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Q9UKR3 (KLK13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-13

EC=3.4.21.-
Alternative name(s):
Kallikrein-like protein 4
Short name=KLK-L4
Gene names
Name:KLK13
Synonyms:KLKL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in prostate, breast, testis and salivary gland.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 277261Kallikrein-13
PRO_0000027957

Regions

Domain36 – 263228Peptidase S1

Sites

Active site761Charge relay system By similarity
Active site1241Charge relay system By similarity
Active site2181Charge relay system By similarity

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 178 By similarity
Disulfide bond61 ↔ 77 By similarity
Disulfide bond157 ↔ 224 By similarity
Disulfide bond189 ↔ 203 By similarity
Disulfide bond214 ↔ 239 By similarity

Natural variations

Natural variant1091H → Y.
Corresponds to variant rs34089525 [ dbSNP | Ensembl ].
VAR_051857

Sequences

Sequence LengthMass (Da)Tools
Q9UKR3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BA8A9E8DCFB5D542

FASTA27730,570
        10         20         30         40         50         60 
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ AALLVQGRLL 

        70         80         90        100        110        120 
CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLN 

       130        140        150        160        170        180 
HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN 

       190        200        210        220        230        240 
IQLRSDEECR QVYPGKITDN MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG 

       250        260        270 
QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues."
Yousef G.M., Chang A., Diamandis E.P.
J. Biol. Chem. 275:11891-11898(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Understanding the accuracy of statistical haplotype inference with sequence data of known phase."
Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F., Hixson J.E.
Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169.
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF135024 Genomic DNA. Translation: AAD26425.2.
EU091477 Genomic DNA. Translation: ABU63130.1.
AC011473 Genomic DNA. Translation: AAG23259.1.
CH471135 Genomic DNA. Translation: EAW71979.1.
BC069334 mRNA. Translation: AAH69334.1.
BC069543 mRNA. Translation: AAH69543.1.
AL050220 mRNA. Translation: CAB43320.2.
CCDSCCDS12822.1.
PIRT08808.
RefSeqNP_056411.1. NM_015596.1.
UniGeneHs.165296.

3D structure databases

ProteinModelPortalQ9UKR3.
SMRQ9UKR3. Positions 39-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117538. 2 interactions.
MINTMINT-4721648.
STRING9606.ENSP00000156476.

Chemistry

BindingDBQ9UKR3.
ChEMBLCHEMBL4863.

Protein family/group databases

MEROPSS01.306.

PTM databases

PhosphoSiteQ9UKR3.

Polymorphism databases

DMDM9296990.

Proteomic databases

PaxDbQ9UKR3.
PRIDEQ9UKR3.

Protocols and materials databases

DNASU26085.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000595793; ENSP00000470555; ENSG00000167759.
GeneID26085.
KEGGhsa:26085.
UCSCuc002pvn.3. human.

Organism-specific databases

CTD26085.
GeneCardsGC19M051559.
HGNCHGNC:6361. KLK13.
HPACAB025453.
HPA019487.
MIM605505. gene.
neXtProtNX_Q9UKR3.
PharmGKBPA30150.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidQ9UKR3.
KOK09463.
OMALWIRETI.
PhylomeDBQ9UKR3.
TreeFamTF331065.

Enzyme and pathway databases

BRENDA3.4.21.119. 2681.
ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9UKR3.
BgeeQ9UKR3.
CleanExHS_KLK13.
GenevestigatorQ9UKR3.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKLK13.
GenomeRNAi26085.
NextBio48003.
PMAP-CutDBQ9UKR3.
PROQ9UKR3.
SOURCESearch...

Entry information

Entry nameKLK13_HUMAN
AccessionPrimary (citable) accession number: Q9UKR3
Secondary accession number(s): A7UNK6, Q9Y433
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM