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Protein

Zinc finger protein Helios

Gene

IKZF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with Ikaros at centromeric heterochromatin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000030419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Helios
Alternative name(s):
Ikaros family zinc finger protein 2
Gene namesi
Name:IKZF2
Synonyms:HELIOS, ZNFN1A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13177. IKZF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22807.
OpenTargetsiENSG00000030419.
PharmGKBiPA162391927.

Polymorphism and mutation databases

BioMutaiIKZF2.
DMDMi116242509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470921 – 526Zinc finger protein HeliosAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKS7.
PaxDbiQ9UKS7.
PeptideAtlasiQ9UKS7.
PRIDEiQ9UKS7.

PTM databases

iPTMnetiQ9UKS7.
PhosphoSitePlusiQ9UKS7.

Miscellaneous databases

PMAP-CutDBQ9UKS7.

Expressioni

Gene expression databases

BgeeiENSG00000030419.
CleanExiHS_IKZF2.
ExpressionAtlasiQ9UKS7. baseline and differential.
GenevisibleiQ9UKS7. HS.

Organism-specific databases

HPAiHPA059142.

Interactioni

Subunit structurei

Interacts with IKZF4 AND IKZF5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AQP1P299723EBI-3893057,EBI-745213
CTBP2P565453EBI-3893057,EBI-741533
CTBP2Q8IY443EBI-3893057,EBI-10171902
Hoxa1P090223EBI-3893057,EBI-3957603From a different organism.
LONRF1Q17RB83EBI-3893057,EBI-2341787

Protein-protein interaction databases

BioGridi116485. 17 interactors.
IntActiQ9UKS7. 8 interactors.
STRINGi9606.ENSP00000410447.

Structurei

3D structure databases

ProteinModelPortaliQ9UKS7.
SMRiQ9UKS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiQ9UKS7.
KOiK09220.
PhylomeDBiQ9UKS7.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METEAIDGYI TCDNELSPER EHSNMAIDLT SSTPNGQHAS PSHMTSTNSV
60 70 80 90 100
KLEMQSDEEC DRKPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQELQ
110 120 130 140 150
GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT
160 170 180 190 200
QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY
210 220 230 240 250
CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI
260 270 280 290 300
MDNNISLVPF ERPAVIEKLT GNMGKRKSST PQKFVGEKLM RFSYPDIHFD
310 320 330 340 350
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHP PSTIAEVAPV
360 370 380 390 400
ISSAYSQVYH PNRIERPISR ETADSHENNM DGPISLIRPK SRPQEREASP
410 420 430 440 450
SNSCLDSTDS ESSHDDHQSY QGHPALNPKR KQSPAYMKED VKALDTTKAP
460 470 480 490 500
KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE
510 520
CNICGYRSQD RYEFSSHIVR GEHTFH
Length:526
Mass (Da):59,574
Last modified:October 17, 2006 - v2
Checksum:i949BE60E242BA8E8
GO
Isoform 2 (identifier: Q9UKS7-2) [UniParc]FASTAAdd to basket
Also known as: Helios 1v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.

Show »
Length:500
Mass (Da):56,765
Checksum:i544DCEABB3FA6B54
GO
Isoform 3 (identifier: Q9UKS7-3) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex3,4)

The sequence of this isoform differs from the canonical sequence as follows:
     137-148: ERPFHCNQCGAS → VAVVKTTFSEFC
     149-526: Missing.

Show »
Length:148
Mass (Da):16,247
Checksum:iAD853102487B5D43
GO
Isoform 4 (identifier: Q9UKS7-4) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex6)v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.
     238-285: Missing.

Show »
Length:452
Mass (Da):51,353
Checksum:i8FC57AD8EDEE1C03
GO
Isoform 5 (identifier: Q9UKS7-5) [UniParc]FASTAAdd to basket
Also known as: Helios 1+2a,2b, Helios 1v+2a, Helios del(Ex3)+2a

The sequence of this isoform differs from the canonical sequence as follows:
     47-52: TNSVKL → RSFSKI
     53-526: Missing.

Show »
Length:52
Mass (Da):5,725
Checksum:iB38751A5F5596CC3
GO
Isoform 6 (identifier: Q9UKS7-6) [UniParc]FASTAAdd to basket
Also known as: Helios 1+5a, Helios 1+5a,5b

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: VP → DS
     240-526: Missing.

Show »
Length:239
Mass (Da):26,802
Checksum:i4BC57CA088E5E06E
GO
Isoform 7 (identifier: Q9UKS7-7) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex5)v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.
     192-237: Missing.

Show »
Length:454
Mass (Da):51,424
Checksum:i5F535D03AAC3758D
GO
Isoform 8 (identifier: Q9UKS7-8) [UniParc]FASTAAdd to basket
Also known as: Helios S

The sequence of this isoform differs from the canonical sequence as follows:
     46-341: Missing.

Show »
Length:230
Mass (Da):25,979
Checksum:i887F78570777EE1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4E → D in AAF09441 (PubMed:10541817).Curated1
Sequence conflicti4E → D in AAS99855 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99857 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99858 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99859 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99860 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99861 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99862 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99863 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99864 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99865 (Ref. 2) Curated1
Sequence conflicti69D → N in AAF09441 (PubMed:10541817).Curated1
Sequence conflicti69D → N in AAS99857 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99859 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99861 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99862 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99863 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99864 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02822793N → S.Corresponds to variant rs16849611dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05534446 – 341Missing in isoform 8. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_05534547 – 52TNSVKL → RSFSKI in isoform 5. 1 Publication6
Alternative sequenceiVSP_05534653 – 526Missing in isoform 5. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_006845111 – 136Missing in isoform 2, isoform 4 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_055347137 – 148ERPFH…QCGAS → VAVVKTTFSEFC in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_055348149 – 526Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_055349192 – 237Missing in isoform 7. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_055350238 – 285Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_055351238 – 239VP → DS in isoform 6. 1 Publication2
Alternative sequenceiVSP_055352240 – 526Missing in isoform 6. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130863 mRNA. Translation: AAF09441.1.
AY587062 mRNA. Translation: AAS99855.1.
AY587064 mRNA. Translation: AAS99857.1.
AY587065 mRNA. Translation: AAS99858.1.
AY587066 mRNA. Translation: AAS99859.1.
AY587067 mRNA. Translation: AAS99860.1.
AY587068 mRNA. Translation: AAS99861.1.
AY587069 mRNA. Translation: AAS99862.1.
AY587070 mRNA. Translation: AAS99863.1.
AY587071 mRNA. Translation: AAS99864.1.
AY587072 mRNA. Translation: AAS99865.1.
BC028936 mRNA. Translation: AAH28936.1.
CCDSiCCDS2395.1. [Q9UKS7-1]
CCDS46507.1. [Q9UKS7-2]
RefSeqiNP_001072994.1. NM_001079526.1. [Q9UKS7-2]
NP_057344.2. NM_016260.2. [Q9UKS7-1]
XP_005246441.1. XM_005246384.4. [Q9UKS7-1]
XP_005246442.1. XM_005246385.3. [Q9UKS7-1]
XP_011509116.1. XM_011510814.2. [Q9UKS7-1]
XP_016859078.1. XM_017003589.1. [Q9UKS7-2]
XP_016859079.1. XM_017003590.1. [Q9UKS7-2]
UniGeneiHs.604950.

Genome annotation databases

EnsembliENST00000374319; ENSP00000363439; ENSG00000030419. [Q9UKS7-2]
ENST00000374326; ENSP00000363446; ENSG00000030419. [Q9UKS7-5]
ENST00000412444; ENSP00000413680; ENSG00000030419. [Q9UKS7-5]
ENST00000431520; ENSP00000396253; ENSG00000030419. [Q9UKS7-6]
ENST00000434687; ENSP00000412869; ENSG00000030419. [Q9UKS7-1]
ENST00000439848; ENSP00000389548; ENSG00000030419. [Q9UKS7-3]
ENST00000453575; ENSP00000411444; ENSG00000030419. [Q9UKS7-5]
GeneIDi22807.
KEGGihsa:22807.
UCSCiuc002ven.5. human. [Q9UKS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130863 mRNA. Translation: AAF09441.1.
AY587062 mRNA. Translation: AAS99855.1.
AY587064 mRNA. Translation: AAS99857.1.
AY587065 mRNA. Translation: AAS99858.1.
AY587066 mRNA. Translation: AAS99859.1.
AY587067 mRNA. Translation: AAS99860.1.
AY587068 mRNA. Translation: AAS99861.1.
AY587069 mRNA. Translation: AAS99862.1.
AY587070 mRNA. Translation: AAS99863.1.
AY587071 mRNA. Translation: AAS99864.1.
AY587072 mRNA. Translation: AAS99865.1.
BC028936 mRNA. Translation: AAH28936.1.
CCDSiCCDS2395.1. [Q9UKS7-1]
CCDS46507.1. [Q9UKS7-2]
RefSeqiNP_001072994.1. NM_001079526.1. [Q9UKS7-2]
NP_057344.2. NM_016260.2. [Q9UKS7-1]
XP_005246441.1. XM_005246384.4. [Q9UKS7-1]
XP_005246442.1. XM_005246385.3. [Q9UKS7-1]
XP_011509116.1. XM_011510814.2. [Q9UKS7-1]
XP_016859078.1. XM_017003589.1. [Q9UKS7-2]
XP_016859079.1. XM_017003590.1. [Q9UKS7-2]
UniGeneiHs.604950.

3D structure databases

ProteinModelPortaliQ9UKS7.
SMRiQ9UKS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116485. 17 interactors.
IntActiQ9UKS7. 8 interactors.
STRINGi9606.ENSP00000410447.

PTM databases

iPTMnetiQ9UKS7.
PhosphoSitePlusiQ9UKS7.

Polymorphism and mutation databases

BioMutaiIKZF2.
DMDMi116242509.

Proteomic databases

EPDiQ9UKS7.
PaxDbiQ9UKS7.
PeptideAtlasiQ9UKS7.
PRIDEiQ9UKS7.

Protocols and materials databases

DNASUi22807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374319; ENSP00000363439; ENSG00000030419. [Q9UKS7-2]
ENST00000374326; ENSP00000363446; ENSG00000030419. [Q9UKS7-5]
ENST00000412444; ENSP00000413680; ENSG00000030419. [Q9UKS7-5]
ENST00000431520; ENSP00000396253; ENSG00000030419. [Q9UKS7-6]
ENST00000434687; ENSP00000412869; ENSG00000030419. [Q9UKS7-1]
ENST00000439848; ENSP00000389548; ENSG00000030419. [Q9UKS7-3]
ENST00000453575; ENSP00000411444; ENSG00000030419. [Q9UKS7-5]
GeneIDi22807.
KEGGihsa:22807.
UCSCiuc002ven.5. human. [Q9UKS7-1]

Organism-specific databases

CTDi22807.
DisGeNETi22807.
GeneCardsiIKZF2.
HGNCiHGNC:13177. IKZF2.
HPAiHPA059142.
MIMi606234. gene.
neXtProtiNX_Q9UKS7.
OpenTargetsiENSG00000030419.
PharmGKBiPA162391927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiQ9UKS7.
KOiK09220.
PhylomeDBiQ9UKS7.
TreeFamiTF331189.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000030419-MONOMER.

Miscellaneous databases

ChiTaRSiIKZF2. human.
GeneWikiiIKZF2.
GenomeRNAii22807.
PMAP-CutDBQ9UKS7.
PROiQ9UKS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000030419.
CleanExiHS_IKZF2.
ExpressionAtlasiQ9UKS7. baseline and differential.
GenevisibleiQ9UKS7. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIKZF2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKS7
Secondary accession number(s): Q53YJ5
, Q6PQC5, Q6PQC6, Q6PQC7, Q6PQC8, Q6PQD0, Q6PQD1, Q8N6S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.