ID ERG28_HUMAN Reviewed; 140 AA. AC Q9UKR5; Q9P093; Q9UPI2; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 179. DE RecName: Full=Ergosterol biosynthetic protein 28 homolog; GN Name=ERG28 {ECO:0000312|HGNC:HGNC:1187}; GN Synonyms=C14orf1 {ECO:0000312|HGNC:HGNC:1187}; GN ORFNames=AD-011, HSPC288, x0006; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10449901; DOI=10.1159/000015296; RA Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.; RT "A novel human gene, encoding a potential membrane protein conserved from RT yeast to man, is strongly expressed in testis and cancer cell lines."; RL Cytogenet. Cell Genet. 85:217-220(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Umbilical cord blood; RX PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for 300 RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor RT cells."; RL Genome Res. 10:1546-1560(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=11230166; DOI=10.1101/gr.gr1547r; RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., RA Klein M., Poustka A.; RT "Towards a catalog of human genes and proteins: sequencing and analysis of RT 500 novel complete protein coding human cDNAs."; RL Genome Res. 11:422-435(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Adrenal gland; RX PubMed=10931946; DOI=10.1073/pnas.160270997; RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., RA Chen M.-D., Chen J.-L.; RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis RT and full-length cDNA cloning."; RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- INTERACTION: CC Q9UKR5; P41181: AQP2; NbExp=3; IntAct=EBI-711490, EBI-12701138; CC Q9UKR5; Q92482: AQP3; NbExp=3; IntAct=EBI-711490, EBI-2808854; CC Q9UKR5; Q13520: AQP6; NbExp=3; IntAct=EBI-711490, EBI-13059134; CC Q9UKR5; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-711490, EBI-747430; CC Q9UKR5; P19397: CD53; NbExp=3; IntAct=EBI-711490, EBI-6657396; CC Q9UKR5; P04233-2: CD74; NbExp=3; IntAct=EBI-711490, EBI-12222807; CC Q9UKR5; O00501: CLDN5; NbExp=3; IntAct=EBI-711490, EBI-18400628; CC Q9UKR5; O95471: CLDN7; NbExp=3; IntAct=EBI-711490, EBI-740744; CC Q9UKR5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-711490, EBI-6942903; CC Q9UKR5; P49447: CYB561; NbExp=3; IntAct=EBI-711490, EBI-8646596; CC Q9UKR5; Q15125: EBP; NbExp=3; IntAct=EBI-711490, EBI-3915253; CC Q9UKR5; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-711490, EBI-18535450; CC Q9UKR5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-711490, EBI-711490; CC Q9UKR5; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-711490, EBI-18636064; CC Q9UKR5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-711490, EBI-18304435; CC Q9UKR5; O15552: FFAR2; NbExp=3; IntAct=EBI-711490, EBI-2833872; CC Q9UKR5; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-711490, EBI-12175685; CC Q9UKR5; O00258: GET1; NbExp=3; IntAct=EBI-711490, EBI-18908258; CC Q9UKR5; O95377: GJB5; NbExp=3; IntAct=EBI-711490, EBI-3909454; CC Q9UKR5; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-711490, EBI-13345167; CC Q9UKR5; O60883: GPR37L1; NbExp=3; IntAct=EBI-711490, EBI-2927498; CC Q9UKR5; Q8TED1: GPX8; NbExp=3; IntAct=EBI-711490, EBI-11721746; CC Q9UKR5; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-711490, EBI-1052304; CC Q9UKR5; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-711490, EBI-10266796; CC Q9UKR5; P48051: KCNJ6; NbExp=3; IntAct=EBI-711490, EBI-12017638; CC Q9UKR5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-711490, EBI-2820517; CC Q9UKR5; Q6UWN5: LYPD5; NbExp=3; IntAct=EBI-711490, EBI-17200970; CC Q9UKR5; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-711490, EBI-373355; CC Q9UKR5; O14880: MGST3; NbExp=3; IntAct=EBI-711490, EBI-724754; CC Q9UKR5; Q6IN84: MRM1; NbExp=3; IntAct=EBI-711490, EBI-5454865; CC Q9UKR5; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-711490, EBI-12806656; CC Q9UKR5; Q15800: MSMO1; NbExp=3; IntAct=EBI-711490, EBI-949102; CC Q9UKR5; Q96E29: MTERF3; NbExp=3; IntAct=EBI-711490, EBI-7825321; CC Q9UKR5; P15941-11: MUC1; NbExp=3; IntAct=EBI-711490, EBI-17263240; CC Q9UKR5; Q68D85: NCR3LG1; NbExp=3; IntAct=EBI-711490, EBI-14061804; CC Q9UKR5; O95167: NDUFA3; NbExp=3; IntAct=EBI-711490, EBI-1246131; CC Q9UKR5; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-711490, EBI-716063; CC Q9UKR5; Q3MUY2: PIGY; NbExp=3; IntAct=EBI-711490, EBI-3920125; CC Q9UKR5; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-711490, EBI-7545592; CC Q9UKR5; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-711490, EBI-10192441; CC Q9UKR5; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-711490, EBI-3920694; CC