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Protein

Zinc finger protein Aiolos

Gene

IKZF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • mesoderm development Source: ProtInc
  • regulation of apoptotic process Source: UniProtKB
  • regulation of B cell differentiation Source: UniProtKB
  • regulation of B cell proliferation Source: UniProtKB
  • regulation of lymphocyte differentiation Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

B-cell activation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
Gene namesi
Name:IKZF3
Synonyms:ZNFN1A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:13178. IKZF3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37750.

Polymorphism and mutation databases

BioMutaiIKZF3.
DMDMi212276437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Zinc finger protein AiolosPRO_0000047090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei326 – 3261Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UKT9.
PaxDbiQ9UKT9.
PRIDEiQ9UKT9.

PTM databases

PhosphoSiteiQ9UKT9.

Expressioni

Tissue specificityi

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.1 Publication

Inductioni

Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.1 Publication

Gene expression databases

BgeeiQ9UKT9.
CleanExiHS_IKZF3.
GenevisibleiQ9UKT9. HS.

Organism-specific databases

HPAiCAB017105.
HPA024377.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABLIM3O949293EBI-747204,EBI-351267
AESQ081173EBI-747204,EBI-717810
AKAP9Q99996-23EBI-747204,EBI-9641546
AQP1P299723EBI-747204,EBI-745213
ARMC7Q9H6L43EBI-747204,EBI-742909
ATPAF2Q8N5M14EBI-747204,EBI-1166928
BCAS2O759343EBI-747204,EBI-1050106
C1orf109Q9NX043EBI-747204,EBI-8643161
CDKN1AP389363EBI-747204,EBI-375077
CDKN2DP552734EBI-747204,EBI-745859
CHCHD2Q9Y6H13EBI-747204,EBI-2321769
EFHC1Q5JVL45EBI-747204,EBI-743105
EMC2Q150063EBI-747204,EBI-359031
EXOC8Q8IYI63EBI-747204,EBI-742102
EXOSC5Q9NQT43EBI-747204,EBI-371876
FANCLQ9NW383EBI-747204,EBI-2339898
FARS2O953633EBI-747204,EBI-2513774
FBF1Q8TES7-63EBI-747204,EBI-10244131
FOXP3Q9BZS12EBI-747204,EBI-983719
GEMP550403EBI-747204,EBI-744104
GRB2P629933EBI-747204,EBI-401755
HNRNPFP525973EBI-747204,EBI-352986
ING5Q8WYH83EBI-747204,EBI-488533
KAT5Q929933EBI-747204,EBI-399080
KRT19P087273EBI-747204,EBI-742756
LGALS14Q8TCE93EBI-747204,EBI-10274069
LMO1P258003EBI-747204,EBI-8639312
LMO2P257913EBI-747204,EBI-739696
MAGOHBQ96A724EBI-747204,EBI-746778
MORN3Q6PF183EBI-747204,EBI-9675802
MRPL28Q130843EBI-747204,EBI-723426
MRPL53Q96EL33EBI-747204,EBI-2513715
NATD1Q8N6N63EBI-747204,EBI-8656665
NEK6Q9HC983EBI-747204,EBI-740364
OAZ3Q9UMX23EBI-747204,EBI-10281601
OSGIN1Q9UJX03EBI-747204,EBI-9057006
PCID2Q5JVF33EBI-747204,EBI-1051701
PFDN5Q994713EBI-747204,EBI-357275
PIK3R2O004593EBI-747204,EBI-346930
PIN1Q135263EBI-747204,EBI-714158
POLMQ6PIY23EBI-747204,EBI-10253863
POLR1CO151603EBI-747204,EBI-1055079
PPP1R16BQ96T493EBI-747204,EBI-10293968
PRKAA1Q131313EBI-747204,EBI-1181405
PRKAB2O437414EBI-747204,EBI-1053424
PSMA1P257863EBI-747204,EBI-359352
RAD51DO757713EBI-747204,EBI-1055693
RCOR3Q9P2K34EBI-747204,EBI-743428
RHOAP615863EBI-747204,EBI-446668
SPG21Q9NZD83EBI-747204,EBI-742688
STAMBPL1Q96FJ03EBI-747204,EBI-745021
STK16O757163EBI-747204,EBI-749295
STX11O755583EBI-747204,EBI-714135
TBC1D22BQ9NU193EBI-747204,EBI-8787464
TCAF1Q9Y4C24EBI-747204,EBI-750484
TEKT4Q8WW244EBI-747204,EBI-750487
TRAPPC6AO758653EBI-747204,EBI-743573
TRIM42A1L4B63EBI-747204,EBI-10172216
TSSK3Q96PN83EBI-747204,EBI-3918381
TSTD2Q5T7W73EBI-747204,EBI-8994397
ZGPATQ8N5A53EBI-747204,EBI-3439227

