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Protein

Apoptotic chromatin condensation inducer in the nucleus

Gene

ACIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.5 Publications

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • nucleic acid binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • apoptotic chromosome condensation Source: UniProtKB
  • cellular component disassembly involved in execution phase of apoptosis Source: Reactome
  • erythrocyte differentiation Source: UniProtKB
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • positive regulation of monocyte differentiation Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Apoptosis, mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SIGNORiQ9UKV3.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptotic chromatin condensation inducer in the nucleus
Short name:
Acinus
Gene namesi
Name:ACIN1
Synonyms:ACINUS, KIAA0670
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17066. ACIN1.

Subcellular locationi

GO - Cellular componenti

  • ASAP complex Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • nuclear speck Source: UniProtKB
  • nucleolus Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1093 – 10931D → A: Abolishes cleavage by CASP3 and chromatin condensation activity. 1 Publication

Organism-specific databases

PharmGKBiPA134912489.

Polymorphism and mutation databases

BioMutaiACIN1.
DMDMi308153407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13411341Apoptotic chromatin condensation inducer in the nucleusPRO_0000064436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki5 – 5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei166 – 1661PhosphoserineCombined sources
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei216 – 2161PhosphoserineCombined sources
Modified residuei240 – 2401PhosphoserineCombined sources
Modified residuei243 – 2431PhosphoserineCombined sources
Modified residuei254 – 2541PhosphothreonineCombined sources
Cross-linki268 – 268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei269 – 2691PhosphothreonineCombined sources
Modified residuei295 – 2951PhosphoserineCombined sources
Cross-linki305 – 305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315 – 315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei326 – 3261PhosphothreonineCombined sources
Modified residuei328 – 3281PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources
Modified residuei384 – 3841PhosphoserineCombined sources
Modified residuei386 – 3861PhosphoserineCombined sources
Modified residuei388 – 3881PhosphoserineCombined sources
Modified residuei393 – 3931PhosphothreonineCombined sources
Modified residuei400 – 4001PhosphoserineCombined sources
Modified residuei410 – 4101PhosphoserineCombined sources
Modified residuei414 – 4141PhosphothreonineCombined sources
Modified residuei420 – 4201PhosphothreonineCombined sources
Modified residuei434 – 4341Phosphoserine; in variant Pro-447Combined sources
Modified residuei453 – 4531Phosphoserine; in variant Pro-447Combined sources
Modified residuei478 – 4781PhosphoserineCombined sources
Modified residuei490 – 4901PhosphoserineCombined sources
Modified residuei512 – 5121PhosphotyrosineCombined sources
Modified residuei522 – 5221PhosphoserineCombined sources
Cross-linki532 – 532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei561 – 5611PhosphoserineCombined sources
Modified residuei654 – 6541N6,N6,N6-trimethyllysine; by EHMT2; alternate1 Publication
Modified residuei654 – 6541N6,N6-dimethyllysine; by EHMT2; alternate1 Publication
Modified residuei655 – 6551PhosphoserineCombined sources
Modified residuei657 – 6571PhosphoserineCombined sources
Modified residuei682 – 6821PhosphothreonineCombined sources
Modified residuei710 – 7101PhosphoserineCombined sources
Modified residuei714 – 7141PhosphoserineCombined sources
Modified residuei717 – 7171N6-acetyllysineCombined sources
Modified residuei720 – 7201PhosphothreonineCombined sources
Modified residuei729 – 7291PhosphoserineCombined sources
Modified residuei825 – 8251PhosphoserineCombined sources
Modified residuei838 – 8381PhosphoserineCombined sources
Modified residuei861 – 8611N6-acetyllysineBy similarity
Modified residuei895 – 8951PhosphoserineCombined sources
Modified residuei898 – 8981PhosphoserineCombined sources
Modified residuei976 – 9761PhosphothreonineCombined sources
Modified residuei987 – 9871PhosphoserineCombined sources
Modified residuei990 – 9901PhosphoserineCombined sources
Modified residuei1004 – 10041PhosphoserineCombined sources
Modified residuei1180 – 11801Phosphoserine; by SRPK2 and PKB/AKT11 Publication
Isoform 4 (identifier: Q9UKV3-5)
Modified residuei825 – 8251PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.1 Publication
Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1093 – 10942Cleavage; by caspase-3

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKV3.
MaxQBiQ9UKV3.
PaxDbiQ9UKV3.
PeptideAtlasiQ9UKV3.
PRIDEiQ9UKV3.

PTM databases

iPTMnetiQ9UKV3.
PhosphoSiteiQ9UKV3.
SwissPalmiQ9UKV3.

Miscellaneous databases

PMAP-CutDBQ9UKV3.

Expressioni

Tissue specificityi

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Gene expression databases

BgeeiENSG00000100813.
CleanExiHS_ACIN1.
ExpressionAtlasiQ9UKV3. baseline and differential.
GenevisibleiQ9UKV3. HS.

Organism-specific databases

HPAiHPA000657.

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
API5Q9BZZ52EBI-6976596,EBI-1048422
PCBD1P614572EBI-396258,EBI-740475

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116634. 112 interactions.
DIPiDIP-32963N.
IntActiQ9UKV3. 27 interactions.
MINTiMINT-5006704.
STRINGi9606.ENSP00000262710.

Structurei

3D structure databases

ProteinModelPortaliQ9UKV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 10635SAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1210 – 123728Sufficient for interaction with RNPS1 and SAP18 and formation of th ASAP complexBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 442301Glu-richAdd
BLAST
Compositional biasi573 – 676104Ser-richAdd
BLAST
Compositional biasi1114 – 113118Pro-richAdd
BLAST
Compositional biasi1132 – 1341210Arg/Asp/Glu/Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2416. Eukaryota.
ENOG4111HR1. LUCA.
GeneTreeiENSGT00710000106790.
HOGENOMiHOG000088615.
HOVERGENiHBG050449.
InParanoidiQ9UKV3.
KOiK12875.
OMAiPENDVPE.
OrthoDBiEOG091G0MO8.
PhylomeDBiQ9UKV3.
TreeFamiTF320727.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR032552. RSB_motif.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF16294. RSB_motif. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKV3-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRRKHPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG
60 70 80 90 100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK
110 120 130 140 150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ
160 170 180 190 200
RLEREAREAA ELEEASAESE DEMIHPEGVA SLLPPDFQSS LERPELELSR
210 220 230 240 250
HSPRKSSSIS EEKGDSDDEK PRKGERRSSR VRQARAAKLS EGSQPAEEEE
260 270 280 290 300
DQETPSRNLR VRADRNLKTE EEEEEEEEEE EDDEEEEGDD EGQKSREAPI
310 320 330 340 350
LKEFKEEGEE IPRVKPEEMM DERPKTRSQE QEVLERGGRF TRSQEEARKS
360 370 380 390 400
HLARQQQEKE MKTTSPLEEE EREIKSSQGL KEKSKSPSPP RLTEDRKKAS
410 420 430 440 450
LVALPEQTAS EEETPPPLLT KEASSPPPHP QLHSEEEIEP MEGPAPAVLI
460 470 480 490 500
QLSPPNTDAD TRELLVSQHT VQLVGGLSPL SSPSDTKAES PAEKVPEESV
510 520 530 540 550
LPLVQKSTLA DYSAQKDLEP ESDRSAQPLP LKIEELALAK GITEECLKQP
560 570 580 590 600
SLEQKEGRRA SHTLLPSHRL KQSADSSSSR SSSSSSSSSR SRSRSPDSSG
610 620 630 640 650
SRSHSPLRSK QRDVAQARTH ANPRGRPKMG SRSTSESRSR SRSRSRSASS
660 670 680 690 700
NSRKSLSPGV SRDSSTSYTE TKDPSSGQEV ATPPVPQLQV CEPKERTSTS
710 720 730 740 750
SSSVQARRLS QPESAEKHVT QRLQPERGSP KKCEAEEAEP PAATQPQTSE
760 770 780 790 800
TQTSHLPESE RIHHTVEEKE EVTMDTSENR PENDVPEPPM PIADQVSNDD
810 820 830 840 850
RPEGSVEDEE KKESSLPKSF KRKISVVSAT KGVPAGNSDT EGGQPGRKRR
860 870 880 890 900
WGASTATTQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED
910 920 930 940 950
ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE EKEPEAEPPV
960 970 980 990 1000
PPQVSVEVAL PPPAEHEVKK VTLGDTLTRR SISQQKSGVS ITIDDPVRTA
1010 1020 1030 1040 1050
QVPSPPRGKI SNIVHISNLV RPFTLGQLKE LLGRTGTLVE EAFWIDKIKS
1060 1070 1080 1090 1100
HCFVTYSTVE EAVATRTALH GVKWPQSNPK FLCADYAEQD ELDYHRGLLV
1110 1120 1130 1140 1150
DRPSETKTEE QGIPRPLHPP PPPPVQPPQH PRAEQREQER AVREQWAERE
1160 1170 1180 1190 1200
REMERRERTR SEREWDRDKV REGPRSRSRS RDRRRKERAK SKEKKSEKKE
1210 1220 1230 1240 1250
KAQEEPPAKL LDDLFRKTKA APCIYWLPLT DSQIVQKEAE RAERAKEREK
1260 1270 1280 1290 1300
RRKEQEEEEQ KEREKEAERE RNRQLEREKR REHSRERDRE RERERERDRG
1310 1320 1330 1340
DRDRDRERDR ERGRERDRRD TKRHSRSRSR STPVRDRGGR R
Length:1,341
Mass (Da):151,862
Last modified:October 5, 2010 - v2
Checksum:iDCCBF310A4680691
GO
Isoform 2 (identifier: Q9UKV3-2) [UniParc]FASTAAdd to basket
Also known as: S'

