Q9UKR3 (KLK13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kallikrein-13
EC=3.4.21.-

Alternative name(s):
Kallikrein-like protein 4
Short name=KLK-L4

Gene names

Name:	KLK13
Synonyms:	KLKL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Probable.
Tissue specificity	Expressed in prostate, breast, testis and salivary gland.
Sequence similarities	Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 12642628. Source: UniProtKB extracellular region Traceable author statement Ref.1. Source: UniProtKB
Molecular_function	serine-type endopeptidase activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 277	261	Kallikrein-13		PRO_0000027957
Regions
	Domain	36 – 263	228	Peptidase S1
Sites
	Active site	76	1	Charge relay system By similarity
	Active site	124	1	Charge relay system By similarity
	Active site	218	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 178		By similarity
	Disulfide bond	61 ↔ 77		By similarity
	Disulfide bond	157 ↔ 224		By similarity
	Disulfide bond	189 ↔ 203		By similarity
	Disulfide bond	214 ↔ 239		By similarity
Natural variations
	Natural variant	109	1	H → Y. Corresponds to variant rs34089525 [ dbSNP | Ensembl ].		VAR_051857

Sequences

	Sequence		Length	Mass (Da)
	Q9UKR3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BA8A9E8DCFB5D542	FASTA	277	30,570
	10 20 30 40 50 60 MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ AALLVQGRLL 70 80 90 100 110 120 CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLN 130 140 150 160 170 180 HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN 190 200 210 220 230 240 IQLRSDEECR QVYPGKITDN MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG 250 260 270 QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues." Yousef G.M., Chang A., Diamandis E.P. J. Biol. Chem. 275:11891-11898(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Understanding the accuracy of statistical haplotype inference with sequence data of known phase." Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F., Hixson J.E. Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF135024 Genomic DNA. Translation: AAD26425.2. EU091477 Genomic DNA. Translation: ABU63130.1. AC011473 Genomic DNA. Translation: AAG23259.1. CH471135 Genomic DNA. Translation: EAW71979.1. BC069334 mRNA. Translation: AAH69334.1. BC069543 mRNA. Translation: AAH69543.1. AL050220 mRNA. Translation: CAB43320.2.
IPI	IPI00007726.
PIR	T08808.
RefSeq	NP_056411.1. NM_015596.1.
UniGene	Hs.165296.
3D structure databases
ProteinModelPortal	Q9UKR3.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4721648.
STRING	9606.ENSP00000156476.
Protein family/group databases
MEROPS	S01.306.
PTM databases
PhosphoSite	Q9UKR3.
Polymorphism databases
DMDM	9296990.
Proteomic databases
PaxDb	Q9UKR3.
PRIDE	Q9UKR3.
Protocols and materials databases
DNASU	26085.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000595793; ENSP00000470555; ENSG00000167759.
GeneID	26085.
KEGG	hsa:26085.
UCSC	uc002pvn.3. human.
Organism-specific databases
CTD	26085.
GeneCards	GC19M051559.
HGNC	HGNC:6361. KLK13.
HPA	CAB025453. HPA019487.
MIM	605505. gene.
neXtProt	NX_Q9UKR3.
PharmGKB	PA30150.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000251820.
HOVERGEN	HBG013304.
InParanoid	Q9UKR3.
KO	K09463.
OMA	SQEYPKI.
OrthoDB	EOG4XKV7F.
PhylomeDB	Q9UKR3.
Enzyme and pathway databases
BRENDA	3.4.21.119. 2681.
Gene expression databases
ArrayExpress	Q9UKR3.
Bgee	Q9UKR3.
CleanEx	HS_KLK13.
Genevestigator	Q9UKR3.
GermOnline	ENSG00000167759. Homo sapiens.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9UKR3.
ChEMBL	CHEMBL4863.
GenomeRNAi	26085.
NextBio	48003.
PMAP-CutDB	Q9UKR3.
SOURCE	Search...

Entry information

Entry name

KLK13_HUMAN

Accession

Primary (citable) accession number: Q9UKR3
Secondary accession number(s): A7UNK6, Q9Y433

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.