Protein-protein interaction databases

BioGridi116484. 86 interactions.
IntActiQ9UKT9. 70 interactions.
MINTiMINT-1454530.
STRINGi9606.ENSP00000344544.

Structurei

3D structure databases

ProteinModelPortaliQ9UKT9.
SMRiQ9UKT9. Positions 101-255, 442-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG274203.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG060914.
InParanoidiQ9UKT9.
KOiK09220.
OMAiYPIALTR.
OrthoDBiEOG79GT61.
PhylomeDBiQ9UKT9.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

This entry describes 16 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKT9-1) [UniParc]FASTAAdd to basket

Also known as: Aio-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED
60 70 80 90 100
EDIGDDSMKV KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK
110 120 130 140 150
LERHVVSFDS SRPTSGKMNC DVCGLSCISF NVLMVHKRSH TGERPFQCNQ
160 170 180 190 200
CGASFTQKGN LLRHIKLHTG EKPFKCHLCN YACQRRDALT GHLRTHSVEK
210 220 230 240 250
PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE ARHIKAEMGS
260 270 280 290 300
ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ
310 320 330 340 350
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE
360 370 380 390 400
MSNGAPQELE KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI
410 420 430 440 450
YQQNHMVLSR ARNGMPLLKE VPRSYELLKP PPICPRDSVK VINKEGEVMD
460 470 480 490 500
VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF ECNMCGYRSH DRYEFSSHIA

RGEHRALLK
Length:509
Mass (Da):58,023
Last modified:November 4, 2008 - v2
Checksum:iD1BB4A0A9A71B81A
GO
Isoform 2 (identifier: Q9UKT9-2) [UniParc]FASTAAdd to basket

Also known as: Aio-del4

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.

Show »
Length:453
Mass (Da):51,632
Checksum:i85DEFC62034A738F
GO
Isoform 3 (identifier: Q9UKT9-3) [UniParc]FASTAAdd to basket

Also known as: Aio-del5

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Show »
Length:470
Mass (Da):53,401
Checksum:i18998C960E99C78A
GO
Isoform 4 (identifier: Q9UKT9-4) [UniParc]FASTAAdd to basket

Also known as: Aio-del6

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.

Show »
Length:470
Mass (Da):53,743
Checksum:i979F785A6B93BC6E
GO
Isoform 5 (identifier: Q9UKT9-5) [UniParc]FASTAAdd to basket

Also known as: Aio-del4,5

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.

Show »
Length:414
Mass (Da):47,010
Checksum:iDD4C8159B8417844
GO
Isoform 6 (identifier: Q9UKT9-6) [UniParc]FASTAAdd to basket

Also known as: Aio-del5,6

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:431
Mass (Da):49,121
Checksum:i540F806622DCBB56
GO
Isoform 7 (identifier: Q9UKT9-7) [UniParc]FASTAAdd to basket

Also known as: Aio-del2

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.

Show »
Length:475
Mass (Da):54,417
Checksum:i00694E8BA86FFEC5
GO
Isoform 8 (identifier: Q9UKT9-8) [UniParc]FASTAAdd to basket

Also known as: Aio-del2,5

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.

Show »
Length:436
Mass (Da):49,795
Checksum:i965862E0B68846E0
GO
Isoform 9 (identifier: Q9UKT9-9) [UniParc]FASTAAdd to basket

Also known as: Aio-del3

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Show »
Length:422
Mass (Da):47,958
Checksum:i42308DF0B90BA4DF
GO
Isoform 10 (identifier: Q9UKT9-10) [UniParc]FASTAAdd to basket

Also known as: Aio-del3,4

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.

Show »
Length:366
Mass (Da):41,567
Checksum:iA4E825FDBF860925
GO
Isoform 11 (identifier: Q9UKT9-11) [UniParc]FASTAAdd to basket

Also known as: Aio-del3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.

Show »
Length:327
Mass (Da):36,945
Checksum:iD90D2FFBA757F7B9
GO
Isoform 12 (identifier: Q9UKT9-12) [UniParc]FASTAAdd to basket

Also known as: Aio-del3,4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.

Show »
Length:288
Mass (Da):32,665
Checksum:iECA1D13AA6312CAB
GO
Isoform 13 (identifier: Q9UKT9-13) [UniParc]FASTAAdd to basket

Also known as: Aio-del4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.

Show »
Length:375
Mass (Da):42,730
Checksum:i7AE6138A9450AAF5
GO
Isoform 14 (identifier: Q9UKT9-14) [UniParc]FASTAAdd to basket

Also known as: Aio-1-5a

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.

Show »
Length:263
Mass (Da):30,029
Checksum:iF12F178DB5F635A3
GO
Isoform 15 (identifier: Q9UKT9-15) [UniParc]FASTAAdd to basket

Also known as: Aio-del4-5a

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

Show »
Length:453
Mass (Da):51,880
Checksum:i8C2E108E02143972
GO
Isoform 16 (identifier: Q9UKT9-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,973
Checksum:i74F8C25D67B30D67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti321 – 3211R → C in AAF13493 (PubMed:10552935).Curated
Sequence conflicti321 – 3211R → C in CAC80427 (PubMed:11745366).Curated
Sequence conflicti321 – 3211R → C in CAC80428 (PubMed:11745366).Curated
Sequence conflicti321 – 3211R → C in CAC80429 (PubMed:11745366).Curated
Sequence conflicti321 – 3211R → C in CAC80430 (PubMed:11745366).Curated
Sequence conflicti321 – 3211R → C in CAC80431 (PubMed:11745366).Curated
Sequence conflicti361 – 3611K → R in AAF13493 (PubMed:10552935).Curated
Sequence conflicti361 – 3611K → R in CAC80427 (PubMed:11745366).Curated
Sequence conflicti361 – 3611K → R in CAC80428 (PubMed:11745366).Curated
Sequence conflicti361 – 3611K → R in CAC80429 (PubMed:11745366).Curated
Sequence conflicti361 – 3611K → R in CAC80430 (PubMed:11745366).Curated
Sequence conflicti361 – 3611K → R in CAC80431 (PubMed:11745366).Curated
Sequence conflicti365 – 3651H → L in AAF13493 (PubMed:10552935).Curated
Sequence conflicti365 – 3651H → L in CAC80427 (PubMed:11745366).Curated
Sequence conflicti365 – 3651H → L in CAC80428 (PubMed:11745366).Curated
Sequence conflicti365 – 3651H → L in CAC80429 (PubMed:11745366).Curated
Sequence conflicti365 – 3651H → L in CAC80430 (PubMed:11745366).Curated
Sequence conflicti365 – 3651H → L in CAC80431 (PubMed:11745366).Curated
Sequence conflicti443 – 4431N → D in AAF13493 (PubMed:10552935).Curated
Sequence conflicti443 – 4431N → D in CAC80427 (PubMed:11745366).Curated
Sequence conflicti443 – 4431N → D in CAC80428 (PubMed:11745366).Curated
Sequence conflicti443 – 4431N → D in CAC80429 (PubMed:11745366).Curated
Sequence conflicti443 – 4431N → D in CAC80430 (PubMed:11745366).Curated
Sequence conflicti443 – 4431N → D in CAC80431 (PubMed:11745366).Curated
Sequence conflicti487 – 4871Y → D in AAF13493 (PubMed:10552935).Curated
Sequence conflicti487 – 4871Y → D in CAC80427 (PubMed:11745366).Curated
Sequence conflicti487 – 4871Y → D in CAC80428 (PubMed:11745366).Curated
Sequence conflicti487 – 4871Y → D in CAC80429 (PubMed:11745366).Curated
Sequence conflicti487 – 4871Y → D in CAC80430 (PubMed:11745366).Curated
Sequence conflicti487 – 4871Y → D in CAC80431 (PubMed:11745366).Curated
Sequence conflicti506 – 5061A → S in AAF13493 (PubMed:10552935).Curated
Sequence conflicti506 – 5061A → S in CAC80427 (PubMed:11745366).Curated
Sequence conflicti506 – 5061A → S in CAC80428 (PubMed:11745366).Curated
Sequence conflicti506 – 5061A → S in CAC80429 (PubMed:11745366).Curated
Sequence conflicti506 – 5061A → S in CAC80430 (PubMed:11745366).Curated
Sequence conflicti506 – 5061A → S in CAC80431 (PubMed:11745366).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771E → Q Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064724

