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Protein

Tetraspanin-16

Gene

TSPAN16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-16
Short name:
Tspan-16
Alternative name(s):
Tetraspanin TM4-B
Transmembrane 4 superfamily member 16
Gene namesi
Name:TSPAN16
Synonyms:TM4SF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30725. TSPAN16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 373ExtracellularSequence analysis
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Topological domaini59 – 591CytoplasmicSequence analysis
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9414ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Topological domaini116 – 245130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989909.

Polymorphism and mutation databases

DMDMi11135364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Tetraspanin-16PRO_0000219264Add
BLAST

Proteomic databases

PaxDbiQ9UKR8.
PRIDEiQ9UKR8.

Expressioni

Tissue specificityi

Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues.

Gene expression databases

BgeeiQ9UKR8.
CleanExiHS_TSPAN16.
ExpressionAtlasiQ9UKR8. baseline and differential.
GenevisibleiQ9UKR8. HS.

Organism-specific databases

HPAiHPA041579.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319486.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00510000049338.
HOGENOMiHOG000148746.
HOVERGENiHBG072118.
InParanoidiQ9UKR8.
KOiK17357.
OMAiTTGHTYP.
OrthoDBiEOG751NGC.
PhylomeDBiQ9UKR8.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS
60 70 80 90 100
SAYLLHVGNL CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM
110 120 130 140 150
EVTAATVVLL FFPIVGDVAL EHTFVTLRKN YRGYNEPDDY STQWNLVMEK
160 170 180 190 200
LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC KSIGSVSCDG RDVSPNVIHQ
210 220 230 240
KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG LELLA
Length:245
Mass (Da):26,266
Last modified:May 1, 2000 - v1
Checksum:i064CDE593AB2B48C
GO
Isoform 2 (identifier: Q9UKR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:244
Mass (Da):26,058
Checksum:i181A30E73108AF59
GO
Isoform 3 (identifier: Q9UKR8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-114: Missing.
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:219
Mass (Da):23,339
Checksum:i6CBC140433B8550A
GO
Isoform 4 (identifier: Q9UKR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-160: LKCCGVNNYT → GLSKYFFSSL
     161-245: Missing.

Show »
Length:160
Mass (Da):17,205
Checksum:i5FD6572C76DBAB6F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531Y → D.
Corresponds to variant rs34162761 [ dbSNP | Ensembl ].
VAR_052329
Natural varianti55 – 551L → P.
Corresponds to variant rs17001344 [ dbSNP | Ensembl ].
VAR_052330
Natural varianti233 – 2331S → C.
Corresponds to variant rs318687 [ dbSNP | Ensembl ].
VAR_052331

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 11425Missing in isoform 3. CuratedVSP_056723Add
BLAST
Alternative sequencei151 – 16010LKCCGVNNYT → GLSKYFFSSL in isoform 4. 1 PublicationVSP_056724
Alternative sequencei161 – 24585Missing in isoform 4. 1 PublicationVSP_056725Add
BLAST
Alternative sequencei230 – 24516RWGSR…LELLA → LPGILATLLLFIKLG in isoform 2 and isoform 3. CuratedVSP_056726Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133424 mRNA. Translation: AAF08363.1.
AC011472 Genomic DNA. No translation available.
AC024575 Genomic DNA. No translation available.
AC098777 Genomic DNA. No translation available.
BC029908 mRNA. Translation: AAH29908.1.
CCDSiCCDS12256.1. [Q9UKR8-1]
CCDS62549.1. [Q9UKR8-2]
CCDS62550.1. [Q9UKR8-3]
RefSeqiNP_001269438.1. NM_001282509.1. [Q9UKR8-2]
NP_001269439.1. NM_001282510.1. [Q9UKR8-3]
NP_036598.1. NM_012466.3. [Q9UKR8-1]
UniGeneiHs.579784.

Genome annotation databases

EnsembliENST00000316737; ENSP00000319486; ENSG00000130167. [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167. [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167. [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167. [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167. [Q9UKR8-4]
GeneIDi26526.
KEGGihsa:26526.
UCSCiuc002mqv.3. human. [Q9UKR8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133424 mRNA. Translation: AAF08363.1.
AC011472 Genomic DNA. No translation available.
AC024575 Genomic DNA. No translation available.
AC098777 Genomic DNA. No translation available.
BC029908 mRNA. Translation: AAH29908.1.
CCDSiCCDS12256.1. [Q9UKR8-1]
CCDS62549.1. [Q9UKR8-2]
CCDS62550.1. [Q9UKR8-3]
RefSeqiNP_001269438.1. NM_001282509.1. [Q9UKR8-2]
NP_001269439.1. NM_001282510.1. [Q9UKR8-3]
NP_036598.1. NM_012466.3. [Q9UKR8-1]
UniGeneiHs.579784.

3D structure databases

ProteinModelPortaliQ9UKR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319486.

Polymorphism and mutation databases

DMDMi11135364.

Proteomic databases

PaxDbiQ9UKR8.
PRIDEiQ9UKR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316737; ENSP00000319486; ENSG00000130167. [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167. [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167. [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167. [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167. [Q9UKR8-4]
GeneIDi26526.
KEGGihsa:26526.
UCSCiuc002mqv.3. human. [Q9UKR8-1]

Organism-specific databases

CTDi26526.
GeneCardsiTSPAN16.
H-InvDBHIX0039973.
HGNCiHGNC:30725. TSPAN16.
HPAiHPA041579.
neXtProtiNX_Q9UKR8.
PharmGKBiPA134989909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00510000049338.
HOGENOMiHOG000148746.
HOVERGENiHBG072118.
InParanoidiQ9UKR8.
KOiK17357.
OMAiTTGHTYP.
OrthoDBiEOG751NGC.
PhylomeDBiQ9UKR8.
TreeFamiTF316345.

Miscellaneous databases

ChiTaRSiTSPAN16. human.
GenomeRNAii26526.
PROiQ9UKR8.

Gene expression databases

BgeeiQ9UKR8.
CleanExiHS_TSPAN16.
ExpressionAtlasiQ9UKR8. baseline and differential.
GenevisibleiQ9UKR8. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular characterisation of a novel tetraspanin protein, TM4-B."
    Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
    Biochim. Biophys. Acta 1447:93-99(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.

Entry informationi

Entry nameiTSN16_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR8
Secondary accession number(s): K7EN22, K7EPD8, Q8N6J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.