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Q9UKT9

- IKZF3_HUMAN

UniProt

Q9UKT9 - IKZF3_HUMAN

Protein

Zinc finger protein Aiolos

Gene

IKZF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB
    5. sequence-specific DNA binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW
    2. mesoderm development Source: ProtInc
    3. regulation of apoptotic process Source: UniProtKB
    4. regulation of B cell differentiation Source: UniProtKB
    5. regulation of B cell proliferation Source: UniProtKB
    6. regulation of lymphocyte differentiation Source: UniProtKB
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    B-cell activation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein Aiolos
    Alternative name(s):
    Ikaros family zinc finger protein 3
    Gene namesi
    Name:IKZF3
    Synonyms:ZNFN1A3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:13178. IKZF3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Zinc finger protein AiolosPRO_0000047090Add
    BLAST

    Post-translational modificationi

    Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UKT9.
    PaxDbiQ9UKT9.
    PRIDEiQ9UKT9.

    PTM databases

    PhosphoSiteiQ9UKT9.

    Expressioni

    Tissue specificityi

    Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.1 Publication

    Inductioni

    Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9UKT9.
    BgeeiQ9UKT9.
    CleanExiHS_IKZF3.
    GenevestigatoriQ9UKT9.

    Organism-specific databases

    HPAiCAB017105.
    HPA024377.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FOXP3Q9BZS12EBI-747204,EBI-983719

    Protein-protein interaction databases

    BioGridi116484. 18 interactions.
    IntActiQ9UKT9. 15 interactions.
    MINTiMINT-1454530.
    STRINGi9606.ENSP00000418684.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKT9.
    SMRiQ9UKT9. Positions 101-255, 442-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG274203.
    HOVERGENiHBG060914.
    InParanoidiQ9UKT9.
    KOiK09220.
    OMAiYPIALTR.
    OrthoDBiEOG79GT61.
    PhylomeDBiQ9UKT9.
    TreeFamiTF331189.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequences (16)i

    Sequence statusi: Complete.

    This entry describes 16 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKT9-1) [UniParc]FASTAAdd to Basket

    Also known as: Aio-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED    50
    EDIGDDSMKV KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK 100
    LERHVVSFDS SRPTSGKMNC DVCGLSCISF NVLMVHKRSH TGERPFQCNQ 150
    CGASFTQKGN LLRHIKLHTG EKPFKCHLCN YACQRRDALT GHLRTHSVEK 200
    PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE ARHIKAEMGS 250
    ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ 300
    TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE 350
    MSNGAPQELE KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI 400
    YQQNHMVLSR ARNGMPLLKE VPRSYELLKP PPICPRDSVK VINKEGEVMD 450
    VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF ECNMCGYRSH DRYEFSSHIA 500
    RGEHRALLK 509
    Length:509
    Mass (Da):58,023
    Last modified:November 4, 2008 - v2
    Checksum:iD1BB4A0A9A71B81A
    GO
    Isoform 2 (identifier: Q9UKT9-2) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del4

    The sequence of this isoform differs from the canonical sequence as follows:
         142-197: Missing.

    Show »
    Length:453
    Mass (Da):51,632
    Checksum:i85DEFC62034A738F
    GO
    Isoform 3 (identifier: Q9UKT9-3) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del5

    The sequence of this isoform differs from the canonical sequence as follows:
         198-236: Missing.

    Show »
    Length:470
    Mass (Da):53,401
    Checksum:i18998C960E99C78A
    GO
    Isoform 4 (identifier: Q9UKT9-4) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del6

    The sequence of this isoform differs from the canonical sequence as follows:
         237-275: Missing.

    Show »
    Length:470
    Mass (Da):53,743
    Checksum:i979F785A6B93BC6E
    GO
    Isoform 5 (identifier: Q9UKT9-5) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del4,5

    The sequence of this isoform differs from the canonical sequence as follows:
         142-236: Missing.

    Show »
    Length:414
    Mass (Da):47,010
    Checksum:iDD4C8159B8417844
    GO
    Isoform 6 (identifier: Q9UKT9-6) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del5,6

    The sequence of this isoform differs from the canonical sequence as follows:
         198-275: Missing.

