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Q9UKW6 (ELF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Epithelium-restricted ESE-1-related Ets factor
Epithelium-specific Ets transcription factor 2
Short name=ESE-2
Gene names
Name:ELF5
Synonyms:ESE2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Ref.2

Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. Ref.2

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. Ref.1 Ref.2

Domain

The PNT domain acts as a transcriptional activator By similarity.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKW6-1)

Also known as: ESE-2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKW6-2)

Also known as: ESE-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
Isoform 3 (identifier: Q9UKW6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     130-148: YSFFNDAEESKATIKDYAD → QCSEGQTSRGGTRIRTKQL
     149-265: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265ETS-related transcription factor Elf-5
PRO_0000204092

Regions

Domain43 – 12987PNT
DNA binding173 – 25482ETS

Natural variations

Alternative sequence1 – 1010Missing in isoform 2 and isoform 3.
VSP_014510
Alternative sequence130 – 14819YSFFN…KDYAD → QCSEGQTSRGGTRIRTKQL in isoform 3.
VSP_014511
Alternative sequence149 – 265117Missing in isoform 3.
VSP_014512

Experimental info

Sequence conflict2501V → M in AAD22960. Ref.2
Sequence conflict2501V → M in AAD22961. Ref.2

Secondary structure

................ 265
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ESE-2a) [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 43821A79A45768FE

FASTA26531,263
        10         20         30         40         50         60 
MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH 

        70         80         90        100        110        120 
PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF 

       130        140        150        160        170        180 
ILQNIRTQGY SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR 

       190        200        210        220        230        240 
DLLLSPEENC GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG 

       250        260 
ILERVDRRLV YKFGKNAHGW QEDKL 

« Hide

Isoform 2 (ESE-2b) [UniParc].

Checksum: AE61C5B178ECB555
Show »

FASTA25530,121
Isoform 3 [UniParc].

Checksum: CD6912714A9AF817
Show »

FASTA13816,121

References

« Hide 'large scale' references
[1]"A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Lung.
[2]"Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes."
Oettgen P., Kas K., Dube A., Gu X., Grall F., Thamrongsak U., Akbarali Y., Finger E., Boltax J., Endress G., Munger K., Kunsch C., Libermann T.A.
J. Biol. Chem. 274:29439-29452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Kidney.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF049703 mRNA. Translation: AAC79755.1.
AF115402 mRNA. Translation: AAD22960.1.
AF115403 mRNA. Translation: AAD22961.1.
AK074633 mRNA. Translation: BAC11101.1.
AK290817 mRNA. Translation: BAF83506.1.
AL137224 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68169.1.
BC029743 mRNA. Translation: AAH29743.1.
RefSeqNP_001230009.1. NM_001243080.1.
NP_001230010.1. NM_001243081.1.
NP_001413.1. NM_001422.3.
NP_938195.1. NM_198381.1.
UniGeneHs.11713.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WWXNMR-A172-265[»]
ProteinModelPortalQ9UKW6.
SMRQ9UKW6. Positions 28-129, 174-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108316. 8 interactions.
IntActQ9UKW6. 6 interactions.
MINTMINT-1448100.
STRING9606.ENSP00000311010.

Polymorphism databases

DMDM68565549.

Proteomic databases

PRIDEQ9UKW6.

Protocols and materials databases

DNASU2001.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257832; ENSP00000257832; ENSG00000135374. [Q9UKW6-2]
ENST00000312319; ENSP00000311010; ENSG00000135374. [Q9UKW6-1]
ENST00000532417; ENSP00000436386; ENSG00000135374. [Q9UKW6-3]
GeneID2001.
KEGGhsa:2001.
UCSCuc001mvo.1. human. [Q9UKW6-1]
uc001mvq.2. human. [Q9UKW6-3]

Organism-specific databases

CTD2001.
GeneCardsGC11M034500.
HGNCHGNC:3320. ELF5.
MIM605169. gene.
neXtProtNX_Q9UKW6.
PharmGKBPA27748.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296414.
HOGENOMHOG000232188.
HOVERGENHBG074143.
InParanoidQ9UKW6.
KOK17101.
OMASQGYSFF.
OrthoDBEOG7M0NRR.
PhylomeDBQ9UKW6.
TreeFamTF318679.

Gene expression databases

ArrayExpressQ9UKW6.
BgeeQ9UKW6.
CleanExHS_ELF5.
GenevestigatorQ9UKW6.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9UKW6.
GeneWikiELF5.
GenomeRNAi2001.
NextBio8095.
PROQ9UKW6.
SOURCESearch...

Entry information

Entry nameELF5_HUMAN
AccessionPrimary (citable) accession number: Q9UKW6
Secondary accession number(s): A8K452 expand/collapse secondary AC list , O95175, Q8N2K9, Q96QY3, Q9UKW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM