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Protein

Kallikrein-13

Gene

KLK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Charge relay systemBy similarity1
Active sitei124Charge relay systemBy similarity1
Active sitei218Charge relay systemBy similarity1

GO - Molecular functioni

  • hydrolase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.119 2681
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.306

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-13 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 4
Short name:
KLK-L4
Gene namesi
Name:KLK13
Synonyms:KLKL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167759.12
HGNCiHGNC:6361 KLK13
MIMi605505 gene
neXtProtiNX_Q9UKR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26085
OpenTargetsiENSG00000167759
PharmGKBiPA30150

Chemistry databases

ChEMBLiCHEMBL4863

Polymorphism and mutation databases

BioMutaiKLK13
DMDMi9296990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002795717 – 277Kallikrein-13Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 178PROSITE-ProRule annotation
Disulfide bondi61 ↔ 77PROSITE-ProRule annotation
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi189 ↔ 203PROSITE-ProRule annotation
Disulfide bondi214 ↔ 239PROSITE-ProRule annotation
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR3
PeptideAtlasiQ9UKR3
PRIDEiQ9UKR3

PTM databases

iPTMnetiQ9UKR3
PhosphoSitePlusiQ9UKR3

Miscellaneous databases

PMAP-CutDBiQ9UKR3

Expressioni

Tissue specificityi

Expressed in prostate, breast, testis and salivary gland.

Gene expression databases

BgeeiENSG00000167759
CleanExiHS_KLK13
ExpressionAtlasiQ9UKR3 baseline and differential
GenevisibleiQ9UKR3 HS

Organism-specific databases

HPAiHPA062136

Interactioni

Protein-protein interaction databases

BioGridi117538, 5 interactors
STRINGi9606.ENSP00000470555

Structurei

3D structure databases

ProteinModelPortaliQ9UKR3
SMRiQ9UKR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 263Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9UKR3
KOiK09463
OMAiLWIRETI
OrthoDBiEOG091G0DF7
PhylomeDBiQ9UKR3
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ
60 70 80 90 100
AALLVQGRLL CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV
110 120 130 140 150
REVVHSIPHP EYRRSPTHLN HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR
160 170 180 190 200
LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN IQLRSDEECR QVYPGKITDN
210 220 230 240 250
MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG QPDRPGVYTR
260 270
VSRYVLWIRE TIRKYETQQQ KWLKGPQ
Length:277
Mass (Da):30,570
Last modified:May 1, 2000 - v1
Checksum:iBA8A9E8DCFB5D542
GO
Isoform 2 (identifier: Q9UKR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-169: Missing.

Show »
Length:125
Mass (Da):13,986
Checksum:iD510DC802F4A6243
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051857109H → Y. Corresponds to variant dbSNP:rs34089525Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05663118 – 169Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135024 Genomic DNA Translation: AAD26425.2
AB108823 mRNA Translation: BAC75825.1
EU091477 Genomic DNA Translation: ABU63130.1
AC011473 Genomic DNA Translation: AAG23259.1
CH471135 Genomic DNA Translation: EAW71979.1
BC069334 mRNA Translation: AAH69334.1
BC069543 mRNA Translation: AAH69543.1
AL050220 mRNA Translation: CAB43320.2
CCDSiCCDS12822.1 [Q9UKR3-1]
PIRiT08808
RefSeqiNP_001335107.1, NM_001348178.1 [Q9UKR3-2]
NP_056411.1, NM_015596.2 [Q9UKR3-1]
UniGeneiHs.165296

Genome annotation databases

EnsembliENST00000335422; ENSP00000334079; ENSG00000167759 [Q9UKR3-2]
ENST00000595793; ENSP00000470555; ENSG00000167759 [Q9UKR3-1]
GeneIDi26085
KEGGihsa:26085
UCSCiuc002pvn.4 human [Q9UKR3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLK13_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR3
Secondary accession number(s): A7UNK6, Q86VI8, Q9Y433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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