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Protein

Urotensin-2 receptor

Gene

UTS2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • urotensin II receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2 receptor
Short name:
UR-2-R
Alternative name(s):
G-protein coupled receptor 14
Urotensin II receptor
Short name:
UR-II-R
Gene namesi
Name:UTS2R
Synonyms:GPR14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4468. UTS2R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence analysisAdd
BLAST
Transmembranei55 – 7723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 8710CytoplasmicSequence analysis
Transmembranei88 – 11326Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini114 – 12411ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14622Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini147 – 16721CytoplasmicSequence analysisAdd
BLAST
Transmembranei168 – 18619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini187 – 20923ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 25826CytoplasmicSequence analysisAdd
BLAST
Transmembranei259 – 28426Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini285 – 29713ExtracellularSequence analysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini319 – 38971CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: Ensembl
  • early endosome Source: Ensembl
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28857.

Chemistry

ChEMBLiCHEMBL3764.
GuidetoPHARMACOLOGYi365.

Polymorphism and mutation databases

BioMutaiUTS2R.
DMDMi8928474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Urotensin-2 receptorPRO_0000070193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKP6.
PRIDEiQ9UKP6.

Expressioni

Tissue specificityi

Most abundant expression in the heart and pancreas.

Gene expression databases

BgeeiQ9UKP6.
CleanExiHS_UTS2R.
GenevisibleiQ9UKP6. HS.

Interactioni

Protein-protein interaction databases

BioGridi109097. 1 interaction.
STRINGi9606.ENSP00000323516.

Chemistry

BindingDBiQ9UKP6.

Structurei

3D structure databases

ProteinModelPortaliQ9UKP6.
SMRiQ9UKP6. Positions 29-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiQ9UKP6.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG76QFHM.
PhylomeDBiQ9UKP6.
TreeFamiTF334200.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTPESPSS FPGLAATGSS VPEPPGGPNA TLNSSWASPT EPSSLEDLVA
60 70 80 90 100
TGTIGTLLSA MGVVGVVGNA YTLVVTCRSL RAVASMYVYV VNLALADLLY
110 120 130 140 150
LLSIPFIVAT YVTKEWHFGD VGCRVLFGLD FLTMHASIFT LTVMSSERYA
160 170 180 190 200
AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL TLPVMLAMRL VRRGPKSLCL
210 220 230 240 250
PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR SQRASFKRAR
260 270 280 290 300
RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYHQAPLAP RTARIVNYLT
310 320 330 340 350
TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RGPGSGGGRG PVPSLQPRAR
360 370 380
FQRCSGRSLS SCSPQPTDSL VLAPAAPARP APEGPRAPA
Length:389
Mass (Da):42,130
Last modified:May 1, 2000 - v1
Checksum:i6D6A88DBF78400CE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701A → P.
Corresponds to variant rs34442190 [ dbSNP | Ensembl ].
VAR_049451
Natural varianti146 – 1461S → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035768

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140631 Genomic DNA. Translation: AAD55578.1.
CH471099 Genomic DNA. Translation: EAW89768.1.
BC136490 mRNA. Translation: AAI36491.1.
CCDSiCCDS11810.1.
RefSeqiNP_061822.1. NM_018949.2.
UniGeneiHs.192720.

Genome annotation databases

EnsembliENST00000313135; ENSP00000323516; ENSG00000181408.
GeneIDi2837.
KEGGihsa:2837.
UCSCiuc010wvl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140631 Genomic DNA. Translation: AAD55578.1.
CH471099 Genomic DNA. Translation: EAW89768.1.
BC136490 mRNA. Translation: AAI36491.1.
CCDSiCCDS11810.1.
RefSeqiNP_061822.1. NM_018949.2.
UniGeneiHs.192720.

3D structure databases

ProteinModelPortaliQ9UKP6.
SMRiQ9UKP6. Positions 29-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109097. 1 interaction.
STRINGi9606.ENSP00000323516.

Chemistry

BindingDBiQ9UKP6.
ChEMBLiCHEMBL3764.
GuidetoPHARMACOLOGYi365.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiUTS2R.
DMDMi8928474.

Proteomic databases

PaxDbiQ9UKP6.
PRIDEiQ9UKP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313135; ENSP00000323516; ENSG00000181408.
GeneIDi2837.
KEGGihsa:2837.
UCSCiuc010wvl.3. human.

Organism-specific databases

CTDi2837.
GeneCardsiUTS2R.
HGNCiHGNC:4468. UTS2R.
MIMi600896. gene.
neXtProtiNX_Q9UKP6.
PharmGKBiPA28857.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiQ9UKP6.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG76QFHM.
PhylomeDBiQ9UKP6.
TreeFamiTF334200.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiUrotensin-II_receptor.
GenomeRNAii2837.
PROiQ9UKP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKP6.
CleanExiHS_UTS2R.
GenevisibleiQ9UKP6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain."
    Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.
    Biochem. Biophys. Res. Commun. 310:860-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A UROTENSIN-2B RECEPTOR.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-146.

Entry informationi

Entry nameiUR2R_HUMAN
AccessioniPrimary (citable) accession number: Q9UKP6
Secondary accession number(s): B2RMV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.