Q9UKT9 (IKZF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein Aiolos

Alternative name(s):
Ikaros family zinc finger protein 3

Gene names

Name:	IKZF3
Synonyms:	ZNFN1A3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Ref.6
Subunit structure	Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. Ref.3 Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Nucleus. Cytoplasm Ref.3 Ref.6.
Tissue specificity	Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. Ref.3
Induction	Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells. Ref.9
Post-translational modification	Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Sequence similarities	Belongs to the Ikaros C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	B-cell activation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW mesoderm development Traceable author statement Ref.1. Source: ProtInc regulation of B cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB regulation of B cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB regulation of apoptotic process Inferred from mutant phenotype Ref.6. Source: UniProtKB regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay Ref.6Ref.3. Source: UniProtKB nucleus Inferred from direct assay Ref.6Ref.3. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	protein heterodimerization activity Inferred from direct assay Ref.3. Source: UniProtKB protein homodimerization activity Inferred from direct assay Ref.3. Source: UniProtKB sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FOXP3	Q9BZS1	2	EBI-747204,EBI-983719

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKT9-1)

Also known as: Aio-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKT9-2)

Also known as: Aio-del4;

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.

Isoform 3 (identifier: Q9UKT9-3)

Also known as: Aio-del5;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Isoform 4 (identifier: Q9UKT9-4)

Also known as: Aio-del6;

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.

Isoform 5 (identifier: Q9UKT9-5)

Also known as: Aio-del4,5;

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.

Isoform 6 (identifier: Q9UKT9-6)

Also known as: Aio-del5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Isoform 7 (identifier: Q9UKT9-7)

Also known as: Aio-del2;

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.

Isoform 8 (identifier: Q9UKT9-8)

Also known as: Aio-del2,5;

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.

Isoform 9 (identifier: Q9UKT9-9)

Also known as: Aio-del3;

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Isoform 10 (identifier: Q9UKT9-10)

Also known as: Aio-del3,4;

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.

Isoform 11 (identifier: Q9UKT9-11)

Also known as: Aio-del3,4,5;

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.

Isoform 12 (identifier: Q9UKT9-12)

Also known as: Aio-del3,4,5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.

Isoform 13 (identifier: Q9UKT9-13)

Also known as: Aio-del4,5,6;

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.

Isoform 14 (identifier: Q9UKT9-14)

Also known as: Aio-1-5a;

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.

Isoform 15 (identifier: Q9UKT9-15)

Also known as: Aio-del4-5a;

