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Protein

F-box/WD repeat-containing protein 2

Gene

FBXW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: ProtInc

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • protein ubiquitination Source: GOC
  • proteolysis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
SignaLinkiQ9UKT8.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2
Protein MD6
Gene namesi
Name:FBXW2
Synonyms:FBW2, FWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13608. FBXW2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28052.

Polymorphism and mutation databases

BioMutaiFBXW2.
DMDMi60416443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454F-box/WD repeat-containing protein 2PRO_0000050988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UKT8.
MaxQBiQ9UKT8.
PaxDbiQ9UKT8.
PRIDEiQ9UKT8.

PTM databases

iPTMnetiQ9UKT8.
PhosphoSiteiQ9UKT8.

Expressioni

Gene expression databases

BgeeiQ9UKT8.
CleanExiHS_FBXW2.
ExpressionAtlasiQ9UKT8. baseline and differential.
GenevisibleiQ9UKT8. HS.

Organism-specific databases

HPAiHPA067878.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC37Q165432EBI-914727,EBI-295634
HSP90AB1P082382EBI-914727,EBI-352572
NUDCQ9Y2662EBI-914727,EBI-357298
SKP1P632083EBI-914727,EBI-307486

Protein-protein interaction databases

BioGridi117603. 20 interactions.
DIPiDIP-37972N.
IntActiQ9UKT8. 14 interactions.
MINTiMINT-108586.
STRINGi9606.ENSP00000363036.

Structurei

3D structure databases

ProteinModelPortaliQ9UKT8.
SMRiQ9UKT8. Positions 40-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 10148F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati139 – 17537WD 1Add
BLAST
Repeati179 – 21335WD 2Add
BLAST
Repeati217 – 25539WD 3Add
BLAST
Repeati259 – 30648WD 4Add
BLAST
Repeati313 – 35240WD 5Add
BLAST
Repeati364 – 40340WD 6Add
BLAST
Repeati410 – 45243WD 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQD2. Eukaryota.
ENOG410XP3H. LUCA.
GeneTreeiENSGT00760000119106.
HOVERGENiHBG051593.
InParanoidiQ9UKT8.
KOiK10261.
OMAiQTHTCAT.
OrthoDBiEOG7PS1F6.
PhylomeDBiQ9UKT8.
TreeFamiTF333134.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET
60 70 80 90 100
LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT
110 120 130 140 150
ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR
160 170 180 190 200
VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV
210 220 230 240 250
TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYNDELDI LVSGSADFTV
260 270 280 290 300
KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
310 320 330 340 350
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW
360 370 380 390 400
DFASYDILRV IKTPEIANLA LLGFGDIFAL LFDNRYLYIM DLRTESLISR
410 420 430 440 450
WPLPEYRKSK RGSSFLAGEA SWLNGLDGHN DTGLVFATSM PDHSIHLVLW

KEHG
Length:454
Mass (Da):51,512
Last modified:March 1, 2005 - v2
Checksum:iF182998504BF2734
GO
Isoform 2 (identifier: Q9UKT8-2) [UniParc]FASTAAdd to basket

Also known as: MD6b

The sequence of this isoform differs from the canonical sequence as follows:
     164-228: Missing.

