ID   ANGL2_HUMAN             Reviewed;         493 AA.
AC   Q9UKU9; Q5JT58;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-JAN-2012, entry version 96.
DE   RecName: Full=Angiopoietin-related protein 2;
DE   AltName: Full=Angiopoietin-like protein 2;
DE   Flags: Precursor;
GN   Name=ANGPTL2; Synonyms=ARP2; ORFNames=UNQ170/PRO196;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   MEDLINE=99403103; PubMed=10473614; DOI=10.1074/jbc.274.37.26523;
RA   Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G.,
RA   Koh G.Y.;
RT   "Molecular cloning, expression, and characterization of angiopoietin-
RT   related protein. angiopoietin-related protein induces endothelial cell
RT   sprouting.";
RL   J. Biol. Chem. 274:26523-26528(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces sprouting in endothelial cells through an
CC       autocrine and paracrine action.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Widely expressed in heart, small intestine,
CC       spleen and stomach. Also found in lower levels in colon, ovary,
CC       adrenal gland, skeletal muscle and in prostate.
CC   -!- PTM: N-glycosylated.
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
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DR   EMBL; AF125175; AAD55357.1; -; mRNA.
DR   EMBL; AY358274; AAQ88641.1; -; mRNA.
DR   EMBL; AL356862; CAI39725.1; -; Genomic_DNA.
DR   EMBL; BC012368; AAH12368.1; -; mRNA.
DR   IPI; IPI00007800; -.
DR   RefSeq; NP_036230.1; NM_012098.2.
DR   UniGene; Hs.653262; -.
DR   ProteinModelPortal; Q9UKU9; -.
DR   SMR; Q9UKU9; 274-488.
DR   STRING; Q9UKU9; -.
DR   DMDM; 13626119; -.
DR   PRIDE; Q9UKU9; -.
DR   Ensembl; ENST00000373425; ENSP00000362524; ENSG00000136859.
DR   GeneID; 23452; -.
DR   KEGG; hsa:23452; -.
DR   UCSC; uc004bqr.1; human.
DR   CTD; 23452; -.
DR   GeneCards; GC09M129849; -.
DR   H-InvDB; HIX0008390; -.
DR   HGNC; HGNC:490; ANGPTL2.
DR   HPA; HPA040933; -.
DR   HPA; HPA041299; -.
DR   MIM; 605001; gene.
DR   neXtProt; NX_Q9UKU9; -.
DR   eggNOG; prNOG19246; -.
DR   GeneTree; ENSGT00560000076728; -.
DR   HOGENOM; HBG446224; -.
DR   HOVERGEN; HBG103336; -.
DR   InParanoid; Q9UKU9; -.
DR   OMA; AHNQSEI; -.
DR   OrthoDB; EOG4TXBRT; -.
DR   PhylomeDB; Q9UKU9; -.
DR   NextBio; 45741; -.
DR   ArrayExpress; Q9UKU9; -.
DR   Bgee; Q9UKU9; -.
DR   CleanEx; HS_ANGPTL2; -.
DR   Genevestigator; Q9UKU9; -.
DR   GermOnline; ENSG00000136859; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005102; F:receptor binding; TAS:ProtInc.
DR   GO; GO:0007275; P:multicellular organismal development; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR014715; Fibrinogen_a/b/g_C_2.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Gene3D; G3DSA:4.10.530.10; Fibrinogen_a/b/g_C_2; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen_a/b/g_C; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23    493       Angiopoietin-related protein 2.
FT                                /FTId=PRO_0000009120.
FT   DOMAIN      269    489       Fibrinogen C-terminal.
FT   COILED       76    115       Potential.
FT   COILED      152    206       Potential.
FT   CARBOHYD    164    164       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    192    192       N-linked (GlcNAc...) (Potential).
FT   DISULFID    278    307       By similarity.
FT   DISULFID    430    443       By similarity.
SQ   SEQUENCE   493 AA;  57104 MW;  0F2ADECE53D185CA CRC64;
     MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES QDKCTYTFIV
     PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV
     KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE
     HKYQHLATLA HNQSEIIAQL EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN
     EIQSDQNLKV LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN
     RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ
     GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD
     RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK
     VVMMIRPNPN TFH
//