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Protein

ETS-related transcription factor Elf-5

Gene

ELF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.1 Publication
Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 25482ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Epithelium-restricted ESE-1-related Ets factor
Epithelium-specific Ets transcription factor 2
Short name:
ESE-2
Gene namesi
Name:ELF5
Synonyms:ESE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3320. ELF5.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27748.

Polymorphism and mutation databases

BioMutaiELF5.
DMDMi68565549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265ETS-related transcription factor Elf-5PRO_0000204092Add
BLAST

Proteomic databases

PRIDEiQ9UKW6.

Expressioni

Tissue specificityi

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.2 Publications

Gene expression databases

BgeeiQ9UKW6.
CleanExiHS_ELF5.
ExpressionAtlasiQ9UKW6. baseline and differential.
GenevisibleiQ9UKW6. HS.

Interactioni

Protein-protein interaction databases

BioGridi108316. 8 interactions.
IntActiQ9UKW6. 6 interactions.
MINTiMINT-1448100.
STRINGi9606.ENSP00000311010.

Structurei

Secondary structure

1
265
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi175 – 18410Combined sources
Turni186 – 1883Combined sources
Beta strandi194 – 1974Combined sources
Turni198 – 2014Combined sources
Beta strandi202 – 2043Combined sources
Helixi208 – 21811Combined sources
Helixi226 – 23914Combined sources
Beta strandi240 – 2434Combined sources
Beta strandi246 – 2538Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WWXNMR-A172-265[»]
ProteinModelPortaliQ9UKW6.
SMRiQ9UKW6. Positions 174-265.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKW6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 12987PNTPROSITE-ProRule annotationAdd
BLAST

Domaini

The PNT domain acts as a transcriptional activator.By similarity

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG296414.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ9UKW6.
KOiK17101.
OMAiSQGYSFF.
OrthoDBiEOG7M0NRR.
PhylomeDBiQ9UKW6.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKW6-1) [UniParc]FASTAAdd to basket

Also known as: ESE-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT
60 70 80 90 100
ACDSYWTSVH PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC
110 120 130 140 150
SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY SFFNDAEESK ATIKDYADSN
160 170 180 190 200
CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC GILEWEDREQ
210 220 230 240 250
GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV
260
YKFGKNAHGW QEDKL
Length:265
Mass (Da):31,263
Last modified:July 5, 2005 - v2
Checksum:i43821A79A45768FE
GO
Isoform 2 (identifier: Q9UKW6-2) [UniParc]FASTAAdd to basket

Also known as: ESE-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:255
Mass (Da):30,121
Checksum:iAE61C5B178ECB555
GO
Isoform 3 (identifier: Q9UKW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     130-148: YSFFNDAEESKATIKDYAD → QCSEGQTSRGGTRIRTKQL
     149-265: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):16,121
Checksum:iCD6912714A9AF817
GO
Isoform 4 (identifier: Q9UKW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     51-146: ACDSYWTSVH...EESKATIKDY → D

Show »
Length:160
Mass (Da):18,866
Checksum:i511FDAE3E4E6A31F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501V → M in AAD22960 (PubMed:10506207).Curated
Sequence conflicti250 – 2501V → M in AAD22961 (PubMed:10506207).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_014510
Alternative sequencei51 – 14696ACDSY…TIKDY → D in isoform 4. 1 PublicationVSP_054662Add
BLAST
Alternative sequencei130 – 14819YSFFN…KDYAD → QCSEGQTSRGGTRIRTKQL in isoform 3. 1 PublicationVSP_014511Add
BLAST
Alternative sequencei149 – 265117Missing in isoform 3. 1 PublicationVSP_014512Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049703 mRNA. Translation: AAC79755.1.
DQ123839 mRNA. Translation: AAZ98848.1.
AF115402 mRNA. Translation: AAD22960.1.
AF115403 mRNA. Translation: AAD22961.1.
AK074633 mRNA. Translation: BAC11101.1.
AK290817 mRNA. Translation: BAF83506.1.
AL137224 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68169.1.
BC029743 mRNA. Translation: AAH29743.1.
CCDSiCCDS58129.1. [Q9UKW6-4]
CCDS7892.1. [Q9UKW6-1]
CCDS7893.1. [Q9UKW6-2]
RefSeqiNP_001230009.1. NM_001243080.1. [Q9UKW6-4]
NP_001230010.1. NM_001243081.1.
NP_001413.1. NM_001422.3. [Q9UKW6-2]
NP_938195.1. NM_198381.1. [Q9UKW6-1]
UniGeneiHs.11713.

