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Q9UKR0

- KLK12_HUMAN

UniProt

Q9UKR0 - KLK12_HUMAN

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Protein
Kallikrein-12
Gene
KLK12, KLKL5, UNQ669/PRO1303
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay system By similarity
Active sitei108 – 1081Charge relay system By similarity
Active sitei200 – 2001Charge relay system By similarity

GO - Molecular functioni

  1. peptidase activity Source: UniProtKB
  2. serine-type endopeptidase activity Source: UniProtKB
  3. serine-type peptidase activity Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-12 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 5
Short name:
KLK-L5
Gene namesi
Name:KLK12
Synonyms:KLKL5
ORF Names:UNQ669/PRO1303
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6360. KLK12.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 248231Kallikrein-12
PRO_0000027956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)1 Publication
Disulfide bondi28 ↔ 161 By similarity
Disulfide bondi47 ↔ 63 By similarity
Disulfide bondi133 ↔ 235 By similarity
Disulfide bondi140 ↔ 206 By similarity
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi172 ↔ 186 By similarity
Disulfide bondi196 ↔ 222 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR0.
PRIDEiQ9UKR0.

PTM databases

PhosphoSiteiQ9UKR0.

Expressioni

Gene expression databases

ArrayExpressiQ9UKR0.
BgeeiQ9UKR0.
CleanExiHS_KLK12.
GenevestigatoriQ9UKR0.

Organism-specific databases

HPAiCAB025473.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UKR0.
SMRiQ9UKR0. Positions 22-248.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 246225Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
KOiK09621.
OMAiVPGQDAC.
OrthoDBiEOG75B84T.
PhylomeDBiQ9UKR0.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKR0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV    50
LIDHRWVLTA AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG 100
ASTSHEHDLR LLRLRLPVRV TSSVQPLPLP NDCATAGTEC HVSGWGITNH 150
PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI TSNMVCAGGV PGQDACQGDS 200
GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW IRMIMRNN 248
Length:248
Mass (Da):26,734
Last modified:May 1, 2000 - v1
Checksum:iBB473E98F8BAF703
GO
Isoform 2 (identifier: Q9UKR0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-248: KYVDWIRMIMRNN → NSTLVGLGTSWNFNSCQPF

Show »
Length:254
Mass (Da):27,067
Checksum:i704A1552D34DF188
GO
Isoform 3 (identifier: Q9UKR0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: SRYWVRLGEH...STSHEHDLRL → RPIPGSAPVP...RRPGAGCLPG
     112-248: Missing.

Show »
Length:111
Mass (Da):11,984
Checksum:i3E8EAB4295635D8D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 11146SRYWV…HDLRL → RPIPGSAPVPQPLHRLPCHL PWCVSRENHEQHGVCRRRPG AGCLPG in isoform 3.
VSP_045851Add
BLAST
Alternative sequencei112 – 248137Missing in isoform 3.
VSP_045852Add
BLAST
Alternative sequencei236 – 24813KYVDW…IMRNN → NSTLVGLGTSWNFNSCQPF in isoform 2.
VSP_005403Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2.
AF135025 Genomic DNA. Translation: AAF06065.1.
AF135025 Genomic DNA. Translation: AAF06066.1.
AF243527 Genomic DNA. Translation: AAG33365.1.
AY358524 mRNA. Translation: AAQ88888.1.
AC011473 Genomic DNA. Translation: AAG23258.1.
CH471135 Genomic DNA. Translation: EAW71976.1.
CCDSiCCDS12820.1. [Q9UKR0-2]
CCDS12821.1. [Q9UKR0-1]
CCDS54298.1. [Q9UKR0-3]
RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
NP_665901.1. NM_145894.1. [Q9UKR0-1]
NP_665902.1. NM_145895.1. [Q9UKR0-3]
XP_005259008.1. XM_005258951.1. [Q9UKR0-3]
UniGeneiHs.411572.

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
GeneIDi43849.
KEGGihsa:43849.
UCSCiuc002pvg.1. human. [Q9UKR0-1]
uc002pvh.1. human. [Q9UKR0-2]
uc002pvj.1. human.

Polymorphism databases

DMDMi9296989.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2 .
AF135025 Genomic DNA. Translation: AAF06065.1 .
AF135025 Genomic DNA. Translation: AAF06066.1 .
AF243527 Genomic DNA. Translation: AAG33365.1 .
AY358524 mRNA. Translation: AAQ88888.1 .
AC011473 Genomic DNA. Translation: AAG23258.1 .
CH471135 Genomic DNA. Translation: EAW71976.1 .
CCDSi CCDS12820.1. [Q9UKR0-2 ]
CCDS12821.1. [Q9UKR0-1 ]
CCDS54298.1. [Q9UKR0-3 ]
RefSeqi NP_062544.1. NM_019598.2. [Q9UKR0-2 ]
NP_665901.1. NM_145894.1. [Q9UKR0-1 ]
NP_665902.1. NM_145895.1. [Q9UKR0-3 ]
XP_005259008.1. XM_005258951.1. [Q9UKR0-3 ]
UniGenei Hs.411572.

3D structure databases

ProteinModelPortali Q9UKR0.
SMRi Q9UKR0. Positions 22-248.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9UKR0.
ChEMBLi CHEMBL4943.

Protein family/group databases

MEROPSi S01.020.

PTM databases

PhosphoSitei Q9UKR0.

Polymorphism databases

DMDMi 9296989.

Proteomic databases

PaxDbi Q9UKR0.
PRIDEi Q9UKR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250351 ; ENSP00000250351 ; ENSG00000186474 . [Q9UKR0-2 ]
ENST00000319590 ; ENSP00000324181 ; ENSG00000186474 . [Q9UKR0-1 ]
ENST00000525263 ; ENSP00000436458 ; ENSG00000186474 . [Q9UKR0-1 ]
ENST00000529888 ; ENSP00000434036 ; ENSG00000186474 . [Q9UKR0-3 ]
GeneIDi 43849.
KEGGi hsa:43849.
UCSCi uc002pvg.1. human. [Q9UKR0-1 ]
uc002pvh.1. human. [Q9UKR0-2 ]
uc002pvj.1. human.

Organism-specific databases

CTDi 43849.
GeneCardsi GC19M051532.
HGNCi HGNC:6360. KLK12.
HPAi CAB025473.
MIMi 605539. gene.
neXtProti NX_Q9UKR0.
PharmGKBi PA30149.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
KOi K09621.
OMAi VPGQDAC.
OrthoDBi EOG75B84T.
PhylomeDBi Q9UKR0.
TreeFami TF331065.

Miscellaneous databases

GeneWikii KLK12.
GenomeRNAii 43849.
NextBioi 53004.
PROi Q9UKR0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKR0.
Bgeei Q9UKR0.
CleanExi HS_KLK12.
Genevestigatori Q9UKR0.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."
    Yousef G.M., Luo L.-Y., Diamandis E.P.
    Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. "Cloning of new alternatively spliced forms of the kallikrein-like gene 5 (KLK-L5)."
    Yousef G.M., Magklara A., Scorilas A., Diamandis E.P.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
  3. "The new human kallikrein gene family: implications in carcinogenesis."
    Diamandis E.P., Yousef G.M., Luo L.Y., Magklara A., Obiezu C.V.
    Trends Endocrinol. Metab. 11:54-60(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-24.
    Tissue: Milk.

Entry informationi

Entry nameiKLK12_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR0
Secondary accession number(s): Q9UKR1, Q9UKR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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