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Protein

F-box/LRR-repeat protein 21

Gene

FBXL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 21
Alternative name(s):
F-box and leucine-rich repeat protein 21
F-box and leucine-rich repeat protein 3B
F-box/LRR-repeat protein 3B
Gene namesi
Name:FBXL21
Synonyms:FBL21, FBL3, FBXL3B, FBXL3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13600. FBXL21.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

  • Note: Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity).By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
  • SCF ubiquitin ligase complex Source: UniProtKB
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28023.

Polymorphism and mutation databases

BioMutaiFBXL21.
DMDMi37537865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434F-box/LRR-repeat protein 21PRO_0000119873Add
BLAST

Proteomic databases

PRIDEiQ9UKT6.

PTM databases

iPTMnetiQ9UKT6.
PhosphoSiteiQ9UKT6.

Expressioni

Organism-specific databases

HPAiHPA060297.

Interactioni

Subunit structurei

Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.By similarity1 Publication

Protein-protein interaction databases

BioGridi117614. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UKT6.
SMRiQ9UKT6. Positions 41-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 8547F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati158 – 18730LRR 1Add
BLAST
Repeati190 – 21324LRR 2Add
BLAST
Repeati214 – 23926LRR 3Add
BLAST
Repeati242 – 26524LRR 4Add
BLAST
Repeati322 – 34726LRR 5Add
BLAST
Repeati349 – 37426LRR 6Add
BLAST
Repeati375 – 40026LRR 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG051587.
InParanoidiQ9UKT6.
KOiK10287.
PhylomeDBiQ9UKT6.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRNSLSVEN KIVQLSGAAK QPKVGFYSSL NQTHTHTVLL DWGSLPHHVV
60 70 80 90 100
LQIFQYLPLL DRACASSVCR RWNEVFHISD LWRKFEFELN QSATSSFKST
110 120 130 140 150
HPDLIQQIIK KHFAHLQYVS FKVDSSAESA EAACDILSQL VNCSIQTLGL
160 170 180 190 200
ISTAKPSFMN VSESHFVSAL TVVFINSKSL SSIKIEDTPV DDPSLKILVA
210 220 230 240 250
NNSDTLRLPK MSSCPHVSSD GILCVADRCQ GLRELALNYY ILTDELFLAL
260 270 280 290 300
SSETHVNLEH LRIDVVSENP GQIKFHAVKK HSWDALIKHS PRVNVVMHFF
310 320 330 340 350
LYEEEFETFF KEETPVTHLY FGRSVSKVVL GRVGLNCPRL IELVVCANDL
360 370 380 390 400
QPLDNELICI AEHCTNLTAL GLSKCEVSCS AFIRFVRLCE RRLTQLSVME
410 420 430
EVLIPDEDYS LDEIHTEVSK YLGRVWFPDV MPLW
Length:434
Mass (Da):49,152
Last modified:May 1, 2000 - v1
Checksum:i1D35DB334899224E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761F → L.
Corresponds to variant rs7705168 [ dbSNP | Ensembl ].
VAR_049034
Natural varianti209 – 2091P → L.
Corresponds to variant rs40986 [ dbSNP | Ensembl ].
VAR_049035

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129533 mRNA. Translation: AAF04467.1.
AC002428 Genomic DNA. No translation available.
RefSeqiNP_036291.2. NM_012159.4.
UniGeneiHs.591275.

Genome annotation databases

GeneIDi26223.
KEGGihsa:26223.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129533 mRNA. Translation: AAF04467.1.
AC002428 Genomic DNA. No translation available.
RefSeqiNP_036291.2. NM_012159.4.
UniGeneiHs.591275.

3D structure databases

ProteinModelPortaliQ9UKT6.
SMRiQ9UKT6. Positions 41-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117614. 6 interactions.

PTM databases

iPTMnetiQ9UKT6.
PhosphoSiteiQ9UKT6.

Polymorphism and mutation databases

BioMutaiFBXL21.
DMDMi37537865.

Proteomic databases

PRIDEiQ9UKT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26223.
KEGGihsa:26223.

Organism-specific databases

CTDi26223.
GeneCardsiFBXL21.
HGNCiHGNC:13600. FBXL21.
HPAiHPA060297.
MIMi609087. gene.
neXtProtiNX_Q9UKT6.
PharmGKBiPA28023.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051587.
InParanoidiQ9UKT6.
KOiK10287.
PhylomeDBiQ9UKT6.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii26223.
NextBioi48365.
PROiQ9UKT6.
SOURCEiSearch...

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SKP1 AND CUL1.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFXL21_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The reference genome sequence codes for a stop codon instead of a Tyr in position 56, suggesting that this gene may be a pseudogene, at least in some part of the population.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.