Q9UKV3 (ACINU_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 109.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Apoptotic chromatin condensation inducer in the nucleus Short name=Acinus | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1341 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Ref.1 Ref.18 |
| Subunit structure | Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner. Ref.8 Ref.18 Ref.25 |
| Subcellular location | Nucleus. Nucleus speckle. Nucleus › nucleoplasm. Note: Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm. Ref.8 Ref.18 |
| Tissue specificity | Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies. |
| Post-translational modification | Phosphorylation on Ser-1180 by SRPK2 upregulates its stimulatory effect on cyclin A1. Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form. |
| Sequence similarities | Contains 1 SAP domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing Polymorphism |
| PTM | Acetylation Isopeptide bond Methylation Phosphoprotein Ubl conjugation |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | apoptotic chromosome condensation Inferred from direct assay Ref.1. Source: UniProtKB erythrocyte differentiationInferred from expression pattern. Source: UniProtKB positive regulation of monocyte differentiationInferred from expression pattern. Source: UniProtKB |
| Cellular component | cytosol Traceable author statement. Source: Reactome |
| Molecular function | ATPase activity Non-traceable author statement Ref.1. Source: UniProtKB enzyme bindingNon-traceable author statement Ref.1. Source: UniProtKB nucleic acid bindingNon-traceable author statement Ref.1. Source: UniProtKB nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PCBD1 | P61457 | 2 | EBI-396258,EBI-740475 |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9UKV3-1) Also known as: L; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9UKV3-2) Also known as: S'; The sequence of this isoform differs from the canonical sequence as follows: 1-727: Missing. 728-766: GSPKKCEAEE...PESERIHHTV → MSPADRCRSA...DQSSRTRGLP | ||||||
| Isoform 3 (identifier: Q9UKV3-3) Also known as: S; The sequence of this isoform differs from the canonical sequence as follows: 1-758: Missing. 759-766: SERIHHTV → MLSESKEG | ||||||
| Isoform 4 (identifier: Q9UKV3-5) The sequence of this isoform differs from the canonical sequence as follows: 829-829: Missing. 873-884: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1341 | 1341 | Apoptotic chromatin condensation inducer in the nucleus | PRO_0000064436 | |||||
Regions | |||||||||
| Domain | 72 – 106 | 35 | SAP | ||||||
| Compositional bias | 142 – 442 | 301 | Glu-rich | ||||||
| Compositional bias | 573 – 676 | 104 | Ser-rich | ||||||
| Compositional bias | 1114 – 1131 | 18 | Pro-rich | ||||||
| Compositional bias | 1132 – 1341 | 210 | Arg/Asp/Glu/Lys-rich | ||||||
Sites | |||||||||
| Site | 1093 – 1094 | 2 | Cleavage; by caspase-3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 166 | 1 | Phosphoserine Ref.22 | ||||||
| Modified residue | 169 | 1 | Phosphoserine Ref.22 | ||||||
| Modified residue | 208 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 216 | 1 | Phosphoserine Ref.11 Ref.14 Ref.22 Ref.23 | ||||||
| Modified residue | 228 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 229 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 240 | 1 | Phosphoserine Ref.9 Ref.11 Ref.22 Ref.26 | ||||||
| Modified residue | 243 | 1 | Phosphoserine Ref.9 Ref.11 Ref.22 Ref.26 | ||||||
| Modified residue | 254 | 1 | Phosphothreonine Ref.12 Ref.14 Ref.16 Ref.22 Ref.24 Ref.26 | ||||||
| Modified residue | 256 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 269 | 1 | Phosphothreonine Ref.22 Ref.26 | ||||||
| Modified residue | 295 | 1 | Phosphoserine Ref.22 | ||||||
| Modified residue | 328 | 1 | Phosphoserine Ref.11 Ref.22 Ref.26 | ||||||
| Modified residue | 365 | 1 | Phosphoserine Ref.9 Ref.11 Ref.16 Ref.22 Ref.26 | ||||||
| Modified residue | 384 | 1 | Phosphoserine Ref.11 Ref.14 Ref.22 | ||||||
| Modified residue | 386 | 1 | Phosphoserine Ref.9 Ref.10 Ref.11 Ref.14 Ref.22 | ||||||
| Modified residue | 388 | 1 | Phosphoserine Ref.9 Ref.10 Ref.14 Ref.22 | ||||||
