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Protein

Kallikrein-9

Gene

KLK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay systemBy similarity
Active sitei111 – 1111Charge relay systemBy similarity
Active sitei204 – 2041Charge relay systemBy similarity

GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B40. 2681.

Protein family/group databases

MEROPSiS01.307.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-9 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 3
Short name:
KLK-L3
Gene namesi
Name:KLK9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6370. KLK9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30159.

Polymorphism and mutation databases

BioMutaiKLK9.
DMDMi9296988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 250235Kallikrein-9PRO_0000027952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 164PROSITE-ProRule annotation
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi136 ↔ 238PROSITE-ProRule annotation
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi175 ↔ 189PROSITE-ProRule annotation
Disulfide bondi200 ↔ 225PROSITE-ProRule annotation
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKQ9.
PRIDEiQ9UKQ9.

PTM databases

PhosphoSiteiQ9UKQ9.

Expressioni

Tissue specificityi

Skin, thymus, trachea, cerebellum and spinal cord.

Gene expression databases

BgeeiQ9UKQ9.
CleanExiHS_KLK9.
ExpressionAtlasiQ9UKQ9. baseline and differential.
GenevisibleiQ9UKQ9. HS.

Organism-specific databases

HPAiCAB025049.

Interactioni

Protein-protein interaction databases

BioGridi129846. 11 interactions.
IntActiQ9UKQ9. 10 interactions.
STRINGi9606.ENSP00000366028.

Structurei

3D structure databases

ProteinModelPortaliQ9UKQ9.
SMRiQ9UKQ9. Positions 26-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 249227Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000143451.
HOVERGENiHBG013304.
InParanoidiQ9UKQ9.
KOiK09618.
OMAiRKTMEDN.
PhylomeDBiQ9UKQ9.
TreeFamiTF331065.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLGLLCALL SLLAGHGWAD TRAIGAEECR PNSQPWQAGL FHLTRLFCGA
60 70 80 90 100
TLISDRWLLT AAHCRKPYLW VRLGEHHLWK WEGPEQLFRV TDFFPHPGFN
110 120 130 140 150
KDLSANDHND DIMLIRLPRQ ARLSPAVQPL NLSQTCVSPG MQCLISGWGA
160 170 180 190 200
VSSPKALFPV TLQCANISIL ENKLCHWAYP GHISDSMLCA GLWEGGRGSC
210 220 230 240 250
QGDSGGPLVC NGTLAGVVSG GAEPCSRPRR PAVYTSVCHY LDWIQEIMEN
Length:250
Mass (Da):27,513
Last modified:May 1, 2000 - v1
Checksum:iF2785245B063E98B
GO
Isoform 2 (identifier: Q9UKQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-61: HGWADTRAIG...LISDRWLLTA → ICGSALESTT...APMTTMMTSC
     62-250: Missing.

Show »
Length:61
Mass (Da):6,142
Checksum:i52598E4DC19642A9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 6146HGWAD…WLLTA → ICGSALESTTSGNGRVRSSC SGLRTSSPTLASTRTSAPMT TMMTSC in isoform 2. 1 PublicationVSP_057044Add
BLAST
Alternative sequencei62 – 250189Missing in isoform 2. 1 PublicationVSP_057045Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135026 Genomic DNA. Translation: AAD26427.2.
AF243527 Genomic DNA. Translation: AAG33362.1.
AY551001 mRNA. Translation: AAS55655.1.
AC011473 Genomic DNA. Translation: AAG23255.1.
AC011483 Genomic DNA. No translation available.
CCDSiCCDS12816.1. [Q9UKQ9-1]
RefSeqiNP_036447.1. NM_012315.1. [Q9UKQ9-1]
UniGeneiHs.448942.

Genome annotation databases

EnsembliENST00000544410; ENSP00000443289; ENSG00000213022. [Q9UKQ9-2]
ENST00000594211; ENSP00000469417; ENSG00000213022. [Q9UKQ9-1]
GeneIDi284366.
KEGGihsa:284366.
UCSCiuc002pux.2. human. [Q9UKQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135026 Genomic DNA. Translation: AAD26427.2.
AF243527 Genomic DNA. Translation: AAG33362.1.
AY551001 mRNA. Translation: AAS55655.1.
AC011473 Genomic DNA. Translation: AAG23255.1.
AC011483 Genomic DNA. No translation available.
CCDSiCCDS12816.1. [Q9UKQ9-1]
RefSeqiNP_036447.1. NM_012315.1. [Q9UKQ9-1]
UniGeneiHs.448942.

3D structure databases

ProteinModelPortaliQ9UKQ9.
SMRiQ9UKQ9. Positions 26-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129846. 11 interactions.
IntActiQ9UKQ9. 10 interactions.
STRINGi9606.ENSP00000366028.

Protein family/group databases

MEROPSiS01.307.

PTM databases

PhosphoSiteiQ9UKQ9.

Polymorphism and mutation databases

BioMutaiKLK9.
DMDMi9296988.

Proteomic databases

PaxDbiQ9UKQ9.
PRIDEiQ9UKQ9.

Protocols and materials databases

DNASUi284366.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000544410; ENSP00000443289; ENSG00000213022. [Q9UKQ9-2]
ENST00000594211; ENSP00000469417; ENSG00000213022. [Q9UKQ9-1]
GeneIDi284366.
KEGGihsa:284366.
UCSCiuc002pux.2. human. [Q9UKQ9-1]

Organism-specific databases

CTDi284366.
GeneCardsiKLK9.
HGNCiHGNC:6370. KLK9.
HPAiCAB025049.
MIMi605504. gene.
neXtProtiNX_Q9UKQ9.
PharmGKBiPA30159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000143451.
HOVERGENiHBG013304.
InParanoidiQ9UKQ9.
KOiK09618.
OMAiRKTMEDN.
PhylomeDBiQ9UKQ9.
TreeFamiTF331065.

Enzyme and pathway databases

BRENDAi3.4.21.B40. 2681.

Miscellaneous databases

GeneWikiiKLK9.
GenomeRNAii284366.
NextBioi94790.
PROiQ9UKQ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKQ9.
CleanExiHS_KLK9.
ExpressionAtlasiQ9UKQ9. baseline and differential.
GenevisibleiQ9UKQ9. HS.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."
    Yousef G.M., Luo L.-Y., Diamandis E.P.
    Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3."
    Yousef G.M., Diamandis E.P.
    Genomics 65:184-194(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of new splice variants of the human kallikrein gene 9."
    Kurlender L.E., Michael I.P., Diamandis E.P.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKLK9_HUMAN
AccessioniPrimary (citable) accession number: Q9UKQ9
Secondary accession number(s): Q6QA55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.