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Protein

Kallikrein-12

Gene

KLK12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Charge relay systemBy similarity1
Active sitei108Charge relay systemBy similarity1
Active sitei200Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: UniProtKB

GO - Biological processi

  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167758-MONOMER.
BRENDAi3.4.21.B43. 2681.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Protein family/group databases

MEROPSiS01.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-12 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 5
Short name:
KLK-L5
Gene namesi
Name:KLK12
Synonyms:KLKL5
ORF Names:UNQ669/PRO1303
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6360. KLK12.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi43849.
OpenTargetsiENSG00000186474.
PharmGKBiPA30149.

Chemistry databases

ChEMBLiCHEMBL4943.

Polymorphism and mutation databases

BioMutaiKLK12.
DMDMi9296989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002795618 – 248Kallikrein-12Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)1 Publication1
Disulfide bondi28 ↔ 161PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi133 ↔ 235PROSITE-ProRule annotation
Disulfide bondi140 ↔ 206PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Disulfide bondi196 ↔ 222PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR0.
PeptideAtlasiQ9UKR0.
PRIDEiQ9UKR0.

PTM databases

PhosphoSitePlusiQ9UKR0.

Expressioni

Gene expression databases

BgeeiENSG00000186474.
CleanExiHS_KLK12.
ExpressionAtlasiQ9UKR0. baseline and differential.
GenevisibleiQ9UKR0. HS.

Organism-specific databases

HPAiCAB025473.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000250351.

Structurei

3D structure databases

ProteinModelPortaliQ9UKR0.
SMRiQ9UKR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR0.
KOiK09621.
OMAiGWGTTNH.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9UKR0.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV
60 70 80 90 100
LIDHRWVLTA AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG
110 120 130 140 150
ASTSHEHDLR LLRLRLPVRV TSSVQPLPLP NDCATAGTEC HVSGWGITNH
160 170 180 190 200
PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI TSNMVCAGGV PGQDACQGDS
210 220 230 240
GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW IRMIMRNN
Length:248
Mass (Da):26,734
Last modified:May 1, 2000 - v1
Checksum:iBB473E98F8BAF703
GO
Isoform 2 (identifier: Q9UKR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-248: KYVDWIRMIMRNN → NSTLVGLGTSWNFNSCQPF

Show »
Length:254
Mass (Da):27,067
Checksum:i704A1552D34DF188
GO
Isoform 3 (identifier: Q9UKR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: SRYWVRLGEH...STSHEHDLRL → RPIPGSAPVP...RRPGAGCLPG
     112-248: Missing.

Show »
Length:111
Mass (Da):11,984
Checksum:i3E8EAB4295635D8D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04585166 – 111SRYWV…HDLRL → RPIPGSAPVPQPLHRLPCHL PWCVSRENHEQHGVCRRRPG AGCLPG in isoform 3. CuratedAdd BLAST46
Alternative sequenceiVSP_045852112 – 248Missing in isoform 3. CuratedAdd BLAST137
Alternative sequenceiVSP_005403236 – 248KYVDW…IMRNN → NSTLVGLGTSWNFNSCQPF in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2.
AF135025 Genomic DNA. Translation: AAF06065.1.
AF135025 Genomic DNA. Translation: AAF06066.1.
AF243527 Genomic DNA. Translation: AAG33365.1.
AY358524 mRNA. Translation: AAQ88888.1.
AC011473 Genomic DNA. Translation: AAG23258.1.
CH471135 Genomic DNA. Translation: EAW71976.1.
CCDSiCCDS12820.1. [Q9UKR0-2]
CCDS12821.1. [Q9UKR0-1]
CCDS54298.1. [Q9UKR0-3]
RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
NP_665901.1. NM_145894.1. [Q9UKR0-1]
NP_665902.1. NM_145895.1. [Q9UKR0-3]
XP_005259008.1. XM_005258951.3. [Q9UKR0-3]
UniGeneiHs.411572.

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
GeneIDi43849.
KEGGihsa:43849.
UCSCiuc002pvg.1. human. [Q9UKR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA. Translation: AAD26426.2.
AF135025 Genomic DNA. Translation: AAF06065.1.
AF135025 Genomic DNA. Translation: AAF06066.1.
AF243527 Genomic DNA. Translation: AAG33365.1.
AY358524 mRNA. Translation: AAQ88888.1.
AC011473 Genomic DNA. Translation: AAG23258.1.
CH471135 Genomic DNA. Translation: EAW71976.1.
CCDSiCCDS12820.1. [Q9UKR0-2]
CCDS12821.1. [Q9UKR0-1]
CCDS54298.1. [Q9UKR0-3]
RefSeqiNP_062544.1. NM_019598.2. [Q9UKR0-2]
NP_665901.1. NM_145894.1. [Q9UKR0-1]
NP_665902.1. NM_145895.1. [Q9UKR0-3]
XP_005259008.1. XM_005258951.3. [Q9UKR0-3]
UniGeneiHs.411572.

3D structure databases

ProteinModelPortaliQ9UKR0.
SMRiQ9UKR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000250351.

Chemistry databases

ChEMBLiCHEMBL4943.

Protein family/group databases

MEROPSiS01.020.

PTM databases

PhosphoSitePlusiQ9UKR0.

Polymorphism and mutation databases

BioMutaiKLK12.
DMDMi9296989.

Proteomic databases

PaxDbiQ9UKR0.
PeptideAtlasiQ9UKR0.
PRIDEiQ9UKR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474. [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474. [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474. [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474. [Q9UKR0-3]
GeneIDi43849.
KEGGihsa:43849.
UCSCiuc002pvg.1. human. [Q9UKR0-1]

Organism-specific databases

CTDi43849.
DisGeNETi43849.
GeneCardsiKLK12.
HGNCiHGNC:6360. KLK12.
HPAiCAB025473.
MIMi605539. gene.
neXtProtiNX_Q9UKR0.
OpenTargetsiENSG00000186474.
PharmGKBiPA30149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UKR0.
KOiK09621.
OMAiGWGTTNH.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9UKR0.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167758-MONOMER.
BRENDAi3.4.21.B43. 2681.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiKLK12.
GenomeRNAii43849.
PROiQ9UKR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186474.
CleanExiHS_KLK12.
ExpressionAtlasiQ9UKR0. baseline and differential.
GenevisibleiQ9UKR0. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK12_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR0
Secondary accession number(s): Q9UKR1, Q9UKR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.