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Q9UKT9 (IKZF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
Gene names
Name:IKZF3
Synonyms:ZNFN1A3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Ref.8

Subunit structure

Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L);this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. Ref.3 Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location

Nucleus. Cytoplasm Ref.3 Ref.8.

Tissue specificity

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. Ref.3

Induction

Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells. Ref.11

Post-translational modification

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Sequence similarities

Belongs to the Ikaros C2H2-type zinc-finger protein family.

Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processB-cell activation
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell activation

Inferred from electronic annotation. Source: UniProtKB-KW

mesoderm development

Traceable author statement Ref.1. Source: ProtInc

regulation of B cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of B cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of apoptotic process

Inferred from mutant phenotype Ref.8. Source: UniProtKB

regulation of lymphocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay Ref.8Ref.3. Source: UniProtKB

nucleus

Inferred from direct assay Ref.8Ref.3. Source: UniProtKB

plasma membrane

Inferred from direct assay. Source: HPA

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.8Ref.10. Source: UniProtKB

protein heterodimerization activity

Inferred from direct assay Ref.3. Source: UniProtKB

protein homodimerization activity

Inferred from direct assay Ref.3. Source: UniProtKB

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FOXP3Q9BZS12EBI-747204,EBI-983719

Alternative products

This entry describes 16 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKT9-1)

Also known as: Aio-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKT9-2)

Also known as: Aio-del4;

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
Isoform 3 (identifier: Q9UKT9-3)

Also known as: Aio-del5;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.
Isoform 4 (identifier: Q9UKT9-4)

Also known as: Aio-del6;

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.
Isoform 5 (identifier: Q9UKT9-5)

Also known as: Aio-del4,5;

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.
Isoform 6 (identifier: Q9UKT9-6)

Also known as: Aio-del5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
Isoform 7 (identifier: Q9UKT9-7)

Also known as: Aio-del2;

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
Isoform 8 (identifier: Q9UKT9-8)

Also known as: Aio-del2,5;

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.
Isoform 9 (identifier: Q9UKT9-9)

Also known as: Aio-del3;

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.
Isoform 10 (identifier: Q9UKT9-10)

Also known as: Aio-del3,4;

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.
Isoform 11 (identifier: Q9UKT9-11)

Also known as: Aio-del3,4,5;

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.
Isoform 12 (identifier: Q9UKT9-12)

Also known as: Aio-del3,4,5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.
Isoform 13 (identifier: Q9UKT9-13)

Also known as: Aio-del4,5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.
Isoform 14 (identifier: Q9UKT9-14)

Also known as: Aio-1-5a;

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.
Isoform 15 (identifier: Q9UKT9-15)

Also known as: Aio-del4-5a;

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
Isoform 16 (identifier: Q9UKT9-16)

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Zinc finger protein Aiolos
PRO_0000047090

Regions

Zinc finger118 – 14023C2H2-type 1
Zinc finger146 – 16823C2H2-type 2
Zinc finger174 – 19623C2H2-type 3
Zinc finger202 – 22423C2H2-type 4; atypical
Zinc finger452 – 47423C2H2-type 5
Zinc finger480 – 50425C2H2-type 6; atypical

Natural variations

Alternative sequence1 – 247247Missing in isoform 16.
VSP_055353
Alternative sequence21 – 5434Missing in isoform 7 and isoform 8.
VSP_041274
Alternative sequence55 – 275221Missing in isoform 12.
VSP_041275
Alternative sequence55 – 236182Missing in isoform 11.
VSP_041276
Alternative sequence55 – 197143Missing in isoform 10.
VSP_041277
Alternative sequence55 – 14187Missing in isoform 9.
VSP_041278
Alternative sequence142 – 275134Missing in isoform 13.
VSP_041279
Alternative sequence142 – 23695Missing in isoform 5.
VSP_006841
Alternative sequence142 – 19756Missing in isoform 2 and isoform 15.
VSP_006840
Alternative sequence198 – 27578Missing in isoform 6.
VSP_006843
Alternative sequence198 – 23639Missing in isoform 3 and isoform 8.
VSP_006842
Alternative sequence237 – 27539Missing in isoform 4.
VSP_006844
Alternative sequence237 – 26327ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15.
VSP_041280
Alternative sequence264 – 509246Missing in isoform 14.
VSP_041281
Natural variant2771E → Q Found in a renal cell carcinoma sample; somatic mutation. Ref.13
VAR_064724

Experimental info

Sequence conflict3211R → C in AAF13493. Ref.1
Sequence conflict3211R → C in CAC80427. Ref.2
Sequence conflict3211R → C in CAC80428. Ref.2
Sequence conflict3211R → C in CAC80429. Ref.2
Sequence conflict3211R → C in CAC80430. Ref.2
Sequence conflict3211R → C in CAC80431. Ref.2
Sequence conflict3611K → R in AAF13493. Ref.1
Sequence conflict3611K → R in CAC80427. Ref.2
Sequence conflict3611K → R in CAC80428. Ref.2
Sequence conflict3611K → R in CAC80429. Ref.2
Sequence conflict3611K → R in CAC80430. Ref.2
Sequence conflict3611K → R in CAC80431. Ref.2
Sequence conflict3651H → L in AAF13493. Ref.1
Sequence conflict3651H → L in CAC80427. Ref.2
Sequence conflict3651H → L in CAC80428. Ref.2
Sequence conflict3651H → L in CAC80429. Ref.2
Sequence conflict3651H → L in CAC80430. Ref.2
Sequence conflict3651H → L in CAC80431. Ref.2
Sequence conflict4431N → D in AAF13493. Ref.1
Sequence conflict4431N → D in CAC80427. Ref.2
Sequence conflict4431N → D in CAC80428. Ref.2
Sequence conflict4431N → D in CAC80429. Ref.2
Sequence conflict4431N → D in CAC80430. Ref.2
Sequence conflict4431N → D in CAC80431. Ref.2
Sequence conflict4871Y → D in AAF13493. Ref.1
Sequence conflict4871Y → D in CAC80427. Ref.2
Sequence conflict4871Y → D in CAC80428. Ref.2
Sequence conflict4871Y → D in CAC80429. Ref.2
Sequence conflict4871Y → D in CAC80430. Ref.2
Sequence conflict4871Y → D in CAC80431. Ref.2
Sequence conflict5061A → S in AAF13493. Ref.1
Sequence conflict5061A → S in CAC80427. Ref.2
Sequence conflict5061A → S in CAC80428. Ref.2
Sequence conflict5061A → S in CAC80429. Ref.2
Sequence conflict5061A → S in CAC80430. Ref.2
Sequence conflict5061A → S in CAC80431. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Aio-1) [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: D1BB4A0A9A71B81A

FASTA50958,023
        10         20         30         40         50         60 
MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 

        70         80         90        100        110        120 
KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 

       130        140        150        160        170        180 
DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 

       190        200        210        220        230        240 
YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE 

       250        260        270        280        290        300 
ARHIKAEMGS ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ 

       310        320        330        340        350        360 
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE MSNGAPQELE 

       370        380        390        400        410        420 
KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI YQQNHMVLSR ARNGMPLLKE 

       430        440        450        460        470        480 
VPRSYELLKP PPICPRDSVK VINKEGEVMD VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF 

       490        500 
ECNMCGYRSH DRYEFSSHIA RGEHRALLK 

« Hide

Isoform 2 (Aio-del4) [UniParc].

Checksum: 85DEFC62034A738F
Show »

FASTA45351,632
Isoform 3 (Aio-del5) [UniParc].

Checksum: 18998C960E99C78A
Show »

FASTA47053,401
Isoform 4 (Aio-del6) [UniParc].

Checksum: 979F785A6B93BC6E
Show »

FASTA47053,743
Isoform 5 (Aio-del4,5) [UniParc].

Checksum: DD4C8159B8417844
Show »

FASTA41447,010
Isoform 6 (Aio-del5,6) [UniParc].

Checksum: 540F806622DCBB56
Show »

FASTA43149,121
Isoform 7 (Aio-del2) [UniParc].

Checksum: 00694E8BA86FFEC5
Show »

FASTA47554,417
Isoform 8 (Aio-del2,5) [UniParc].

Checksum: 965862E0B68846E0
Show »

FASTA43649,795
Isoform 9 (Aio-del3) [UniParc].

Checksum: 42308DF0B90BA4DF
Show »

FASTA42247,958
Isoform 10 (Aio-del3,4) [UniParc].

Checksum: A4E825FDBF860925
Show »

FASTA36641,567
Isoform 11 (Aio-del3,4,5) [UniParc].

Checksum: D90D2FFBA757F7B9
Show »

FASTA32736,945
Isoform 12 (Aio-del3,4,5,6) [UniParc].

Checksum: ECA1D13AA6312CAB
Show »

FASTA28832,665
Isoform 13 (Aio-del4,5,6) [UniParc].

Checksum: 7AE6138A9450AAF5
Show »

FASTA37542,730
Isoform 14 (Aio-1-5a) [UniParc].

Checksum: F12F178DB5F635A3
Show »

FASTA26330,029
Isoform 15 (Aio-del4-5a) [UniParc].

Checksum: 8C2E108E02143972
Show »

FASTA45351,880
Isoform 16 [UniParc].

Checksum: 74F8C25D67B30D67
Show »

FASTA26229,973

References

« Hide 'large scale' references
[1]"Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping."
Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M.
Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lymphoma.
[2]"Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene."
Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E., Riikonen P., Hammarstrom L., Pelkonen J., Lassila O.
Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
Tissue: Lymphoid tissue.
[3]"Combinatorial effects of splice variants modulate function of Aiolos."
Caballero R., Setien F., Lopez-Serra L., Boix-Chornet M., Fraga M.F., Ropero S., Megias D., Alaminos M., Sanchez-Tapia E.M., Montoya M.C., Esteller M., Gonzalez-Sarmiento R., Ballestar E.
J. Cell Sci. 120:2619-2630(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 16).
Tissue: Spleen and Thymus.
[5]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph.
[8]"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."
Romero F., Martinez-A C., Camonis J., Rebollo A.
EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[9]"Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
Perdomo J., Holmes M., Chong B., Crossley M.
J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH IKZF4 AND IKZF5.
[10]"The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis."
Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A.
J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BCL21L, PHOSPHORYLATION.
[11]"Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."
Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L., Quintana F.J.
Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FOXP3, INDUCTION.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLN-277.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129512 mRNA. Translation: AAF13493.1.
AJ292565 mRNA. Translation: CAC80427.1.
AJ292566 mRNA. Translation: CAC80428.1.
AJ292567 mRNA. Translation: CAC80429.1.
AJ292568 mRNA. Translation: CAC80430.1.
AJ292569 mRNA. Translation: CAC80431.1.
AY377973 mRNA. Translation: AAR84584.1.
AY377975 mRNA. Translation: AAR84586.1.
AY377976 mRNA. Translation: AAR84587.1.
AY377977 mRNA. Translation: AAR84588.1.
AY377978 mRNA. Translation: AAR84589.1.
AY377979 mRNA. Translation: AAR84590.1.
AY377980 mRNA. Translation: AAR84591.1.
AY377981 mRNA. Translation: AAR84592.1.
AY377982 mRNA. Translation: AAR84593.1.
AK301250 mRNA. Translation: BAG62817.1.
AK303495 mRNA. Translation: BAG64529.1.
AC079199 Genomic DNA. No translation available.
AC090844 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60606.1.
BC032707 mRNA. Translation: AAH32707.1.
CCDSCCDS11346.1. [Q9UKT9-1]
CCDS11347.1. [Q9UKT9-2]
CCDS11348.1. [Q9UKT9-3]
CCDS11349.1. [Q9UKT9-4]
CCDS11350.1. [Q9UKT9-5]
CCDS11351.1. [Q9UKT9-6]
CCDS58539.1. [Q9UKT9-8]
CCDS58540.1. [Q9UKT9-7]
CCDS58541.1. [Q9UKT9-12]
CCDS58542.1. [Q9UKT9-11]
CCDS58543.1. [Q9UKT9-10]
CCDS58544.1. [Q9UKT9-9]
CCDS58545.1. [Q9UKT9-13]
RefSeqNP_001244337.1. NM_001257408.1. [Q9UKT9-7]
NP_001244338.1. NM_001257409.1. [Q9UKT9-8]
NP_001244339.1. NM_001257410.1. [Q9UKT9-9]
NP_001244340.1. NM_001257411.1. [Q9UKT9-10]
NP_001244341.1. NM_001257412.1. [Q9UKT9-11]
NP_001244342.1. NM_001257413.1. [Q9UKT9-12]
NP_001244343.1. NM_001257414.1. [Q9UKT9-13]
NP_001271443.1. NM_001284514.1.
NP_001271444.1. NM_001284515.1.
NP_036613.2. NM_012481.4. [Q9UKT9-1]
NP_899051.1. NM_183228.2. [Q9UKT9-2]
NP_899052.1. NM_183229.2. [Q9UKT9-3]
NP_899053.1. NM_183230.2. [Q9UKT9-4]
NP_899054.1. NM_183231.2. [Q9UKT9-5]
NP_899055.1. NM_183232.2. [Q9UKT9-6]
UniGeneHs.371680.