Q9UKR5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-711490, EBI-17247926; CC Q9UKR5; O95470: SGPL1; NbExp=3; IntAct=EBI-711490, EBI-1046170; CC Q9UKR5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-711490, EBI-18159983; CC Q9UKR5; Q9BXS9-3: SLC26A6; NbExp=3; IntAct=EBI-711490, EBI-12814225; CC Q9UKR5; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-711490, EBI-12811757; CC Q9UKR5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-711490, EBI-17280858; CC Q9UKR5; P27105: STOM; NbExp=3; IntAct=EBI-711490, EBI-1211440; CC Q9UKR5; Q16623: STX1A; NbExp=3; IntAct=EBI-711490, EBI-712466; CC Q9UKR5; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-711490, EBI-12947623; CC Q9UKR5; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-711490, EBI-6448756; CC Q9UKR5; Q96A25: TMEM106A; NbExp=3; IntAct=EBI-711490, EBI-3915978; CC Q9UKR5; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-711490, EBI-347385; CC Q9UKR5; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-711490, EBI-12345267; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; CC Multi-pass membrane protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Ubiquitous; strongly expressed in testis and some CC cancer cell lines. CC -!- SIMILARITY: Belongs to the ERG28 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD51373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAF28966.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF134159; AAD54079.1; -; mRNA. DR EMBL; AF161406; AAF28966.1; ALT_INIT; mRNA. DR EMBL; AL136658; CAB66593.1; -; mRNA. DR EMBL; AF136971; AAG49432.1; -; mRNA. DR EMBL; AC007182; AAD51373.1; ALT_SEQ; Genomic_DNA. DR EMBL; BC002444; AAH02444.1; -; mRNA. DR CCDS; CCDS9845.1; -. DR RefSeq; NP_009107.1; NM_007176.3. DR AlphaFoldDB; Q9UKR5; -. DR BioGRID; 116332; 136. DR IntAct; Q9UKR5; 118. DR MINT; Q9UKR5; -. DR STRING; 9606.ENSP00000256319; -. DR iPTMnet; Q9UKR5; -. DR PhosphoSitePlus; Q9UKR5; -. DR SwissPalm; Q9UKR5; -. DR BioMuta; ERG28; -. DR DMDM; 13431328; -. DR EPD; Q9UKR5; -. DR jPOST; Q9UKR5; -. DR MassIVE; Q9UKR5; -. DR MaxQB; Q9UKR5; -. DR PaxDb; 9606-ENSP00000256319; -. DR PeptideAtlas; Q9UKR5; -. DR ProteomicsDB; 84841; -. DR Pumba; Q9UKR5; -. DR TopDownProteomics; Q9UKR5; -. DR Antibodypedia; 51644; 67 antibodies from 15 providers. DR DNASU; 11161; -. DR Ensembl; ENST00000256319.7; ENSP00000256319.6; ENSG00000133935.7. DR GeneID; 11161; -. DR KEGG; hsa:11161; -. DR MANE-Select; ENST00000256319.7; ENSP00000256319.6; NM_007176.4; NP_009107.1. DR UCSC; uc001xrt.4; human. DR AGR; HGNC:1187; -. DR CTD; 11161; -. DR GeneCards; ERG28; -. DR HGNC; HGNC:1187; ERG28. DR HPA; ENSG00000133935; Low tissue specificity. DR MIM; 604576; gene. DR neXtProt; NX_Q9UKR5; -. DR OpenTargets; ENSG00000133935; -. DR PharmGKB; PA25513; -. DR VEuPathDB; HostDB:ENSG00000133935; -. DR eggNOG; KOG3455; Eukaryota. DR GeneTree; ENSGT00390000010925; -. DR HOGENOM; CLU_114589_2_0_1; -. DR InParanoid; Q9UKR5; -. DR OMA; NIAIWTY; -. DR OrthoDB; 5357024at2759; -. DR PhylomeDB; Q9UKR5; -. DR TreeFam; TF300191; -. DR PathwayCommons; Q9UKR5; -. DR SignaLink; Q9UKR5; -. DR BioGRID-ORCS; 11161; 16 hits in 1153 CRISPR screens. DR ChiTaRS; C14orf1; human. DR GeneWiki; C14orf1; -. DR GenomeRNAi; 11161; -. DR Pharos; Q9UKR5; Tbio. DR PRO; PR:Q9UKR5; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q9UKR5; Protein. DR Bgee; ENSG00000133935; Expressed in oocyte and 209 other cell types or tissues. DR ExpressionAtlas; Q9UKR5; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; NAS:UniProtKB. DR GO; GO:0030133; C:transport vesicle; IDA:LIFEdb. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central. DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. DR InterPro; IPR005352; Erg28. DR PANTHER; PTHR15451:SF19; ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG; 1. DR PANTHER; PTHR15451; ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED; 1. DR Pfam; PF03694; Erg28; 1. DR Genevisible; Q9UKR5; HS. PE 1: Evidence at protein level; KW Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; KW Reference proteome; Steroid biosynthesis; Steroid metabolism; KW Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. FT CHAIN 1..140 FT /note="Ergosterol biosynthetic protein 28 homolog" FT /id="PRO_0000193903" FT TRANSMEM 4..24 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 52..72 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 79..99 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 105..125 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 140 AA; 15864 MW; BDD089148BC60E50 CRC64; MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN //