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Protein

Kallikrein-13

Gene

KLK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Charge relay systemBy similarity
Active sitei124 – 1241Charge relay systemBy similarity
Active sitei218 – 2181Charge relay systemBy similarity

GO - Molecular functioni

  • hydrolase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  • protein processing Source: GO_Central
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.119. 2681.
ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiS01.306.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-13 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 4
Short name:
KLK-L4
Gene namesi
Name:KLK13
Synonyms:KLKL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6361. KLK13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30150.

Polymorphism and mutation databases

BioMutaiKLK13.
DMDMi9296990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 277261Kallikrein-13PRO_0000027957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi42 ↔ 178PROSITE-ProRule annotation
Disulfide bondi61 ↔ 77PROSITE-ProRule annotation
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi189 ↔ 203PROSITE-ProRule annotation
Disulfide bondi214 ↔ 239PROSITE-ProRule annotation
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR3.
PRIDEiQ9UKR3.

PTM databases

PhosphoSiteiQ9UKR3.

Miscellaneous databases

PMAP-CutDBQ9UKR3.

Expressioni

Tissue specificityi

Expressed in prostate, breast, testis and salivary gland.

Gene expression databases

BgeeiQ9UKR3.
CleanExiHS_KLK13.
ExpressionAtlasiQ9UKR3. baseline and differential.
GenevisibleiQ9UKR3. HS.

Organism-specific databases

HPAiCAB025453.
HPA019487.

Interactioni

Protein-protein interaction databases

BioGridi117538. 4 interactions.
MINTiMINT-4721648.
STRINGi9606.ENSP00000470555.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR3.
SMRiQ9UKR3. Positions 39-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 263228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR3.
KOiK09463.
OMAiLWIRETI.
PhylomeDBiQ9UKR3.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ
60 70 80 90 100
AALLVQGRLL CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV
110 120 130 140 150
REVVHSIPHP EYRRSPTHLN HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR
160 170 180 190 200
LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN IQLRSDEECR QVYPGKITDN
210 220 230 240 250
MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG QPDRPGVYTR
260 270
VSRYVLWIRE TIRKYETQQQ KWLKGPQ
Length:277
Mass (Da):30,570
Last modified:May 1, 2000 - v1
Checksum:iBA8A9E8DCFB5D542
GO
Isoform 2 (identifier: Q9UKR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-169: Missing.

Show »
Length:125
Mass (Da):13,986
Checksum:iD510DC802F4A6243
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091H → Y.
Corresponds to variant rs34089525 [ dbSNP | Ensembl ].
VAR_051857

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 169152Missing in isoform 2. 1 PublicationVSP_056631Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135024 Genomic DNA. Translation: AAD26425.2.
AB108823 mRNA. Translation: BAC75825.1.
EU091477 Genomic DNA. Translation: ABU63130.1.
AC011473 Genomic DNA. Translation: AAG23259.1.
CH471135 Genomic DNA. Translation: EAW71979.1.
BC069334 mRNA. Translation: AAH69334.1.
BC069543 mRNA. Translation: AAH69543.1.
AL050220 mRNA. Translation: CAB43320.2.
CCDSiCCDS12822.1. [Q9UKR3-1]
PIRiT08808.
RefSeqiNP_056411.1. NM_015596.1. [Q9UKR3-1]
UniGeneiHs.165296.

Genome annotation databases

EnsembliENST00000335422; ENSP00000334079; ENSG00000167759. [Q9UKR3-2]
ENST00000595793; ENSP00000470555; ENSG00000167759. [Q9UKR3-1]
GeneIDi26085.
KEGGihsa:26085.
UCSCiuc002pvn.3. human. [Q9UKR3-1]
uc010eoo.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135024 Genomic DNA. Translation: AAD26425.2.
AB108823 mRNA. Translation: BAC75825.1.
EU091477 Genomic DNA. Translation: ABU63130.1.
AC011473 Genomic DNA. Translation: AAG23259.1.
CH471135 Genomic DNA. Translation: EAW71979.1.
BC069334 mRNA. Translation: AAH69334.1.
BC069543 mRNA. Translation: AAH69543.1.
AL050220 mRNA. Translation: CAB43320.2.
CCDSiCCDS12822.1. [Q9UKR3-1]
PIRiT08808.
RefSeqiNP_056411.1. NM_015596.1. [Q9UKR3-1]
UniGeneiHs.165296.

3D structure databases

ProteinModelPortaliQ9UKR3.
SMRiQ9UKR3. Positions 39-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117538. 4 interactions.
MINTiMINT-4721648.
STRINGi9606.ENSP00000470555.

Chemistry

ChEMBLiCHEMBL4863.

Protein family/group databases

MEROPSiS01.306.

PTM databases

PhosphoSiteiQ9UKR3.

Polymorphism and mutation databases

BioMutaiKLK13.
DMDMi9296990.

Proteomic databases

PaxDbiQ9UKR3.
PRIDEiQ9UKR3.

Protocols and materials databases

DNASUi26085.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335422; ENSP00000334079; ENSG00000167759. [Q9UKR3-2]
ENST00000595793; ENSP00000470555; ENSG00000167759. [Q9UKR3-1]
GeneIDi26085.
KEGGihsa:26085.
UCSCiuc002pvn.3. human. [Q9UKR3-1]
uc010eoo.3. human.

Organism-specific databases

CTDi26085.
GeneCardsiGC19M051559.
HGNCiHGNC:6361. KLK13.
HPAiCAB025453.
HPA019487.
MIMi605505. gene.
neXtProtiNX_Q9UKR3.
PharmGKBiPA30150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR3.
KOiK09463.
OMAiLWIRETI.
PhylomeDBiQ9UKR3.
TreeFamiTF331065.

Enzyme and pathway databases

BRENDAi3.4.21.119. 2681.
ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

GeneWikiiKLK13.
GenomeRNAii26085.
NextBioi48003.
PMAP-CutDBQ9UKR3.
PROiQ9UKR3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKR3.
CleanExiHS_KLK13.
ExpressionAtlasiQ9UKR3. baseline and differential.
GenevisibleiQ9UKR3. HS.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues."
    Yousef G.M., Chang A., Diamandis E.P.
    J. Biol. Chem. 275:11891-11898(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages."
    Komatsu N., Takata M., Otsuki N., Toyama T., Ohka R., Takehara K., Saijoh K.
    J. Invest. Dermatol. 121:542-549(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Skin.
  3. "Understanding the accuracy of statistical haplotype inference with sequence data of known phase."
    Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F., Hixson J.E.
    Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169 (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiKLK13_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR3
Secondary accession number(s): A7UNK6, Q86VI8, Q9Y433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.