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Q9UKR3

- KLK13_HUMAN

UniProt

Q9UKR3 - KLK13_HUMAN

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Protein

Kallikrein-13

Gene

KLK13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Charge relay systemBy similarity
Active sitei124 – 1241Charge relay systemBy similarity
Active sitei218 – 2181Charge relay systemBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB
  2. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. protein processing Source: Ensembl
  2. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.119. 2681.
ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiS01.306.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-13 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 4
Short name:
KLK-L4
Gene namesi
Name:KLK13
Synonyms:KLKL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6361. KLK13.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: UniProt
  5. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 277261Kallikrein-13PRO_0000027957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi42 ↔ 178PROSITE-ProRule annotation
Disulfide bondi61 ↔ 77PROSITE-ProRule annotation
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi189 ↔ 203PROSITE-ProRule annotation
Disulfide bondi214 ↔ 239PROSITE-ProRule annotation
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR3.
PRIDEiQ9UKR3.

PTM databases

PhosphoSiteiQ9UKR3.

Miscellaneous databases

PMAP-CutDBQ9UKR3.

Expressioni

Tissue specificityi

Expressed in prostate, breast, testis and salivary gland.

Gene expression databases

BgeeiQ9UKR3.
CleanExiHS_KLK13.
ExpressionAtlasiQ9UKR3. baseline and differential.
GenevestigatoriQ9UKR3.

Organism-specific databases

HPAiCAB025453.
HPA019487.

Interactioni

Protein-protein interaction databases

BioGridi117538. 4 interactions.
MINTiMINT-4721648.
STRINGi9606.ENSP00000156476.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR3.
SMRiQ9UKR3. Positions 39-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 263228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR3.
KOiK09463.
OMAiLWIRETI.
PhylomeDBiQ9UKR3.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKR3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ
60 70 80 90 100
AALLVQGRLL CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV
110 120 130 140 150
REVVHSIPHP EYRRSPTHLN HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR
160 170 180 190 200
LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN IQLRSDEECR QVYPGKITDN
210 220 230 240 250
MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG QPDRPGVYTR
260 270
VSRYVLWIRE TIRKYETQQQ KWLKGPQ
Length:277
Mass (Da):30,570
Last modified:May 1, 2000 - v1
Checksum:iBA8A9E8DCFB5D542
GO
Isoform 2 (identifier: Q9UKR3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-169: Missing.

Show »
Length:125
Mass (Da):13,986
Checksum:iD510DC802F4A6243
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091H → Y.
Corresponds to variant rs34089525 [ dbSNP | Ensembl ].
VAR_051857

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 169152Missing in isoform 2. 1 PublicationVSP_056631Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135024 Genomic DNA. Translation: AAD26425.2.
AB108823 mRNA. Translation: BAC75825.1.
EU091477 Genomic DNA. Translation: ABU63130.1.
AC011473 Genomic DNA. Translation: AAG23259.1.
CH471135 Genomic DNA. Translation: EAW71979.1.
BC069334 mRNA. Translation: AAH69334.1.
BC069543 mRNA. Translation: AAH69543.1.
AL050220 mRNA. Translation: CAB43320.2.
CCDSiCCDS12822.1. [Q9UKR3-1]
PIRiT08808.
RefSeqiNP_056411.1. NM_015596.1. [Q9UKR3-1]
UniGeneiHs.165296.

Genome annotation databases

EnsembliENST00000335422; ENSP00000334079; ENSG00000167759. [Q9UKR3-2]
ENST00000595793; ENSP00000470555; ENSG00000167759. [Q9UKR3-1]
GeneIDi26085.
KEGGihsa:26085.
UCSCiuc002pvn.3. human. [Q9UKR3-1]

Polymorphism databases

DMDMi9296990.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135024 Genomic DNA. Translation: AAD26425.2 .
AB108823 mRNA. Translation: BAC75825.1 .
EU091477 Genomic DNA. Translation: ABU63130.1 .
AC011473 Genomic DNA. Translation: AAG23259.1 .
CH471135 Genomic DNA. Translation: EAW71979.1 .
BC069334 mRNA. Translation: AAH69334.1 .
BC069543 mRNA. Translation: AAH69543.1 .
AL050220 mRNA. Translation: CAB43320.2 .
CCDSi CCDS12822.1. [Q9UKR3-1 ]
PIRi T08808.
RefSeqi NP_056411.1. NM_015596.1. [Q9UKR3-1 ]
UniGenei Hs.165296.

3D structure databases

ProteinModelPortali Q9UKR3.
SMRi Q9UKR3. Positions 39-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117538. 4 interactions.
MINTi MINT-4721648.
STRINGi 9606.ENSP00000156476.

Chemistry

ChEMBLi CHEMBL4863.

Protein family/group databases

MEROPSi S01.306.

PTM databases

PhosphoSitei Q9UKR3.

Polymorphism databases

DMDMi 9296990.

Proteomic databases

PaxDbi Q9UKR3.
PRIDEi Q9UKR3.

Protocols and materials databases

DNASUi 26085.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335422 ; ENSP00000334079 ; ENSG00000167759 . [Q9UKR3-2 ]
ENST00000595793 ; ENSP00000470555 ; ENSG00000167759 . [Q9UKR3-1 ]
GeneIDi 26085.
KEGGi hsa:26085.
UCSCi uc002pvn.3. human. [Q9UKR3-1 ]

Organism-specific databases

CTDi 26085.
GeneCardsi GC19M051559.
HGNCi HGNC:6361. KLK13.
HPAi CAB025453.
HPA019487.
MIMi 605505. gene.
neXtProti NX_Q9UKR3.
PharmGKBi PA30150.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q9UKR3.
KOi K09463.
OMAi LWIRETI.
PhylomeDBi Q9UKR3.
TreeFami TF331065.

Enzyme and pathway databases

BRENDAi 3.4.21.119. 2681.
Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

GeneWikii KLK13.
GenomeRNAii 26085.
NextBioi 48003.
PMAP-CutDB Q9UKR3.
PROi Q9UKR3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKR3.
CleanExi HS_KLK13.
ExpressionAtlasi Q9UKR3. baseline and differential.
Genevestigatori Q9UKR3.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues."
    Yousef G.M., Chang A., Diamandis E.P.
    J. Biol. Chem. 275:11891-11898(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages."
    Komatsu N., Takata M., Otsuki N., Toyama T., Ohka R., Takehara K., Saijoh K.
    J. Invest. Dermatol. 121:542-549(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Skin.
  3. "Understanding the accuracy of statistical haplotype inference with sequence data of known phase."
    Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F., Hixson J.E.
    Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169 (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiKLK13_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR3
Secondary accession number(s): A7UNK6, Q86VI8, Q9Y433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3