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Q9UKR0

- KLK12_HUMAN

UniProt

Q9UKR0 - KLK12_HUMAN

Protein

Kallikrein-12

Gene

KLK12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Charge relay systemBy similarity
    Active sitei108 – 1081Charge relay systemBy similarity
    Active sitei200 – 2001Charge relay systemBy similarity

    GO - Molecular functioni

    1. peptidase activity Source: UniProtKB
    2. serine-type endopeptidase activity Source: UniProtKB
    3. serine-type peptidase activity Source: UniProtKB

    GO - Biological processi

    1. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.020.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-12 (EC:3.4.21.-)
    Alternative name(s):
    Kallikrein-like protein 5
    Short name:
    KLK-L5
    Gene namesi
    Name:KLK12
    Synonyms:KLKL5
    ORF Names:UNQ669/PRO1303
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6360. KLK12.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30149.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 248231Kallikrein-12PRO_0000027956Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)1 Publication
    Disulfide bondi28 ↔ 161PROSITE-ProRule annotation
    Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 235PROSITE-ProRule annotation
    Disulfide bondi140 ↔ 206PROSITE-ProRule annotation
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi196 ↔ 222PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UKR0.
    PRIDEiQ9UKR0.

    PTM databases

    PhosphoSiteiQ9UKR0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UKR0.
    BgeeiQ9UKR0.
    CleanExiHS_KLK12.
    GenevestigatoriQ9UKR0.

    Organism-specific databases

    HPAiCAB025473.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKR0.
    SMRiQ9UKR0. Positions 22-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 246225Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    KOiK09621.
    OMAiVPGQDAC.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ9UKR0.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV    50
    LIDHRWVLTA AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG 100
    ASTSHEHDLR LLRLRLPVRV TSSVQPLPLP NDCATAGTEC HVSGWGITNH 150
    PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI TSNMVCAGGV PGQDACQGDS 200
    GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW IRMIMRNN 248
    Length:248
    Mass (Da):26,734
    Last modified:May 1, 2000 - v1
    Checksum:iBB473E98F8BAF703
    GO
    Isoform 2 (identifier: Q9UKR0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         236-248: KYVDWIRMIMRNN → NSTLVGLGTSWNFNSCQPF

    Show »
    Length:254
    Mass (Da):27,067
    Checksum:i704A1552D34DF188
    GO
    Isoform 3 (identifier: Q9UKR0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-111: SRYWVRLGEH...STSHEHDLRL → RPIPGSAPVP...RRPGAGCLPG
         112-248: Missing.

    Show »
    Length:111
    Mass (Da):11,984
    Checksum:i3E8EAB4295635D8D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei66 – 11146SRYWV…HDLRL → RPIPGSAPVPQPLHRLPCHL PWCVSRENHEQHGVCRRRPG AGCLPG in isoform 3. CuratedVSP_045851Add
    BLAST
    Alternative sequencei112 – 248137Missing in isoform 3. CuratedVSP_045852Add
    BLAST
    Alternative sequencei236 – 24813KYVDW…IMRNN → NSTLVGLGTSWNFNSCQPF in isoform 2. CuratedVSP_005403Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135025 Genomic DNA. Translation: AAD26426.2.
    AF135025 Genomic DNA. Translation: AAF06065.1.
    AF135025 Genomic DNA. Translation: AAF06066.1.
    AF243527 Genomic DNA. Translation: AAG33365.1.
    AY358524 mRNA. Translation: AAQ88888.1.
    AC011473 Genomic DNA. Translation: AAG23258.1.
    CH471135 Genomic DNA. Translation: EAW71976.1.
    CCDSiCCDS12820.1. [Q9UKR0-2]
    CCDS12821.1. [Q9UKR0-1]
    CCDS54298.1. [Q9UKR0-3]
    RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
    NP_665901.1. NM_145894.1. [Q9UKR0-1]
    NP_665902.1. NM_145895.1. [Q9UKR0-3]
    XP_005259008.1. XM_005258951.1. [Q9UKR0-3]
    UniGeneiHs.411572.

    Genome annotation databases

    EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
    ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
    ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
    ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
    GeneIDi43849.
    KEGGihsa:43849.
    UCSCiuc002pvg.1. human. [Q9UKR0-1]
    uc002pvh.1. human. [Q9UKR0-2]
    uc002pvj.1. human.

    Polymorphism databases

    DMDMi9296989.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135025 Genomic DNA. Translation: AAD26426.2 .
    AF135025 Genomic DNA. Translation: AAF06065.1 .
    AF135025 Genomic DNA. Translation: AAF06066.1 .
    AF243527 Genomic DNA. Translation: AAG33365.1 .
    AY358524 mRNA. Translation: AAQ88888.1 .
    AC011473 Genomic DNA. Translation: AAG23258.1 .
    CH471135 Genomic DNA. Translation: EAW71976.1 .
    CCDSi CCDS12820.1. [Q9UKR0-2 ]
    CCDS12821.1. [Q9UKR0-1 ]
    CCDS54298.1. [Q9UKR0-3 ]
    RefSeqi NP_062544.1. NM_019598.2. [Q9UKR0-2 ]
    NP_665901.1. NM_145894.1. [Q9UKR0-1 ]
    NP_665902.1. NM_145895.1. [Q9UKR0-3 ]
    XP_005259008.1. XM_005258951.1. [Q9UKR0-3 ]
    UniGenei Hs.411572.

    3D structure databases

    ProteinModelPortali Q9UKR0.
    SMRi Q9UKR0. Positions 22-248.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9UKR0.
    ChEMBLi CHEMBL4943.

    Protein family/group databases

    MEROPSi S01.020.

    PTM databases

    PhosphoSitei Q9UKR0.

    Polymorphism databases

    DMDMi 9296989.

    Proteomic databases

    PaxDbi Q9UKR0.
    PRIDEi Q9UKR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250351 ; ENSP00000250351 ; ENSG00000186474 . [Q9UKR0-2 ]
    ENST00000319590 ; ENSP00000324181 ; ENSG00000186474 . [Q9UKR0-1 ]
    ENST00000525263 ; ENSP00000436458 ; ENSG00000186474 . [Q9UKR0-1 ]
    ENST00000529888 ; ENSP00000434036 ; ENSG00000186474 . [Q9UKR0-3 ]
    GeneIDi 43849.
    KEGGi hsa:43849.
    UCSCi uc002pvg.1. human. [Q9UKR0-1 ]
    uc002pvh.1. human. [Q9UKR0-2 ]
    uc002pvj.1. human.

    Organism-specific databases

    CTDi 43849.
    GeneCardsi GC19M051532.
    HGNCi HGNC:6360. KLK12.
    HPAi CAB025473.
    MIMi 605539. gene.
    neXtProti NX_Q9UKR0.
    PharmGKBi PA30149.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    KOi K09621.
    OMAi VPGQDAC.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q9UKR0.
    TreeFami TF331065.

    Miscellaneous databases

    GeneWikii KLK12.
    GenomeRNAii 43849.
    NextBioi 53004.
    PROi Q9UKR0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKR0.
    Bgeei Q9UKR0.
    CleanExi HS_KLK12.
    Genevestigatori Q9UKR0.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."
      Yousef G.M., Luo L.-Y., Diamandis E.P.
      Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    2. "Cloning of new alternatively spliced forms of the kallikrein-like gene 5 (KLK-L5)."
      Yousef G.M., Magklara A., Scorilas A., Diamandis E.P.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
    3. "The new human kallikrein gene family: implications in carcinogenesis."
      Diamandis E.P., Yousef G.M., Luo L.Y., Magklara A., Obiezu C.V.
      Trends Endocrinol. Metab. 11:54-60(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
    4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
      Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-24.
      Tissue: Milk.

    Entry informationi

    Entry nameiKLK12_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKR0
    Secondary accession number(s): Q9UKR1, Q9UKR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3