3D structure databases

ProteinModelPortalQ9UKT9.
SMRQ9UKT9. Positions 101-255, 442-505.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116484. 18 interactions.
IntActQ9UKT9. 15 interactions.
MINTMINT-1454530.
STRING9606.ENSP00000418684.

PTM databases

PhosphoSiteQ9UKT9.

Polymorphism databases

DMDM212276437.

Proteomic databases

MaxQBQ9UKT9.
PaxDbQ9UKT9.
PRIDEQ9UKT9.

Protocols and materials databases

DNASU22806.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293068; ENSP00000462791; ENSG00000161405. [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405. [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405. [Q9UKT9-1]
ENST00000348427; ENSP00000463505; ENSG00000161405.
ENST00000350532; ENSP00000344471; ENSG00000161405. [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405. [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405. [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405. [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405. [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405. [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405. [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405. [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405. [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405. [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405. [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405.
GeneID22806.
KEGGhsa:22806.
UCSCuc002hsu.4. human. [Q9UKT9-1]
uc002hsv.4. human. [Q9UKT9-8]
uc002hsw.4. human. [Q9UKT9-3]
uc002hsx.4. human. [Q9UKT9-2]
uc002hsy.4. human. [Q9UKT9-4]
uc002hsz.4. human. [Q9UKT9-5]
uc002hta.4. human. [Q9UKT9-6]
uc002htd.4. human. [Q9UKT9-7]
uc010cwd.4. human. [Q9UKT9-10]
uc010cwe.4. human. [Q9UKT9-13]
uc010cwf.4. human. [Q9UKT9-11]
uc010cwg.4. human. [Q9UKT9-12]
uc010cwh.4. human. [Q9UKT9-9]

Organism-specific databases

CTD22806.
GeneCardsGC17M037921.
HGNCHGNC:13178. IKZF3.
HPACAB017105.
HPA024377.
MIM606221. gene.
neXtProtNX_Q9UKT9.
PharmGKBPA37750.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274203.
HOVERGENHBG060914.
InParanoidQ9UKT9.
KOK09220.
OMAYPIALTR.
OrthoDBEOG79GT61.
PhylomeDBQ9UKT9.
TreeFamTF331189.

Gene expression databases

ArrayExpressQ9UKT9.
BgeeQ9UKT9.
CleanExHS_IKZF3.
GenevestigatorQ9UKT9.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIKZF3. human.
GeneWikiIKZF3.
GenomeRNAi22806.
NextBio43164.
PROQ9UKT9.
SOURCESearch...

Entry information

Entry nameIKZF3_HUMAN
AccessionPrimary (citable) accession number: Q9UKT9
Secondary accession number(s): B4DVV5 expand/collapse secondary AC list , Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM