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Q9UKQ2

- ADA28_HUMAN

UniProt

Q9UKQ2 - ADA28_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 28

Gene

ADAM28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi169 – 1691Zinc; in inhibited formBy similarity
    Metal bindingi339 – 3391Zinc; catalyticBy similarity
    Active sitei340 – 3401PROSITE-ProRule annotation
    Metal bindingi343 – 3431Zinc; catalyticBy similarity
    Metal bindingi349 – 3491Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. metallopeptidase activity Source: BHF-UCL
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM12.224.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 28 (EC:3.4.24.-)
    Short name:
    ADAM 28
    Alternative name(s):
    Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
    Short name:
    eMDC II
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L
    Short name:
    MDC-L
    Gene namesi
    Name:ADAM28
    Synonyms:ADAM23, MDCL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:206. ADAM28.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24523.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 198180By similarityPRO_0000029128Add
    BLAST
    Chaini199 – 775577Disintegrin and metalloproteinase domain-containing protein 28PRO_0000029129Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi315 ↔ 394By similarity
    Disulfide bondi354 ↔ 378By similarity
    Disulfide bondi356 ↔ 361By similarity
    Disulfide bondi465 ↔ 485By similarity
    Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi629 ↔ 639By similarity
    Disulfide bondi633 ↔ 645By similarity
    Disulfide bondi647 ↔ 656By similarity

    Post-translational modificationi

    Pro-domain removal and maturation may be, at least in part, autocatalytic.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9UKQ2.
    PRIDEiQ9UKQ2.

    PTM databases

    PhosphoSiteiQ9UKQ2.

    Expressioni

    Tissue specificityi

    Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.

    Gene expression databases

    ArrayExpressiQ9UKQ2.
    BgeeiQ9UKQ2.
    CleanExiHS_ADAM23.
    HS_ADAM28.
    GenevestigatoriQ9UKQ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265769.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKQ2.
    SMRiQ9UKQ2. Positions 199-658.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini199 – 665467ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini687 – 77589CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei666 – 68621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 399196Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini407 – 49387DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 65733EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi167 – 1748Cysteine switchBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi494 – 628135Cys-richAdd
    BLAST

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277164.
    HOGENOMiHOG000230883.
    HOVERGENiHBG006978.
    InParanoidiQ9UKQ2.
    KOiK08614.
    OMAiTSPQIMD.
    OrthoDBiEOG7PGDQ7.
    PhylomeDBiQ9UKQ2.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKQ2-1) [UniParc]FASTAAdd to Basket

    Also known as: MDC-LM

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ    50
    EQFETELKYK MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ 100
    IMDDCYYQGH ILNEKVSDAS ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG 150
    QEHALFKYNP DEKNYDSTCG MDGVLWAHDL QQNIALPATK LVKLKDRKVQ 200
    EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM LYKKLNTHVA 250
    LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE 300
    LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD 350
    DYSCKCPSTI CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL 400
    PTDIISTPIC GNQLVEMGED CDCGTSEECT NICCDAKTCK IKATFQCALG 450
    ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG KSGNCPDDRF QVNGFPCHHG 500
    KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK YGYCRRVDDT 550
    LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV 600
    ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG 650
    WIPPDCDDSS VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR 700
    PLSTTGTRPH KQKRKPQMVK AVQPQEMSQM KPHVYDLPVE GNEPPASFHK 750
    DTNALPPTVF KDNPVSTPKD SNPKA 775
    Length:775
    Mass (Da):87,148
    Last modified:January 11, 2011 - v3
    Checksum:i895E0985840F971C
    GO
    Isoform 2 (identifier: Q9UKQ2-2) [UniParc]FASTAAdd to Basket

    Also known as: MDC-LS

    The sequence of this isoform differs from the canonical sequence as follows:
         524-540: TEVADKSCYNRNEGGSK → RRTNPFPCACAKENHFR
         541-775: Missing.

    Show »
    Length:540
    Mass (Da):61,232
    Checksum:i65F475E18650D227
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti513 – 5131Q → R in AAD25099. (PubMed:10506182)Curated
    Sequence conflicti513 – 5131Q → R in AAD25100. (PubMed:10506182)Curated
    Sequence conflicti774 – 7741K → E in AAD25099. (PubMed:10506182)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066317
    Natural varianti134 – 1341G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066318
    Natural varianti219 – 2191R → M.
    Corresponds to variant rs9314282 [ dbSNP | Ensembl ].
    VAR_057067
    Natural varianti226 – 2261E → D.
    Corresponds to variant rs17736699 [ dbSNP | Ensembl ].
    VAR_057068
    Natural varianti450 – 4501G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066319
    Natural varianti482 – 4821S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066320
    Natural varianti493 – 4931N → S.
    Corresponds to variant rs7001647 [ dbSNP | Ensembl ].
    VAR_057069
    Natural varianti502 – 5021G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066321
    Natural varianti593 – 5931T → K.
    Corresponds to variant rs36041430 [ dbSNP | Ensembl ].
    VAR_057070
    Natural varianti604 – 6041T → P.
    Corresponds to variant rs35617826 [ dbSNP | Ensembl ].
    VAR_057071
    Natural varianti684 – 6841M → I.
    Corresponds to variant rs7829965 [ dbSNP | Ensembl ].
    VAR_057072
    Natural varianti765 – 7651V → M.4 Publications
    Corresponds to variant rs7814768 [ dbSNP | Ensembl ].
    VAR_024596

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei524 – 54017TEVAD…EGGSK → RRTNPFPCACAKENHFR in isoform 2. 1 PublicationVSP_005486Add
    BLAST
    Alternative sequencei541 – 775235Missing in isoform 2. 1 PublicationVSP_005487Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137334 mRNA. Translation: AAD25099.1.
    AF137335 mRNA. Translation: AAD25100.1.
    AJ242015 mRNA. Translation: CAB42085.1.
    AC044891 Genomic DNA. No translation available.
    AC120193 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63609.1.
    BC136478 mRNA. Translation: AAI36479.1.
    CCDSiCCDS34865.1. [Q9UKQ2-1]
    CCDS47830.1. [Q9UKQ2-2]
    RefSeqiNP_055080.2. NM_014265.4. [Q9UKQ2-1]
    NP_068547.2. NM_021777.3. [Q9UKQ2-2]
    UniGeneiHs.174030.

    Genome annotation databases

    EnsembliENST00000265769; ENSP00000265769; ENSG00000042980. [Q9UKQ2-1]
    ENST00000437154; ENSP00000393699; ENSG00000042980. [Q9UKQ2-2]
    GeneIDi10863.
    KEGGihsa:10863.
    UCSCiuc003xdx.3. human. [Q9UKQ2-2]
    uc003xdy.3. human. [Q9UKQ2-1]

    Polymorphism databases

    DMDMi317373485.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137334 mRNA. Translation: AAD25099.1 .
    AF137335 mRNA. Translation: AAD25100.1 .
    AJ242015 mRNA. Translation: CAB42085.1 .
    AC044891 Genomic DNA. No translation available.
    AC120193 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63609.1 .
    BC136478 mRNA. Translation: AAI36479.1 .
    CCDSi CCDS34865.1. [Q9UKQ2-1 ]
    CCDS47830.1. [Q9UKQ2-2 ]
    RefSeqi NP_055080.2. NM_014265.4. [Q9UKQ2-1 ]
    NP_068547.2. NM_021777.3. [Q9UKQ2-2 ]
    UniGenei Hs.174030.

    3D structure databases

    ProteinModelPortali Q9UKQ2.
    SMRi Q9UKQ2. Positions 199-658.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265769.

    Protein family/group databases

    MEROPSi M12.224.

    PTM databases

    PhosphoSitei Q9UKQ2.

    Polymorphism databases

    DMDMi 317373485.

    Proteomic databases

    PaxDbi Q9UKQ2.
    PRIDEi Q9UKQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265769 ; ENSP00000265769 ; ENSG00000042980 . [Q9UKQ2-1 ]
    ENST00000437154 ; ENSP00000393699 ; ENSG00000042980 . [Q9UKQ2-2 ]
    GeneIDi 10863.
    KEGGi hsa:10863.
    UCSCi uc003xdx.3. human. [Q9UKQ2-2 ]
    uc003xdy.3. human. [Q9UKQ2-1 ]

    Organism-specific databases

    CTDi 10863.
    GeneCardsi GC08P024207.
    H-InvDB HIX0034262.
    HGNCi HGNC:206. ADAM28.
    MIMi 606188. gene.
    neXtProti NX_Q9UKQ2.
    PharmGKBi PA24523.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277164.
    HOGENOMi HOG000230883.
    HOVERGENi HBG006978.
    InParanoidi Q9UKQ2.
    KOi K08614.
    OMAi TSPQIMD.
    OrthoDBi EOG7PGDQ7.
    PhylomeDBi Q9UKQ2.
    TreeFami TF314733.

    Miscellaneous databases

    GeneWikii ADAM28.
    GenomeRNAii 10863.
    NextBioi 41241.
    PROi Q9UKQ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKQ2.
    Bgeei Q9UKQ2.
    CleanExi HS_ADAM23.
    HS_ADAM28.
    Genevestigatori Q9UKQ2.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes."
      Roberts C.M., Tani P.H., Bridges L.C., Laszik Z., Bowditch R.D.
      J. Biol. Chem. 274:29251-29259(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT MET-765.
      Tissue: Lymph node.
    2. "Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis."
      Jury J.A., Perry A.C., Hall L.
      Mol. Hum. Reprod. 5:1127-1134(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-765.
      Tissue: Epididymis.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-765.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-765.
      Tissue: Brain.
    6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
      Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLU-65; GLU-134; GLU-450; PHE-482 AND ASP-502.

    Entry informationi

    Entry nameiADA28_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKQ2
    Secondary accession number(s): B2RMV5, Q9Y339, Q9Y3S0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 140 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3