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Q9UKP4

- ATS7_HUMAN

UniProt

Q9UKP4 - ATS7_HUMAN

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 7

Gene
ADAMTS7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metalloprotease that may play a role in the degradation of COMP.1 Publication

Cofactori

Binds 1 zinc ion per subunit By similarity.1 Publication

pH dependencei

Optimum pH is between 7.5 and 9.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi204 – 2041Zinc; in inhibited form By similarity
Metal bindingi388 – 3881Zinc; catalytic By similarity
Active sitei389 – 3891 By similarity
Metal bindingi392 – 3921Zinc; catalytic By similarity
Metal bindingi398 – 3981Zinc; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: BHF-UCL
  2. metallopeptidase activity Source: ProtInc
  3. protein binding Source: BHF-UCL
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular response to BMP stimulus Source: BHF-UCL
  2. cellular response to interleukin-1 Source: BHF-UCL
  3. cellular response to tumor necrosis factor Source: BHF-UCL
  4. negative regulation of chondrocyte differentiation Source: BHF-UCL
  5. proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.231.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 7 (EC:3.4.24.-)
Short name:
ADAM-TS 7
Short name:
ADAM-TS7
Short name:
ADAMTS-7
Alternative name(s):
COMPase
Gene namesi
Name:ADAMTS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:223. ADAMTS7.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity
Note: Also found associated with the external cell surface By similarity.

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Propeptidei28 – 236209PRO_0000029176Add
BLAST
Chaini237 – 16861450A disintegrin and metalloproteinase with thrombospondin motifs 7PRO_0000029177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi318 ↔ 372 By similarity
Disulfide bondi347 ↔ 354 By similarity
Disulfide bondi366 ↔ 447 By similarity
Disulfide bondi405 ↔ 431 By similarity
Disulfide bondi474 ↔ 497 By similarity
Disulfide bondi485 ↔ 503 By similarity
Disulfide bondi492 ↔ 522 By similarity
Disulfide bondi516 ↔ 527 By similarity
Disulfide bondi550 ↔ 587 By similarity
Disulfide bondi554 ↔ 592 By similarity
Disulfide bondi565 ↔ 577 By similarity
Glycosylationi693 – 6931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi778 – 7781N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.1 Publication
May be cleaved by a furin endopeptidase By similarity. The precursor is sequentially processed.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Proteoglycan, Zymogen

Proteomic databases

PaxDbiQ9UKP4.
PRIDEiQ9UKP4.

PTM databases

PhosphoSiteiQ9UKP4.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.2 Publications

Inductioni

Up-regulated in articular cartilage and synovium from arthritis patients.1 Publication

Gene expression databases

BgeeiQ9UKP4.
CleanExiHS_ADAMTS7.
GenevestigatoriQ9UKP4.

Organism-specific databases

HPAiHPA034581.

Interactioni

Subunit structurei

Interacts with COMP.1 Publication

Protein-protein interaction databases

IntActiQ9UKP4. 3 interactions.
STRINGi9606.ENSP00000373472.

Structurei

3D structure databases

ProteinModelPortaliQ9UKP4.
SMRiQ9UKP4. Positions 239-713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini242 – 452211Peptidase M12BAdd
BLAST
Domaini462 – 53776DisintegrinAdd
BLAST
Domaini538 – 59356TSP type-1 1Add
BLAST
Domaini821 – 88060TSP type-1 2Add
BLAST
Domaini881 – 94060TSP type-1 3Add
BLAST
Domaini942 – 99554TSP type-1 4Add
BLAST
Domaini1411 – 145949TSP type-1 5Add
BLAST
Domaini1462 – 152261TSP type-1 6Add
BLAST
Domaini1523 – 156745TSP type-1 7Add
BLAST
Domaini1569 – 162961TSP type-1 8Add
BLAST
Domaini1632 – 167241PLACAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni698 – 809112SpacerAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi202 – 2098Cysteine switch By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi595 – 697103Cys-richAdd
BLAST

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 PLAC domain.
Contains 8 TSP type-1 domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG237764.
HOGENOMiHOG000015092.
HOVERGENiHBG050620.
KOiK08622.
OMAiKGKYCVG.
OrthoDBiEOG7V765X.
PhylomeDBiQ9UKP4.
TreeFamiTF313537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 7 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 8 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 8 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 7 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKP4-1 [UniParc]FASTAAdd to Basket

