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Q9UKR5

- ERG28_HUMAN

UniProt

Q9UKR5 - ERG28_HUMAN

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Protein
Probable ergosterol biosynthetic protein 28
Gene
C14orf1, AD-011, HSPC288, x0006
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ergosterol biosynthetic protein 28
Gene namesi
Name:C14orf1
ORF Names:AD-011, HSPC288, x0006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1187. C14orf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Transmembranei79 – 9921Helical; Reviewed prediction
Add
BLAST
Transmembranei105 – 12521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
  3. transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Probable ergosterol biosynthetic protein 28
PRO_0000193903Add
BLAST

Proteomic databases

MaxQBiQ9UKR5.
PaxDbiQ9UKR5.
PeptideAtlasiQ9UKR5.
PRIDEiQ9UKR5.

Expressioni

Tissue specificityi

Ubiquitous; strongly expressed in testis and some cancer cell lines.

Gene expression databases

ArrayExpressiQ9UKR5.
BgeeiQ9UKR5.
CleanExiHS_C14orf1.
GenevestigatoriQ9UKR5.

Organism-specific databases

HPAiHPA043172.

Interactioni

Protein-protein interaction databases

BioGridi116332. 63 interactions.
IntActiQ9UKR5. 61 interactions.
MINTiMINT-1376742.
STRINGi9606.ENSP00000256319.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG28 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236838.
HOGENOMiHOG000164093.
HOVERGENiHBG051505.
InParanoidiQ9UKR5.
OMAiFIYKTAP.
OrthoDBiEOG77T166.
PhylomeDBiQ9UKR5.
TreeFamiTF300191.

Family and domain databases

InterProiIPR005352. Erg28.
[Graphical view]
PfamiPF03694. Erg28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKR5-1 [UniParc]FASTAAdd to Basket

« Hide

MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA    50
RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT 100
AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN 140
Length:140
Mass (Da):15,864
Last modified:May 1, 2000 - v1
Checksum:iBDD089148BC60E50
GO

Sequence cautioni

The sequence AAF28966.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAD51373.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
CCDSiCCDS9845.1.
RefSeqiNP_009107.1. NM_007176.3.
UniGeneiHs.15106.

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
GeneIDi11161.
KEGGihsa:11161.
UCSCiuc001xrt.3. human.

Polymorphism databases

DMDMi13431328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134159 mRNA. Translation: AAD54079.1 .
AF161406 mRNA. Translation: AAF28966.1 . Different initiation.
AL136658 mRNA. Translation: CAB66593.1 .
AF136971 mRNA. Translation: AAG49432.1 .
AC007182 Genomic DNA. Translation: AAD51373.1 . Sequence problems.
BC002444 mRNA. Translation: AAH02444.1 .
CCDSi CCDS9845.1.
RefSeqi NP_009107.1. NM_007176.3.
UniGenei Hs.15106.

3D structure databases

ProteinModelPortali Q9UKR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116332. 63 interactions.
IntActi Q9UKR5. 61 interactions.
MINTi MINT-1376742.
STRINGi 9606.ENSP00000256319.

Polymorphism databases

DMDMi 13431328.

Proteomic databases

MaxQBi Q9UKR5.
PaxDbi Q9UKR5.
PeptideAtlasi Q9UKR5.
PRIDEi Q9UKR5.

Protocols and materials databases

DNASUi 11161.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256319 ; ENSP00000256319 ; ENSG00000133935 .
GeneIDi 11161.
KEGGi hsa:11161.
UCSCi uc001xrt.3. human.

Organism-specific databases

CTDi 11161.
GeneCardsi GC14M076116.
HGNCi HGNC:1187. C14orf1.
HPAi HPA043172.
MIMi 604576. gene.
neXtProti NX_Q9UKR5.
PharmGKBi PA25513.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236838.
HOGENOMi HOG000164093.
HOVERGENi HBG051505.
InParanoidi Q9UKR5.
OMAi FIYKTAP.
OrthoDBi EOG77T166.
PhylomeDBi Q9UKR5.
TreeFami TF300191.

Miscellaneous databases

ChiTaRSi C14orf1. human.
GeneWikii C14orf1.
GenomeRNAii 11161.
NextBioi 42459.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKR5.
Bgeei Q9UKR5.
CleanExi HS_C14orf1.
Genevestigatori Q9UKR5.

Family and domain databases

InterProi IPR005352. Erg28.
[Graphical view ]
Pfami PF03694. Erg28. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines."
    Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.
    Cytogenet. Cell Genet. 85:217-220(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERG28_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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