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Q9UKW6

- ELF5_HUMAN

UniProt

Q9UKW6 - ELF5_HUMAN

Protein

ETS-related transcription factor Elf-5

Gene

ELF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.1 Publication
    Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi173 – 25482ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. cell proliferation Source: ProtInc
    3. ectoderm development Source: Ensembl
    4. mammary gland epithelial cell differentiation Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-5
    Alternative name(s):
    E74-like factor 5
    Epithelium-restricted ESE-1-related Ets factor
    Epithelium-specific Ets transcription factor 2
    Short name:
    ESE-2
    Gene namesi
    Name:ELF5
    Synonyms:ESE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3320. ELF5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27748.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265ETS-related transcription factor Elf-5PRO_0000204092Add
    BLAST

    Proteomic databases

    PRIDEiQ9UKW6.

    Expressioni

    Tissue specificityi

    Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.2 Publications

    Gene expression databases

    ArrayExpressiQ9UKW6.
    BgeeiQ9UKW6.
    CleanExiHS_ELF5.
    GenevestigatoriQ9UKW6.

    Interactioni

    Protein-protein interaction databases

    BioGridi108316. 8 interactions.
    IntActiQ9UKW6. 6 interactions.
    MINTiMINT-1448100.
    STRINGi9606.ENSP00000311010.

    Structurei

    Secondary structure

    1
    265
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi175 – 18410
    Turni186 – 1883
    Beta strandi194 – 1974
    Turni198 – 2014
    Beta strandi202 – 2043
    Helixi208 – 21811
    Helixi226 – 23914
    Beta strandi240 – 2434
    Beta strandi246 – 2538

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WWXNMR-A172-265[»]
    ProteinModelPortaliQ9UKW6.
    SMRiQ9UKW6. Positions 174-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UKW6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 12987PNTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PNT domain acts as a transcriptional activator.By similarity

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG296414.
    HOGENOMiHOG000232188.
    HOVERGENiHBG074143.
    InParanoidiQ9UKW6.
    KOiK17101.
    OMAiIVIVATC.
    OrthoDBiEOG7M0NRR.
    PhylomeDBiQ9UKW6.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKW6-1) [UniParc]FASTAAdd to Basket

    Also known as: ESE-2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT    50
    ACDSYWTSVH PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC 100
    SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY SFFNDAEESK ATIKDYADSN 150
    CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC GILEWEDREQ 200
    GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV 250
    YKFGKNAHGW QEDKL 265
    Length:265
    Mass (Da):31,263
    Last modified:July 5, 2005 - v2
    Checksum:i43821A79A45768FE
    GO
    Isoform 2 (identifier: Q9UKW6-2) [UniParc]FASTAAdd to Basket

    Also known as: ESE-2b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.

    Show »
    Length:255
    Mass (Da):30,121
    Checksum:iAE61C5B178ECB555
    GO
    Isoform 3 (identifier: Q9UKW6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.
         130-148: YSFFNDAEESKATIKDYAD → QCSEGQTSRGGTRIRTKQL
         149-265: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:138
    Mass (Da):16,121
    Checksum:iCD6912714A9AF817
    GO
    Isoform 4 (identifier: Q9UKW6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.
         51-146: ACDSYWTSVH...EESKATIKDY → D

    Show »
    Length:160
    Mass (Da):18,866
    Checksum:i511FDAE3E4E6A31F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501V → M in AAD22960. (PubMed:10506207)Curated
    Sequence conflicti250 – 2501V → M in AAD22961. (PubMed:10506207)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_014510
    Alternative sequencei51 – 14696ACDSY…TIKDY → D in isoform 4. 1 PublicationVSP_054662Add
    BLAST
    Alternative sequencei130 – 14819YSFFN…KDYAD → QCSEGQTSRGGTRIRTKQL in isoform 3. 1 PublicationVSP_014511Add
    BLAST
    Alternative sequencei149 – 265117Missing in isoform 3. 1 PublicationVSP_014512Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049703 mRNA. Translation: AAC79755.1.
    DQ123839 mRNA. Translation: AAZ98848.1.
    AF115402 mRNA. Translation: AAD22960.1.
    AF115403 mRNA. Translation: AAD22961.1.
    AK074633 mRNA. Translation: BAC11101.1.
    AK290817 mRNA. Translation: BAF83506.1.
    AL137224 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68169.1.
    BC029743 mRNA. Translation: AAH29743.1.
    CCDSiCCDS58129.1. [Q9UKW6-4]
    CCDS7892.1. [Q9UKW6-1]
    CCDS7893.1. [Q9UKW6-2]
    RefSeqiNP_001230009.1. NM_001243080.1. [Q9UKW6-4]
    NP_001230010.1. NM_001243081.1.
    NP_001413.1. NM_001422.3. [Q9UKW6-2]
    NP_938195.1. NM_198381.1. [Q9UKW6-1]
    UniGeneiHs.11713.

