Reviewed,
UniProtKB/Swiss-Prot Q9UKR3 (KLK13_HUMAN)
Last modified
January 19, 2010.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Kallikrein-13 EC=3.4.21.- Alternative name(s): Kallikrein-like protein 4 Short name=KLK-L4 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Secreted Probable. |
| Tissue specificity | Expressed in prostate, breast, testis and salivary gland. |
| Sequence similarities | Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Ref.1 Non-traceable author statement. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB serine-type endopeptidase activity Ref.1Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 16 | 16 | Potential | ||||||||
| Chain | 17 – 277 | 261 | Kallikrein-13 | PRO_0000027957 | |||||||
Regions | |||||||||||
| Domain | 36 – 263 | 228 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 76 | 1 | Charge relay system By similarity | ||||||||
| Active site | 124 | 1 | Charge relay system By similarity | ||||||||
| Active site | 218 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 30 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 225 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 42 ↔ 178 | By similarity | |||||||||
| Disulfide bond | 61 ↔ 77 | By similarity | |||||||||
| Disulfide bond | 157 ↔ 224 | By similarity | |||||||||
| Disulfide bond | 189 ↔ 203 | By similarity | |||||||||
| Disulfide bond | 214 ↔ 239 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 109 | 1 | H → Y: dbSNP rs34089525. | VAR_051857 | |||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF135024 Genomic DNA. Translation: AAD26425.2. EU091477 Genomic DNA. Translation: ABU63130.1. AC011473 Genomic DNA. Translation: AAG23259.1. CH471135 Genomic DNA. Translation: EAW71979.1. BC069334 mRNA. Translation: AAH69334.1. BC069543 mRNA. Translation: AAH69543.1. AL050220 mRNA. Translation: CAB43320.2. |
| IPI | IPI00007726. |
| PIR | T08808. |
| RefSeq | NP_056411.1. |
| UniGene | Hs.165296 |
3D structure databases | |
| SMR | Q9UKR3. Positions 37-263. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UKR3. |
Protein family/group databases | |
| MEROPS | S01.306. |
Proteomic databases | |
| PRIDE | Q9UKR3. |
Genome annotation databases | |
| Ensembl | ENST00000156476; ENSP00000156476; ENSG00000167759; Homo sapiens. [Genome view] |
| GeneID | 26085. |
| KEGG | hsa:26085. |
| UCSC | uc002pvn.1. human. |
Organism-specific databases | |
| CTD | 26085. |
| GeneCards | GC19M056251. |
| H-InvDB | HIX0015376. |
| HGNC | HGNC:6361. KLK13. |
| HPA | HPA019487. |
| MIM | 605505. gene. |
| PharmGKB | PA30150. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG755338. |
| HOVERGEN | Q9UKR3. |
| InParanoid | Q9UKR3. |
| OMA | ELQSPVQ. |
| OrthoDB | EOG9CZF11. |
| PhylomeDB | Q9UKR3. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.119. 247. |
Gene expression databases | |
| ArrayExpress | Q9UKR3. |
| Bgee | Q9UKR3. |
| CleanEx | HS_KLK13. |
| Genevestigator | Q9UKR3. |
| GermOnline | ENSG00000167759. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. IPR009003. Ser/Cys_Pept_Trypsin-like. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 48003. |
| PMAP-CutDB | Q9UKR3. |
| SOURCE | Search... |
Entry information
| Entry name | KLK13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UKR3 Secondary accession number(s): A7UNK6, Q9Y433 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