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 247247Missing in isoform 16. 1 PublicationVSP_055353Add
BLAST
Alternative sequencei21 – 5434Missing in isoform 7 and isoform 8. 1 PublicationVSP_041274Add
BLAST
Alternative sequencei55 – 275221Missing in isoform 12. 1 PublicationVSP_041275Add
BLAST
Alternative sequencei55 – 236182Missing in isoform 11. 1 PublicationVSP_041276Add
BLAST
Alternative sequencei55 – 197143Missing in isoform 10. 1 PublicationVSP_041277Add
BLAST
Alternative sequencei55 – 14187Missing in isoform 9. 1 PublicationVSP_041278Add
BLAST
Alternative sequencei142 – 275134Missing in isoform 13. 1 PublicationVSP_041279Add
BLAST
Alternative sequencei142 – 23695Missing in isoform 5. 1 PublicationVSP_006841Add
BLAST
Alternative sequencei142 – 19756Missing in isoform 2 and isoform 15. 2 PublicationsVSP_006840Add
BLAST
Alternative sequencei198 – 27578Missing in isoform 6. 1 PublicationVSP_006843Add
BLAST
Alternative sequencei198 – 23639Missing in isoform 3 and isoform 8. 2 PublicationsVSP_006842Add
BLAST
Alternative sequencei237 – 27539Missing in isoform 4. 1 PublicationVSP_006844Add
BLAST
Alternative sequencei237 – 26327ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15. 1 PublicationVSP_041280Add
BLAST
Alternative sequencei264 – 509246Missing in isoform 14. 1 PublicationVSP_041281Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129512 mRNA. Translation: AAF13493.1.
AJ292565 mRNA. Translation: CAC80427.1.
AJ292566 mRNA. Translation: CAC80428.1.
AJ292567 mRNA. Translation: CAC80429.1.
AJ292568 mRNA. Translation: CAC80430.1.
AJ292569 mRNA. Translation: CAC80431.1.
AY377973 mRNA. Translation: AAR84584.1.
AY377975 mRNA. Translation: AAR84586.1.
AY377976 mRNA. Translation: AAR84587.1.
AY377977 mRNA. Translation: AAR84588.1.
AY377978 mRNA. Translation: AAR84589.1.
AY377979 mRNA. Translation: AAR84590.1.
AY377980 mRNA. Translation: AAR84591.1.
AY377981 mRNA. Translation: AAR84592.1.
AY377982 mRNA. Translation: AAR84593.1.
AK301250 mRNA. Translation: BAG62817.1.
AK303495 mRNA. Translation: BAG64529.1.
AC079199 Genomic DNA. No translation available.
AC090844 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60606.1.
BC032707 mRNA. Translation: AAH32707.1.
CCDSiCCDS11346.1. [Q9UKT9-1]
CCDS11347.1. [Q9UKT9-2]
CCDS11348.1. [Q9UKT9-3]
CCDS11349.1. [Q9UKT9-4]
CCDS11350.1. [Q9UKT9-5]
CCDS11351.1. [Q9UKT9-6]
CCDS58539.1. [Q9UKT9-8]
CCDS58540.1. [Q9UKT9-7]
CCDS58541.1. [Q9UKT9-12]
CCDS58542.1. [Q9UKT9-11]
CCDS58543.1. [Q9UKT9-10]
CCDS58544.1. [Q9UKT9-9]
CCDS58545.1. [Q9UKT9-13]
CCDS74055.1. [Q9UKT9-16]
RefSeqiNP_001244337.1. NM_001257408.1. [Q9UKT9-7]
NP_001244338.1. NM_001257409.1. [Q9UKT9-8]
NP_001244339.1. NM_001257410.1. [Q9UKT9-9]
NP_001244340.1. NM_001257411.1. [Q9UKT9-10]
NP_001244341.1. NM_001257412.1. [Q9UKT9-11]
NP_001244342.1. NM_001257413.1. [Q9UKT9-12]
NP_001244343.1. NM_001257414.1. [Q9UKT9-13]
NP_001271443.1. NM_001284514.1. [Q9UKT9-16]
NP_001271444.1. NM_001284515.1. [Q9UKT9-16]
NP_001271445.1. NM_001284516.1. [Q9UKT9-16]
NP_036613.2. NM_012481.4. [Q9UKT9-1]
NP_899051.1. NM_183228.2. [Q9UKT9-2]
NP_899052.1. NM_183229.2. [Q9UKT9-3]
NP_899053.1. NM_183230.2. [Q9UKT9-4]
NP_899054.1. NM_183231.2. [Q9UKT9-5]
NP_899055.1. NM_183232.2. [Q9UKT9-6]
UniGeneiHs.371680.