The sequence of this isoform differs from the canonical sequence as follows:
     1-727: Missing.
     728-766: GSPKKCEAEE...PESERIHHTV → MSPADRCRSA...DQSSRTRGLP

Show »
Length:614
Mass (Da):70,948
Checksum:i2E994FB0FA922F4C
GO
Isoform 3 (identifier: Q9UKV3-3) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     1-758: Missing.
     759-766: SERIHHTV → MLSESKEG

Show »
Length:583
Mass (Da):67,566
Checksum:iF227265F2F6BBF68
GO
Isoform 4 (identifier: Q9UKV3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: Missing.
     873-884: Missing.

Show »
Length:1,328
Mass (Da):150,557
Checksum:i47A3C106859D46DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391Q → H in BAA31645 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571R → K.
Corresponds to variant rs11555803 [ dbSNP | Ensembl ].
VAR_050632
Natural varianti311 – 3111I → M.
Corresponds to variant rs3811182 [ dbSNP | Ensembl ].
VAR_022031
Natural varianti447 – 4471A → P.Combined sources5 Publications
Corresponds to variant rs941719 [ dbSNP | Ensembl ].
VAR_061547
Natural varianti467 – 4671S → P.
Corresponds to variant rs1885097 [ dbSNP | Ensembl ].
VAR_022032
Natural varianti478 – 4781S → F.
Corresponds to variant rs3751501 [ dbSNP | Ensembl ].
VAR_022033
Natural varianti1160 – 11601R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs754494408 [ dbSNP | Ensembl ].
VAR_035777

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 758758Missing in isoform 3. 2 PublicationsVSP_004026Add
BLAST
Alternative sequencei1 – 727727Missing in isoform 2. 1 PublicationVSP_004025Add
BLAST
Alternative sequencei728 – 76639GSPKK…IHHTV → MSPADRCRSANTIEPATTSS LALFLLLQRDQSSRTRGLP in isoform 2. 1 PublicationVSP_004028Add
BLAST
Alternative sequencei759 – 7668SERIHHTV → MLSESKEG in isoform 3. 2 PublicationsVSP_004029
Alternative sequencei829 – 8291Missing in isoform 4. 1 PublicationVSP_042204
Alternative sequencei873 – 88412Missing in isoform 4. 1 PublicationVSP_042205Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124726 mRNA. Translation: AAD56724.1.
AF124727 mRNA. Translation: AAD56725.1.
AF124728 mRNA. Translation: AAD56726.1.
BX247975 mRNA. Translation: CAD62309.1.
AL117258 Genomic DNA. No translation available.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66187.1.
CH471078 Genomic DNA. Translation: EAW66188.1.
BC140805 mRNA. Translation: AAI40806.1.
AB014570 mRNA. Translation: BAA31645.2.
AL050382 mRNA. Translation: CAB43681.2.
CCDSiCCDS53887.1. [Q9UKV3-3]
CCDS53888.1. [Q9UKV3-2]
CCDS55905.1. [Q9UKV3-5]
CCDS9587.1. [Q9UKV3-1]
RefSeqiNP_001158286.1. NM_001164814.1.
NP_001158287.1. NM_001164815.1.
NP_001158288.1. NM_001164816.1. [Q9UKV3-2]
NP_001158289.1. NM_001164817.1. [Q9UKV3-3]
NP_055792.1. NM_014977.3.
XP_005267475.1. XM_005267418.1. [Q9UKV3-3]
UniGeneiHs.124490.

