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Q9UKT9

- IKZF3_HUMAN

UniProt

Q9UKT9 - IKZF3_HUMAN

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Protein

Zinc finger protein Aiolos

Gene
IKZF3, ZNFN1A3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1Add
BLAST
Zinc fingeri146 – 16823C2H2-type 2Add
BLAST
Zinc fingeri174 – 19623C2H2-type 3Add
BLAST
Zinc fingeri202 – 22423C2H2-type 4; atypicalAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 5Add
BLAST
Zinc fingeri480 – 50425C2H2-type 6; atypicalAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. protein binding Source: UniProtKB
  3. protein heterodimerization activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. sequence-specific DNA binding Source: Ensembl
  6. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. mesoderm development Source: ProtInc
  3. regulation of apoptotic process Source: UniProtKB
  4. regulation of B cell differentiation Source: Ensembl
  5. regulation of B cell proliferation Source: Ensembl
  6. regulation of lymphocyte differentiation Source: UniProtKB
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

B-cell activation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
Gene namesi
Name:IKZF3
Synonyms:ZNFN1A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:13178. IKZF3.

Subcellular locationi

Nucleus. Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Zinc finger protein AiolosPRO_0000047090Add
BLAST

Post-translational modificationi

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UKT9.
PaxDbiQ9UKT9.
PRIDEiQ9UKT9.

PTM databases

PhosphoSiteiQ9UKT9.

Expressioni

Tissue specificityi

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.1 Publication

Inductioni

Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.1 Publication

Gene expression databases

ArrayExpressiQ9UKT9.
BgeeiQ9UKT9.
CleanExiHS_IKZF3.
GenevestigatoriQ9UKT9.

Organism-specific databases

HPAiCAB017105.
HPA024377.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXP3Q9BZS12EBI-747204,EBI-983719

Protein-protein interaction databases

BioGridi116484. 18 interactions.
IntActiQ9UKT9. 15 interactions.
MINTiMINT-1454530.
STRINGi9606.ENSP00000418684.

Structurei

3D structure databases

ProteinModelPortaliQ9UKT9.
SMRiQ9UKT9. Positions 101-255, 442-505.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG274203.
HOVERGENiHBG060914.
InParanoidiQ9UKT9.
KOiK09220.
OMAiYPIALTR.
OrthoDBiEOG79GT61.
PhylomeDBiQ9UKT9.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

This entry describes 16 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKT9-1) [UniParc]FASTAAdd to Basket

Also known as: Aio-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED    50
EDIGDDSMKV KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK 100
LERHVVSFDS SRPTSGKMNC DVCGLSCISF NVLMVHKRSH TGERPFQCNQ 150
CGASFTQKGN LLRHIKLHTG EKPFKCHLCN YACQRRDALT GHLRTHSVEK 200
PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE ARHIKAEMGS 250
ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ 300
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE 350
MSNGAPQELE KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI 400
YQQNHMVLSR ARNGMPLLKE VPRSYELLKP PPICPRDSVK VINKEGEVMD 450
VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF ECNMCGYRSH DRYEFSSHIA 500
RGEHRALLK 509
Length:509
Mass (Da):58,023
Last modified:November 4, 2008 - v2
Checksum:iD1BB4A0A9A71B81A
GO
Isoform 2 (identifier: Q9UKT9-2) [UniParc]FASTAAdd to Basket

Also known as: Aio-del4

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.

Show »
Length:453
Mass (Da):51,632
Checksum:i85DEFC62034A738F
GO
Isoform 3 (identifier: Q9UKT9-3) [UniParc]FASTAAdd to Basket

Also known as: Aio-del5

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Show »
Length:470
Mass (Da):53,401
Checksum:i18998C960E99C78A
GO
Isoform 4 (identifier: Q9UKT9-4) [UniParc]FASTAAdd to Basket

Also known as: Aio-del6

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.

Show »
Length:470
Mass (Da):53,743
Checksum:i979F785A6B93BC6E
GO
Isoform 5 (identifier: Q9UKT9-5) [UniParc]FASTAAdd to Basket

Also known as: Aio-del4,5

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.

Show »
Length:414
Mass (Da):47,010
Checksum:iDD4C8159B8417844
GO
Isoform 6 (identifier: Q9UKT9-6) [UniParc]FASTAAdd to Basket

Also known as: Aio-del5,6

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:431
Mass (Da):49,121
Checksum:i540F806622DCBB56
GO
Isoform 7 (identifier: Q9UKT9-7) [UniParc]FASTAAdd to Basket

Also known as: Aio-del2

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.