Show »
Length:389
Mass (Da):44,466
Checksum:i88120AFAA4DF5A51
GO

Sequence cautioni

The sequence AAF04465.1 differs from that shown. Reason: Frameshift at position 420. Curated
The sequence AAF13226.1 differs from that shown. Reason: Frameshift at position 420. Curated
The sequence AAP97276.1 differs from that shown. Reason: Frameshift at position 420. Curated
The sequence AAP97280.1 differs from that shown. Reason: Frameshift at position 420. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051E → G in BAB14051 (PubMed:14702039).Curated
Sequence conflicti408 – 4081K → E in AAF04465 (PubMed:10531037).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei164 – 22865Missing in isoform 2. 1 PublicationVSP_012983Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176698 mRNA. Translation: AAF13226.1. Frameshift.
AF145024 mRNA. Translation: AAP97276.1. Frameshift.
AF193594 mRNA. Translation: AAP97280.1. Frameshift.
AK022484 mRNA. Translation: BAB14051.1.
AK091860 mRNA. Translation: BAG52430.1.
AL161911 Genomic DNA. Translation: CAI95113.1.
BC018738 mRNA. Translation: AAH18738.1.
BC110334 mRNA. Translation: AAI10335.1.
AF129531 mRNA. Translation: AAF04465.1. Frameshift.
CCDSiCCDS43872.1. [Q9UKT8-1]
RefSeqiNP_036296.2. NM_012164.3. [Q9UKT8-1]
XP_005251967.1. XM_005251910.2. [Q9UKT8-1]
UniGeneiHs.494985.

Genome annotation databases

EnsembliENST00000608872; ENSP00000476369; ENSG00000119402. [Q9UKT8-1]
GeneIDi26190.
KEGGihsa:26190.
UCSCiuc004bkm.2. human. [Q9UKT8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176698 mRNA. Translation: AAF13226.1. Frameshift.
AF145024 mRNA. Translation: AAP97276.1. Frameshift.
AF193594 mRNA. Translation: AAP97280.1. Frameshift.
AK022484 mRNA. Translation: BAB14051.1.
AK091860 mRNA. Translation: BAG52430.1.
AL161911 Genomic DNA. Translation: CAI95113.1.
BC018738 mRNA. Translation: AAH18738.1.
BC110334 mRNA. Translation: AAI10335.1.
AF129531 mRNA. Translation: AAF04465.1. Frameshift.
CCDSiCCDS43872.1. [Q9UKT8-1]
RefSeqiNP_036296.2. NM_012164.3. [Q9UKT8-1]
XP_005251967.1. XM_005251910.2. [Q9UKT8-1]
UniGeneiHs.494985.

3D structure databases

ProteinModelPortaliQ9UKT8.
SMRiQ9UKT8. Positions 40-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117603. 20 interactions.
DIPiDIP-37972N.
IntActiQ9UKT8. 14 interactions.
MINTiMINT-108586.
STRINGi9606.ENSP00000363036.

PTM databases

iPTMnetiQ9UKT8.
PhosphoSiteiQ9UKT8.

Polymorphism and mutation databases

BioMutaiFBXW2.
DMDMi60416443.

Proteomic databases

EPDiQ9UKT8.
MaxQBiQ9UKT8.
PaxDbiQ9UKT8.
PRIDEiQ9UKT8.

Protocols and materials databases

DNASUi26190.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000608872; ENSP00000476369; ENSG00000119402. [Q9UKT8-1]
GeneIDi26190.
KEGGihsa:26190.
UCSCiuc004bkm.2. human. [Q9UKT8-1]

Organism-specific databases

CTDi26190.
GeneCardsiFBXW2.
HGNCiHGNC:13608. FBXW2.
HPAiHPA067878.
MIMi609071. gene.
neXtProtiNX_Q9UKT8.
PharmGKBiPA28052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQD2. Eukaryota.
ENOG410XP3H. LUCA.
GeneTreeiENSGT00760000119106.
HOVERGENiHBG051593.
InParanoidiQ9UKT8.
KOiK10261.
OMAiQTHTCAT.
OrthoDBiEOG7PS1F6.
PhylomeDBiQ9UKT8.
TreeFamiTF333134.

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
SignaLinkiQ9UKT8.

Miscellaneous databases

ChiTaRSiFBXW2. human.
GeneWikiiFBXW2.
GenomeRNAii26190.
PROiQ9UKT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKT8.
CleanExiHS_FBXW2.
ExpressionAtlasiQ9UKT8. baseline and differential.
GenevisibleiQ9UKT8. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and characterization of human MD6 protein."
    Zhou Y., Yu L., Zhao S.Y.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Mammary gland.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-422 (ISOFORM 1), INTERACTION WITH SKP1 AND CUL1.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFBXW2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT8
Secondary accession number(s): B3KRL8
, Q4VXH2, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.