Genome annotation databases

EnsembliENST00000257832; ENSP00000257832; ENSG00000135374. [Q9UKW6-2]
ENST00000312319; ENSP00000311010; ENSG00000135374. [Q9UKW6-1]
ENST00000429939; ENSP00000407589; ENSG00000135374. [Q9UKW6-4]
ENST00000532417; ENSP00000436386; ENSG00000135374. [Q9UKW6-3]
GeneIDi2001.
KEGGihsa:2001.
UCSCiuc001mvo.1. human. [Q9UKW6-1]
uc001mvq.2. human. [Q9UKW6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049703 mRNA. Translation: AAC79755.1.
DQ123839 mRNA. Translation: AAZ98848.1.
AF115402 mRNA. Translation: AAD22960.1.
AF115403 mRNA. Translation: AAD22961.1.
AK074633 mRNA. Translation: BAC11101.1.
AK290817 mRNA. Translation: BAF83506.1.
AL137224 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68169.1.
BC029743 mRNA. Translation: AAH29743.1.
CCDSiCCDS58129.1. [Q9UKW6-4]
CCDS7892.1. [Q9UKW6-1]
CCDS7893.1. [Q9UKW6-2]
RefSeqiNP_001230009.1. NM_001243080.1. [Q9UKW6-4]
NP_001230010.1. NM_001243081.1.
NP_001413.1. NM_001422.3. [Q9UKW6-2]
NP_938195.1. NM_198381.1. [Q9UKW6-1]
UniGeneiHs.11713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WWXNMR-A172-265[»]
ProteinModelPortaliQ9UKW6.
SMRiQ9UKW6. Positions 174-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108316. 8 interactions.
IntActiQ9UKW6. 6 interactions.
MINTiMINT-1448100.
STRINGi9606.ENSP00000311010.

Polymorphism and mutation databases

BioMutaiELF5.
DMDMi68565549.

Proteomic databases

PRIDEiQ9UKW6.

Protocols and materials databases

DNASUi2001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257832; ENSP00000257832; ENSG00000135374. [Q9UKW6-2]
ENST00000312319; ENSP00000311010; ENSG00000135374. [Q9UKW6-1]
ENST00000429939; ENSP00000407589; ENSG00000135374. [Q9UKW6-4]
ENST00000532417; ENSP00000436386; ENSG00000135374. [Q9UKW6-3]
GeneIDi2001.
KEGGihsa:2001.
UCSCiuc001mvo.1. human. [Q9UKW6-1]
uc001mvq.2. human. [Q9UKW6-3]

Organism-specific databases

CTDi2001.
GeneCardsiGC11M034500.
HGNCiHGNC:3320. ELF5.
MIMi605169. gene.
neXtProtiNX_Q9UKW6.
PharmGKBiPA27748.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG296414.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ9UKW6.
KOiK17101.
OMAiSQGYSFF.
OrthoDBiEOG7M0NRR.
PhylomeDBiQ9UKW6.
TreeFamiTF318679.

Miscellaneous databases

EvolutionaryTraceiQ9UKW6.
GeneWikiiELF5.
GenomeRNAii2001.
NextBioi8095.
PROiQ9UKW6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKW6.
CleanExiHS_ELF5.
ExpressionAtlasiQ9UKW6. baseline and differential.
GenevisibleiQ9UKW6. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
    Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
    Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes."
    Oettgen P., Kas K., Dube A., Gu X., Grall F., Thamrongsak U., Akbarali Y., Finger E., Boltax J., Endress G., Munger K., Kunsch C., Libermann T.A.
    J. Biol. Chem. 274:29439-29452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Urinary bladder.

Entry informationi

Entry nameiELF5_HUMAN
AccessioniPrimary (citable) accession number: Q9UKW6
Secondary accession number(s): A6XAE6
, A8K452, O95175, Q8N2K9, Q96QY3, Q9UKW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.