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Q9UKR3

- KLK13_HUMAN

UniProt

Q9UKR3 - KLK13_HUMAN

Protein

Kallikrein-13

Gene

KLK13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Charge relay systemBy similarity
    Active sitei124 – 1241Charge relay systemBy similarity
    Active sitei218 – 2181Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. protein processing Source: Ensembl
    2. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.119. 2681.
    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Protein family/group databases

    MEROPSiS01.306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-13 (EC:3.4.21.-)
    Alternative name(s):
    Kallikrein-like protein 4
    Short name:
    KLK-L4
    Gene namesi
    Name:KLK13
    Synonyms:KLKL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6361. KLK13.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30150.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 277261Kallikrein-13PRO_0000027957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi42 ↔ 178PROSITE-ProRule annotation
    Disulfide bondi61 ↔ 77PROSITE-ProRule annotation
    Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
    Disulfide bondi189 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi214 ↔ 239PROSITE-ProRule annotation
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UKR3.
    PRIDEiQ9UKR3.

    PTM databases

    PhosphoSiteiQ9UKR3.

    Miscellaneous databases

    PMAP-CutDBQ9UKR3.

    Expressioni

    Tissue specificityi

    Expressed in prostate, breast, testis and salivary gland.

    Gene expression databases

    ArrayExpressiQ9UKR3.
    BgeeiQ9UKR3.
    CleanExiHS_KLK13.
    GenevestigatoriQ9UKR3.

    Organism-specific databases

    HPAiCAB025453.
    HPA019487.

    Interactioni

    Protein-protein interaction databases

    BioGridi117538. 2 interactions.
    MINTiMINT-4721648.
    STRINGi9606.ENSP00000156476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKR3.
    SMRiQ9UKR3. Positions 39-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 263228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ9UKR3.
    KOiK09463.
    OMAiLWIRETI.
    PhylomeDBiQ9UKR3.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKR3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ    50
    AALLVQGRLL CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV 100
    REVVHSIPHP EYRRSPTHLN HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR 150
    LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN IQLRSDEECR QVYPGKITDN 200
    MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG QPDRPGVYTR 250
    VSRYVLWIRE TIRKYETQQQ KWLKGPQ 277
    Length:277
    Mass (Da):30,570
    Last modified:May 1, 2000 - v1
    Checksum:iBA8A9E8DCFB5D542
    GO
    Isoform 2 (identifier: Q9UKR3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-169: Missing.

    Show »
    Length:125
    Mass (Da):13,986
    Checksum:iD510DC802F4A6243
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091H → Y.
    Corresponds to variant rs34089525 [ dbSNP | Ensembl ].
    VAR_051857

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 169152Missing in isoform 2. 1 PublicationVSP_056631Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135024 Genomic DNA. Translation: AAD26425.2.
    AB108823 mRNA. Translation: BAC75825.1.
    EU091477 Genomic DNA. Translation: ABU63130.1.
    AC011473 Genomic DNA. Translation: AAG23259.1.
    CH471135 Genomic DNA. Translation: EAW71979.1.
    BC069334 mRNA. Translation: AAH69334.1.
    BC069543 mRNA. Translation: AAH69543.1.
    AL050220 mRNA. Translation: CAB43320.2.
    CCDSiCCDS12822.1.
    PIRiT08808.
    RefSeqiNP_056411.1. NM_015596.1.
    UniGeneiHs.165296.

    Genome annotation databases

    EnsembliENST00000335422; ENSP00000334079; ENSG00000167759.
    ENST00000595793; ENSP00000470555; ENSG00000167759.
    GeneIDi26085.
    KEGGihsa:26085.
    UCSCiuc002pvn.3. human.

    Polymorphism databases

    DMDMi9296990.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135024 Genomic DNA. Translation: AAD26425.2 .
    AB108823 mRNA. Translation: BAC75825.1 .
    EU091477 Genomic DNA. Translation: ABU63130.1 .
    AC011473 Genomic DNA. Translation: AAG23259.1 .
    CH471135 Genomic DNA. Translation: EAW71979.1 .
    BC069334 mRNA. Translation: AAH69334.1 .
    BC069543 mRNA. Translation: AAH69543.1 .
    AL050220 mRNA. Translation: CAB43320.2 .
    CCDSi CCDS12822.1.
    PIRi T08808.
    RefSeqi NP_056411.1. NM_015596.1.
    UniGenei Hs.165296.

    3D structure databases

    ProteinModelPortali Q9UKR3.
    SMRi Q9UKR3. Positions 39-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117538. 2 interactions.
    MINTi MINT-4721648.
    STRINGi 9606.ENSP00000156476.

    Chemistry

    BindingDBi Q9UKR3.
    ChEMBLi CHEMBL4863.

    Protein family/group databases

    MEROPSi S01.306.

    PTM databases

    PhosphoSitei Q9UKR3.

    Polymorphism databases

    DMDMi 9296990.

    Proteomic databases

    PaxDbi Q9UKR3.
    PRIDEi Q9UKR3.

    Protocols and materials databases

    DNASUi 26085.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335422 ; ENSP00000334079 ; ENSG00000167759 .
    ENST00000595793 ; ENSP00000470555 ; ENSG00000167759 .
    GeneIDi 26085.
    KEGGi hsa:26085.
    UCSCi uc002pvn.3. human.

    Organism-specific databases

    CTDi 26085.
    GeneCardsi GC19M051559.
    HGNCi HGNC:6361. KLK13.
    HPAi CAB025453.
    HPA019487.
    MIMi 605505. gene.
    neXtProti NX_Q9UKR3.
    PharmGKBi PA30150.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q9UKR3.
    KOi K09463.
    OMAi LWIRETI.
    PhylomeDBi Q9UKR3.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.119. 2681.
    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    GeneWikii KLK13.
    GenomeRNAii 26085.
    NextBioi 48003.
    PMAP-CutDB Q9UKR3.
    PROi Q9UKR3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKR3.
    Bgeei Q9UKR3.
    CleanExi HS_KLK13.
    Genevestigatori Q9UKR3.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues."
      Yousef G.M., Chang A., Diamandis E.P.
      J. Biol. Chem. 275:11891-11898(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages."
      Komatsu N., Takata M., Otsuki N., Toyama T., Ohka R., Takehara K., Saijoh K.
      J. Invest. Dermatol. 121:542-549(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
      Tissue: Skin.
    3. "Understanding the accuracy of statistical haplotype inference with sequence data of known phase."
      Andres A.M., Clark A.G., Shimmin L., Boerwinkle E., Sing C.F., Hixson J.E.
      Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169 (ISOFORM 1).
      Tissue: Uterus.

    Entry informationi

    Entry nameiKLK13_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKR3
    Secondary accession number(s): A7UNK6, Q86VI8, Q9Y433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3