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Protein

F-box/LRR-repeat protein 21

Gene

FBXL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).By similarity

Caution

The reference genome sequence codes for a stop codon instead of a Tyr in position 56, suggesting that this gene may be a pseudogene, at least in some part of the population.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiological rhythms, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 21
Alternative name(s):
F-box and leucine-rich repeat protein 21
F-box and leucine-rich repeat protein 3B
F-box/LRR-repeat protein 3B
Gene namesi
Name:FBXL21
Synonyms:FBL21, FBL3, FBXL3B, FBXL3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13600 FBXL21
MIMi609087 gene
neXtProtiNX_Q9UKT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26223
PharmGKBiPA28023

Polymorphism and mutation databases

BioMutaiFBXL21
DMDMi37537865

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198731 – 434F-box/LRR-repeat protein 21Add BLAST434

Proteomic databases

PeptideAtlasiQ9UKT6
PRIDEiQ9UKT6

PTM databases

iPTMnetiQ9UKT6
PhosphoSitePlusiQ9UKT6

Expressioni

Organism-specific databases

HPAiHPA053283

Interactioni

Subunit structurei

Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.By similarity1 Publication

Protein-protein interaction databases

BioGridi117614, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9UKT6
SMRiQ9UKT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 85F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati158 – 187LRR 1Add BLAST30
Repeati190 – 213LRR 2Add BLAST24
Repeati214 – 239LRR 3Add BLAST26
Repeati242 – 265LRR 4Add BLAST24
Repeati322 – 347LRR 5Add BLAST26
Repeati349 – 374LRR 6Add BLAST26
Repeati375 – 400LRR 7Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG051587
InParanoidiQ9UKT6
PhylomeDBiQ9UKT6

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRNSLSVEN KIVQLSGAAK QPKVGFYSSL NQTHTHTVLL DWGSLPHHVV
60 70 80 90 100
LQIFQYLPLL DRACASSVCR RWNEVFHISD LWRKFEFELN QSATSSFKST
110 120 130 140 150
HPDLIQQIIK KHFAHLQYVS FKVDSSAESA EAACDILSQL VNCSIQTLGL
160 170 180 190 200
ISTAKPSFMN VSESHFVSAL TVVFINSKSL SSIKIEDTPV DDPSLKILVA
210 220 230 240 250
NNSDTLRLPK MSSCPHVSSD GILCVADRCQ GLRELALNYY ILTDELFLAL
260 270 280 290 300
SSETHVNLEH LRIDVVSENP GQIKFHAVKK HSWDALIKHS PRVNVVMHFF
310 320 330 340 350
LYEEEFETFF KEETPVTHLY FGRSVSKVVL GRVGLNCPRL IELVVCANDL
360 370 380 390 400
QPLDNELICI AEHCTNLTAL GLSKCEVSCS AFIRFVRLCE RRLTQLSVME
410 420 430
EVLIPDEDYS LDEIHTEVSK YLGRVWFPDV MPLW
Length:434
Mass (Da):49,152
Last modified:May 1, 2000 - v1
Checksum:i1D35DB334899224E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04903476F → L. Corresponds to variant dbSNP:rs7705168Ensembl.1
Natural variantiVAR_049035209P → L. Corresponds to variant dbSNP:rs40986Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129533 mRNA Translation: AAF04467.1
AC002428 Genomic DNA No translation available.
RefSeqiNP_036291.2, NM_012159.4
UniGeneiHs.591275

Genome annotation databases

GeneIDi26223

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFXL21_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health