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Protein

Probable ergosterol biosynthetic protein 28

Gene

C14orf1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111711-MONOMER.
ZFISH:ENSG00000133935-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ergosterol biosynthetic protein 28
Gene namesi
Name:C14orf1
ORF Names:AD-011, HSPC288, x0006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1187. C14orf1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB
  • transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11161.
OpenTargetsiENSG00000133935.
PharmGKBiPA25513.

Polymorphism and mutation databases

BioMutaiC14orf1.
DMDMi13431328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001939031 – 140Probable ergosterol biosynthetic protein 28Add BLAST140

Proteomic databases

EPDiQ9UKR5.
MaxQBiQ9UKR5.
PaxDbiQ9UKR5.
PeptideAtlasiQ9UKR5.
PRIDEiQ9UKR5.
TopDownProteomicsiQ9UKR5.

PTM databases

iPTMnetiQ9UKR5.
PhosphoSitePlusiQ9UKR5.

Expressioni

Tissue specificityi

Ubiquitous; strongly expressed in testis and some cancer cell lines.

Gene expression databases

BgeeiENSG00000133935.
CleanExiHS_C14orf1.
ExpressionAtlasiQ9UKR5. baseline and differential.
GenevisibleiQ9UKR5. HS.

Organism-specific databases

HPAiHPA043172.
HPA063568.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116332. 64 interactors.
IntActiQ9UKR5. 61 interactors.
MINTiMINT-1376742.
STRINGi9606.ENSP00000256319.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG28 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3455. Eukaryota.
ENOG4111J9X. LUCA.
GeneTreeiENSGT00390000010925.
HOGENOMiHOG000164093.
HOVERGENiHBG051505.
InParanoidiQ9UKR5.
OMAiVQSFRDH.
OrthoDBiEOG091G16N5.
PhylomeDBiQ9UKR5.
TreeFamiTF300191.

Family and domain databases

InterProiIPR005352. Erg28.
[Graphical view]
PfamiPF03694. Erg28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA
60 70 80 90 100
RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT
110 120 130 140
AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN
Length:140
Mass (Da):15,864
Last modified:May 1, 2000 - v1
Checksum:iBDD089148BC60E50
GO

Sequence cautioni

The sequence AAD51373 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF28966 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
CCDSiCCDS9845.1.
RefSeqiNP_009107.1. NM_007176.3.
UniGeneiHs.15106.

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
GeneIDi11161.
KEGGihsa:11161.
UCSCiuc001xrt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
CCDSiCCDS9845.1.
RefSeqiNP_009107.1. NM_007176.3.
UniGeneiHs.15106.

3D structure databases

ProteinModelPortaliQ9UKR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116332. 64 interactors.
IntActiQ9UKR5. 61 interactors.
MINTiMINT-1376742.
STRINGi9606.ENSP00000256319.

PTM databases

iPTMnetiQ9UKR5.
PhosphoSitePlusiQ9UKR5.

Polymorphism and mutation databases

BioMutaiC14orf1.
DMDMi13431328.

Proteomic databases

EPDiQ9UKR5.
MaxQBiQ9UKR5.
PaxDbiQ9UKR5.
PeptideAtlasiQ9UKR5.
PRIDEiQ9UKR5.
TopDownProteomicsiQ9UKR5.

Protocols and materials databases

DNASUi11161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935.
GeneIDi11161.
KEGGihsa:11161.
UCSCiuc001xrt.4. human.

Organism-specific databases

CTDi11161.
DisGeNETi11161.
GeneCardsiC14orf1.
HGNCiHGNC:1187. C14orf1.
HPAiHPA043172.
HPA063568.
MIMi604576. gene.
neXtProtiNX_Q9UKR5.
OpenTargetsiENSG00000133935.
PharmGKBiPA25513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3455. Eukaryota.
ENOG4111J9X. LUCA.
GeneTreeiENSGT00390000010925.
HOGENOMiHOG000164093.
HOVERGENiHBG051505.
InParanoidiQ9UKR5.
OMAiVQSFRDH.
OrthoDBiEOG091G16N5.
PhylomeDBiQ9UKR5.
TreeFamiTF300191.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111711-MONOMER.
ZFISH:ENSG00000133935-MONOMER.

Miscellaneous databases

ChiTaRSiC14orf1. human.
GeneWikiiC14orf1.
GenomeRNAii11161.
PROiQ9UKR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133935.
CleanExiHS_C14orf1.
ExpressionAtlasiQ9UKR5. baseline and differential.
GenevisibleiQ9UKR5. HS.

Family and domain databases

InterProiIPR005352. Erg28.
[Graphical view]
PfamiPF03694. Erg28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERG28_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.