| Modified residue | 393 | 1 | Phosphothreonine Ref.11 Ref.22 | ||||||
| Modified residue | 400 | 1 | Phosphoserine Ref.26 | ||||||
| Modified residue | 408 | 1 | Phosphothreonine Ref.11 Ref.24 Ref.26 | ||||||
| Modified residue | 410 | 1 | Phosphoserine Ref.11 Ref.22 Ref.24 Ref.26 | ||||||
| Modified residue | 414 | 1 | Phosphothreonine Ref.9 Ref.22 Ref.24 Ref.26 | ||||||
| Modified residue | 424 | 1 | Phosphoserine Ref.19 | ||||||
| Modified residue | 425 | 1 | Phosphoserine Ref.14 Ref.19 Ref.22 | ||||||
| Modified residue | 434 | 1 | Phosphoserine Ref.19 Ref.22 | ||||||
| Modified residue | 453 | 1 | Phosphoserine Ref.19 Ref.22 | ||||||
| Modified residue | 478 | 1 | Phosphoserine Ref.26 | ||||||
| Modified residue | 490 | 1 | Phosphoserine Ref.11 Ref.22 Ref.26 | ||||||
| Modified residue | 512 | 1 | Phosphotyrosine Ref.22 | ||||||
| Modified residue | 561 | 1 | Phosphoserine Ref.14 Ref.22 | ||||||
| Modified residue | 654 | 1 | N6,N6,N6-trimethyllysine; by EHMT2; alternate Ref.21 | ||||||
| Modified residue | 654 | 1 | N6,N6-dimethyllysine; by EHMT2; alternate Ref.21 | ||||||
| Modified residue | 655 | 1 | Phosphoserine Ref.11 Ref.22 Ref.24 | ||||||
| Modified residue | 657 | 1 | Phosphoserine Ref.9 Ref.11 Ref.16 Ref.17 Ref.22 Ref.24 | ||||||
| Modified residue | 661 | 1 | Phosphoserine Ref.9 Ref.16 | ||||||
| Modified residue | 664 | 1 | Phosphoserine Ref.24 | ||||||
| Modified residue | 675 | 1 | Phosphoserine Ref.24 | ||||||
| Modified residue | 676 | 1 | Phosphoserine Ref.9 Ref.24 | ||||||
| Modified residue | 682 | 1 | Phosphothreonine Ref.9 Ref.12 Ref.22 Ref.24 | ||||||
| Modified residue | 710 | 1 | Phosphoserine Ref.10 Ref.11 Ref.13 Ref.14 Ref.20 Ref.22 | ||||||
| Modified residue | 714 | 1 | Phosphoserine Ref.13 Ref.22 | ||||||
| Modified residue | 717 | 1 | N6-acetyllysine Ref.27 | ||||||
| Modified residue | 720 | 1 | Phosphothreonine Ref.22 | ||||||
| Modified residue | 729 | 1 | Phosphoserine Ref.11 Ref.13 Ref.14 | ||||||
| Modified residue | 814 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 815 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 825 | 1 | Phosphoserine Ref.24 | ||||||
| Modified residue | 830 | 1 | Phosphothreonine Ref.14 | ||||||
| Modified residue | 838 | 1 | Phosphoserine Ref.14 Ref.22 Ref.24 Ref.26 | ||||||
| Modified residue | 840 | 1 | Phosphothreonine Ref.24 | ||||||
| Modified residue | 895 | 1 | Phosphoserine Ref.19 | ||||||
| Modified residue | 898 | 1 | Phosphoserine Ref.19 | ||||||
| Modified residue | 976 | 1 | Phosphothreonine Ref.14 | ||||||
| Modified residue | 978 | 1 | Phosphothreonine Ref.14 | ||||||
| Modified residue | 981 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 983 | 1 | Phosphoserine Ref.14 | ||||||
| Modified residue | 987 | 1 | Phosphoserine Ref.26 | ||||||
| Modified residue | 990 | 1 | Phosphoserine Ref.26 | ||||||
| Modified residue | 1004 | 1 | Phosphoserine Ref.9 Ref.11 Ref.12 Ref.13 Ref.19 Ref.22 Ref.24 Ref.26 | ||||||
| Modified residue | 1176 | 1 | Phosphoserine Ref.11 Ref.14 | ||||||
| Modified residue | 1178 | 1 | Phosphoserine Ref.11 Ref.14 | ||||||
| Modified residue | 1180 | 1 | Phosphoserine; by SRPK2 and PKB/AKT1 Ref.14 Ref.18 | ||||||
| Modified residue | 1284 | 1 | Phosphoserine Ref.11 | ||||||
| Modified residue | 1329 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 1331 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 1332 | 1 | Phosphothreonine By similarity | ||||||
| Cross-link | 5 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.15 | |||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 758 | 758 | Missing in isoform 3. | VSP_004026 | |||||
| Alternative sequence | 1 – 727 | 727 | Missing in isoform 2. | VSP_004025 | |||||
| Alternative sequence | 728 – 766 | 39 | GSPKK…IHHTV → MSPADRCRSANTIEPATTSS LALFLLLQRDQSSRTRGLP in isoform 2. | VSP_004028 | |||||
| Alternative sequence | 759 – 766 | 8 | SERIHHTV → MLSESKEG in isoform 3. | VSP_004029 | |||||
| Alternative sequence | 829 | 1 | Missing in isoform 4. | VSP_042204 | |||||
| Alternative sequence | 873 – 884 | 12 | Missing in isoform 4. | VSP_042205 | |||||
| Natural variant | 257 | 1 | R → K. Corresponds to variant rs11555803 [ dbSNP | Ensembl ]. | VAR_050632 | |||||