Genome annotation databases

EnsembliENST00000293068; ENSP00000462791; ENSG00000161405. [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405. [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405. [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405. [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405. [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405. [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405. [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405. [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405. [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405. [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405. [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405. [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405. [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405. [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405. [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405. [Q9UKT9-16]
GeneIDi22806.
KEGGihsa:22806.
UCSCiuc002hsu.4. human. [Q9UKT9-1]
uc002hsv.4. human. [Q9UKT9-8]
uc002hsw.4. human. [Q9UKT9-3]
uc002hsx.4. human. [Q9UKT9-2]
uc002hsy.4. human. [Q9UKT9-4]
uc002hsz.4. human. [Q9UKT9-5]
uc002hta.4. human. [Q9UKT9-6]
uc002htd.4. human. [Q9UKT9-7]
uc010cwd.4. human. [Q9UKT9-10]
uc010cwe.4. human. [Q9UKT9-13]
uc010cwf.4. human. [Q9UKT9-11]
uc010cwg.4. human. [Q9UKT9-12]
uc010cwh.4. human. [Q9UKT9-9]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129512 mRNA. Translation: AAF13493.1.
AJ292565 mRNA. Translation: CAC80427.1.
AJ292566 mRNA. Translation: CAC80428.1.
AJ292567 mRNA. Translation: CAC80429.1.
AJ292568 mRNA. Translation: CAC80430.1.
AJ292569 mRNA. Translation: CAC80431.1.
AY377973 mRNA. Translation: AAR84584.1.
AY377975 mRNA. Translation: AAR84586.1.
AY377976 mRNA. Translation: AAR84587.1.
AY377977 mRNA. Translation: AAR84588.1.
AY377978 mRNA. Translation: AAR84589.1.
AY377979 mRNA. Translation: AAR84590.1.
AY377980 mRNA. Translation: AAR84591.1.
AY377981 mRNA. Translation: AAR84592.1.
AY377982 mRNA. Translation: AAR84593.1.
AK301250 mRNA. Translation: BAG62817.1.
AK303495 mRNA. Translation: BAG64529.1.
AC079199 Genomic DNA. No translation available.
AC090844 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60606.1.
BC032707 mRNA. Translation: AAH32707.1.
CCDSiCCDS11346.1. [Q9UKT9-1]
CCDS11347.1. [Q9UKT9-2]
CCDS11348.1. [Q9UKT9-3]
CCDS11349.1. [Q9UKT9-4]
CCDS11350.1. [Q9UKT9-5]
CCDS11351.1. [Q9UKT9-6]
CCDS58539.1. [Q9UKT9-8]
CCDS58540.1. [Q9UKT9-7]
CCDS58541.1. [Q9UKT9-12]
CCDS58542.1. [Q9UKT9-11]
CCDS58543.1. [Q9UKT9-10]
CCDS58544.1. [Q9UKT9-9]
CCDS58545.1. [Q9UKT9-13]
CCDS74055.1. [Q9UKT9-16]
RefSeqiNP_001244337.1. NM_001257408.1. [Q9UKT9-7]
NP_001244338.1. NM_001257409.1. [Q9UKT9-8]
NP_001244339.1. NM_001257410.1. [Q9UKT9-9]
NP_001244340.1. NM_001257411.1. [Q9UKT9-10]
NP_001244341.1. NM_001257412.1. [Q9UKT9-11]
NP_001244342.1. NM_001257413.1. [Q9UKT9-12]
NP_001244343.1. NM_001257414.1. [Q9UKT9-13]
NP_001271443.1. NM_001284514.1. [Q9UKT9-16]
NP_001271444.1. NM_001284515.1. [Q9UKT9-16]
NP_001271445.1. NM_001284516.1. [Q9UKT9-16]
NP_036613.2. NM_012481.4. [Q9UKT9-1]
NP_899051.1. NM_183228.2. [Q9UKT9-2]
NP_899052.1. NM_183229.2. [Q9UKT9-3]
NP_899053.1. NM_183230.2. [Q9UKT9-4]
NP_899054.1. NM_183231.2. [Q9UKT9-5]
NP_899055.1. NM_183232.2. [Q9UKT9-6]
UniGeneiHs.371680.

