ID   KLK13_HUMAN             Reviewed;         277 AA.
AC   Q9UKR3; A7UNK6; Q9Y433;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   19-JAN-2010, entry version 84.
DE   RecName: Full=Kallikrein-13;
DE            EC=3.4.21.-;
DE   AltName: Full=Kallikrein-like protein 4;
DE            Short=KLK-L4;
DE   Flags: Precursor;
GN   Name=KLK13; Synonyms=KLKL4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20229789; PubMed=10766816; DOI=10.1074/jbc.275.16.11891;
RA   Yousef G.M., Chang A., Diamandis E.P.;
RT   "Identification and characterization of KLK-L4, a new kallikrein-like
RT   gene that appears to be down-regulated in breast cancer tissues.";
RL   J. Biol. Chem. 275:11891-11898(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17922479; DOI=10.1002/gepi.20185;
RA   Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F.,
RA   Hixson J.E.;
RT   "Understanding the accuracy of statistical haplotype inference with
RT   sequence data of known phase.";
RL   Genet. Epidemiol. 31:659-671(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169.
RC   TISSUE=Uterus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted (Probable).
CC   -!- TISSUE SPECIFICITY: Expressed in prostate, breast, testis and
CC       salivary gland.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Kallikrein
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   EMBL; AF135024; AAD26425.2; -; Genomic_DNA.
DR   EMBL; EU091477; ABU63130.1; -; Genomic_DNA.
DR   EMBL; AC011473; AAG23259.1; -; Genomic_DNA.
DR   EMBL; CH471135; EAW71979.1; -; Genomic_DNA.
DR   EMBL; BC069334; AAH69334.1; -; mRNA.
DR   EMBL; BC069543; AAH69543.1; -; mRNA.
DR   EMBL; AL050220; CAB43320.2; -; mRNA.
DR   IPI; IPI00007726; -.
DR   PIR; T08808; T08808.
DR   RefSeq; NP_056411.1; -.
DR   UniGene; Hs.165296; -.
DR   SMR; Q9UKR3; 37-263.
DR   STRING; Q9UKR3; -.
DR   MEROPS; S01.306; -.
DR   PRIDE; Q9UKR3; -.
DR   Ensembl; ENST00000156476; ENSP00000156476; ENSG00000167759; Homo sapiens.
DR   GeneID; 26085; -.
DR   KEGG; hsa:26085; -.
DR   UCSC; uc002pvn.1; human.
DR   CTD; 26085; -.
DR   GeneCards; GC19M056251; -.
DR   H-InvDB; HIX0015376; -.
DR   HGNC; HGNC:6361; KLK13.
DR   HPA; HPA019487; -.
DR   MIM; 605505; gene.
DR   PharmGKB; PA30150; -.
DR   HOGENOM; HBG755338; -.
DR   HOVERGEN; Q9UKR3; -.
DR   InParanoid; Q9UKR3; -.
DR   OMA; ELQSPVQ; -.
DR   OrthoDB; EOG9CZF11; -.
DR   PhylomeDB; Q9UKR3; -.
DR   BRENDA; 3.4.21.119; 247.
DR   NextBio; 48003; -.
DR   PMAP-CutDB; Q9UKR3; -.
DR   ArrayExpress; Q9UKR3; -.
DR   Bgee; Q9UKR3; -.
DR   CleanEx; HS_KLK13; -.
DR   Genevestigator; Q9UKR3; -.
DR   GermOnline; ENSG00000167759; Homo sapiens.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; NAS:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; NAS:UniProtKB.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR009003; Ser/Cys_Pept_Trypsin-like.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase;
KW   Polymorphism; Protease; Secreted; Serine protease; Signal.
FT   SIGNAL        1     16       Potential.
FT   CHAIN        17    277       Kallikrein-13.
FT                                /FTId=PRO_0000027957.
FT   DOMAIN       36    263       Peptidase S1.
FT   ACT_SITE     76     76       Charge relay system (By similarity).
FT   ACT_SITE    124    124       Charge relay system (By similarity).
FT   ACT_SITE    218    218       Charge relay system (By similarity).
FT   CARBOHYD     30     30       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    225    225       N-linked (GlcNAc...) (Potential).
FT   DISULFID     42    178       By similarity.
FT   DISULFID     61     77       By similarity.
FT   DISULFID    157    224       By similarity.
FT   DISULFID    189    203       By similarity.
FT   DISULFID    214    239       By similarity.
FT   VARIANT     109    109       H -> Y (in dbSNP:rs34089525).
FT                                /FTId=VAR_051857.
SQ   SEQUENCE   277 AA;  30570 MW;  BA8A9E8DCFB5D542 CRC64;
     MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ AALLVQGRLL
     CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLN
     HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN
     IQLRSDEECR QVYPGKITDN MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG
     QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ
//