Q9UKR5 (ERG28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ergosterol biosynthetic protein 28

Gene names

Name:	C14orf1
ORF Names:	AD-011, HSPC288, x0006

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitous; strongly expressed in testis and some cancer cell lines.
Sequence similarities	Belongs to the ERG28 family.
Sequence caution	The sequence AAD51373.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAF28966.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB transport vesicle Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Probable ergosterol biosynthetic protein 28		PRO_0000193903
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9UKR5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BDD089148BC60E50	FASTA	140	15,864
	10 20 30 40 50 60 MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS 70 80 90 100 110 120 SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG 130 140 MLVGLRYLEV EPVSRQKKRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines." Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A. Cytogenet. Cell Genet. 85:217-220(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF134159 mRNA. Translation: AAD54079.1. AF161406 mRNA. Translation: AAF28966.1. Different initiation. AL136658 mRNA. Translation: CAB66593.1. AF136971 mRNA. Translation: AAG49432.1. AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems. BC002444 mRNA. Translation: AAH02444.1.
IPI	IPI00007730.
RefSeq	NP_009107.1. NM_007176.3.
UniGene	Hs.15106.
3D structure databases
ProteinModelPortal	Q9UKR5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKR5. 51 interactions.
MINT	MINT-1376742.
STRING	9606.ENSP00000256319.
Polymorphism databases
DMDM	13431328.
Proteomic databases
PaxDb	Q9UKR5.
PeptideAtlas	Q9UKR5.
PRIDE	Q9UKR5.
Protocols and materials databases
DNASU	11161.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256319; ENSP00000256319; ENSG00000133935.
GeneID	11161.
KEGG	hsa:11161.
UCSC	uc001xrt.3. human.
Organism-specific databases
CTD	11161.
GeneCards	GC14M076116.
HGNC	HGNC:1187. C14orf1.
HPA	HPA043172.
MIM	604576. gene.
neXtProt	NX_Q9UKR5.
PharmGKB	PA25513.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236838.
HOGENOM	HOG000164093.
HOVERGEN	HBG051505.
InParanoid	Q9UKR5.
OMA	ITLWTFF.
OrthoDB	EOG4STS5X.
PhylomeDB	Q9UKR5.
Gene expression databases
ArrayExpress	Q9UKR5.
Bgee	Q9UKR5.
CleanEx	HS_C14orf1.
Genevestigator	Q9UKR5.
GermOnline	ENSG00000133935. Homo sapiens.
Family and domain databases
InterPro	IPR005352. Erg28. [Graphical view]
Pfam	PF03694. Erg28. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C14orf1. human.
GenomeRNAi	11161.
NextBio	42459.
SOURCE	Search...

Entry information

Entry name

ERG28_HUMAN

Accession

Primary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.