Genome annotation databases

EnsembliENST00000262710; ENSP00000262710; ENSG00000100813. [Q9UKV3-1]
ENST00000338631; ENSP00000345541; ENSG00000100813. [Q9UKV3-2]
ENST00000357481; ENSP00000350073; ENSG00000100813. [Q9UKV3-3]
ENST00000397341; ENSP00000380502; ENSG00000100813. [Q9UKV3-3]
ENST00000555053; ENSP00000451328; ENSG00000100813. [Q9UKV3-5]
GeneIDi22985.
KEGGihsa:22985.
UCSCiuc001wip.5. human. [Q9UKV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124726 mRNA. Translation: AAD56724.1.
AF124727 mRNA. Translation: AAD56725.1.
AF124728 mRNA. Translation: AAD56726.1.
BX247975 mRNA. Translation: CAD62309.1.
AL117258 Genomic DNA. No translation available.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66187.1.
CH471078 Genomic DNA. Translation: EAW66188.1.
BC140805 mRNA. Translation: AAI40806.1.
AB014570 mRNA. Translation: BAA31645.2.
AL050382 mRNA. Translation: CAB43681.2.
CCDSiCCDS53887.1. [Q9UKV3-3]
CCDS53888.1. [Q9UKV3-2]
CCDS55905.1. [Q9UKV3-5]
CCDS9587.1. [Q9UKV3-1]
RefSeqiNP_001158286.1. NM_001164814.1.
NP_001158287.1. NM_001164815.1.
NP_001158288.1. NM_001164816.1. [Q9UKV3-2]
NP_001158289.1. NM_001164817.1. [Q9UKV3-3]
NP_055792.1. NM_014977.3.
XP_005267475.1. XM_005267418.1. [Q9UKV3-3]
UniGeneiHs.124490.

3D structure databases

ProteinModelPortaliQ9UKV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116634. 112 interactions.
DIPiDIP-32963N.
IntActiQ9UKV3. 27 interactions.
MINTiMINT-5006704.
STRINGi9606.ENSP00000262710.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

PTM databases

iPTMnetiQ9UKV3.
PhosphoSiteiQ9UKV3.
SwissPalmiQ9UKV3.

Polymorphism and mutation databases

BioMutaiACIN1.
DMDMi308153407.

Proteomic databases

EPDiQ9UKV3.
MaxQBiQ9UKV3.
PaxDbiQ9UKV3.
PeptideAtlasiQ9UKV3.
PRIDEiQ9UKV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262710; ENSP00000262710; ENSG00000100813. [Q9UKV3-1]
ENST00000338631; ENSP00000345541; ENSG00000100813. [Q9UKV3-2]
ENST00000357481; ENSP00000350073; ENSG00000100813. [Q9UKV3-3]
ENST00000397341; ENSP00000380502; ENSG00000100813. [Q9UKV3-3]
ENST00000555053; ENSP00000451328; ENSG00000100813. [Q9UKV3-5]
GeneIDi22985.
KEGGihsa:22985.
UCSCiuc001wip.5. human. [Q9UKV3-1]

Organism-specific databases

CTDi22985.
GeneCardsiACIN1.
HGNCiHGNC:17066. ACIN1.
HPAiHPA000657.
MIMi604562. gene.
neXtProtiNX_Q9UKV3.
PharmGKBiPA134912489.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2416. Eukaryota.
ENOG4111HR1. LUCA.
GeneTreeiENSGT00710000106790.
HOGENOMiHOG000088615.
HOVERGENiHBG050449.
InParanoidiQ9UKV3.
KOiK12875.
OMAiPENDVPE.
OrthoDBiEOG091G0MO8.
PhylomeDBiQ9UKV3.
TreeFamiTF320727.

Enzyme and pathway databases

ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SIGNORiQ9UKV3.

Miscellaneous databases

ChiTaRSiACIN1. human.
GeneWikiiACIN1.
GenomeRNAii22985.
PMAP-CutDBQ9UKV3.
PROiQ9UKV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100813.
CleanExiHS_ACIN1.
ExpressionAtlasiQ9UKV3. baseline and differential.
GenevisibleiQ9UKV3. HS.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR032552. RSB_motif.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF16294. RSB_motif. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACINU_HUMAN
AccessioniPrimary (citable) accession number: Q9UKV3
Secondary accession number(s): B2RTT4
, D3DS45, O75158, Q9UG91, Q9UKV1, Q9UKV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Structural and functional studies of the ASAP complex have been conducted with a chimeric complex involving a conserved fragment of Drosophila melanogaster Acinus/hkl.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.