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Protein

Tetraspanin-16

Gene

TSPAN16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-16
Short name:
Tspan-16
Alternative name(s):
Tetraspanin TM4-B
Transmembrane 4 superfamily member 16
Gene namesi
Name:TSPAN16
Synonyms:TM4SF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30725. TSPAN16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 37ExtracellularSequence analysis3
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59CytoplasmicSequence analysis1
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 94ExtracellularSequence analysisAdd BLAST14
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 245CytoplasmicSequence analysisAdd BLAST130

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26526.
OpenTargetsiENSG00000130167.
PharmGKBiPA134989909.

Polymorphism and mutation databases

DMDMi11135364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192641 – 245Tetraspanin-16Add BLAST245

Proteomic databases

PaxDbiQ9UKR8.
PeptideAtlasiQ9UKR8.
PRIDEiQ9UKR8.

Expressioni

Tissue specificityi

Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues.

Gene expression databases

BgeeiENSG00000130167.
CleanExiHS_TSPAN16.
ExpressionAtlasiQ9UKR8. baseline and differential.
GenevisibleiQ9UKR8. HS.

Organism-specific databases

HPAiHPA041579.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319486.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00510000049338.
HOGENOMiHOG000148746.
HOVERGENiHBG072118.
InParanoidiQ9UKR8.
KOiK17357.
OMAiTTGHTYP.
OrthoDBiEOG091G0S1O.
PhylomeDBiQ9UKR8.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS
60 70 80 90 100
SAYLLHVGNL CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM
110 120 130 140 150
EVTAATVVLL FFPIVGDVAL EHTFVTLRKN YRGYNEPDDY STQWNLVMEK
160 170 180 190 200
LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC KSIGSVSCDG RDVSPNVIHQ
210 220 230 240
KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG LELLA
Length:245
Mass (Da):26,266
Last modified:May 1, 2000 - v1
Checksum:i064CDE593AB2B48C
GO
Isoform 2 (identifier: Q9UKR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:244
Mass (Da):26,058
Checksum:i181A30E73108AF59
GO
Isoform 3 (identifier: Q9UKR8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-114: Missing.
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:219
Mass (Da):23,339
Checksum:i6CBC140433B8550A
GO
Isoform 4 (identifier: Q9UKR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-160: LKCCGVNNYT → GLSKYFFSSL
     161-245: Missing.

Show »
Length:160
Mass (Da):17,205
Checksum:i5FD6572C76DBAB6F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05232953Y → D.Corresponds to variant rs34162761dbSNPEnsembl.1
Natural variantiVAR_05233055L → P.Corresponds to variant rs17001344dbSNPEnsembl.1
Natural variantiVAR_052331233S → C.Corresponds to variant rs318687dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05672390 – 114Missing in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_056724151 – 160LKCCGVNNYT → GLSKYFFSSL in isoform 4. 1 Publication10
Alternative sequenceiVSP_056725161 – 245Missing in isoform 4. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_056726230 – 245RWGSR…LELLA → LPGILATLLLFIKLG in isoform 2 and isoform 3. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133424 mRNA. Translation: AAF08363.1.
AC011472 Genomic DNA. No translation available.
AC024575 Genomic DNA. No translation available.
AC098777 Genomic DNA. No translation available.
BC029908 mRNA. Translation: AAH29908.1.
CCDSiCCDS12256.1. [Q9UKR8-1]
CCDS62549.1. [Q9UKR8-2]
CCDS62550.1. [Q9UKR8-3]
RefSeqiNP_001269438.1. NM_001282509.1. [Q9UKR8-2]
NP_001269439.1. NM_001282510.1. [Q9UKR8-3]
NP_036598.1. NM_012466.3. [Q9UKR8-1]
UniGeneiHs.579784.

Genome annotation databases

EnsembliENST00000316737; ENSP00000319486; ENSG00000130167. [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167. [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167. [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167. [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167. [Q9UKR8-4]
GeneIDi26526.
KEGGihsa:26526.
UCSCiuc002mqv.3. human. [Q9UKR8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133424 mRNA. Translation: AAF08363.1.
AC011472 Genomic DNA. No translation available.
AC024575 Genomic DNA. No translation available.
AC098777 Genomic DNA. No translation available.
BC029908 mRNA. Translation: AAH29908.1.
CCDSiCCDS12256.1. [Q9UKR8-1]
CCDS62549.1. [Q9UKR8-2]
CCDS62550.1. [Q9UKR8-3]
RefSeqiNP_001269438.1. NM_001282509.1. [Q9UKR8-2]
NP_001269439.1. NM_001282510.1. [Q9UKR8-3]
NP_036598.1. NM_012466.3. [Q9UKR8-1]
UniGeneiHs.579784.

3D structure databases

ProteinModelPortaliQ9UKR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319486.

Polymorphism and mutation databases

DMDMi11135364.

Proteomic databases

PaxDbiQ9UKR8.
PeptideAtlasiQ9UKR8.
PRIDEiQ9UKR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316737; ENSP00000319486; ENSG00000130167. [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167. [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167. [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167. [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167. [Q9UKR8-4]
GeneIDi26526.
KEGGihsa:26526.
UCSCiuc002mqv.3. human. [Q9UKR8-1]

Organism-specific databases

CTDi26526.
DisGeNETi26526.
GeneCardsiTSPAN16.
H-InvDBHIX0039973.
HGNCiHGNC:30725. TSPAN16.
HPAiHPA041579.
neXtProtiNX_Q9UKR8.
OpenTargetsiENSG00000130167.
PharmGKBiPA134989909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00510000049338.
HOGENOMiHOG000148746.
HOVERGENiHBG072118.
InParanoidiQ9UKR8.
KOiK17357.
OMAiTTGHTYP.
OrthoDBiEOG091G0S1O.
PhylomeDBiQ9UKR8.
TreeFamiTF316345.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130167-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN16. human.
GenomeRNAii26526.
PROiQ9UKR8.

Gene expression databases

BgeeiENSG00000130167.
CleanExiHS_TSPAN16.
ExpressionAtlasiQ9UKR8. baseline and differential.
GenevisibleiQ9UKR8. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN16_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR8
Secondary accession number(s): K7EN22, K7EPD8, Q8N6J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.