    Genome annotation databases

    EnsembliENST00000257832; ENSP00000257832; ENSG00000135374. [Q9UKW6-2]
    ENST00000312319; ENSP00000311010; ENSG00000135374. [Q9UKW6-1]
    ENST00000429939; ENSP00000407589; ENSG00000135374. [Q9UKW6-4]
    ENST00000532417; ENSP00000436386; ENSG00000135374. [Q9UKW6-3]
    GeneIDi2001.
    KEGGihsa:2001.
    UCSCiuc001mvo.1. human. [Q9UKW6-1]
    uc001mvq.2. human. [Q9UKW6-3]

    Polymorphism databases

    DMDMi68565549.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049703 mRNA. Translation: AAC79755.1 .
    DQ123839 mRNA. Translation: AAZ98848.1 .
    AF115402 mRNA. Translation: AAD22960.1 .
    AF115403 mRNA. Translation: AAD22961.1 .
    AK074633 mRNA. Translation: BAC11101.1 .
    AK290817 mRNA. Translation: BAF83506.1 .
    AL137224 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68169.1 .
    BC029743 mRNA. Translation: AAH29743.1 .
    CCDSi CCDS58129.1. [Q9UKW6-4 ]
    CCDS7892.1. [Q9UKW6-1 ]
    CCDS7893.1. [Q9UKW6-2 ]
    RefSeqi NP_001230009.1. NM_001243080.1. [Q9UKW6-4 ]
    NP_001230010.1. NM_001243081.1.
    NP_001413.1. NM_001422.3. [Q9UKW6-2 ]
    NP_938195.1. NM_198381.1. [Q9UKW6-1 ]
    UniGenei Hs.11713.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WWX NMR - A 172-265 [» ]
    ProteinModelPortali Q9UKW6.
    SMRi Q9UKW6. Positions 174-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108316. 8 interactions.
    IntActi Q9UKW6. 6 interactions.
    MINTi MINT-1448100.
    STRINGi 9606.ENSP00000311010.

    Polymorphism databases

    DMDMi 68565549.

    Proteomic databases

    PRIDEi Q9UKW6.

    Protocols and materials databases

    DNASUi 2001.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257832 ; ENSP00000257832 ; ENSG00000135374 . [Q9UKW6-2 ]
    ENST00000312319 ; ENSP00000311010 ; ENSG00000135374 . [Q9UKW6-1 ]
    ENST00000429939 ; ENSP00000407589 ; ENSG00000135374 . [Q9UKW6-4 ]
    ENST00000532417 ; ENSP00000436386 ; ENSG00000135374 . [Q9UKW6-3 ]
    GeneIDi 2001.
    KEGGi hsa:2001.
    UCSCi uc001mvo.1. human. [Q9UKW6-1 ]
    uc001mvq.2. human. [Q9UKW6-3 ]

    Organism-specific databases

    CTDi 2001.
    GeneCardsi GC11M034500.
    HGNCi HGNC:3320. ELF5.
    MIMi 605169. gene.
    neXtProti NX_Q9UKW6.
    PharmGKBi PA27748.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296414.
    HOGENOMi HOG000232188.
    HOVERGENi HBG074143.
    InParanoidi Q9UKW6.
    KOi K17101.
    OMAi IVIVATC.
    OrthoDBi EOG7M0NRR.
    PhylomeDBi Q9UKW6.
    TreeFami TF318679.

    Miscellaneous databases

    EvolutionaryTracei Q9UKW6.
    GeneWikii ELF5.
    GenomeRNAii 2001.
    NextBioi 8095.
    PROi Q9UKW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKW6.
    Bgeei Q9UKW6.
    CleanExi HS_ELF5.
    Genevestigatori Q9UKW6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
      Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
      Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), TISSUE SPECIFICITY.
      Tissue: Lung.
    2. "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes."
      Oettgen P., Kas K., Dube A., Gu X., Grall F., Thamrongsak U., Akbarali Y., Finger E., Boltax J., Endress G., Munger K., Kunsch C., Libermann T.A.
      J. Biol. Chem. 274:29439-29452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Urinary bladder.

    Entry informationi

    Entry nameiELF5_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKW6
    Secondary accession number(s): A6XAE6
    , A8K452, O95175, Q8N2K9, Q96QY3, Q9UKW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3