« Hide

MPGGPSPRSP APLLRPLLLL LCALAPGAPG PAPGRATEGR AALDIVHPVR     50
VDAGGSFLSY ELWPRALRKR DVSVRRDAPA FYELQYRGRE LRFNLTANQH 100
LLAPGFVSET RRRGGLGRAH IRAHTPACHL LGEVQDPELE GGLAAISACD 150
GLKGVFQLSN EDYFIEPLDS APARPGHAQP HVVYKRQAPE RLAQRGDSSA 200
PSTCGVQVYP ELESRRERWE QRQQWRRPRL RRLHQRSVSK EKWVETLVVA 250
DAKMVEYHGQ PQVESYVLTI MNMVAGLFHD PSIGNPIHIT IVRLVLLEDE 300
EEDLKITHHA DNTLKSFCKW QKSINMKGDA HPLHHDTAIL LTRKDLCAAM 350
NRPCETLGLS HVAGMCQPHR SCSINEDTGL PLAFTVAHEL GHSFGIQHDG 400
SGNDCEPVGK RPFIMSPQLL YDAAPLTWSR CSRQYITRFL DRGWGLCLDD 450
PPAKDIIDFP SVPPGVLYDV SHQCRLQYGA YSAFCEDMDN VCHTLWCSVG 500
TTCHSKLDAA VDGTRCGENK WCLSGECVPV GFRPEAVDGG WSGWSAWSIC 550
SRSCGMGVQS AERQCTQPTP KYKGRYCVGE RKRFRLCNLQ ACPAGRPSFR 600
HVQCSHFDAM LYKGQLHTWV PVVNDVNPCE LHCRPANEYF AEKLRDAVVD 650
GTPCYQVRAS RDLCINGICK NVGCDFEIDS GAMEDRCGVC HGNGSTCHTV 700
SGTFEEAEGL GYVDVGLIPA GAREIRIQEV AEAANFLALR SEDPEKYFLN 750
GGWTIQWNGD YQVAGTTFTY ARRGNWENLT SPGPTKEPVW IQLLFQESNP 800
GVHYEYTIHR EAGGHDEVPP PVFSWHYGPW TKCTVTCGRG VQRQNVYCLE 850
RQAGPVDEEH CDPLGRPDDQ QRKCSEQPCP ARWWAGEWQL CSSSCGPGGL 900
SRRAVLCIRS VGLDEQSALE PPACEHLPRP PTETPCNRHV PCPATWAVGN 950
WSQCSVTCGE GTQRRNVLCT NDTGVPCDEA QQPASEVTCS LPLCRWPLGT 1000
LGPEGSGSGS SSHELFNEAD FIPHHLAPRP SPASSPKPGT MGNAIEEEAP 1050
ELDLPGPVFV DDFYYDYNFI NFHEDLSYGP SEEPDLDLAG TGDRTPPPHS 1100
HPAAPSTGSP VPATEPPAAK EEGVLGPWSP SPWPSQAGRS PPPPSEQTPG 1150
NPLINFLPEE DTPIGAPDLG LPSLSWPRVS TDGLQTPATP ESQNDFPVGK 1200
DSQSQLPPPW RDRTNEVFKD DEEPKGRGAP HLPPRPSSTL PPLSPVGSTH 1250
SSPSPDVAEL WTGGTVAWEP ALEGGLGPVD SELWPTVGVA SLLPPPIAPL 1300
PEMKVRDSSL EPGTPSFPTP GPGSWDLQTV AVWGTFLPTT LTGLGHMPEP 1350
ALNPGPKGQP ESLSPEVPLS SRLLSTPAWD SPANSHRVPE TQPLAPSLAE 1400
AGPPADPLVV RNAGWQAGNW SECSTTCGLG AVWRPVRCSS GRDEDCAPAG 1450
RPQPARRCHL RPCATWHSGN WSKCSRSCGG GSSVRDVQCV DTRDLRPLRP 1500
FHCQPGPAKP PAHRPCGAQP CLSWYTSSWR ECSEACGGGE QQRLVTCPEP 1550
GLCEEALRPN TTRPCNTHPC TQWVVGPWGQ CSGPCGGGVQ RRLVKCVNTQ 1600
TGLPEEDSDQ CGHEAWPESS RPCGTEDCEP VEPPRCERDR LSFGFCETLR 1650
LLGRCQLPTI RTQCCRSCSP PSHGAPSRGH QRVARR 1686
Length:1,686
Mass (Da):184,095
Last modified:September 2, 2008 - v2
Checksum:iAB38264B8E8DB740
GO