Show »
Length:475
Mass (Da):54,417
Checksum:i00694E8BA86FFEC5
GO
Isoform 8 (identifier: Q9UKT9-8) [UniParc]FASTAAdd to Basket

Also known as: Aio-del2,5

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.

Show »
Length:436
Mass (Da):49,795
Checksum:i965862E0B68846E0
GO
Isoform 9 (identifier: Q9UKT9-9) [UniParc]FASTAAdd to Basket

Also known as: Aio-del3

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Show »
Length:422
Mass (Da):47,958
Checksum:i42308DF0B90BA4DF
GO
Isoform 10 (identifier: Q9UKT9-10) [UniParc]FASTAAdd to Basket

Also known as: Aio-del3,4

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.

Show »
Length:366
Mass (Da):41,567
Checksum:iA4E825FDBF860925
GO
Isoform 11 (identifier: Q9UKT9-11) [UniParc]FASTAAdd to Basket

Also known as: Aio-del3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.

Show »
Length:327
Mass (Da):36,945
Checksum:iD90D2FFBA757F7B9
GO
Isoform 12 (identifier: Q9UKT9-12) [UniParc]FASTAAdd to Basket

Also known as: Aio-del3,4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.

Show »
Length:288
Mass (Da):32,665
Checksum:iECA1D13AA6312CAB
GO
Isoform 13 (identifier: Q9UKT9-13) [UniParc]FASTAAdd to Basket

Also known as: Aio-del4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.

Show »
Length:375
Mass (Da):42,730
Checksum:i7AE6138A9450AAF5
GO
Isoform 14 (identifier: Q9UKT9-14) [UniParc]FASTAAdd to Basket

Also known as: Aio-1-5a

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.

Show »
Length:263
Mass (Da):30,029
Checksum:iF12F178DB5F635A3
GO
Isoform 15 (identifier: Q9UKT9-15) [UniParc]FASTAAdd to Basket

Also known as: Aio-del4-5a

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

Show »
Length:453
Mass (Da):51,880
Checksum:i8C2E108E02143972
GO
Isoform 16 (identifier: Q9UKT9-16) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Note: No experimental confirmation available.

Show »
Length:262
Mass (Da):29,973
Checksum:i74F8C25D67B30D67
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771E → Q Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064724

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 247247Missing in isoform 16. VSP_055353Add
BLAST
Alternative sequencei21 – 5434Missing in isoform 7 and isoform 8. VSP_041274Add
BLAST
Alternative sequencei55 – 275221Missing in isoform 12. VSP_041275Add
BLAST
Alternative sequencei55 – 236182Missing in isoform 11. VSP_041276Add
BLAST
Alternative sequencei55 – 197143Missing in isoform 10. VSP_041277Add
BLAST
Alternative sequencei55 – 14187Missing in isoform 9. VSP_041278Add
BLAST
Alternative sequencei142 – 275134Missing in isoform 13. VSP_041279Add
BLAST
Alternative sequencei142 – 23695Missing in isoform 5. VSP_006841Add
BLAST
Alternative sequencei142 – 19756Missing in isoform 2 and isoform 15. VSP_006840Add
BLAST
Alternative sequencei198 – 27578Missing in isoform 6. VSP_006843Add
BLAST
Alternative sequencei198 – 23639Missing in isoform 3 and isoform 8. VSP_006842Add
BLAST
Alternative sequencei237 – 27539Missing in isoform 4. VSP_006844Add
BLAST
Alternative sequencei237 – 26327ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15. VSP_041280Add
BLAST
Alternative sequencei264 – 509246Missing in isoform 14. VSP_041281Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti321 – 3211R → C in AAF13493. 1 Publication
Sequence conflicti321 – 3211R → C in CAC80427. 1 Publication
Sequence conflicti321 – 3211R → C in CAC80428. 1 Publication
Sequence conflicti321 – 3211R → C in CAC80429. 1 Publication
Sequence conflicti321 – 3211R → C in CAC80430. 1 Publication
Sequence conflicti321 – 3211R → C in CAC80431. 1 Publication
Sequence conflicti361 – 3611K → R in AAF13493. 1 Publication
Sequence conflicti361 – 3611K → R in CAC80427. 1 Publication
Sequence conflicti361 – 3611K → R in CAC80428. 1 Publication
Sequence conflicti361 – 3611K → R in CAC80429. 1 Publication
Sequence conflicti361 – 3611K → R in CAC80430. 1 Publication
Sequence conflicti361 – 3611K → R in CAC80431. 1 Publication
Sequence conflicti365 – 3651H → L in AAF13493. 1 Publication
Sequence conflicti365 – 3651H → L in CAC80427. 1 Publication
Sequence conflicti365 – 3651H → L in CAC80428. 1 Publication
Sequence conflicti365 – 3651H → L in CAC80429. 1 Publication
Sequence conflicti365 – 3651H → L in CAC80430. 1 Publication
Sequence conflicti365 – 3651H → L in CAC80431. 1 Publication
Sequence conflicti443 – 4431N → D in AAF13493. 1 Publication
Sequence conflicti443 – 4431N → D in CAC80427. 1 Publication
Sequence conflicti443 – 4431N → D in CAC80428. 1 Publication
Sequence conflicti443 – 4431N → D in CAC80429. 1 Publication
Sequence conflicti443 – 4431N → D in CAC80430. 1 Publication
Sequence conflicti443 – 4431N → D in CAC80431. 1 Publication
Sequence conflicti487 – 4871Y → D in AAF13493. 1 Publication
Sequence conflicti487 – 4871Y → D in CAC80427. 1 Publication
Sequence conflicti487 – 4871Y → D in CAC80428. 1 Publication
Sequence conflicti487 – 4871Y → D in CAC80429. 1 Publication
Sequence conflicti487 – 4871Y → D in CAC80430. 1 Publication
Sequence conflicti487 – 4871Y → D in CAC80431. 1 Publication
Sequence conflicti506 – 5061A → S in AAF13493. 1 Publication
Sequence conflicti506 – 5061A → S in CAC80427. 1 Publication
Sequence conflicti506 – 5061A → S in CAC80428. 1 Publication
Sequence conflicti506 – 5061A → S in CAC80429. 1 Publication
Sequence conflicti506 – 5061A → S in CAC80430. 1 Publication
Sequence conflicti506 – 5061A → S in CAC80431. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129512 mRNA. Translation: AAF13493.1.
AJ292565 mRNA. Translation: CAC80427.1.
AJ292566 mRNA. Translation: CAC80428.1.
AJ292567 mRNA. Translation: CAC80429.1.
AJ292568 mRNA. Translation: CAC80430.1.
AJ292569 mRNA. Translation: CAC80431.1.
AY377973 mRNA. Translation: AAR84584.1.
AY377975 mRNA. Translation: AAR84586.1.
AY377976 mRNA. Translation: AAR84587.1.
AY377977 mRNA. Translation: AAR84588.1.
AY377978 mRNA. Translation: AAR84589.1.
AY377979 mRNA. Translation: AAR84590.1.
AY377980 mRNA. Translation: AAR84591.1.
AY377981 mRNA. Translation: AAR84592.1.
AY377982 mRNA. Translation: AAR84593.1.
AK301250 mRNA. Translation: BAG62817.1.
AK303495 mRNA. Translation: BAG64529.1.
AC079199 Genomic DNA. No translation available.
AC090844 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60606.1.
BC032707 mRNA. Translation: AAH32707.1.
CCDSiCCDS11346.1. [Q9UKT9-1]
CCDS11347.1. [Q9UKT9-2]
CCDS11348.1. [Q9UKT9-3]
CCDS11349.1. [Q9UKT9-4]
CCDS11350.1. [Q9UKT9-5]
CCDS11351.1. [Q9UKT9-6]
CCDS58539.1. [Q9UKT9-8]
CCDS58540.1. [Q9UKT9-7]
CCDS58541.1. [Q9UKT9-12]
CCDS58542.1. [Q9UKT9-11]
CCDS58543.1. [Q9UKT9-10]
CCDS58544.1. [Q9UKT9-9]
CCDS58545.1. [Q9UKT9-13]
RefSeqiNP_001244337.1. NM_001257408.1. [Q9UKT9-7]
NP_001244338.1. NM_001257409.1. [Q9UKT9-8]
NP_001244339.1. NM_001257410.1. [Q9UKT9-9]
NP_001244340.1. NM_001257411.1. [Q9UKT9-10]
NP_001244341.1. NM_001257412.1. [Q9UKT9-11]
NP_001244342.1. NM_001257413.1. [Q9UKT9-12]
NP_001244343.1. NM_001257414.1. [Q9UKT9-13]
NP_001271443.1. NM_001284514.1.
NP_001271444.1. NM_001284515.1.
NP_001271445.1. NM_001284516.1.
NP_036613.2. NM_012481.4. [Q9UKT9-1]
NP_899051.1. NM_183228.2. [Q9UKT9-2]
NP_899052.1. NM_183229.2. [Q9UKT9-3]
NP_899053.1. NM_183230.2. [Q9UKT9-4]
NP_899054.1. NM_183231.2. [Q9UKT9-5]
NP_899055.1. NM_183232.2. [Q9UKT9-6]
UniGeneiHs.371680.

