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Q9UKR5 (ERG28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ergosterol biosynthetic protein 28
Gene names
Name:C14orf1
ORF Names:AD-011, HSPC288, x0006
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous; strongly expressed in testis and some cancer cell lines.

Sequence similarities

Belongs to the ERG28 family.

Sequence caution

The sequence AAD51373.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAF28966.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Probable ergosterol biosynthetic protein 28
PRO_0000193903

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane105 – 12521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UKR5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BDD089148BC60E50

FASTA14015,864
        10         20         30         40         50         60 
MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS 

        70         80         90        100        110        120 
SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG 

       130        140 
MLVGLRYLEV EPVSRQKKRN 

« Hide

References

« Hide 'large scale' references
[1]"A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines."
Veitia R.A., Ottolenghi C., Bissery M.-C., Fellous A.
Cytogenet. Cell Genet. 85:217-220(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adrenal gland.
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF134159 mRNA. Translation: AAD54079.1.
AF161406 mRNA. Translation: AAF28966.1. Different initiation.
AL136658 mRNA. Translation: CAB66593.1.
AF136971 mRNA. Translation: AAG49432.1.
AC007182 Genomic DNA. Translation: AAD51373.1. Sequence problems.
BC002444 mRNA. Translation: AAH02444.1.
RefSeqNP_009107.1. NM_007176.3.
UniGeneHs.15106.

3D structure databases

ProteinModelPortalQ9UKR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116332. 63 interactions.
IntActQ9UKR5. 61 interactions.
MINTMINT-1376742.
STRING9606.ENSP00000256319.

Polymorphism databases

DMDM13431328.

Proteomic databases

PaxDbQ9UKR5.
PeptideAtlasQ9UKR5.
PRIDEQ9UKR5.

Protocols and materials databases

DNASU11161.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256319; ENSP00000256319; ENSG00000133935.
GeneID11161.
KEGGhsa:11161.
UCSCuc001xrt.3. human.

Organism-specific databases

CTD11161.
GeneCardsGC14M076116.
HGNCHGNC:1187. C14orf1.
HPAHPA043172.
MIM604576. gene.
neXtProtNX_Q9UKR5.
PharmGKBPA25513.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG236838.
HOGENOMHOG000164093.
HOVERGENHBG051505.
InParanoidQ9UKR5.
OMAVQSFRDH.
OrthoDBEOG77T166.
PhylomeDBQ9UKR5.
TreeFamTF300191.

Gene expression databases

ArrayExpressQ9UKR5.
BgeeQ9UKR5.
CleanExHS_C14orf1.
GenevestigatorQ9UKR5.

Family and domain databases

InterProIPR005352. Erg28.
[Graphical view]
PfamPF03694. Erg28. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC14orf1. human.
GeneWikiC14orf1.
GenomeRNAi11161.
NextBio42459.
SOURCESearch...

Entry information

Entry nameERG28_HUMAN
AccessionPrimary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM