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Protein

Kallikrein-12

Gene

KLK12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay systemBy similarity
Active sitei108 – 1081Charge relay systemBy similarity
Active sitei200 – 2001Charge relay systemBy similarity

GO - Molecular functioni

  1. peptidase activity Source: UniProtKB
  2. serine-type endopeptidase activity Source: UniProtKB
  3. serine-type peptidase activity Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-12 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 5
Short name:
KLK-L5
Gene namesi
Name:KLK12
Synonyms:KLKL5
ORF Names:UNQ669/PRO1303
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6360. KLK12.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 248231Kallikrein-12PRO_0000027956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)1 Publication
Disulfide bondi28 ↔ 161PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi133 ↔ 235PROSITE-ProRule annotation
Disulfide bondi140 ↔ 206PROSITE-ProRule annotation
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Disulfide bondi196 ↔ 222PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR0.
PRIDEiQ9UKR0.

PTM databases

PhosphoSiteiQ9UKR0.

Expressioni

Gene expression databases

BgeeiQ9UKR0.
CleanExiHS_KLK12.
ExpressionAtlasiQ9UKR0. baseline and differential.
GenevestigatoriQ9UKR0.

Organism-specific databases

HPAiCAB025473.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR0.
SMRiQ9UKR0. Positions 22-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 246225Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR0.
KOiK09621.
OMAiGWGTTNH.
OrthoDBiEOG75B84T.
PhylomeDBiQ9UKR0.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKR0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV
60 70 80 90 100
LIDHRWVLTA AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG
110 120 130 140 150
ASTSHEHDLR LLRLRLPVRV TSSVQPLPLP NDCATAGTEC HVSGWGITNH
160 170 180 190 200
PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI TSNMVCAGGV PGQDACQGDS
210 220 230 240
GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW IRMIMRNN
Length:248
Mass (Da):26,734
Last modified:May 1, 2000 - v1
Checksum:iBB473E98F8BAF703
GO
Isoform 2 (identifier: Q9UKR0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-248: KYVDWIRMIMRNN → NSTLVGLGTSWNFNSCQPF

Show »
Length:254
Mass (Da):27,067
Checksum:i704A1552D34DF188
GO
Isoform 3 (identifier: Q9UKR0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: SRYWVRLGEH...STSHEHDLRL → RPIPGSAPVP...RRPGAGCLPG
     112-248: Missing.

Show »
Length:111
Mass (Da):11,984
Checksum:i3E8EAB4295635D8D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 11146SRYWV…HDLRL → RPIPGSAPVPQPLHRLPCHL PWCVSRENHEQHGVCRRRPG AGCLPG in isoform 3. CuratedVSP_045851Add
BLAST
Alternative sequencei112 – 248137Missing in isoform 3. CuratedVSP_045852Add
BLAST
Alternative sequencei236 – 24813KYVDW…IMRNN → NSTLVGLGTSWNFNSCQPF in isoform 2. CuratedVSP_005403Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2.
AF135025 Genomic DNA. Translation: AAF06065.1.
AF135025 Genomic DNA. Translation: AAF06066.1.
AF243527 Genomic DNA. Translation: AAG33365.1.
AY358524 mRNA. Translation: AAQ88888.1.
AC011473 Genomic DNA. Translation: AAG23258.1.
CH471135 Genomic DNA. Translation: EAW71976.1.
CCDSiCCDS12820.1. [Q9UKR0-2]
CCDS12821.1. [Q9UKR0-1]
CCDS54298.1. [Q9UKR0-3]
RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
NP_665901.1. NM_145894.1. [Q9UKR0-1]
NP_665902.1. NM_145895.1. [Q9UKR0-3]
XP_005259008.1. XM_005258951.1. [Q9UKR0-3]
UniGeneiHs.411572.

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
GeneIDi43849.
KEGGihsa:43849.
UCSCiuc002pvg.1. human. [Q9UKR0-1]
uc002pvh.1. human. [Q9UKR0-2]
uc002pvj.1. human.

Polymorphism databases

DMDMi9296989.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2.
AF135025 Genomic DNA. Translation: AAF06065.1.
AF135025 Genomic DNA. Translation: AAF06066.1.
AF243527 Genomic DNA. Translation: AAG33365.1.
AY358524 mRNA. Translation: AAQ88888.1.
AC011473 Genomic DNA. Translation: AAG23258.1.
CH471135 Genomic DNA. Translation: EAW71976.1.
CCDSiCCDS12820.1. [Q9UKR0-2]
CCDS12821.1. [Q9UKR0-1]
CCDS54298.1. [Q9UKR0-3]
RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
NP_665901.1. NM_145894.1. [Q9UKR0-1]
NP_665902.1. NM_145895.1. [Q9UKR0-3]
XP_005259008.1. XM_005258951.1. [Q9UKR0-3]
UniGeneiHs.411572.

3D structure databases

ProteinModelPortaliQ9UKR0.
SMRiQ9UKR0. Positions 22-248.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL4943.

Protein family/group databases

MEROPSiS01.020.

PTM databases

PhosphoSiteiQ9UKR0.

Polymorphism databases

DMDMi9296989.

Proteomic databases

PaxDbiQ9UKR0.
PRIDEiQ9UKR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
GeneIDi43849.
KEGGihsa:43849.
UCSCiuc002pvg.1. human. [Q9UKR0-1]
uc002pvh.1. human. [Q9UKR0-2]
uc002pvj.1. human.

Organism-specific databases

CTDi43849.
GeneCardsiGC19M051532.
HGNCiHGNC:6360. KLK12.
HPAiCAB025473.
MIMi605539. gene.
neXtProtiNX_Q9UKR0.
PharmGKBiPA30149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR0.
KOiK09621.
OMAiGWGTTNH.
OrthoDBiEOG75B84T.
PhylomeDBiQ9UKR0.
TreeFamiTF331065.

Miscellaneous databases

GeneWikiiKLK12.
GenomeRNAii43849.
NextBioi53004.
PROiQ9UKR0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKR0.
CleanExiHS_KLK12.
ExpressionAtlasiQ9UKR0. baseline and differential.
GenevestigatoriQ9UKR0.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."
    Yousef G.M., Luo L.-Y., Diamandis E.P.
    Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. "Cloning of new alternatively spliced forms of the kallikrein-like gene 5 (KLK-L5)."
    Yousef G.M., Magklara A., Scorilas A., Diamandis E.P.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
  3. "The new human kallikrein gene family: implications in carcinogenesis."
    Diamandis E.P., Yousef G.M., Luo L.Y., Magklara A., Obiezu C.V.
    Trends Endocrinol. Metab. 11:54-60(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-24.
    Tissue: Milk.

Entry informationi

Entry nameiKLK12_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR0
Secondary accession number(s): Q9UKR1, Q9UKR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.