Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable ergosterol biosynthetic protein 28

Gene

C14orf1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ergosterol biosynthetic protein 28
Gene namesi
Name:C14orf1
ORF Names:AD-011, HSPC288, x0006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1187. C14orf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25513.

Polymorphism and mutation databases

BioMutaiC14orf1.
DMDMi13431328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Probable ergosterol biosynthetic protein 28PRO_0000193903Add
BLAST

Proteomic databases

MaxQBiQ9UKR5.
PaxDbiQ9UKR5.
PeptideAtlasiQ9UKR5.
PRIDEiQ9UKR5.

Expressioni

Tissue specificityi

Ubiquitous; strongly expressed in testis and some cancer cell lines.

Gene expression databases

BgeeiQ9UKR5.
CleanExiHS_C14orf1.
ExpressionAtlasiQ9UKR5. baseline and differential.
GenevisibleiQ9UKR5. HS.

Organism-specific databases

HPAiHPA043172.

Interactioni

Protein-protein interaction databases

BioGridi116332. 65 interactions.
IntActiQ9UKR5. 61 interactions.
MINTiMINT-1376742.
STRINGi9606.ENSP00000256319.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG28 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236838.
GeneTreeiENSGT00390000010925.
HOGENOMiHOG000164093.
HOVERGENiHBG051505.
InParanoidiQ9UKR5.
OMAiVQSFRDH.
OrthoDBiEOG77T166.
PhylomeDBiQ9UKR5.
TreeFamiTF300191.

Family and domain databases

InterProiIPR005352. Erg28.
[Graphical view]
PfamiPF03694. Erg28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA
60 70 80 90 100
RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT
110 120 130 140
AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN
Length:140
Mass (Da):15,864
Last modified:May 1, 2000 - v1
Checksum:iBDD089148BC60E50
GO

Sequence cautioni

The sequence AAD51373.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAF28966.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
CCDSiCCDS9845.1.
RefSeqiNP_009107.1. NM_007176.3.
UniGeneiHs.15106.

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
GeneIDi11161.
KEGGihsa:11161.
UCSCiuc001xrt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
CCDSiCCDS9845.1.
RefSeqiNP_009107.1. NM_007176.3.
UniGeneiHs.15106.

3D structure databases

ProteinModelPortaliQ9UKR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116332. 65 interactions.
IntActiQ9UKR5. 61 interactions.
MINTiMINT-1376742.
STRINGi9606.ENSP00000256319.

Polymorphism and mutation databases

BioMutaiC14orf1.
DMDMi13431328.

Proteomic databases

MaxQBiQ9UKR5.
PaxDbiQ9UKR5.
PeptideAtlasiQ9UKR5.
PRIDEiQ9UKR5.

Protocols and materials databases

DNASUi11161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
GeneIDi11161.
KEGGihsa:11161.
UCSCiuc001xrt.3. human.

Organism-specific databases

CTDi11161.
GeneCardsiGC14M076116.
HGNCiHGNC:1187. C14orf1.
HPAiHPA043172.
MIMi604576. gene.
neXtProtiNX_Q9UKR5.
PharmGKBiPA25513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236838.
GeneTreeiENSGT00390000010925.
HOGENOMiHOG000164093.
HOVERGENiHBG051505.
InParanoidiQ9UKR5.
OMAiVQSFRDH.
OrthoDBiEOG77T166.
PhylomeDBiQ9UKR5.
TreeFamiTF300191.

Miscellaneous databases

ChiTaRSiC14orf1. human.
GeneWikiiC14orf1.
GenomeRNAii11161.
NextBioi42459.
PROiQ9UKR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKR5.
CleanExiHS_C14orf1.
ExpressionAtlasiQ9UKR5. baseline and differential.
GenevisibleiQ9UKR5. HS.

Family and domain databases

InterProiIPR005352. Erg28.
[Graphical view]
PfamiPF03694. Erg28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines."
    Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.
    Cytogenet. Cell Genet. 85:217-220(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERG28_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.