
RefSeqiNP_001093582.1. NM_001100112.1. [Q9UKX2-1]
NP_060004.3. NM_017534.5. [Q9UKX2-1]
UniGeneiHs.667534.

Genome annotation databases

EnsembliENST00000245503; ENSP00000245503; ENSG00000125414. [Q9UKX2-1]
ENST00000397183; ENSP00000380367; ENSG00000125414. [Q9UKX2-1]
ENST00000532183; ENSP00000433944; ENSG00000125414. [Q9UKX2-2]
ENST00000622564; ENSP00000482463; ENSG00000125414. [Q9UKX2-2]
GeneIDi4620.
KEGGihsa:4620.
UCSCiuc002gmp.5. human. [Q9UKX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111784 mRNA. Translation: AAD29950.1.
BX510904 mRNA. Translation: CAD91136.1.
AC005323 Genomic DNA. No translation available.
BC093082 mRNA. Translation: AAH93082.1.
BC126409 mRNA. Translation: AAI26410.1.
S73840 mRNA. Translation: AAC13916.1.
Z32858 mRNA. Translation: CAA83687.1.
CCDSiCCDS11156.1. [Q9UKX2-1]
PIRiI51912.
RefSeqiNP_001093582.1. NM_001100112.1. [Q9UKX2-1]
NP_060004.3. NM_017534.5. [Q9UKX2-1]
UniGeneiHs.667534.

3D structure databases

ProteinModelPortaliQ9UKX2.
SMRiQ9UKX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110705. 16 interactors.
IntActiQ9UKX2. 6 interactors.
MINTiMINT-2821903.
STRINGi9606.ENSP00000245503.

PTM databases

iPTMnetiQ9UKX2.
PhosphoSitePlusiQ9UKX2.

Polymorphism and mutation databases

BioMutaiMYH2.
DMDMi13431716.

2D gel databases

UCD-2DPAGEQ9UKX2.

Proteomic databases

EPDiQ9UKX2.
PaxDbiQ9UKX2.
PeptideAtlasiQ9UKX2.
PRIDEiQ9UKX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245503; ENSP00000245503; ENSG00000125414. [Q9UKX2-1]
ENST00000397183; ENSP00000380367; ENSG00000125414. [Q9UKX2-1]
ENST00000532183; ENSP00000433944; ENSG00000125414. [Q9UKX2-2]
ENST00000622564; ENSP00000482463; ENSG00000125414. [Q9UKX2-2]
GeneIDi4620.
KEGGihsa:4620.
UCSCiuc002gmp.5. human. [Q9UKX2-1]

Organism-specific databases

CTDi4620.
DisGeNETi4620.
GeneCardsiMYH2.
HGNCiHGNC:7572. MYH2.
HPAiCAB010760.
HPA001349.
MalaCardsiMYH2.
MIMi160740. gene.
605637. phenotype.
neXtProtiNX_Q9UKX2.
OpenTargetsiENSG00000125414.
Orphaneti363677. Childhood-onset autosomal recessive myopathy with external ophthalmoplegia.
79091. Hereditary inclusion body myopathy - joint contractures - ophthalmoplegia.
PharmGKBiPA31369.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ9UKX2.
KOiK10352.
OMAiQITSNRK.
OrthoDBiEOG091G07UM.
PhylomeDBiQ9UKX2.
TreeFamiTF314375.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125414-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
SIGNORiQ9UKX2.

Miscellaneous databases

GeneWikiiMYH2.
GenomeRNAii4620.
PROiQ9UKX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125414.
CleanExiHS_MYH2.
ExpressionAtlasiQ9UKX2. baseline and differential.
GenevisibleiQ9UKX2. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKX2
Secondary accession number(s): A0AVL4
, Q14322, Q16229, Q567P6, Q86T56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.