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Protein

F-box/WD repeat-containing protein 2

Gene

FBXW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • post-translational protein modification Source: Reactome
  • protein polyubiquitination Source: Reactome
  • proteolysis Source: ProtInc

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9UKT8

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2
Protein MD6
Gene namesi
Name:FBXW2
Synonyms:FBW2, FWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119402.16
HGNCiHGNC:13608 FBXW2
MIMi609071 gene
neXtProtiNX_Q9UKT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119402
PharmGKBiPA28052

Polymorphism and mutation databases

BioMutaiFBXW2
DMDMi60416443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509881 – 454F-box/WD repeat-containing protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UKT8
PaxDbiQ9UKT8
PeptideAtlasiQ9UKT8
PRIDEiQ9UKT8

PTM databases

iPTMnetiQ9UKT8
PhosphoSitePlusiQ9UKT8

Expressioni

Gene expression databases

BgeeiENSG00000119402
CleanExiHS_FBXW2
ExpressionAtlasiQ9UKT8 baseline and differential
GenevisibleiQ9UKT8 HS

Organism-specific databases

HPAiHPA067878

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117603, 22 interactors
CORUMiQ9UKT8
DIPiDIP-37972N
IntActiQ9UKT8, 14 interactors
MINTiQ9UKT8
STRINGi9606.ENSP00000363036

Structurei

3D structure databases

ProteinModelPortaliQ9UKT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 101F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati139 – 175WD 1Add BLAST37
Repeati179 – 213WD 2Add BLAST35
Repeati217 – 255WD 3Add BLAST39
Repeati259 – 306WD 4Add BLAST48
Repeati313 – 352WD 5Add BLAST40
Repeati364 – 403WD 6Add BLAST40
Repeati410 – 452WD 7Add BLAST43

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00910000144137
HOVERGENiHBG051593
InParanoidiQ9UKT8
KOiK10261
OMAiQTHTCAT
OrthoDBiEOG091G060Z
PhylomeDBiQ9UKT8
TreeFamiTF333134

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET
60 70 80 90 100
LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT
110 120 130 140 150
ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR
160 170 180 190 200
VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV
210 220 230 240 250
TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYNDELDI LVSGSADFTV
260 270 280 290 300
KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
310 320 330 340 350
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW
360 370 380 390 400
DFASYDILRV IKTPEIANLA LLGFGDIFAL LFDNRYLYIM DLRTESLISR
410 420 430 440 450
WPLPEYRKSK RGSSFLAGEA SWLNGLDGHN DTGLVFATSM PDHSIHLVLW

KEHG
Length:454
Mass (Da):51,512
Last modified:March 1, 2005 - v2
Checksum:iF182998504BF2734
GO
Isoform 2 (identifier: Q9UKT8-2) [UniParc]FASTAAdd to basket
Also known as: MD6b

The sequence of this isoform differs from the canonical sequence as follows:
     164-228: Missing.

Show »
Length:389
Mass (Da):44,466
Checksum:i88120AFAA4DF5A51
GO

Sequence cautioni

The sequence AAF04465 differs from that shown. Reason: Frameshift at position 420.Curated
The sequence AAF13226 differs from that shown. Reason: Frameshift at position 420.Curated
The sequence AAP97276 differs from that shown. Reason: Frameshift at position 420.Curated
The sequence AAP97280 differs from that shown. Reason: Frameshift at position 420.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405E → G in BAB14051 (PubMed:14702039).Curated1
Sequence conflicti408K → E in AAF04465 (PubMed:10531037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012983164 – 228Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176698 mRNA Translation: AAF13226.1 Frameshift.
AF145024 mRNA Translation: AAP97276.1 Frameshift.
AF193594 mRNA Translation: AAP97280.1 Frameshift.
AK022484 mRNA Translation: BAB14051.1
AK091860 mRNA Translation: BAG52430.1
AL161911 Genomic DNA No translation available.
BC018738 mRNA Translation: AAH18738.1
BC110334 mRNA Translation: AAI10335.1
AF129531 mRNA Translation: AAF04465.1 Frameshift.
CCDSiCCDS43872.1 [Q9UKT8-1]
RefSeqiNP_036296.2, NM_012164.3 [Q9UKT8-1]
XP_005251967.1, XM_005251910.3 [Q9UKT8-1]
XP_016870104.1, XM_017014615.1 [Q9UKT8-2]
UniGeneiHs.494985

Genome annotation databases

EnsembliENST00000608872; ENSP00000476369; ENSG00000119402 [Q9UKT8-1]
GeneIDi26190
KEGGihsa:26190
UCSCiuc004bkm.2 human [Q9UKT8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBXW2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT8
Secondary accession number(s): B3KRL8
, Q4VXH2, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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