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Protein

Kallikrein-9

Gene

KLK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay systemBy similarity1
Active sitei111Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B40. 2681.

Protein family/group databases

MEROPSiS01.307.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-9 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 3
Short name:
KLK-L3
Gene namesi
Name:KLK9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213022.5.
HGNCiHGNC:6370. KLK9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284366.
OpenTargetsiENSG00000213022.
ENSG00000269741.
PharmGKBiPA30159.

Polymorphism and mutation databases

BioMutaiKLK9.
DMDMi9296988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000002795216 – 250Kallikrein-9Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 164PROSITE-ProRule annotation
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 238PROSITE-ProRule annotation
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 189PROSITE-ProRule annotation
Disulfide bondi200 ↔ 225PROSITE-ProRule annotation
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKQ9.
PeptideAtlasiQ9UKQ9.
PRIDEiQ9UKQ9.

PTM databases

iPTMnetiQ9UKQ9.
PhosphoSitePlusiQ9UKQ9.

Expressioni

Tissue specificityi

Skin, thymus, trachea, cerebellum and spinal cord.

Gene expression databases

BgeeiENSG00000213022.
CleanExiHS_KLK9.
ExpressionAtlasiQ9UKQ9. baseline and differential.
GenevisibleiQ9UKQ9. HS.

Organism-specific databases

HPAiCAB025049.

Interactioni

Protein-protein interaction databases

BioGridi129846. 11 interactors.
IntActiQ9UKQ9. 10 interactors.
STRINGi9606.ENSP00000366028.

Structurei

3D structure databases

ProteinModelPortaliQ9UKQ9.
SMRiQ9UKQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 249Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000143451.
HOVERGENiHBG013304.
InParanoidiQ9UKQ9.
KOiK09618.
OMAiRKTMEDN.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UKQ9.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLGLLCALL SLLAGHGWAD TRAIGAEECR PNSQPWQAGL FHLTRLFCGA
60 70 80 90 100
TLISDRWLLT AAHCRKPYLW VRLGEHHLWK WEGPEQLFRV TDFFPHPGFN
110 120 130 140 150
KDLSANDHND DIMLIRLPRQ ARLSPAVQPL NLSQTCVSPG MQCLISGWGA
160 170 180 190 200
VSSPKALFPV TLQCANISIL ENKLCHWAYP GHISDSMLCA GLWEGGRGSC
210 220 230 240 250
QGDSGGPLVC NGTLAGVVSG GAEPCSRPRR PAVYTSVCHY LDWIQEIMEN
Length:250
Mass (Da):27,513
Last modified:May 1, 2000 - v1
Checksum:iF2785245B063E98B
GO
Isoform 2 (identifier: Q9UKQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-61: HGWADTRAIG...LISDRWLLTA → ICGSALESTT...APMTTMMTSC
     62-250: Missing.

Show »
Length:61
Mass (Da):6,142
Checksum:i52598E4DC19642A9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05704416 – 61HGWAD…WLLTA → ICGSALESTTSGNGRVRSSC SGLRTSSPTLASTRTSAPMT TMMTSC in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_05704562 – 250Missing in isoform 2. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135026 Genomic DNA. Translation: AAD26427.2.
AF243527 Genomic DNA. Translation: AAG33362.1.
AY551001 mRNA. Translation: AAS55655.1.
AC011473 Genomic DNA. Translation: AAG23255.1.
AC011483 Genomic DNA. No translation available.
CCDSiCCDS12816.1. [Q9UKQ9-1]
RefSeqiNP_036447.1. NM_012315.1. [Q9UKQ9-1]
UniGeneiHs.448942.

Genome annotation databases

EnsembliENST00000544410; ENSP00000443289; ENSG00000213022. [Q9UKQ9-2]
ENST00000594211; ENSP00000469417; ENSG00000213022. [Q9UKQ9-1]
GeneIDi284366.
KEGGihsa:284366.
UCSCiuc002pux.2. human. [Q9UKQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKLK9_HUMAN
AccessioniPrimary (citable) accession number: Q9UKQ9
Secondary accession number(s): Q6QA55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families