    Show »
    Length:431
    Mass (Da):49,121
    Checksum:i540F806622DCBB56
    GO
    Isoform 7 (identifier: Q9UKT9-7) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del2

    The sequence of this isoform differs from the canonical sequence as follows:
         21-54: Missing.

    Show »
    Length:475
    Mass (Da):54,417
    Checksum:i00694E8BA86FFEC5
    GO
    Isoform 8 (identifier: Q9UKT9-8) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del2,5

    The sequence of this isoform differs from the canonical sequence as follows:
         21-54: Missing.
         198-236: Missing.

    Show »
    Length:436
    Mass (Da):49,795
    Checksum:i965862E0B68846E0
    GO
    Isoform 9 (identifier: Q9UKT9-9) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del3

    The sequence of this isoform differs from the canonical sequence as follows:
         55-141: Missing.

    Show »
    Length:422
    Mass (Da):47,958
    Checksum:i42308DF0B90BA4DF
    GO
    Isoform 10 (identifier: Q9UKT9-10) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del3,4

    The sequence of this isoform differs from the canonical sequence as follows:
         55-197: Missing.

    Show »
    Length:366
    Mass (Da):41,567
    Checksum:iA4E825FDBF860925
    GO
    Isoform 11 (identifier: Q9UKT9-11) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del3,4,5

    The sequence of this isoform differs from the canonical sequence as follows:
         55-236: Missing.

    Show »
    Length:327
    Mass (Da):36,945
    Checksum:iD90D2FFBA757F7B9
    GO
    Isoform 12 (identifier: Q9UKT9-12) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del3,4,5,6

    The sequence of this isoform differs from the canonical sequence as follows:
         55-275: Missing.

    Show »
    Length:288
    Mass (Da):32,665
    Checksum:iECA1D13AA6312CAB
    GO
    Isoform 13 (identifier: Q9UKT9-13) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del4,5,6

    The sequence of this isoform differs from the canonical sequence as follows:
         142-275: Missing.

    Show »
    Length:375
    Mass (Da):42,730
    Checksum:i7AE6138A9450AAF5
    GO
    Isoform 14 (identifier: Q9UKT9-14) [UniParc]FASTAAdd to Basket

    Also known as: Aio-1-5a

    The sequence of this isoform differs from the canonical sequence as follows:
         237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
         264-509: Missing.

    Show »
    Length:263
    Mass (Da):30,029
    Checksum:iF12F178DB5F635A3
    GO
    Isoform 15 (identifier: Q9UKT9-15) [UniParc]FASTAAdd to Basket

    Also known as: Aio-del4-5a

    The sequence of this isoform differs from the canonical sequence as follows:
         142-197: Missing.
         237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

    Show »
    Length:453
    Mass (Da):51,880
    Checksum:i8C2E108E02143972
    GO
    Isoform 16 (identifier: Q9UKT9-16) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-247: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:262
    Mass (Da):29,973
    Checksum:i74F8C25D67B30D67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti321 – 3211R → C in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti321 – 3211R → C in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti321 – 3211R → C in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti321 – 3211R → C in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti321 – 3211R → C in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti321 – 3211R → C in CAC80431. (PubMed:11745366)Curated
    Sequence conflicti361 – 3611K → R in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti361 – 3611K → R in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti361 – 3611K → R in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti361 – 3611K → R in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti361 – 3611K → R in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti361 – 3611K → R in CAC80431. (PubMed:11745366)Curated
    Sequence conflicti365 – 3651H → L in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti365 – 3651H → L in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti365 – 3651H → L in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti365 – 3651H → L in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti365 – 3651H → L in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti365 – 3651H → L in CAC80431. (PubMed:11745366)Curated
    Sequence conflicti443 – 4431N → D in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti443 – 4431N → D in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti443 – 4431N → D in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti443 – 4431N → D in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti443 – 4431N → D in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti443 – 4431N → D in CAC80431. (PubMed:11745366)Curated
    Sequence conflicti487 – 4871Y → D in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti487 – 4871Y → D in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti487 – 4871Y → D in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti487 – 4871Y → D in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti487 – 4871Y → D in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti487 – 4871Y → D in CAC80431. (PubMed:11745366)Curated
    Sequence conflicti506 – 5061A → S in AAF13493. (PubMed:10552935)Curated
    Sequence conflicti506 – 5061A → S in CAC80427. (PubMed:11745366)Curated
    Sequence conflicti506 – 5061A → S in CAC80428. (PubMed:11745366)Curated
    Sequence conflicti506 – 5061A → S in CAC80429. (PubMed:11745366)Curated
    Sequence conflicti506 – 5061A → S in CAC80430. (PubMed:11745366)Curated
    Sequence conflicti506 – 5061A → S in CAC80431. (PubMed:11745366)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti277 – 2771E → Q Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
    VAR_064724

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 247247Missing in isoform 16. 1 PublicationVSP_055353Add
    BLAST
    Alternative sequencei21 – 5434Missing in isoform 7 and isoform 8. 1 PublicationVSP_041274Add
    BLAST
    Alternative sequencei55 – 275221Missing in isoform 12. 1 PublicationVSP_041275Add
    BLAST
    Alternative sequencei55 – 236182Missing in isoform 11. 1 PublicationVSP_041276Add
    BLAST
    Alternative sequencei55 – 197143Missing in isoform 10. 1 PublicationVSP_041277Add
    BLAST
    Alternative sequencei55 – 14187Missing in isoform 9. 1 PublicationVSP_041278Add
    BLAST
    Alternative sequencei142 – 275134Missing in isoform 13. 1 PublicationVSP_041279Add
    BLAST
    Alternative sequencei142 – 23695Missing in isoform 5. 1 PublicationVSP_006841Add
    BLAST
    Alternative sequencei142 – 19756Missing in isoform 2 and isoform 15. 2 PublicationsVSP_006840Add
    BLAST
    Alternative sequencei198 – 27578Missing in isoform 6. 1 PublicationVSP_006843Add
    BLAST
    Alternative sequencei198 – 23639Missing in isoform 3 and isoform 8. 2 PublicationsVSP_006842Add
    BLAST
    Alternative sequencei237 – 27539Missing in isoform 4. 1 PublicationVSP_006844Add
    BLAST
    Alternative sequencei237 – 26327ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15. 1 PublicationVSP_041280Add
    BLAST
    Alternative sequencei264 – 509246Missing in isoform 14. 1 PublicationVSP_041281Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129512 mRNA. Translation: AAF13493.1.
    AJ292565 mRNA. Translation: CAC80427.1.
    AJ292566 mRNA. Translation: CAC80428.1.
    AJ292567 mRNA. Translation: CAC80429.1.
    AJ292568 mRNA. Translation: CAC80430.1.
    AJ292569 mRNA. Translation: CAC80431.1.
    AY377973 mRNA. Translation: AAR84584.1.
    AY377975 mRNA. Translation: AAR84586.1.
    AY377976 mRNA. Translation: AAR84587.1.
    AY377977 mRNA. Translation: AAR84588.1.
    AY377978 mRNA. Translation: AAR84589.1.
    AY377979 mRNA. Translation: AAR84590.1.
    AY377980 mRNA. Translation: AAR84591.1.
    AY377981 mRNA. Translation: AAR84592.1.
    AY377982 mRNA. Translation: AAR84593.1.
    AK301250 mRNA. Translation: BAG62817.1.
    AK303495 mRNA. Translation: BAG64529.1.
    AC079199 Genomic DNA. No translation available.
    AC090844 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60606.1.
    BC032707 mRNA. Translation: AAH32707.1.
    CCDSiCCDS11346.1. [Q9UKT9-1]
    CCDS11347.1. [Q9UKT9-2]
    CCDS11348.1. [Q9UKT9-3]
    CCDS11349.1. [Q9UKT9-4]
    CCDS11350.1. [Q9UKT9-5]
    CCDS11351.1. [Q9UKT9-6]
    CCDS58539.1. [Q9UKT9-8]
    CCDS58540.1. [Q9UKT9-7]
    CCDS58541.1. [Q9UKT9-12]
    CCDS58542.1. [Q9UKT9-11]
    CCDS58543.1. [Q9UKT9-10]
    CCDS58544.1. [Q9UKT9-9]
    CCDS58545.1. [Q9UKT9-13]
    RefSeqiNP_001244337.1. NM_001257408.1. [Q9UKT9-7]
    NP_001244338.1. NM_001257409.1. [Q9UKT9-8]
    NP_001244339.1. NM_001257410.1. [Q9UKT9-9]
    NP_001244340.1. NM_001257411.1. [Q9UKT9-10]
    NP_001244341.1. NM_001257412.1. [Q9UKT9-11]
    NP_001244342.1. NM_001257413.1. [Q9UKT9-12]
    NP_001244343.1. NM_001257414.1. [Q9UKT9-13]
    NP_001271443.1. NM_001284514.1.
    NP_001271444.1. NM_001284515.1.
    NP_001271445.1. NM_001284516.1.
    NP_036613.2. NM_012481.4. [Q9UKT9-1]
    NP_899051.1. NM_183228.2. [Q9UKT9-2]
    NP_899052.1. NM_183229.2. [Q9UKT9-3]
    NP_899053.1. NM_183230.2. [Q9UKT9-4]
    NP_899054.1. NM_183231.2. [Q9UKT9-5]
    NP_899055.1. NM_183232.2. [Q9UKT9-6]
    UniGeneiHs.371680.

    Genome annotation databases

    EnsembliENST00000293068; ENSP00000462791; ENSG00000161405. [Q9UKT9-14]
    ENST00000346243; ENSP00000341977; ENSG00000161405. [Q9UKT9-6]
    ENST00000346872; ENSP00000344544; ENSG00000161405. [Q9UKT9-1]
    ENST00000348427; ENSP00000463505; ENSG00000161405.
    ENST00000350532; ENSP00000344471; ENSG00000161405. [Q9UKT9-4]
    ENST00000351680; ENSP00000345622; ENSG00000161405. [Q9UKT9-3]
    ENST00000377944; ENSP00000367179; ENSG00000161405. [Q9UKT9-10]
    ENST00000377945; ENSP00000367180; ENSG00000161405. [Q9UKT9-13]
    ENST00000377952; ENSP00000367188; ENSG00000161405. [Q9UKT9-12]
    ENST00000377958; ENSP00000367194; ENSG00000161405. [Q9UKT9-9]
    ENST00000394189; ENSP00000377741; ENSG00000161405. [Q9UKT9-11]
    ENST00000439016; ENSP00000403027; ENSG00000161405. [Q9UKT9-5]
    ENST00000439167; ENSP00000403776; ENSG00000161405. [Q9UKT9-8]
    ENST00000467757; ENSP00000420463; ENSG00000161405. [Q9UKT9-2]
    ENST00000535189; ENSP00000438972; ENSG00000161405. [Q9UKT9-7]
    ENST00000583368; ENSP00000462452; ENSG00000161405. [Q9UKT9-16]
    GeneIDi22806.
    KEGGihsa:22806.
    UCSCiuc002hsu.4. human. [Q9UKT9-1]
    uc002hsv.4. human. [Q9UKT9-8]
    uc002hsw.4. human. [Q9UKT9-3]
    uc002hsx.4. human. [Q9UKT9-2]
    uc002hsy.4. human. [Q9UKT9-4]
    uc002hsz.4. human. [Q9UKT9-5]
    uc002hta.4. human. [Q9UKT9-6]
    uc002htd.4. human. [Q9UKT9-7]
    uc010cwd.4. human. [Q9UKT9-10]
    uc010cwe.4. human. [Q9UKT9-13]
    uc010cwf.4. human. [Q9UKT9-11]
    uc010cwg.4. human. [Q9UKT9-12]
    uc010cwh.4. human. [Q9UKT9-9]

    Polymorphism databases

    DMDMi212276437.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129512 mRNA. Translation: AAF13493.1 .
    AJ292565 mRNA. Translation: CAC80427.1 .
    AJ292566 mRNA. Translation: CAC80428.1 .
    AJ292567 mRNA. Translation: CAC80429.1 .
    AJ292568 mRNA. Translation: CAC80430.1 .
    AJ292569 mRNA. Translation: CAC80431.1 .
    AY377973 mRNA. Translation: AAR84584.1 .
    AY377975 mRNA. Translation: AAR84586.1 .
    AY377976 mRNA. Translation: AAR84587.1 .
    AY377977 mRNA. Translation: AAR84588.1 .
    AY377978 mRNA. Translation: AAR84589.1 .
    AY377979 mRNA. Translation: AAR84590.1 .
    AY377980 mRNA. Translation: AAR84591.1 .
    AY377981 mRNA. Translation: AAR84592.1 .
    AY377982 mRNA. Translation: AAR84593.1 .
    AK301250 mRNA. Translation: BAG62817.1 .
    AK303495 mRNA. Translation: BAG64529.1 .
    AC079199 Genomic DNA. No translation available.
    AC090844 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60606.1 .
    BC032707 mRNA. Translation: AAH32707.1 .
    CCDSi CCDS11346.1. [Q9UKT9-1 ]
    CCDS11347.1. [Q9UKT9-2 ]
    CCDS11348.1. [Q9UKT9-3 ]
    CCDS11349.1. [Q9UKT9-4 ]
    CCDS11350.1. [Q9UKT9-5 ]
    CCDS11351.1. [Q9UKT9-6 ]
    CCDS58539.1. [Q9UKT9-8 ]
    CCDS58540.1. [Q9UKT9-7 ]
    CCDS58541.1. [Q9UKT9-12 ]
    CCDS58542.1. [Q9UKT9-11 ]
    CCDS58543.1. [Q9UKT9-10 ]
    CCDS58544.1. [Q9UKT9-9 ]
    CCDS58545.1. [Q9UKT9-13 ]
    RefSeqi NP_001244337.1. NM_001257408.1. [Q9UKT9-7 ]
    NP_001244338.1. NM_001257409.1. [Q9UKT9-8 ]
    NP_001244339.1. NM_001257410.1. [Q9UKT9-9 ]
    NP_001244340.1. NM_001257411.1. [Q9UKT9-10 ]
    NP_001244341.1. NM_001257412.1. [Q9UKT9-11 ]
    NP_001244342.1. NM_001257413.1. [Q9UKT9-12 ]
    NP_001244343.1. NM_001257414.1. [Q9UKT9-13 ]
    NP_001271443.1. NM_001284514.1.
    NP_001271444.1. NM_001284515.1.
    NP_001271445.1. NM_001284516.1.
    NP_036613.2. NM_012481.4. [Q9UKT9-1 ]
    NP_899051.1. NM_183228.2. [Q9UKT9-2 ]
    NP_899052.1. NM_183229.2. [Q9UKT9-3 ]
    NP_899053.1. NM_183230.2. [Q9UKT9-4 ]
    NP_899054.1. NM_183231.2. [Q9UKT9-5 ]
    NP_899055.1. NM_183232.2. [Q9UKT9-6 ]
    UniGenei Hs.371680.

    3D structure databases

    ProteinModelPortali Q9UKT9.
    SMRi Q9UKT9. Positions 101-255, 442-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116484. 18 interactions.
    IntActi Q9UKT9. 15 interactions.
    MINTi MINT-1454530.
    STRINGi 9606.ENSP00000418684.

    PTM databases

    PhosphoSitei Q9UKT9.

    Polymorphism databases

    DMDMi 212276437.

    Proteomic databases

    MaxQBi Q9UKT9.
    PaxDbi Q9UKT9.
    PRIDEi Q9UKT9.

    Protocols and materials databases

    DNASUi 22806.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293068 ; ENSP00000462791 ; ENSG00000161405 . [Q9UKT9-14 ]
    ENST00000346243 ; ENSP00000341977 ; ENSG00000161405 . [Q9UKT9-6 ]
    ENST00000346872 ; ENSP00000344544 ; ENSG00000161405 . [Q9UKT9-1 ]
    ENST00000348427 ; ENSP00000463505 ; ENSG00000161405 .
    ENST00000350532 ; ENSP00000344471 ; ENSG00000161405 . [Q9UKT9-4 ]
    ENST00000351680 ; ENSP00000345622 ; ENSG00000161405 . [Q9UKT9-3 ]
    ENST00000377944 ; ENSP00000367179 ; ENSG00000161405 . [Q9UKT9-10 ]
    ENST00000377945 ; ENSP00000367180 ; ENSG00000161405 . [Q9UKT9-13 ]
    ENST00000377952 ; ENSP00000367188 ; ENSG00000161405 . [Q9UKT9-12 ]
    ENST00000377958 ; ENSP00000367194 ; ENSG00000161405 . [Q9UKT9-9 ]
    ENST00000394189 ; ENSP00000377741 ; ENSG00000161405 . [Q9UKT9-11 ]
    ENST00000439016 ; ENSP00000403027 ; ENSG00000161405 . [Q9UKT9-5 ]
    ENST00000439167 ; ENSP00000403776 ; ENSG00000161405 . [Q9UKT9-8 ]
    ENST00000467757 ; ENSP00000420463 ; ENSG00000161405 . [Q9UKT9-2 ]
    ENST00000535189 ; ENSP00000438972 ; ENSG00000161405 . [Q9UKT9-7 ]
    ENST00000583368 ; ENSP00000462452 ; ENSG00000161405 . [Q9UKT9-16 ]
    GeneIDi 22806.
    KEGGi hsa:22806.
    UCSCi uc002hsu.4. human. [Q9UKT9-1 ]
    uc002hsv.4. human. [Q9UKT9-8 ]
    uc002hsw.4. human. [Q9UKT9-3 ]
    uc002hsx.4. human. [Q9UKT9-2 ]
    uc002hsy.4. human. [Q9UKT9-4 ]
    uc002hsz.4. human. [Q9UKT9-5 ]
    uc002hta.4. human. [Q9UKT9-6 ]
    uc002htd.4. human. [Q9UKT9-7 ]
    uc010cwd.4. human. [Q9UKT9-10 ]
    uc010cwe.4. human. [Q9UKT9-13 ]
    uc010cwf.4. human. [Q9UKT9-11 ]
    uc010cwg.4. human. [Q9UKT9-12 ]
    uc010cwh.4. human. [Q9UKT9-9 ]

    Organism-specific databases

    CTDi 22806.
    GeneCardsi GC17M037921.
    HGNCi HGNC:13178. IKZF3.
    HPAi CAB017105.
    HPA024377.
    MIMi 606221. gene.
    neXtProti NX_Q9UKT9.
    PharmGKBi PA37750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274203.
    HOVERGENi HBG060914.
    InParanoidi Q9UKT9.
    KOi K09220.
    OMAi YPIALTR.
    OrthoDBi EOG79GT61.
    PhylomeDBi Q9UKT9.
    TreeFami TF331189.

    Miscellaneous databases

    ChiTaRSi IKZF3. human.
    GeneWikii IKZF3.
    GenomeRNAii 22806.
    NextBioi 35475564.
    PROi Q9UKT9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKT9.
    Bgeei Q9UKT9.
    CleanExi HS_IKZF3.
    Genevestigatori Q9UKT9.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping."
      Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M.
      Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymphoma.
    2. "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene."
      Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E., Riikonen P., Hammarstrom L., Pelkonen J., Lassila O.
      Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
      Tissue: Lymphoid tissue.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 16).
      Tissue: Spleen and Thymus.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    8. "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."
      Romero F., Martinez-A C., Camonis J., Rebollo A.
      EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    9. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
      Perdomo J., Holmes M., Chong B., Crossley M.
      J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IKZF4 AND IKZF5.
    10. "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis."
      Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A.
      J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCL21L, PHOSPHORYLATION.
    11. "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."
      Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L., Quintana F.J.
      Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FOXP3, INDUCTION.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT GLN-277.

    Entry informationi

    Entry nameiIKZF3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKT9
    Secondary accession number(s): B4DVV5
    , Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3