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Zinc finger protein Aiolos		PRO_0000047090
Regions
	Zinc finger	118 – 140	23	C2H2-type 1
	Zinc finger	146 – 168	23	C2H2-type 2
	Zinc finger	174 – 196	23	C2H2-type 3
	Zinc finger	202 – 224	23	C2H2-type 4; atypical
	Zinc finger	452 – 474	23	C2H2-type 5
	Zinc finger	480 – 504	25	C2H2-type 6; atypical
Natural variations
	Alternative sequence	21 – 54	34	Missing in isoform 7 and isoform 8.		VSP_041274
	Alternative sequence	55 – 275	221	Missing in isoform 12.		VSP_041275
	Alternative sequence	55 – 236	182	Missing in isoform 11.		VSP_041276
	Alternative sequence	55 – 197	143	Missing in isoform 10.		VSP_041277
	Alternative sequence	55 – 141	87	Missing in isoform 9.		VSP_041278
	Alternative sequence	142 – 275	134	Missing in isoform 13.		VSP_041279
	Alternative sequence	142 – 236	95	Missing in isoform 5.		VSP_006841
	Alternative sequence	142 – 197	56	Missing in isoform 2 and isoform 15.		VSP_006840
	Alternative sequence	198 – 275	78	Missing in isoform 6.		VSP_006843
	Alternative sequence	198 – 236	39	Missing in isoform 3 and isoform 8.		VSP_006842
	Alternative sequence	237 – 275	39	Missing in isoform 4.		VSP_006844
	Alternative sequence	237 – 263	27	ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15.		VSP_041280
	Alternative sequence	264 – 509	246	Missing in isoform 14.		VSP_041281
	Natural variant	277	1	E → Q Found in a renal cell carcinoma sample; somatic mutation. Ref.11		VAR_064724
Experimental info
	Sequence conflict	321	1	R → C in AAF13493. Ref.1
	Sequence conflict	321	1	R → C in CAC80427. Ref.2
	Sequence conflict	321	1	R → C in CAC80428. Ref.2
	Sequence conflict	321	1	R → C in CAC80429. Ref.2
	Sequence conflict	321	1	R → C in CAC80430. Ref.2
	Sequence conflict	321	1	R → C in CAC80431. Ref.2
	Sequence conflict	361	1	K → R in AAF13493. Ref.1
	Sequence conflict	361	1	K → R in CAC80427. Ref.2
	Sequence conflict	361	1	K → R in CAC80428. Ref.2
	Sequence conflict	361	1	K → R in CAC80429. Ref.2
	Sequence conflict	361	1	K → R in CAC80430. Ref.2
	Sequence conflict	361	1	K → R in CAC80431. Ref.2
	Sequence conflict	365	1	H → L in AAF13493. Ref.1
	Sequence conflict	365	1	H → L in CAC80427. Ref.2
	Sequence conflict	365	1	H → L in CAC80428. Ref.2
	Sequence conflict	365	1	H → L in CAC80429. Ref.2
	Sequence conflict	365	1	H → L in CAC80430. Ref.2
	Sequence conflict	365	1	H → L in CAC80431. Ref.2
	Sequence conflict	443	1	N → D in AAF13493. Ref.1
	Sequence conflict	443	1	N → D in CAC80427. Ref.2
	Sequence conflict	443	1	N → D in CAC80428. Ref.2
	Sequence conflict	443	1	N → D in CAC80429. Ref.2
	Sequence conflict	443	1	N → D in CAC80430. Ref.2
	Sequence conflict	443	1	N → D in CAC80431. Ref.2
	Sequence conflict	487	1	Y → D in AAF13493. Ref.1
	Sequence conflict	487	1	Y → D in CAC80427. Ref.2
	Sequence conflict	487	1	Y → D in CAC80428. Ref.2
	Sequence conflict	487	1	Y → D in CAC80429. Ref.2
	Sequence conflict	487	1	Y → D in CAC80430. Ref.2
	Sequence conflict	487	1	Y → D in CAC80431. Ref.2
	Sequence conflict	506	1	A → S in AAF13493. Ref.1
	Sequence conflict	506	1	A → S in CAC80427. Ref.2
	Sequence conflict	506	1	A → S in CAC80428. Ref.2
	Sequence conflict	506	1	A → S in CAC80429. Ref.2
	Sequence conflict	506	1	A → S in CAC80430. Ref.2
	Sequence conflict	506	1	A → S in CAC80431. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Aio-1) [UniParc]. Last modified November 4, 2008. Version 2. Checksum: D1BB4A0A9A71B81A	FASTA	509	58,023
