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Q9UKQ2

- ADA28_HUMAN

UniProt

Q9UKQ2 - ADA28_HUMAN

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Protein

Disintegrin and metalloproteinase domain-containing protein 28

Gene

ADAM28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi169 – 1691Zinc; in inhibited formBy similarity
Metal bindingi339 – 3391Zinc; catalyticBy similarity
Active sitei340 – 3401PROSITE-ProRule annotation
Metal bindingi343 – 3431Zinc; catalyticBy similarity
Metal bindingi349 – 3491Zinc; catalyticBy similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. metallopeptidase activity Source: BHF-UCL
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.224.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 28 (EC:3.4.24.-)
Short name:
ADAM 28
Alternative name(s):
Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
Short name:
eMDC II
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L
Short name:
MDC-L
Gene namesi
Name:ADAM28
Synonyms:ADAM23, MDCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:206. ADAM28.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24523.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 198180By similarityPRO_0000029128Add
BLAST
Chaini199 – 775577Disintegrin and metalloproteinase domain-containing protein 28PRO_0000029129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi315 ↔ 394By similarity
Disulfide bondi354 ↔ 378By similarity
Disulfide bondi356 ↔ 361By similarity
Disulfide bondi465 ↔ 485By similarity
Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi629 ↔ 639By similarity
Disulfide bondi633 ↔ 645By similarity
Disulfide bondi647 ↔ 656By similarity

Post-translational modificationi

Pro-domain removal and maturation may be, at least in part, autocatalytic.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UKQ2.
PRIDEiQ9UKQ2.

PTM databases

PhosphoSiteiQ9UKQ2.

Expressioni

Tissue specificityi

Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.

Gene expression databases

BgeeiQ9UKQ2.
CleanExiHS_ADAM23.
HS_ADAM28.
ExpressionAtlasiQ9UKQ2. baseline and differential.
GenevestigatoriQ9UKQ2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265769.

Structurei

3D structure databases

ProteinModelPortaliQ9UKQ2.
SMRiQ9UKQ2. Positions 199-657.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini199 – 665467ExtracellularSequence AnalysisAdd
BLAST
Topological domaini687 – 77589CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei666 – 68621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 399196Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini407 – 49387DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini625 – 65733EGF-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi167 – 1748Cysteine switchBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi494 – 628135Cys-richAdd
BLAST

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277164.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9UKQ2.
KOiK08614.
OMAiTSPQIMD.
OrthoDBiEOG7PGDQ7.
PhylomeDBiQ9UKQ2.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKQ2-1) [UniParc]FASTAAdd to Basket

Also known as: MDC-LM

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ
60 70 80 90 100
EQFETELKYK MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ
110 120 130 140 150
IMDDCYYQGH ILNEKVSDAS ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG
160 170 180 190 200
QEHALFKYNP DEKNYDSTCG MDGVLWAHDL QQNIALPATK LVKLKDRKVQ
210 220 230 240 250
EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM LYKKLNTHVA
260 270 280 290 300
LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE
310 320 330 340 350
LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD
360 370 380 390 400
DYSCKCPSTI CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL
410 420 430 440 450
PTDIISTPIC GNQLVEMGED CDCGTSEECT NICCDAKTCK IKATFQCALG
460 470 480 490 500
ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG KSGNCPDDRF QVNGFPCHHG
510 520 530 540 550
KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK YGYCRRVDDT
560 570 580 590 600
LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV
610 620 630 640 650
ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG
660 670 680 690 700
WIPPDCDDSS VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR
710 720 730 740 750
PLSTTGTRPH KQKRKPQMVK AVQPQEMSQM KPHVYDLPVE GNEPPASFHK
760 770
DTNALPPTVF KDNPVSTPKD SNPKA
Length:775
Mass (Da):87,148
Last modified:January 11, 2011 - v3
Checksum:i895E0985840F971C
GO
Isoform 2 (identifier: Q9UKQ2-2) [UniParc]FASTAAdd to Basket

Also known as: MDC-LS

The sequence of this isoform differs from the canonical sequence as follows:
     524-540: TEVADKSCYNRNEGGSK → RRTNPFPCACAKENHFR
     541-775: Missing.

Show »
Length:540
Mass (Da):61,232
Checksum:i65F475E18650D227
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 5131Q → R in AAD25099. (PubMed:10506182)Curated
Sequence conflicti513 – 5131Q → R in AAD25100. (PubMed:10506182)Curated
Sequence conflicti774 – 7741K → E in AAD25099. (PubMed:10506182)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066317
Natural varianti134 – 1341G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066318
Natural varianti219 – 2191R → M.
Corresponds to variant rs9314282 [ dbSNP | Ensembl ].
VAR_057067
Natural varianti226 – 2261E → D.
Corresponds to variant rs17736699 [ dbSNP | Ensembl ].
VAR_057068
Natural varianti450 – 4501G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066319
Natural varianti482 – 4821S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066320
Natural varianti493 – 4931N → S.
Corresponds to variant rs7001647 [ dbSNP | Ensembl ].
VAR_057069
Natural varianti502 – 5021G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066321
Natural varianti593 – 5931T → K.
Corresponds to variant rs36041430 [ dbSNP | Ensembl ].
VAR_057070
Natural varianti604 – 6041T → P.
Corresponds to variant rs35617826 [ dbSNP | Ensembl ].
VAR_057071
Natural varianti684 – 6841M → I.
Corresponds to variant rs7829965 [ dbSNP | Ensembl ].
VAR_057072
Natural varianti765 – 7651V → M.4 Publications
Corresponds to variant rs7814768 [ dbSNP | Ensembl ].
VAR_024596

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei524 – 54017TEVAD…EGGSK → RRTNPFPCACAKENHFR in isoform 2. 1 PublicationVSP_005486Add
BLAST
Alternative sequencei541 – 775235Missing in isoform 2. 1 PublicationVSP_005487Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137334 mRNA. Translation: AAD25099.1.
AF137335 mRNA. Translation: AAD25100.1.
AJ242015 mRNA. Translation: CAB42085.1.
AC044891 Genomic DNA. No translation available.
AC120193 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63609.1.
BC136478 mRNA. Translation: AAI36479.1.
CCDSiCCDS34865.1. [Q9UKQ2-1]
CCDS47830.1. [Q9UKQ2-2]
RefSeqiNP_055080.2. NM_014265.4. [Q9UKQ2-1]
NP_068547.2. NM_021777.3. [Q9UKQ2-2]
UniGeneiHs.174030.

Genome annotation databases

EnsembliENST00000265769; ENSP00000265769; ENSG00000042980. [Q9UKQ2-1]
ENST00000437154; ENSP00000393699; ENSG00000042980. [Q9UKQ2-2]
GeneIDi10863.
KEGGihsa:10863.
UCSCiuc003xdx.3. human. [Q9UKQ2-2]
uc003xdy.3. human. [Q9UKQ2-1]

Polymorphism databases

DMDMi317373485.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137334 mRNA. Translation: AAD25099.1 .
AF137335 mRNA. Translation: AAD25100.1 .
AJ242015 mRNA. Translation: CAB42085.1 .
AC044891 Genomic DNA. No translation available.
AC120193 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63609.1 .
BC136478 mRNA. Translation: AAI36479.1 .
CCDSi CCDS34865.1. [Q9UKQ2-1 ]
CCDS47830.1. [Q9UKQ2-2 ]
RefSeqi NP_055080.2. NM_014265.4. [Q9UKQ2-1 ]
NP_068547.2. NM_021777.3. [Q9UKQ2-2 ]
UniGenei Hs.174030.

3D structure databases

ProteinModelPortali Q9UKQ2.
SMRi Q9UKQ2. Positions 199-657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265769.

Protein family/group databases

MEROPSi M12.224.

PTM databases

PhosphoSitei Q9UKQ2.

Polymorphism databases

DMDMi 317373485.

Proteomic databases

PaxDbi Q9UKQ2.
PRIDEi Q9UKQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265769 ; ENSP00000265769 ; ENSG00000042980 . [Q9UKQ2-1 ]
ENST00000437154 ; ENSP00000393699 ; ENSG00000042980 . [Q9UKQ2-2 ]
GeneIDi 10863.
KEGGi hsa:10863.
UCSCi uc003xdx.3. human. [Q9UKQ2-2 ]
uc003xdy.3. human. [Q9UKQ2-1 ]

Organism-specific databases

CTDi 10863.
GeneCardsi GC08P024151.
H-InvDB HIX0034262.
HGNCi HGNC:206. ADAM28.
MIMi 606188. gene.
neXtProti NX_Q9UKQ2.
PharmGKBi PA24523.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277164.
GeneTreei ENSGT00760000118888.
HOGENOMi HOG000230883.
HOVERGENi HBG006978.
InParanoidi Q9UKQ2.
KOi K08614.
OMAi TSPQIMD.
OrthoDBi EOG7PGDQ7.
PhylomeDBi Q9UKQ2.
TreeFami TF314733.

Miscellaneous databases

GeneWikii ADAM28.
GenomeRNAii 10863.
NextBioi 41241.
PROi Q9UKQ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKQ2.
CleanExi HS_ADAM23.
HS_ADAM28.
ExpressionAtlasi Q9UKQ2. baseline and differential.
Genevestigatori Q9UKQ2.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes."
    Roberts C.M., Tani P.H., Bridges L.C., Laszik Z., Bowditch R.D.
    J. Biol. Chem. 274:29251-29259(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT MET-765.
    Tissue: Lymph node.
  2. "Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis."
    Jury J.A., Perry A.C., Hall L.
    Mol. Hum. Reprod. 5:1127-1134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-765.
    Tissue: Epididymis.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-765.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-765.
    Tissue: Brain.
  6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
    Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
    Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLU-65; GLU-134; GLU-450; PHE-482 AND ASP-502.

Entry informationi

Entry nameiADA28_HUMAN
AccessioniPrimary (citable) accession number: Q9UKQ2
Secondary accession number(s): B2RMV5, Q9Y339, Q9Y3S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3