3D structure databases

ProteinModelPortaliQ9UKT9.
SMRiQ9UKT9. Positions 101-255, 442-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116484. 86 interactions.
IntActiQ9UKT9. 70 interactions.
MINTiMINT-1454530.
STRINGi9606.ENSP00000344544.

PTM databases

PhosphoSiteiQ9UKT9.

Polymorphism and mutation databases

BioMutaiIKZF3.
DMDMi212276437.

Proteomic databases

MaxQBiQ9UKT9.
PaxDbiQ9UKT9.
PRIDEiQ9UKT9.

Protocols and materials databases

DNASUi22806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293068; ENSP00000462791; ENSG00000161405. [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405. [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405. [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405. [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405. [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405. [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405. [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405. [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405. [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405. [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405. [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405. [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405. [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405. [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405. [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405. [Q9UKT9-16]
GeneIDi22806.
KEGGihsa:22806.
UCSCiuc002hsu.4. human. [Q9UKT9-1]
uc002hsv.4. human. [Q9UKT9-8]
uc002hsw.4. human. [Q9UKT9-3]
uc002hsx.4. human. [Q9UKT9-2]
uc002hsy.4. human. [Q9UKT9-4]
uc002hsz.4. human. [Q9UKT9-5]
uc002hta.4. human. [Q9UKT9-6]
uc002htd.4. human. [Q9UKT9-7]
uc010cwd.4. human. [Q9UKT9-10]
uc010cwe.4. human. [Q9UKT9-13]
uc010cwf.4. human. [Q9UKT9-11]
uc010cwg.4. human. [Q9UKT9-12]
uc010cwh.4. human. [Q9UKT9-9]

Organism-specific databases

CTDi22806.
GeneCardsiGC17M037921.
HGNCiHGNC:13178. IKZF3.
HPAiCAB017105.
HPA024377.
MIMi606221. gene.
neXtProtiNX_Q9UKT9.
PharmGKBiPA37750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274203.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG060914.
InParanoidiQ9UKT9.
KOiK09220.
OMAiYPIALTR.
OrthoDBiEOG79GT61.
PhylomeDBiQ9UKT9.
TreeFamiTF331189.

Miscellaneous databases

ChiTaRSiIKZF3. human.
GeneWikiiIKZF3.
GenomeRNAii22806.
NextBioi35475564.
PROiQ9UKT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKT9.
CleanExiHS_IKZF3.
GenevisibleiQ9UKT9. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping."
    Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M.
    Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoma.
  2. "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene."
    Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E., Riikonen P., Hammarstrom L., Pelkonen J., Lassila O.
    Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
    Tissue: Lymphoid tissue.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 16).
    Tissue: Spleen and Thymus.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  8. "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."
    Romero F., Martinez-A C., Camonis J., Rebollo A.
    EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  9. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
    Perdomo J., Holmes M., Chong B., Crossley M.
    J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IKZF4 AND IKZF5.
  10. "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis."
    Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A.
    J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL21L, PHOSPHORYLATION.
  11. "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."
    Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L., Quintana F.J.
    Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXP3, INDUCTION.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. Cited for: VARIANT GLN-277.

Entry informationi

Entry nameiIKZF3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT9
Secondary accession number(s): B4DVV5
, Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 4, 2008
Last modified: June 24, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.