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 190 200 210 220 230 240 YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE 250 260 270 280 290 300 ARHIKAEMGS ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ 310 320 330 340 350 360 TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE MSNGAPQELE 370 380 390 400 410 420 KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI YQQNHMVLSR ARNGMPLLKE 430 440 450 460 470 480 VPRSYELLKP PPICPRDSVK VINKEGEVMD VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF 490 500 ECNMCGYRSH DRYEFSSHIA RGEHRALLK
	Isoform 2 (Aio-del4) [UniParc]. Checksum: 85DEFC62034A738F	FASTA	453	51,632
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TVEKPYKCEF CGRSYKQRSS LEEHKERCRT FLQSTDPGDT 190 200 210 220 230 240 ASAEARHIKA EMGSERALVL DRLASNVAKR KSSMPQKFIG EKRHCFDVNY NSSYMYEKES 250 260 270 280 290 300 ELIQTRMMDQ AINNAISYLG AEALRPLVQT PPAPTSEMVP VISSMYPIAL TRAEMSNGAP 310 320 330 340 350 360 QELEKKSIHL PEKSVPSERG LSPNNSGHDS TDTDSNHEER QNHIYQQNHM VLSRARNGMP 370 380 390 400 410 420 LLKEVPRSYE LLKPPPICPR DSVKVINKEG EVMDVYRCDH CRVLFLDYVM FTIHMGCHGF 430 440 450 RDPFECNMCG YRSHDRYEFS SHIARGEHRA LLK
	Isoform 3 (Aio-del5) [UniParc]. Checksum: 18998C960E99C78A	FASTA	470	53,401
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 190 200 210 220 230 240 YACQRRDALT GHLRTHSASA EARHIKAEMG SERALVLDRL ASNVAKRKSS MPQKFIGEKR 250 260 270 280 290 300 HCFDVNYNSS YMYEKESELI QTRMMDQAIN NAISYLGAEA LRPLVQTPPA PTSEMVPVIS 310 320 330 340 350 360 SMYPIALTRA EMSNGAPQEL EKKSIHLPEK SVPSERGLSP NNSGHDSTDT DSNHEERQNH 370 380 390 400 410 420 IYQQNHMVLS RARNGMPLLK EVPRSYELLK PPPICPRDSV KVINKEGEVM DVYRCDHCRV 430 440 450 460 470 LFLDYVMFTI HMGCHGFRDP FECNMCGYRS HDRYEFSSHI ARGEHRALLK
	Isoform 4 (Aio-del6) [UniParc]. Checksum: 979F785A6B93BC6E	FASTA	470	53,743
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 190 200 210 220 230 240 YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTGEKR 250 260 270 280 290 300 HCFDVNYNSS YMYEKESELI QTRMMDQAIN NAISYLGAEA LRPLVQTPPA PTSEMVPVIS 310 320 330 340 350 360 SMYPIALTRA EMSNGAPQEL EKKSIHLPEK SVPSERGLSP NNSGHDSTDT DSNHEERQNH 370 380 390 400 410 420 IYQQNHMVLS RARNGMPLLK EVPRSYELLK PPPICPRDSV KVINKEGEVM DVYRCDHCRV 430 440 450 460 470 LFLDYVMFTI HMGCHGFRDP FECNMCGYRS HDRYEFSSHI ARGEHRALLK
	Isoform 5 (Aio-del4,5) [UniParc]. Checksum: DD4C8159B8417844	FASTA	414	47,010
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TASAEARHIK AEMGSERALV LDRLASNVAK RKSSMPQKFI 190 200 210 220 230 240 GEKRHCFDVN YNSSYMYEKE SELIQTRMMD QAINNAISYL GAEALRPLVQ TPPAPTSEMV 250 260 270 280 290 300 PVISSMYPIA LTRAEMSNGA PQELEKKSIH LPEKSVPSER GLSPNNSGHD STDTDSNHEE 310 320 330 340 350 360 RQNHIYQQNH MVLSRARNGM PLLKEVPRSY ELLKPPPICP RDSVKVINKE GEVMDVYRCD 370 380 390 400 410 HCRVLFLDYV MFTIHMGCHG FRDPFECNMC GYRSHDRYEF SSHIARGEHR ALLK
	Isoform 6 (Aio-del5,6) [UniParc]. Checksum: 540F806622DCBB56	FASTA	431	49,121
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 190 200 210 220 230 240 YACQRRDALT GHLRTHSGEK RHCFDVNYNS SYMYEKESEL IQTRMMDQAI NNAISYLGAE 250 260 270 280 290 300 ALRPLVQTPP APTSEMVPVI SSMYPIALTR AEMSNGAPQE LEKKSIHLPE KSVPSERGLS 310 320 330 340 350 360 PNNSGHDSTD TDSNHEERQN HIYQQNHMVL SRARNGMPLL KEVPRSYELL KPPPICPRDS 370 380 390 400 410 420 VKVINKEGEV MDVYRCDHCR VLFLDYVMFT IHMGCHGFRD PFECNMCGYR SHDRYEFSSH 430 IARGEHRALL K
	Isoform 7 (Aio-del2) [UniParc]. Checksum: 00694E8BA86FFEC5	FASTA	475	54,417