Genome annotation databases

EnsembliENST00000293068; ENSP00000462791; ENSG00000161405. [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405. [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405. [Q9UKT9-1]
ENST00000348427; ENSP00000463505; ENSG00000161405.
ENST00000350532; ENSP00000344471; ENSG00000161405. [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405. [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405. [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405. [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405. [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405. [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405. [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405. [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405. [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405. [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405. [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405.
GeneIDi22806.
KEGGihsa:22806.
UCSCiuc002hsu.4. human. [Q9UKT9-1]
uc002hsv.4. human. [Q9UKT9-8]
uc002hsw.4. human. [Q9UKT9-3]
uc002hsx.4. human. [Q9UKT9-2]
uc002hsy.4. human. [Q9UKT9-4]
uc002hsz.4. human. [Q9UKT9-5]
uc002hta.4. human. [Q9UKT9-6]
uc002htd.4. human. [Q9UKT9-7]
uc010cwd.4. human. [Q9UKT9-10]
uc010cwe.4. human. [Q9UKT9-13]
uc010cwf.4. human. [Q9UKT9-11]
uc010cwg.4. human. [Q9UKT9-12]
uc010cwh.4. human. [Q9UKT9-9]

Polymorphism databases

DMDMi212276437.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129512 mRNA. Translation: AAF13493.1 .
AJ292565 mRNA. Translation: CAC80427.1 .
AJ292566 mRNA. Translation: CAC80428.1 .
AJ292567 mRNA. Translation: CAC80429.1 .
AJ292568 mRNA. Translation: CAC80430.1 .
AJ292569 mRNA. Translation: CAC80431.1 .
AY377973 mRNA. Translation: AAR84584.1 .
AY377975 mRNA. Translation: AAR84586.1 .
AY377976 mRNA. Translation: AAR84587.1 .
AY377977 mRNA. Translation: AAR84588.1 .
AY377978 mRNA. Translation: AAR84589.1 .
AY377979 mRNA. Translation: AAR84590.1 .
AY377980 mRNA. Translation: AAR84591.1 .
AY377981 mRNA. Translation: AAR84592.1 .
AY377982 mRNA. Translation: AAR84593.1 .
AK301250 mRNA. Translation: BAG62817.1 .
AK303495 mRNA. Translation: BAG64529.1 .
AC079199 Genomic DNA. No translation available.
AC090844 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60606.1 .
BC032707 mRNA. Translation: AAH32707.1 .
CCDSi CCDS11346.1. [Q9UKT9-1 ]
CCDS11347.1. [Q9UKT9-2 ]
CCDS11348.1. [Q9UKT9-3 ]
CCDS11349.1. [Q9UKT9-4 ]
CCDS11350.1. [Q9UKT9-5 ]
CCDS11351.1. [Q9UKT9-6 ]
CCDS58539.1. [Q9UKT9-8 ]
CCDS58540.1. [Q9UKT9-7 ]
CCDS58541.1. [Q9UKT9-12 ]
CCDS58542.1. [Q9UKT9-11 ]
CCDS58543.1. [Q9UKT9-10 ]
CCDS58544.1. [Q9UKT9-9 ]
CCDS58545.1. [Q9UKT9-13 ]
RefSeqi NP_001244337.1. NM_001257408.1. [Q9UKT9-7 ]
NP_001244338.1. NM_001257409.1. [Q9UKT9-8 ]
NP_001244339.1. NM_001257410.1. [Q9UKT9-9 ]
NP_001244340.1. NM_001257411.1. [Q9UKT9-10 ]
NP_001244341.1. NM_001257412.1. [Q9UKT9-11 ]
NP_001244342.1. NM_001257413.1. [Q9UKT9-12 ]
NP_001244343.1. NM_001257414.1. [Q9UKT9-13 ]
NP_001271443.1. NM_001284514.1.
NP_001271444.1. NM_001284515.1.
NP_001271445.1. NM_001284516.1.
NP_036613.2. NM_012481.4. [Q9UKT9-1 ]
NP_899051.1. NM_183228.2. [Q9UKT9-2 ]
NP_899052.1. NM_183229.2. [Q9UKT9-3 ]
NP_899053.1. NM_183230.2. [Q9UKT9-4 ]
NP_899054.1. NM_183231.2. [Q9UKT9-5 ]
NP_899055.1. NM_183232.2. [Q9UKT9-6 ]
UniGenei Hs.371680.

3D structure databases

ProteinModelPortali Q9UKT9.
SMRi Q9UKT9. Positions 101-255, 442-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116484. 18 interactions.
IntActi Q9UKT9. 15 interactions.
MINTi MINT-1454530.
STRINGi 9606.ENSP00000418684.

PTM databases

PhosphoSitei Q9UKT9.

Polymorphism databases

DMDMi 212276437.

Proteomic databases

MaxQBi Q9UKT9.
PaxDbi Q9UKT9.
PRIDEi Q9UKT9.

Protocols and materials databases

DNASUi 22806.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293068 ; ENSP00000462791 ; ENSG00000161405 . [Q9UKT9-14 ]
ENST00000346243 ; ENSP00000341977 ; ENSG00000161405 . [Q9UKT9-6 ]
ENST00000346872 ; ENSP00000344544 ; ENSG00000161405 . [Q9UKT9-1 ]
ENST00000348427 ; ENSP00000463505 ; ENSG00000161405 .
ENST00000350532 ; ENSP00000344471 ; ENSG00000161405 . [Q9UKT9-4 ]
ENST00000351680 ; ENSP00000345622 ; ENSG00000161405 . [Q9UKT9-3 ]
ENST00000377944 ; ENSP00000367179 ; ENSG00000161405 . [Q9UKT9-10 ]
ENST00000377945 ; ENSP00000367180 ; ENSG00000161405 . [Q9UKT9-13 ]
ENST00000377952 ; ENSP00000367188 ; ENSG00000161405 . [Q9UKT9-12 ]
ENST00000377958 ; ENSP00000367194 ; ENSG00000161405 . [Q9UKT9-9 ]
ENST00000394189 ; ENSP00000377741 ; ENSG00000161405 . [Q9UKT9-11 ]
ENST00000439016 ; ENSP00000403027 ; ENSG00000161405 . [Q9UKT9-5 ]
ENST00000439167 ; ENSP00000403776 ; ENSG00000161405 . [Q9UKT9-8 ]
ENST00000467757 ; ENSP00000420463 ; ENSG00000161405 . [Q9UKT9-2 ]
ENST00000535189 ; ENSP00000438972 ; ENSG00000161405 . [Q9UKT9-7 ]
ENST00000583368 ; ENSP00000462452 ; ENSG00000161405 .
GeneIDi 22806.
KEGGi hsa:22806.
UCSCi uc002hsu.4. human. [Q9UKT9-1 ]
uc002hsv.4. human. [Q9UKT9-8 ]
uc002hsw.4. human. [Q9UKT9-3 ]
uc002hsx.4. human. [Q9UKT9-2 ]
uc002hsy.4. human. [Q9UKT9-4 ]
uc002hsz.4. human. [Q9UKT9-5 ]
uc002hta.4. human. [Q9UKT9-6 ]
uc002htd.4. human. [Q9UKT9-7 ]
uc010cwd.4. human. [Q9UKT9-10 ]
uc010cwe.4. human. [Q9UKT9-13 ]
uc010cwf.4. human. [Q9UKT9-11 ]
uc010cwg.4. human. [Q9UKT9-12 ]
uc010cwh.4. human. [Q9UKT9-9 ]

Organism-specific databases

CTDi 22806.
GeneCardsi GC17M037921.
HGNCi HGNC:13178. IKZF3.
HPAi CAB017105.
HPA024377.
MIMi 606221. gene.
neXtProti NX_Q9UKT9.
PharmGKBi PA37750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274203.
HOVERGENi HBG060914.
InParanoidi Q9UKT9.
KOi K09220.
OMAi YPIALTR.
OrthoDBi EOG79GT61.
PhylomeDBi Q9UKT9.
TreeFami TF331189.

Miscellaneous databases

ChiTaRSi IKZF3. human.
GeneWikii IKZF3.
GenomeRNAii 22806.
NextBioi 35475564.
PROi Q9UKT9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKT9.
Bgeei Q9UKT9.
CleanExi HS_IKZF3.
Genevestigatori Q9UKT9.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping."
    Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M.
    Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoma.
  2. "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene."
    Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E., Riikonen P., Hammarstrom L., Pelkonen J., Lassila O.
    Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
    Tissue: Lymphoid tissue.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 16).
    Tissue: Spleen and Thymus.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  8. "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."
    Romero F., Martinez-A C., Camonis J., Rebollo A.
    EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  9. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
    Perdomo J., Holmes M., Chong B., Crossley M.
    J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IKZF4 AND IKZF5.
  10. "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis."
    Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A.
    J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL21L, PHOSPHORYLATION.
  11. "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."
    Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L., Quintana F.J.
    Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXP3, INDUCTION.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT GLN-277.

Entry informationi

Entry nameiIKZF3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT9
Secondary accession number(s): B4DVV5
, Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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