Q9UKU0 (ACSL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain-fatty-acid--CoA ligase 6
EC=6.2.1.3

Alternative name(s):
Long-chain acyl-CoA synthetase 6
Short name=LACS 6

Gene names

Name:	ACSL6
Synonyms:	ACS2, FACL6, KIAA0837, LACS5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	697 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Catalytic activity	ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Magnesium.
Subcellular location	Mitochondrion outer membrane; Single-pass type III membrane protein By similarity. Peroxisome membrane; Single-pass type III membrane protein By similarity. Microsome membrane; Single-pass type III membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity.
Tissue specificity	Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain. Ref.1
Developmental stage	Expression is low at earlier stages of erythroid development but is very high in reticulocytes.
Involvement in disease	A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.
Sequence caution	The sequence BAA74860.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Endoplasmic reticulum Membrane Microsome Mitochondrion Mitochondrion outer membrane Peroxisome
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to insulin stimulus Inferred from electronic annotation. Source: Compara fatty acid transport Inferred from electronic annotation. Source: Compara long-chain fatty-acyl-CoA biosynthetic process Traceable author statement. Source: Reactome neuroblast proliferation Inferred from electronic annotation. Source: Compara neuron development Inferred from electronic annotation. Source: Compara phospholipid biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of plasma membrane long-chain fatty acid transport Inferred from electronic annotation. Source: Compara positive regulation of triglyceride biosynthetic process Inferred from electronic annotation. Source: Compara response to gravity Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to steroid hormone stimulus Inferred from electronic annotation. Source: Compara triglyceride biosynthetic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.3PubMed 20429931PubMed 20429931PubMed 20429931. Source: UniProtKB mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: Compara peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activity Inferred from direct assay PubMed 20429931PubMed 20429931. Source: UniProtKB protein homodimerization activity Inferred from direct assay PubMed 20429931PubMed 20429931PubMed 20429931PubMed 20429931. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: Q9UKU0-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9UKU0-1)

Also known as: Long; v2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTFFLVSGGSLWLFVEFVLSLLEKM

Isoform 2 (identifier: Q9UKU0-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     306-330: KVIFPRQDDVLISFLPLAHMFERVI → SQWAPTCADVHISYLPLAHMFERMV
     653-697: VKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM → DLPQCLIQIKVFSKY

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UKU0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     306-330: KVIFPRQDDVLISFLPLAHMFERVI → SQWAPTCADVHISYLPLAHMFERMV

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9UKU0-5)

Also known as: v4;

The sequence of this isoform differs from the canonical sequence as follows:
     306-312: Missing.

Isoform 6 (identifier: Q9UKU0-6)

Also known as: v5;

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: T → TGLSCQEGASATASTQ

Isoform 7 (identifier: Q9UKU0-7)

Also known as: v3;

The sequence of this isoform differs from the canonical sequence as follows:
     31-65: Missing.
     306-345: Missing.

Isoform 8 (identifier: Q9UKU0-8)

Also known as: v1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTFFLVSGGSLWLFVEFVLSLLEKM
     306-330: KVIFPRQDDVLISFLPLAHMFERVI → SQWAPTCADVHISYLPLAHMFERMV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 697	697	Long-chain-fatty-acid--CoA ligase 6		PRO_0000193115
Regions
	Transmembrane	25 – 45	21	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	46 – 697	652	Cytoplasmic Potential
Natural variations
	Alternative sequence	1	1	M → MLTFFLVSGGSLWLFVEFVL SLLEKM in isoform 1 and isoform 8.		VSP_037819
	Alternative sequence	31 – 65	35	Missing in isoform 7.		VSP_037820
	Alternative sequence	192	1	T → TGLSCQEGASATASTQ in isoform 6.		VSP_037821
	Alternative sequence	306 – 345	40	Missing in isoform 7.		VSP_037822
	Alternative sequence	306 – 330	25	KVIFP…FERVI → SQWAPTCADVHISYLPLAHM FERMV in isoform 3, isoform 2 and isoform 8.		VSP_021024
	Alternative sequence	306 – 312	7	Missing in isoform 5.		VSP_037823
	Alternative sequence	653 – 697	45	VKAIH…YSISM → DLPQCLIQIKVFSKY in isoform 2.		VSP_000241
Experimental info
	Sequence conflict	19	1	G → E in AAD47199. Ref.1
	Sequence conflict	46	1	H → Q in AAD47199. Ref.1
	Sequence conflict	257	1	E → A in AAH47453. Ref.7
	Sequence conflict	356	1	K → R in AAZ30714. Ref.3
	Sequence conflict	696	1	S → P in AAD47199. Ref.1
	Sequence conflict	696	1	S → P in AAZ30714. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified March 6, 2007. Version 4. Checksum: AC566177B47D0975	FASTA	697	77,752
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK 250 260 270 280 290 300 CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 310 320 330 340 350 360 LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP 370 380 390 400 410 420 TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI 430 440 450 460 470 480 QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV 490 500 510 520 530 540 GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD 550 560 570 580 590 600 IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI 610 620 630 640 650 660 VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS 670 680 690 DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM
	Isoform 1 (Long) (v2) [UniParc]. Checksum: 2B7D408F2F77C1FB	FASTA	722	80,610
	10 20 30 40 50 60 MLTFFLVSGG SLWLFVEFVL SLLEKMQTQE ILRILRLPEL GDLGQFFRSL SATTLVSMGA 70 80 90 100 110 120 LAAILAYWFT HRPKALQPPC NLLMQSEEVE DSGGARRSVI GSGPQLLTHY YDDARTMYQV 130 140 150 160 170 180 FRRGLSISGN GPCLGFRKPK QPYQWLSYQE VADRAEFLGS GLLQHNCKAC TDQFIGVFAQ 190 200 210 220 230 240 NRPEWIIVEL ACYTYSMVVV PLYDTLGPGA IRYIINTADI STVIVDKPQK AVLLLEHVER 250 260 270 280 290 300 KETPGLKLII LMDPFEEALK ERGQKCGVVI KSMQAVEDCG QENHQAPVPP QPDDLSIVCF 310 320 330 340 350 360 TSGTTGNPKG AMLTHGNVVA DFSGFLKVTE KVIFPRQDDV LISFLPLAHM FERVIQSVVY 370 380 390 400 410 420 CHGGRVGFFQ GDIRLLSDDM KALCPTIFPV VPRLLNRMYD KIFSQANTPL KRWLLEFAAK 430 440 450 460 470 480 RKQAEVRSGI IRNDSIWDEL FFNKIQASLG GCVRMIVTGA APASPTVLGF LRAALGCQVY 490 500 510 520 530 540 EGYGQTECTA GCTFTTPGDW TSGHVGAPLP CNHIKLVDVE ELNYWACKGE GEICVRGPNV 550 560 570 580 590 600 FKGYLKDPDR TKEALDSDGW LHTGDIGKWL PAGTLKIIDR KKHIFKLAQG EYVAPEKIEN 610 620 630 640 650 660 IYIRSQPVAQ IYVHGDSLKA FLVGIVVPDP EVMPSWAQKR GIEGTYADLC TNKDLKKAIL 670 680 690 700 710 720 EDMVRLGKES GLHSFEQVKA IHIHSDMFSV QNGLLTPTLK AKRPELREYF KKQIEELYSI SM
	Isoform 2 (Short) [UniParc]. Checksum: E57CDD86836E7D64	FASTA	667	74,175
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK 250 260 270 280 290 300 CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 310 320 330 340 350 360 LKVTESQWAP TCADVHISYL PLAHMFERMV QSVVYCHGGR VGFFQGDIRL LSDDMKALCP 370 380 390 400 410 420 TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI 430 440 450 460 470 480 QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV 490 500 510 520 530 540 GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD 550 560 570 580 590 600 IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI 610 620 630 640 650 660 VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQDLPQCLIQ IKVFSKY
	Isoform 3 [UniParc]. Checksum: F70642502C212FA7	FASTA	697	77,671
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK 250 260 270 280 290 300 CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 310 320 330 340 350 360 LKVTESQWAP TCADVHISYL PLAHMFERMV QSVVYCHGGR VGFFQGDIRL LSDDMKALCP 370 380 390 400 410 420 TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI 430 440 450 460 470 480 QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV 490 500 510 520 530 540 GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD 550 560 570 580 590 600 IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI 610 620 630 640 650 660 VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS 670 680 690 DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM
	Isoform 5 (v4) [UniParc]. Checksum: 3D96A1B1433CF6F9	FASTA	690	76,883
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK 250 260 270 280 290 300 CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 310 320 330 340 350 360 LKVTEDDVLI SFLPLAHMFE RVIQSVVYCH GGRVGFFQGD IRLLSDDMKA LCPTIFPVVP 370 380 390 400 410 420 RLLNRMYDKI FSQANTPLKR WLLEFAAKRK QAEVRSGIIR NDSIWDELFF NKIQASLGGC 430 440 450 460 470 480 VRMIVTGAAP ASPTVLGFLR AALGCQVYEG YGQTECTAGC TFTTPGDWTS GHVGAPLPCN 490 500 510 520 530 540 HIKLVDVEEL NYWACKGEGE ICVRGPNVFK GYLKDPDRTK EALDSDGWLH TGDIGKWLPA 550 560 570 580 590 600 GTLKIIDRKK HIFKLAQGEY VAPEKIENIY IRSQPVAQIY VHGDSLKAFL VGIVVPDPEV 610 620 630 640 650 660 MPSWAQKRGI EGTYADLCTN KDLKKAILED MVRLGKESGL HSFEQVKAIH IHSDMFSVQN 670 680 690 GLLTPTLKAK RPELREYFKK QIEELYSISM
	Isoform 6 (v5) [UniParc]. Checksum: 1BC1636243762146	FASTA	712	79,144
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTGLSCQEGA SATASTQADI STVIVDKPQK AVLLLEHVER KETPGLKLII 250 260 270 280 290 300 LMDPFEEALK ERGQKCGVVI KSMQAVEDCG QENHQAPVPP QPDDLSIVCF TSGTTGNPKG 310 320 330 340 350 360 AMLTHGNVVA DFSGFLKVTE KVIFPRQDDV LISFLPLAHM FERVIQSVVY CHGGRVGFFQ 370 380 390 400 410 420 GDIRLLSDDM KALCPTIFPV VPRLLNRMYD KIFSQANTPL KRWLLEFAAK RKQAEVRSGI 430 440 450 460 470 480 IRNDSIWDEL FFNKIQASLG GCVRMIVTGA APASPTVLGF LRAALGCQVY EGYGQTECTA 490 500 510 520 530 540 GCTFTTPGDW TSGHVGAPLP CNHIKLVDVE ELNYWACKGE GEICVRGPNV FKGYLKDPDR 550 560 570 580 590 600 TKEALDSDGW LHTGDIGKWL PAGTLKIIDR KKHIFKLAQG EYVAPEKIEN IYIRSQPVAQ 610 620 630 640 650 660 IYVHGDSLKA FLVGIVVPDP EVMPSWAQKR GIEGTYADLC TNKDLKKAIL EDMVRLGKES 670 680 690 700 710 GLHSFEQVKA IHIHSDMFSV QNGLLTPTLK AKRPELREYF KKQIEELYSI SM
	Isoform 7 (v3) [UniParc]. Checksum: E5BE0D13E92599ED	FASTA	622	69,222
	10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL DSGGARRSVI GSGPQLLTHY YDDARTMYQV 70 80 90 100 110 120 FRRGLSISGN GPCLGFRKPK QPYQWLSYQE VADRAEFLGS GLLQHNCKAC TDQFIGVFAQ 130 140 150 160 170 180 NRPEWIIVEL ACYTYSMVVV PLYDTLGPGA IRYIINTADI STVIVDKPQK AVLLLEHVER 190 200 210 220 230 240 KETPGLKLII LMDPFEEALK ERGQKCGVVI KSMQAVEDCG QENHQAPVPP QPDDLSIVCF 250 260 270 280 290 300 TSGTTGNPKG AMLTHGNVVA DFSGFLKVTE GDIRLLSDDM KALCPTIFPV VPRLLNRMYD 310 320 330 340 350 360 KIFSQANTPL KRWLLEFAAK RKQAEVRSGI IRNDSIWDEL FFNKIQASLG GCVRMIVTGA 370 380 390 400 410 420 APASPTVLGF LRAALGCQVY EGYGQTECTA GCTFTTPGDW TSGHVGAPLP CNHIKLVDVE 430 440 450 460 470 480 ELNYWACKGE GEICVRGPNV FKGYLKDPDR TKEALDSDGW LHTGDIGKWL PAGTLKIIDR 490 500 510 520 530 540 KKHIFKLAQG EYVAPEKIEN IYIRSQPVAQ IYVHGDSLKA FLVGIVVPDP EVMPSWAQKR 550 560 570 580 590 600 GIEGTYADLC TNKDLKKAIL EDMVRLGKES GLHSFEQVKA IHIHSDMFSV QNGLLTPTLK 610 620 AKRPELREYF KKQIEELYSI SM
	Isoform 8 (v1) [UniParc]. Checksum: 702D63A8B72BE729	FASTA	722	80,529
	10 20 30 40 50 60 MLTFFLVSGG SLWLFVEFVL SLLEKMQTQE ILRILRLPEL GDLGQFFRSL SATTLVSMGA 70 80 90 100 110 120 LAAILAYWFT HRPKALQPPC NLLMQSEEVE DSGGARRSVI GSGPQLLTHY YDDARTMYQV 130 140 150 160 170 180 FRRGLSISGN GPCLGFRKPK QPYQWLSYQE VADRAEFLGS GLLQHNCKAC TDQFIGVFAQ 190 200 210 220 230 240 NRPEWIIVEL ACYTYSMVVV PLYDTLGPGA IRYIINTADI STVIVDKPQK AVLLLEHVER 250 260 270 280 290 300 KETPGLKLII LMDPFEEALK ERGQKCGVVI KSMQAVEDCG QENHQAPVPP QPDDLSIVCF 310 320 330 340 350 360 TSGTTGNPKG AMLTHGNVVA DFSGFLKVTE SQWAPTCADV HISYLPLAHM FERMVQSVVY 370 380 390 400 410 420 CHGGRVGFFQ GDIRLLSDDM KALCPTIFPV VPRLLNRMYD KIFSQANTPL KRWLLEFAAK 430 440 450 460 470 480 RKQAEVRSGI IRNDSIWDEL FFNKIQASLG GCVRMIVTGA APASPTVLGF LRAALGCQVY 490 500 510 520 530 540 EGYGQTECTA GCTFTTPGDW TSGHVGAPLP CNHIKLVDVE ELNYWACKGE GEICVRGPNV 550 560 570 580 590 600 FKGYLKDPDR TKEALDSDGW LHTGDIGKWL PAGTLKIIDR KKHIFKLAQG EYVAPEKIEN 610 620 630 640 650 660 IYIRSQPVAQ IYVHGDSLKA FLVGIVVPDP EVMPSWAQKR GIEGTYADLC TNKDLKKAIL 670 680 690 700 710 720 EDMVRLGKES GLHSFEQVKA IHIHSDMFSV QNGLLTPTLK AKRPELREYF KKQIEELYSI SM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and molecular characterization of acyl-CoA synthetase in human red cells and erythroid precursor." Malhotra K.T., Malhotra K., Lubin B.H., Kuypers F.A. Biochem. J. 344:135-143(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[2]	"Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)." Yagasaki F., Jinnai I., Yoshida S., Yokoyama Y., Matsuda A., Kusumoto S., Kobayashi H., Terasaki H., Ohyashiki K., Asou N., Murohashi I., Bessho M., Hirashima K. Genes Chromosomes Cancer 26:192-202(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION WITH ETV6. Tissue: Bone marrow.
[3]	"Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains." Soupene E., Kuypers F.A. BMC Mol. Biol. 7:21-21(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [MRNA] OF 253-374 (ISOFORM 5), ALTERNATIVE SPLICING (ISOFORM 8).
[4]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 8).
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF129166 mRNA. Translation: AAD47199.1. AF099740 mRNA. Translation: AAD17853.1. DQ083030 mRNA. Translation: AAZ30713.1. DQ083031 mRNA. Translation: AAZ30714.1. AB020644 mRNA. Translation: BAA74860.1. Different initiation. CR606980 mRNA. No translation available. AC034228 Genomic DNA. No translation available. BC047453 mRNA. Translation: AAH47453.1.
IPI	IPI00296333. IPI00384110. IPI00657816. IPI00657883. IPI00658107. IPI00874262. IPI00879209. IPI00939479.
RefSeq	NP_001009185.1. NM_001009185.2. NP_001192176.1. NM_001205247.1. NP_001192177.1. NM_001205248.1. NP_001192179.1. NM_001205250.1. NP_001192180.1. NM_001205251.1. NP_056071.2. NM_015256.3.
UniGene	Hs.14945.
3D structure databases
ProteinModelPortal	Q9UKU0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKU0. 1 interaction.
STRING	9606.ENSP00000296869.
PTM databases
PhosphoSite	Q9UKU0.
Polymorphism databases
DMDM	146322303.
Proteomic databases
PaxDb	Q9UKU0.
PRIDE	Q9UKU0.
Protocols and materials databases
DNASU	23305.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296869; ENSP00000296869; ENSG00000164398. ENST00000357096; ENSP00000349608; ENSG00000164398. ENST00000379240; ENSP00000368542; ENSG00000164398. ENST00000379244; ENSP00000368546; ENSG00000164398. ENST00000379249; ENSP00000368551; ENSG00000164398. ENST00000379255; ENSP00000368557; ENSG00000164398. ENST00000379264; ENSP00000368566; ENSG00000164398. ENST00000379272; ENSP00000368574; ENSG00000164398. ENST00000413683; ENSP00000415140; ENSG00000164398. ENST00000543479; ENSP00000442124; ENSG00000164398.
GeneID	23305.
KEGG	hsa:23305.
UCSC	uc003kvx.2. human. uc003kvy.2. human. uc003kvz.2. human. uc010jdn.2. human. uc010jdo.2. human.
Organism-specific databases
CTD	23305.
GeneCards	GC05M131146.
HGNC	HGNC:16496. ACSL6.
HPA	HPA040470.
MIM	604443. gene.
neXtProt	NX_Q9UKU0.
PharmGKB	PA27970.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1022.
HOGENOM	HOG000159459.
HOVERGEN	HBG050452.
KO	K01897.
OMA	MFERMVQ.
Enzyme and pathway databases
BioCyc	MetaCyc:HS15193-MONOMER.
BRENDA	6.2.1.3. 2681.
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9UKU0.
Bgee	Q9UKU0.
CleanEx	HS_ACSL6.
Genevestigator	Q9UKU0.
GermOnline	ENSG00000164398. Homo sapiens.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23305.
NextBio	45153.
SOURCE	Search...

Entry information

Entry name

ACSL6_HUMAN

Accession

Primary (citable) accession number: Q9UKU0
Secondary accession number(s): O94924 , O95829, Q108M9, Q108N0, Q86TN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 6, 2007
Last modified:	May 29, 2013
This is version 123 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.