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Q9UKR5

- ERG28_HUMAN

UniProt

Q9UKR5 - ERG28_HUMAN

Protein

Probable ergosterol biosynthetic protein 28

Gene

C14orf1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ergosterol biosynthetic protein 28
    Gene namesi
    Name:C14orf1
    ORF Names:AD-011, HSPC288, x0006
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1187. C14orf1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB
    3. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Probable ergosterol biosynthetic protein 28PRO_0000193903Add
    BLAST

    Proteomic databases

    MaxQBiQ9UKR5.
    PaxDbiQ9UKR5.
    PeptideAtlasiQ9UKR5.
    PRIDEiQ9UKR5.

    Expressioni

    Tissue specificityi

    Ubiquitous; strongly expressed in testis and some cancer cell lines.

    Gene expression databases

    ArrayExpressiQ9UKR5.
    BgeeiQ9UKR5.
    CleanExiHS_C14orf1.
    GenevestigatoriQ9UKR5.

    Organism-specific databases

    HPAiHPA043172.

    Interactioni

    Protein-protein interaction databases

    BioGridi116332. 63 interactions.
    IntActiQ9UKR5. 61 interactions.
    MINTiMINT-1376742.
    STRINGi9606.ENSP00000256319.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG28 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236838.
    HOGENOMiHOG000164093.
    HOVERGENiHBG051505.
    InParanoidiQ9UKR5.
    OMAiFIYKTAP.
    OrthoDBiEOG77T166.
    PhylomeDBiQ9UKR5.
    TreeFamiTF300191.

    Family and domain databases

    InterProiIPR005352. Erg28.
    [Graphical view]
    PfamiPF03694. Erg28. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UKR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA    50
    RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT 100
    AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN 140
    Length:140
    Mass (Da):15,864
    Last modified:May 1, 2000 - v1
    Checksum:iBDD089148BC60E50
    GO

    Sequence cautioni

    The sequence AAF28966.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAD51373.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134159 mRNA. Translation: AAD54079.1.
    AF161406 mRNA. Translation: AAF28966.1. Different initiation.
    AL136658 mRNA. Translation: CAB66593.1.
    AF136971 mRNA. Translation: AAG49432.1.
    AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
    BC002444 mRNA. Translation: AAH02444.1.
    CCDSiCCDS9845.1.
    RefSeqiNP_009107.1. NM_007176.3.
    UniGeneiHs.15106.

    Genome annotation databases

    EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
    GeneIDi11161.
    KEGGihsa:11161.
    UCSCiuc001xrt.3. human.

    Polymorphism databases

    DMDMi13431328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134159 mRNA. Translation: AAD54079.1 .
    AF161406 mRNA. Translation: AAF28966.1 . Different initiation.
    AL136658 mRNA. Translation: CAB66593.1 .
    AF136971 mRNA. Translation: AAG49432.1 .
    AC007182 Genomic DNA. Translation: AAD51373.1 . Sequence problems.
    BC002444 mRNA. Translation: AAH02444.1 .
    CCDSi CCDS9845.1.
    RefSeqi NP_009107.1. NM_007176.3.
    UniGenei Hs.15106.

    3D structure databases

    ProteinModelPortali Q9UKR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116332. 63 interactions.
    IntActi Q9UKR5. 61 interactions.
    MINTi MINT-1376742.
    STRINGi 9606.ENSP00000256319.

    Polymorphism databases

    DMDMi 13431328.

    Proteomic databases

    MaxQBi Q9UKR5.
    PaxDbi Q9UKR5.
    PeptideAtlasi Q9UKR5.
    PRIDEi Q9UKR5.

    Protocols and materials databases

    DNASUi 11161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256319 ; ENSP00000256319 ; ENSG00000133935 .
    GeneIDi 11161.
    KEGGi hsa:11161.
    UCSCi uc001xrt.3. human.

    Organism-specific databases

    CTDi 11161.
    GeneCardsi GC14M076116.
    HGNCi HGNC:1187. C14orf1.
    HPAi HPA043172.
    MIMi 604576. gene.
    neXtProti NX_Q9UKR5.
    PharmGKBi PA25513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236838.
    HOGENOMi HOG000164093.
    HOVERGENi HBG051505.
    InParanoidi Q9UKR5.
    OMAi FIYKTAP.
    OrthoDBi EOG77T166.
    PhylomeDBi Q9UKR5.
    TreeFami TF300191.

    Miscellaneous databases

    ChiTaRSi C14orf1. human.
    GeneWikii C14orf1.
    GenomeRNAii 11161.
    NextBioi 42459.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKR5.
    Bgeei Q9UKR5.
    CleanExi HS_C14orf1.
    Genevestigatori Q9UKR5.

    Family and domain databases

    InterProi IPR005352. Erg28.
    [Graphical view ]
    Pfami PF03694. Erg28. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines."
      Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.
      Cytogenet. Cell Genet. 85:217-220(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiERG28_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKR5
    Secondary accession number(s): Q9P093, Q9UPI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3