Sequence cautioni

The sequence AAD56358.1 differs from that shown. Reason: Probable cloning artifact.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141S → P.
Corresponds to variant rs3825807 [ dbSNP | Ensembl ].
VAR_046112
Natural varianti307 – 3071T → M.1 Publication
Corresponds to variant rs2127898 [ dbSNP | Ensembl ].
VAR_046113
Natural varianti1319 – 13191T → A.1 Publication
Corresponds to variant rs11630236 [ dbSNP | Ensembl ].
VAR_046114
Natural varianti1414 – 14141G → S.1 Publication
Corresponds to variant rs2929155 [ dbSNP | Ensembl ].
VAR_046115
Natural varianti1583 – 15831G → A.1 Publication
Corresponds to variant rs7495616 [ dbSNP | Ensembl ].
VAR_046116

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti642 – 6421E → K in AAD56358. 1 Publication
Sequence conflicti1101 – 11011H → R in AAQ94616. 1 Publication
Sequence conflicti1364 – 13641S → T in AAQ94616. 1 Publication
Sequence conflicti1479 – 14791G → D in AAQ94616. 1 Publication
Sequence conflicti1511 – 15111P → H in AAQ94616. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY327122 mRNA. Translation: AAQ94616.1.
BC061631 mRNA. Translation: AAH61631.1.
AF140675 mRNA. Translation: AAD56358.1. Sequence problems.
CCDSiCCDS32303.1.
RefSeqiNP_055087.2. NM_014272.3.
UniGeneiHs.16441.

Genome annotation databases

EnsembliENST00000388820; ENSP00000373472; ENSG00000136378.
GeneIDi11173.
KEGGihsa:11173.
UCSCiuc002bej.4. human.

Polymorphism databases

DMDMi205371741.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY327122 mRNA. Translation: AAQ94616.1 .
BC061631 mRNA. Translation: AAH61631.1 .
AF140675 mRNA. Translation: AAD56358.1 . Sequence problems.
CCDSi CCDS32303.1.
RefSeqi NP_055087.2. NM_014272.3.
UniGenei Hs.16441.

3D structure databases

ProteinModelPortali Q9UKP4.
SMRi Q9UKP4. Positions 239-713.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9UKP4. 3 interactions.
STRINGi 9606.ENSP00000373472.

Protein family/group databases

MEROPSi M12.231.

PTM databases

PhosphoSitei Q9UKP4.

Polymorphism databases

DMDMi 205371741.

Proteomic databases

PaxDbi Q9UKP4.
PRIDEi Q9UKP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388820 ; ENSP00000373472 ; ENSG00000136378 .
GeneIDi 11173.
KEGGi hsa:11173.
UCSCi uc002bej.4. human.

Organism-specific databases

CTDi 11173.
GeneCardsi GC15M079051.
H-InvDB HIX0012467.
HGNCi HGNC:223. ADAMTS7.
HPAi HPA034581.
MIMi 605009. gene.
neXtProti NX_Q9UKP4.
PharmGKBi PA24551.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237764.
HOGENOMi HOG000015092.
HOVERGENi HBG050620.
KOi K08622.
OMAi KGKYCVG.
OrthoDBi EOG7V765X.
PhylomeDBi Q9UKP4.
TreeFami TF313537.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 11173.
NextBioi 42517.
PROi Q9UKP4.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKP4.
CleanExi HS_ADAMTS7.
Genevestigatori Q9UKP4.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 7 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 8 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 8 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 7 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein."
    Liu C.-J., Kong W., Ilalov K., Yu S., Xu K., Prazak L., Fajardo M., Sehgal B., Di Cesare P.E.
    FASEB J. 20:988-990(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, PH DEPENDENCE, INTERACTION WITH COMP, INDUCTION, TISSUE SPECIFICITY, VARIANTS ALA-1319; SER-1414 AND ALA-1583.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-307.
    Tissue: Ovary.
  3. "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases."
    Hurskainen T.L., Hirohata S., Seldin M.F., Apte S.S.
    J. Biol. Chem. 274:25555-25563(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
  4. "ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain."
    Somerville R.P.T., Longpre J.-M., Apel E.D., Lewis R.M., Wang L.W., Sanes J.R., Leduc R., Apte S.S.
    J. Biol. Chem. 279:35159-35175(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 237-243, IDENTIFICATION, GLYCOSYLATION, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiATS7_HUMAN
AccessioniPrimary (citable) accession number: Q9UKP4
Secondary accession number(s): Q14F51, Q6P7J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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