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA DDSMKVKDEY SERDENVLKS EPMGNAEEPE IPYSYSREYN 70 80 90 100 110 120 EYENIKLERH VVSFDSSRPT SGKMNCDVCG LSCISFNVLM VHKRSHTGER PFQCNQCGAS 130 140 150 160 170 180 FTQKGNLLRH IKLHTGEKPF KCHLCNYACQ RRDALTGHLR THSVEKPYKC EFCGRSYKQR 190 200 210 220 230 240 SSLEEHKERC RTFLQSTDPG DTASAEARHI KAEMGSERAL VLDRLASNVA KRKSSMPQKF 250 260 270 280 290 300 IGEKRHCFDV NYNSSYMYEK ESELIQTRMM DQAINNAISY LGAEALRPLV QTPPAPTSEM 310 320 330 340 350 360 VPVISSMYPI ALTRAEMSNG APQELEKKSI HLPEKSVPSE RGLSPNNSGH DSTDTDSNHE 370 380 390 400 410 420 ERQNHIYQQN HMVLSRARNG MPLLKEVPRS YELLKPPPIC PRDSVKVINK EGEVMDVYRC 430 440 450 460 470 DHCRVLFLDY VMFTIHMGCH GFRDPFECNM CGYRSHDRYE FSSHIARGEH RALLK
	Isoform 8 (Aio-del2,5) [UniParc]. Checksum: 965862E0B68846E0	FASTA	436	49,795
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA DDSMKVKDEY SERDENVLKS EPMGNAEEPE IPYSYSREYN 70 80 90 100 110 120 EYENIKLERH VVSFDSSRPT SGKMNCDVCG LSCISFNVLM VHKRSHTGER PFQCNQCGAS 130 140 150 160 170 180 FTQKGNLLRH IKLHTGEKPF KCHLCNYACQ RRDALTGHLR THSASAEARH IKAEMGSERA 190 200 210 220 230 240 LVLDRLASNV AKRKSSMPQK FIGEKRHCFD VNYNSSYMYE KESELIQTRM MDQAINNAIS 250 260 270 280 290 300 YLGAEALRPL VQTPPAPTSE MVPVISSMYP IALTRAEMSN GAPQELEKKS IHLPEKSVPS 310 320 330 340 350 360 ERGLSPNNSG HDSTDTDSNH EERQNHIYQQ NHMVLSRARN GMPLLKEVPR SYELLKPPPI 370 380 390 400 410 420 CPRDSVKVIN KEGEVMDVYR CDHCRVLFLD YVMFTIHMGC HGFRDPFECN MCGYRSHDRY 430 EFSSHIARGE HRALLK
	Isoform 9 (Aio-del3) [UniParc]. Checksum: 42308DF0B90BA4DF	FASTA	422	47,958
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGGERPFQ 70 80 90 100 110 120 CNQCGASFTQ KGNLLRHIKL HTGEKPFKCH LCNYACQRRD ALTGHLRTHS VEKPYKCEFC 130 140 150 160 170 180 GRSYKQRSSL EEHKERCRTF LQSTDPGDTA SAEARHIKAE MGSERALVLD RLASNVAKRK 190 200 210 220 230 240 SSMPQKFIGE KRHCFDVNYN SSYMYEKESE LIQTRMMDQA INNAISYLGA EALRPLVQTP 250 260 270 280 290 300 PAPTSEMVPV ISSMYPIALT RAEMSNGAPQ ELEKKSIHLP EKSVPSERGL SPNNSGHDST 310 320 330 340 350 360 DTDSNHEERQ NHIYQQNHMV LSRARNGMPL LKEVPRSYEL LKPPPICPRD SVKVINKEGE 370 380 390 400 410 420 VMDVYRCDHC RVLFLDYVMF TIHMGCHGFR DPFECNMCGY RSHDRYEFSS HIARGEHRAL LK
	Isoform 10 (Aio-del3,4) [UniParc]. Checksum: A4E825FDBF860925	FASTA	366	41,567
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGVEKPYK 70 80 90 100 110 120 CEFCGRSYKQ RSSLEEHKER CRTFLQSTDP GDTASAEARH IKAEMGSERA LVLDRLASNV 130 140 150 160 170 180 AKRKSSMPQK FIGEKRHCFD VNYNSSYMYE KESELIQTRM MDQAINNAIS YLGAEALRPL 190 200 210 220 230 240 VQTPPAPTSE MVPVISSMYP IALTRAEMSN GAPQELEKKS IHLPEKSVPS ERGLSPNNSG 250 260 270 280 290 300 HDSTDTDSNH EERQNHIYQQ NHMVLSRARN GMPLLKEVPR SYELLKPPPI CPRDSVKVIN 310 320 330 340 350 360 KEGEVMDVYR CDHCRVLFLD YVMFTIHMGC HGFRDPFECN MCGYRSHDRY EFSSHIARGE HRALLK
	Isoform 11 (Aio-del3,4,5) [UniParc]. Checksum: D90D2FFBA757F7B9	FASTA	327	36,945
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGASAEAR 70 80 90 100 110 120 HIKAEMGSER ALVLDRLASN VAKRKSSMPQ KFIGEKRHCF DVNYNSSYMY EKESELIQTR 130 140 150 160 170 180 MMDQAINNAI SYLGAEALRP LVQTPPAPTS EMVPVISSMY PIALTRAEMS NGAPQELEKK 190 200 210 220 230 240 SIHLPEKSVP SERGLSPNNS GHDSTDTDSN HEERQNHIYQ QNHMVLSRAR NGMPLLKEVP 250 260 270 280 290 300 RSYELLKPPP ICPRDSVKVI NKEGEVMDVY RCDHCRVLFL DYVMFTIHMG CHGFRDPFEC 310 320 NMCGYRSHDR YEFSSHIARG EHRALLK
	Isoform 12 (Aio-del3,4,5,6) [UniParc]. Checksum: ECA1D13AA6312CAB	FASTA	288	32,665
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGGEKRHC 70 80 90 100 110 120 FDVNYNSSYM YEKESELIQT RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSM 130 140 150 160 170 180 YPIALTRAEM SNGAPQELEK KSIHLPEKSV PSERGLSPNN SGHDSTDTDS NHEERQNHIY 190 200 210 220 230 240 QQNHMVLSRA RNGMPLLKEV PRSYELLKPP PICPRDSVKV INKEGEVMDV YRCDHCRVLF 250 260 270 280 LDYVMFTIHM GCHGFRDPFE CNMCGYRSHD RYEFSSHIAR GEHRALLK
	Isoform 13 (Aio-del4,5,6) [UniParc]. Checksum: 7AE6138A9450AAF5	FASTA	375	42,730
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGEKRHCFDV NYNSSYMYEK ESELIQTRMM DQAINNAISY 190 200 210 220 230 240 LGAEALRPLV QTPPAPTSEM VPVISSMYPI ALTRAEMSNG APQELEKKSI HLPEKSVPSE 250 260 270 280 290 300 RGLSPNNSGH DSTDTDSNHE ERQNHIYQQN HMVLSRARNG MPLLKEVPRS YELLKPPPIC 310 320 330 340 350 360 PRDSVKVINK EGEVMDVYRC DHCRVLFLDY VMFTIHMGCH GFRDPFECNM CGYRSHDRYE 370 FSSHIARGEH RALLK
	Isoform 14 (Aio-1-5a) [UniParc]. Checksum: F12F178DB5F635A3	FASTA	263	30,029
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN 190 200 210 220 230 240 YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTGTGW 250 260 GWVELSHLGI RLQDLNVPWC RLH
	Isoform 15 (Aio-del4-5a) [UniParc]. Checksum: 8C2E108E02143972	FASTA	453	51,880
	10 20 30 40 50 60 MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV 70 80 90 100 110 120 KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC 130 140 150 160 170 180 DVCGLSCISF NVLMVHKRSH TVEKPYKCEF CGRSYKQRSS LEEHKERCRT FLQSTDPGDT 190 200 210 220 230 240 GTGWGWVELS HLGIRLQDLN VPWCRLHAKR KSSMPQKFIG EKRHCFDVNY NSSYMYEKES 250 260 270 280 290 300 ELIQTRMMDQ AINNAISYLG AEALRPLVQT PPAPTSEMVP VISSMYPIAL TRAEMSNGAP 310 320 330 340 350 360 QELEKKSIHL PEKSVPSERG LSPNNSGHDS TDTDSNHEER QNHIYQQNHM VLSRARNGMP 370 380 390 400 410 420 LLKEVPRSYE LLKPPPICPR DSVKVINKEG EVMDVYRCDH CRVLFLDYVM FTIHMGCHGF 430 440 450 RDPFECNMCG YRSHDRYEFS SHIARGEHRA LLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping." Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M. Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lymphoma.
[2]	"Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene." Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E., Riikonen P., Hammarstrom L., Pelkonen J., Lassila O. Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING. Tissue: Lymphoid tissue.
[3]	"Combinatorial effects of splice variants modulate function of Aiolos." Caballero R., Setien F., Lopez-Serra L., Boix-Chornet M., Fraga M.F., Ropero S., Megias D., Alaminos M., Sanchez-Tapia E.M., Montoya M.C., Esteller M., Gonzalez-Sarmiento R., Ballestar E. J. Cell Sci. 120:2619-2630(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph.
[6]	"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization." Romero F., Martinez-A C., Camonis J., Rebollo A. EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[7]	"Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities." Perdomo J., Holmes M., Chong B., Crossley M. J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IKZF4 AND IKZF5.
[8]	"The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis." Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A. J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BCL21L, PHOSPHORYLATION.