| Natural variant | 311 | 1 | I → M. Corresponds to variant rs3811182 [ dbSNP | Ensembl ]. | VAR_022031 | |||||
| Natural variant | 447 | 1 | A → P. Ref.1 Ref.2 Ref.4 Ref.6 Corresponds to variant rs941719 [ dbSNP | Ensembl ]. | VAR_061547 | |||||
| Natural variant | 467 | 1 | S → P. Corresponds to variant rs1885097 [ dbSNP | Ensembl ]. | VAR_022032 | |||||
| Natural variant | 478 | 1 | S → F. Corresponds to variant rs3751501 [ dbSNP | Ensembl ]. | VAR_022033 | |||||
| Natural variant | 1160 | 1 | R → Q in a colorectal cancer sample; somatic mutation. Ref.29 | VAR_035777 | |||||
Experimental info | |||||||||
| Mutagenesis | 1093 | 1 | D → A: Abolishes cleavage by CASP3 and chromatin condensation activity. Ref.1 | ||||||
| Sequence conflict | 139 | 1 | Q → H in BAA31645. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." Sahara S., Aoto M., Eguchi Y., Imamoto N., Yoneda Y., Tsujimoto Y. Nature 401:168-173(1999) [PubMed: 10490026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE, FUNCTION, MUTAGENESIS OF ASP-1093, VARIANT PRO-447. |
| [2] | "Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-447. Tissue: Fetal brain. |
| [3] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-447. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT PRO-447. |
| [6] | "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1341 (ISOFORM 1), VARIANT PRO-447. Tissue: Brain. |
| [7] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 798-813. Tissue: Uterus. |
| [8] | "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core." Tange T.O., Shibuya T., Jurica M.S., Moore M.J. RNA 11:1869-1883(2005) [PubMed: 16314458] [Abstract] Cited for: IDENTIFICATION IN A MRNA SPLICING-DEPENDENT EXON JUNCTION COMPLEX, HETERODIMERIZATION, IDENTIFICATION IN A HETEROTRIMERIC COMPLEX, SUBCELLULAR LOCATION, MASS SPECTROMETRY. |
| [9] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; SER-365; SER-386; SER-388; THR-414; SER-657; SER-661; SER-676; THR-682 AND SER-1004, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [10] | "Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-388 AND SER-710, MASS SPECTROMETRY. Tissue: Colon adenocarcinoma. |
| [11] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-240; SER-243; SER-328; SER-365; SER-384; SER-386; THR-393; THR-408; SER-410; SER-490; SER-655; SER-657; SER-710; SER-729; SER-1004; SER-1176; SER-1178 AND SER-1284, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [12] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; THR-682 AND SER-1004, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [13] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710; SER-714; SER-729 AND SER-1004, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [14] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208; SER-216; SER-228; SER-229; THR-254; SER-256; SER-384; SER-386; SER-388; SER-425; SER-561; SER-710; SER-729; SER-814; SER-815; THR-830; SER-838; THR-976; THR-978; SER-981; SER-983; SER-1176; SER-1178 AND SER-1180, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [15] | "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-5, MASS SPECTROMETRY. Tissue: Mammary cancer. |
| [16] | "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; SER-365; SER-657 AND SER-661, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [17] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [18] | "Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1." Jang S.W., Yang S.J., Ehlen A., Dong S., Khoury H., Chen J., Persson J.L., Ye K. Cancer Res. 68:4559-4570(2008) [PubMed: 18559500] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION AT SER-1180 BY SRPK2, INTERACTION WITH SRPK2, SUBCELLULAR LOCATION. |
| [19] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; SER-425; SER-434; SER-453; SER-895; SER-898 AND SER-1004, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [20] | "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710, MASS SPECTROMETRY. Tissue: T-cell. |
| [21] | "Protein lysine methyltransferase G9a acts on non-histone targets." Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R., Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A. Nat. Chem. Biol. 4:344-346(2008) [PubMed: 18438403] [Abstract] Cited for: METHYLATION AT LYS-654, MASS SPECTROMETRY. |
| [22] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-169; SER-216; SER-240; SER-243; THR-254; THR-269; SER-295; SER-328; SER-365; SER-384; SER-386; SER-388; THR-393; SER-410; THR-414; SER-425; SER-434; SER-453; SER-490; TYR-512; SER-561; SER-655; SER-657; THR-682; SER-710; SER-714; THR-720; SER-838 AND SER-1004, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [23] | "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, MASS SPECTROMETRY. Tissue: Liver. |
| [24] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; THR-408; SER-410; THR-414; SER-655; SER-657; SER-664; SER-675; SER-676; THR-682; SER-825; SER-838; THR-840 AND SER-1004, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [25] | "The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation." Rigou P., Piddubnyak V., Faye A., Rain J.-C., Michel L., Calvo F., Poyet J.-L. EMBO J. 28:1576-1588(2009) [PubMed: 19387494] [Abstract] Cited for: INTERACTION WITH API5. |
| [26] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; THR-254; THR-269; SER-328; SER-365; SER-400; THR-408; SER-410; THR-414; SER-478; SER-490; SER-838; SER-987; SER-990 AND SER-1004, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [27] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-717, MASS SPECTROMETRY. |
| [28] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [29] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-1160. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF124726 mRNA. Translation: AAD56724.1. AF124727 mRNA. Translation: AAD56725.1. AF124728 mRNA. Translation: AAD56726.1. BX247975 mRNA. Translation: CAD62309.1. AL117258 Genomic DNA. No translation available. AL132780 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW66187.1. CH471078 Genomic DNA. Translation: EAW66188.1. BC140805 mRNA. Translation: AAI40806.1. AB014570 mRNA. Translation: BAA31645.2. AL050382 mRNA. Translation: CAB43681.2. |
| IPI | IPI00007334. IPI00215975. IPI00297991. IPI00946415. |
| RefSeq | NP_001158286.1. NM_001164814.1. NP_001158287.1. NM_001164815.1. NP_001158288.1. NM_001164816.1. NP_001158289.1. NM_001164817.1. NP_055792.1. NM_014977.3. |
| UniGene | Hs.124490. |
3D structure databases | |
| ProteinModelPortal | Q9UKV3. |
| SMR | Q9UKV3. Positions 72-104. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9UKV3. 7 interactions. |
| MINT | MINT-5006704. |
| STRING | Q9UKV3. |
Protein family/group databases | |
| TCDB | 3.A.18.1.1. nuclear mRNA exporter (mRNA-E) family. |
PTM databases | |
| PhosphoSite | Q9UKV3. |
Polymorphism databases | |
| DMDM | 308153407. |
Proteomic databases | |
| PRIDE | Q9UKV3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000262710; ENSP00000262710; ENSG00000100813. |
| GeneID | 22985. |
| KEGG | hsa:22985. |
| UCSC | uc001wip.2. human. uc001wir.2. human. uc001wit.2. human. |
Organism-specific databases | |
| CTD | 22985. |
| GeneCards | GC14M023527. |
| H-InvDB | HIX0011531. |
| HGNC | HGNC:17066. ACIN1. |
| HPA | HPA000657. |
| MIM | 604562. gene. |
| neXtProt | NX_Q9UKV3. |
| PharmGKB | PA134912489. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG17620. |
| GeneTree | ENSGT00570000079212. |
| HOGENOM | HBG125341. |
| HOVERGEN | HBG050449. |
| InParanoid | Q9UKV3. |
| OMA | RADRNLK. |
| OrthoDB | EOG45QHCG. |
| PhylomeDB | Q9UKV3. |
Enzyme and pathway databases | |
| Reactome | REACT_578. Apoptosis. |
Gene expression databases | |
| ArrayExpress | Q9UKV3. |
| Bgee | Q9UKV3. |
| CleanEx | HS_ACIN1. |
| Genevestigator | Q9UKV3. |
| GermOnline | ENSG00000100813. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR003034. SAP_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. |
| KO | K12875. |
| Pfam | PF02037. SAP. 1 hit. [Graphical view] |
| SMART | SM00360. RRM. 1 hit. SM00513. SAP. 1 hit. [Graphical view] |
| PROSITE | PS50800. SAP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 43823. |
| PMAP-CutDB | Q9UKV3. |
| SOURCE | Search... |
Entry information
| Entry name | ACINU_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UKV3 Secondary accession number(s): B2RTT4 Q9UKV2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with