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Q9UKU9

- ANGL2_HUMAN

UniProt

Q9UKU9 - ANGL2_HUMAN

Protein

Angiopoietin-related protein 2

Gene

ANGPTL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Induces sprouting in endothelial cells through an autocrine and paracrine action.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-related protein 2
    Alternative name(s):
    Angiopoietin-like protein 2
    Gene namesi
    Name:ANGPTL2
    Synonyms:ARP2
    ORF Names:UNQ170/PRO196
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:490. ANGPTL2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24795.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 493471Angiopoietin-related protein 2PRO_0000009120Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi278 ↔ 307PROSITE-ProRule annotation
    Disulfide bondi430 ↔ 443PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UKU9.
    PRIDEiQ9UKU9.

    PTM databases

    PhosphoSiteiQ9UKU9.

    Expressioni

    Tissue specificityi

    Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.

    Gene expression databases

    ArrayExpressiQ9UKU9.
    BgeeiQ9UKU9.
    CleanExiHS_ANGPTL2.
    GenevestigatoriQ9UKU9.

    Organism-specific databases

    HPAiHPA040933.
    HPA041299.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59886N.
    STRINGi9606.ENSP00000362524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKU9.
    SMRiQ9UKU9. Positions 276-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 489221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili76 – 11540Sequence AnalysisAdd
    BLAST
    Coiled coili152 – 20655Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG251988.
    HOGENOMiHOG000037129.
    HOVERGENiHBG103336.
    InParanoidiQ9UKU9.
    OMAiEEHCQRV.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ9UKU9.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UKU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES    50
    QDKCTYTFIV PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK 100
    RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD 150
    NALELSQLEN RILNQTADML QLASKYKDLE HKYQHLATLA HNQSEIIAQL 200
    EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV 250
    LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN 300
    RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG 350
    LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY 400
    HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG 450
    VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH 493
    Length:493
    Mass (Da):57,104
    Last modified:May 1, 2000 - v1
    Checksum:i0F2ADECE53D185CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125175 mRNA. Translation: AAD55357.1.
    AY358274 mRNA. Translation: AAQ88641.1.
    AL356862 Genomic DNA. Translation: CAI39725.1.
    BC012368 mRNA. Translation: AAH12368.1.
    CCDSiCCDS6868.1.
    RefSeqiNP_036230.1. NM_012098.2.
    UniGeneiHs.653262.

    Genome annotation databases

    EnsembliENST00000373425; ENSP00000362524; ENSG00000136859.
    GeneIDi23452.
    KEGGihsa:23452.
    UCSCiuc004bqr.1. human.

    Polymorphism databases

    DMDMi13626119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125175 mRNA. Translation: AAD55357.1 .
    AY358274 mRNA. Translation: AAQ88641.1 .
    AL356862 Genomic DNA. Translation: CAI39725.1 .
    BC012368 mRNA. Translation: AAH12368.1 .
    CCDSi CCDS6868.1.
    RefSeqi NP_036230.1. NM_012098.2.
    UniGenei Hs.653262.

    3D structure databases

    ProteinModelPortali Q9UKU9.
    SMRi Q9UKU9. Positions 276-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59886N.
    STRINGi 9606.ENSP00000362524.

    PTM databases

    PhosphoSitei Q9UKU9.

    Polymorphism databases

    DMDMi 13626119.

    Proteomic databases

    PaxDbi Q9UKU9.
    PRIDEi Q9UKU9.

    Protocols and materials databases

    DNASUi 23452.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373425 ; ENSP00000362524 ; ENSG00000136859 .
    GeneIDi 23452.
    KEGGi hsa:23452.
    UCSCi uc004bqr.1. human.

    Organism-specific databases

    CTDi 23452.
    GeneCardsi GC09M129849.
    HGNCi HGNC:490. ANGPTL2.
    HPAi HPA040933.
    HPA041299.
    MIMi 605001. gene.
    neXtProti NX_Q9UKU9.
    PharmGKBi PA24795.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251988.
    HOGENOMi HOG000037129.
    HOVERGENi HBG103336.
    InParanoidi Q9UKU9.
    OMAi EEHCQRV.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q9UKU9.
    TreeFami TF336658.

    Miscellaneous databases

    GeneWikii ANGPTL2.
    GenomeRNAii 23452.
    NextBioi 45741.
    PROi Q9UKU9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKU9.
    Bgeei Q9UKU9.
    CleanExi HS_ANGPTL2.
    Genevestigatori Q9UKU9.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting."
      Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G., Koh G.Y.
      J. Biol. Chem. 274:26523-26528(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiANGL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKU9
    Secondary accession number(s): Q5JT58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3