[9]	"Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells." Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L., Quintana F.J. Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FOXP3, INDUCTION.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLN-277.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF129512 mRNA. Translation: AAF13493.1. AJ292565 mRNA. Translation: CAC80427.1. AJ292566 mRNA. Translation: CAC80428.1. AJ292567 mRNA. Translation: CAC80429.1. AJ292568 mRNA. Translation: CAC80430.1. AJ292569 mRNA. Translation: CAC80431.1. AY377973 mRNA. Translation: AAR84584.1. AY377975 mRNA. Translation: AAR84586.1. AY377976 mRNA. Translation: AAR84587.1. AY377977 mRNA. Translation: AAR84588.1. AY377978 mRNA. Translation: AAR84589.1. AY377979 mRNA. Translation: AAR84590.1. AY377980 mRNA. Translation: AAR84591.1. AY377981 mRNA. Translation: AAR84592.1. AY377982 mRNA. Translation: AAR84593.1. CH471152 Genomic DNA. Translation: EAW60606.1. BC032707 mRNA. Translation: AAH32707.1.
IPI	IPI00018923. IPI00215852. IPI00215853. IPI00215854. IPI00215855. IPI00215856. IPI00337565. IPI00465194. IPI00465195. IPI00465197. IPI00465198. IPI00797818. IPI00883727. IPI01017985. IPI01018345.
RefSeq	NP_001244337.1. NM_001257408.1. NP_001244338.1. NM_001257409.1. NP_001244339.1. NM_001257410.1. NP_001244340.1. NM_001257411.1. NP_001244341.1. NM_001257412.1. NP_001244342.1. NM_001257413.1. NP_001244343.1. NM_001257414.1. NP_036613.2. NM_012481.4. NP_899051.1. NM_183228.2. NP_899052.1. NM_183229.2. NP_899053.1. NM_183230.2. NP_899054.1. NM_183231.2. NP_899055.1. NM_183232.2.
UniGene	Hs.371680.
3D structure databases
ProteinModelPortal	Q9UKT9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKT9. 6 interactions.
MINT	MINT-1454530.
STRING	9606.ENSP00000418684.
PTM databases
PhosphoSite	Q9UKT9.
Polymorphism databases
DMDM	212276437.
Proteomic databases
PaxDb	Q9UKT9.
PRIDE	Q9UKT9.
Protocols and materials databases
DNASU	22806.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293068; ENSP00000462791; ENSG00000161405. ENST00000346243; ENSP00000341977; ENSG00000161405. ENST00000346872; ENSP00000344544; ENSG00000161405. ENST00000348427; ENSP00000463505; ENSG00000161405. ENST00000350532; ENSP00000344471; ENSG00000161405. ENST00000351680; ENSP00000345622; ENSG00000161405. ENST00000377944; ENSP00000367179; ENSG00000161405. ENST00000377945; ENSP00000367180; ENSG00000161405. ENST00000377952; ENSP00000367188; ENSG00000161405. ENST00000377958; ENSP00000367194; ENSG00000161405. ENST00000394189; ENSP00000377741; ENSG00000161405. ENST00000439016; ENSP00000403027; ENSG00000161405. ENST00000439167; ENSP00000403776; ENSG00000161405. ENST00000467757; ENSP00000420463; ENSG00000161405. ENST00000535189; ENSP00000438972; ENSG00000161405.
GeneID	22806.
KEGG	hsa:22806.
UCSC	uc002hsu.3. human. uc002hsv.3. human. uc002hsw.3. human. uc002hsx.3. human. uc002hsy.3. human. uc002hsz.3. human. uc002hta.3. human. uc002htd.3. human. uc010cwd.3. human. uc010cwe.3. human. uc010cwf.3. human. uc010cwg.3. human. uc010cwh.3. human.
Organism-specific databases
CTD	22806.
GeneCards	GC17M037913.
HGNC	HGNC:13178. IKZF3.
HPA	CAB017105. HPA024377.
MIM	606221. gene.
neXtProt	NX_Q9UKT9.
PharmGKB	PA37750.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274203.
HOVERGEN	HBG060914.
InParanoid	Q9UKT9.
KO	K09220.
OMA	IQTRMMD.
OrthoDB	EOG4D52XF.
PhylomeDB	Q9UKT9.
Enzyme and pathway databases
Pathway_Interaction_DB	il2_1pathway. IL2-mediated signaling events.
Gene expression databases
ArrayExpress	Q9UKT9.
Bgee	Q9UKT9.
CleanEx	HS_IKZF3.
Genevestigator	Q9UKT9.
GermOnline	ENSG00000161405. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IKZF3. human.
GenomeRNAi	22806.
NextBio	43164.
SOURCE	Search...

Entry information

Entry name

IKZF3_HUMAN

Accession

Primary (citable) accession number: Q9UKT9
Secondary accession number(s): Q69BL6 , Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.