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Protein

ETS-related transcription factor Elf-5

Gene

ELF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.1 Publication
Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi173 – 254ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Epithelium-restricted ESE-1-related Ets factor
Epithelium-specific Ets transcription factor 2
Short name:
ESE-2
Gene namesi
Name:ELF5
Synonyms:ESE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000135374.9
HGNCiHGNC:3320 ELF5
MIMi605169 gene
neXtProtiNX_Q9UKW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2001
OpenTargetsiENSG00000135374
PharmGKBiPA27748

Polymorphism and mutation databases

BioMutaiELF5
DMDMi68565549

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040921 – 265ETS-related transcription factor Elf-5Add BLAST265

Proteomic databases

PaxDbiQ9UKW6
PeptideAtlasiQ9UKW6
PRIDEiQ9UKW6

PTM databases

PhosphoSitePlusiQ9UKW6

Expressioni

Tissue specificityi

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.2 Publications

Gene expression databases

BgeeiENSG00000135374
CleanExiHS_ELF5
ExpressionAtlasiQ9UKW6 baseline and differential
GenevisibleiQ9UKW6 HS

Organism-specific databases

HPAiHPA062706

Interactioni

Protein-protein interaction databases

BioGridi108316, 8 interactors
IntActiQ9UKW6, 7 interactors
MINTiQ9UKW6
STRINGi9606.ENSP00000311010

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi175 – 184Combined sources10
Turni186 – 188Combined sources3
Beta strandi194 – 197Combined sources4
Turni198 – 201Combined sources4
Beta strandi202 – 204Combined sources3
Helixi208 – 218Combined sources11
Helixi226 – 239Combined sources14
Beta strandi240 – 243Combined sources4
Beta strandi246 – 253Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWXNMR-A172-265[»]
ProteinModelPortaliQ9UKW6
SMRiQ9UKW6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKW6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 129PNTPROSITE-ProRule annotationAdd BLAST87

Domaini

The PNT domain acts as a transcriptional activator.By similarity

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000232188
HOVERGENiHBG074143
InParanoidiQ9UKW6
KOiK17101
OMAiCHFNVSG
OrthoDBiEOG091G0BE6
PhylomeDBiQ9UKW6
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033069 Elf5
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF15 PTHR11849:SF15, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKW6-1) [UniParc]FASTAAdd to basket
Also known as: ESE-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT
60 70 80 90 100
ACDSYWTSVH PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC
110 120 130 140 150
SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY SFFNDAEESK ATIKDYADSN
160 170 180 190 200
CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC GILEWEDREQ
210 220 230 240 250
GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV
260
YKFGKNAHGW QEDKL
Length:265
Mass (Da):31,263
Last modified:July 5, 2005 - v2
Checksum:i43821A79A45768FE
GO
Isoform 2 (identifier: Q9UKW6-2) [UniParc]FASTAAdd to basket
Also known as: ESE-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:255
Mass (Da):30,121
Checksum:iAE61C5B178ECB555
GO
Isoform 3 (identifier: Q9UKW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     130-148: YSFFNDAEESKATIKDYAD → QCSEGQTSRGGTRIRTKQL
     149-265: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):16,121
Checksum:iCD6912714A9AF817
GO
Isoform 4 (identifier: Q9UKW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     51-146: ACDSYWTSVH...EESKATIKDY → D

Show »
Length:160
Mass (Da):18,866
Checksum:i511FDAE3E4E6A31F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250V → M in AAD22960 (PubMed:10506207).Curated1
Sequence conflicti250V → M in AAD22961 (PubMed:10506207).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145101 – 10Missing in isoform 2, isoform 3 and isoform 4. 4 Publications10
Alternative sequenceiVSP_05466251 – 146ACDSY…TIKDY → D in isoform 4. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_014511130 – 148YSFFN…KDYAD → QCSEGQTSRGGTRIRTKQL in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014512149 – 265Missing in isoform 3. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049703 mRNA Translation: AAC79755.1
DQ123839 mRNA Translation: AAZ98848.1
AF115402 mRNA Translation: AAD22960.1
AF115403 mRNA Translation: AAD22961.1
AK074633 mRNA Translation: BAC11101.1
AK290817 mRNA Translation: BAF83506.1
AL137224 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68169.1
BC029743 mRNA Translation: AAH29743.1
CCDSiCCDS58129.1 [Q9UKW6-4]
CCDS7892.1 [Q9UKW6-1]
CCDS7893.1 [Q9UKW6-2]
RefSeqiNP_001230009.1, NM_001243080.1 [Q9UKW6-4]
NP_001230010.1, NM_001243081.1
NP_001413.1, NM_001422.3 [Q9UKW6-2]
NP_938195.1, NM_198381.1 [Q9UKW6-1]
UniGeneiHs.11713

Genome annotation databases

EnsembliENST00000257832; ENSP00000257832; ENSG00000135374 [Q9UKW6-2]
ENST00000312319; ENSP00000311010; ENSG00000135374 [Q9UKW6-1]
ENST00000429939; ENSP00000407589; ENSG00000135374 [Q9UKW6-4]
ENST00000532417; ENSP00000436386; ENSG00000135374 [Q9UKW6-3]
GeneIDi2001
KEGGihsa:2001
UCSCiuc001mvo.2 human [Q9UKW6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELF5_HUMAN
AccessioniPrimary (citable) accession number: Q9UKW6
Secondary accession number(s): A6XAE6
, A8K452, O95175, Q8N2K9, Q96QY3, Q9UKW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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