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Protein

Integrin beta-1-binding protein 2

Gene

ITGB1BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role during maturation and/or organization of muscles cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Zinc 1PROSITE-ProRule annotation1
Metal bindingi10Zinc 1PROSITE-ProRule annotation1
Metal bindingi24Zinc 1PROSITE-ProRule annotation1
Metal bindingi27Zinc 2PROSITE-ProRule annotation1
Metal bindingi42Zinc 2PROSITE-ProRule annotation1
Metal bindingi43Zinc 2PROSITE-ProRule annotation1
Metal bindingi59Zinc 2PROSITE-ProRule annotation1
Metal bindingi64Zinc 1PROSITE-ProRule annotation1
Metal bindingi149Zinc 3PROSITE-ProRule annotation1
Metal bindingi154Zinc 3PROSITE-ProRule annotation1
Metal bindingi168Zinc 3PROSITE-ProRule annotation1
Metal bindingi171Zinc 4PROSITE-ProRule annotation1
Metal bindingi186Zinc 4PROSITE-ProRule annotation1
Metal bindingi187Zinc 4PROSITE-ProRule annotation1
Metal bindingi203Zinc 4PROSITE-ProRule annotation1
Metal bindingi208Zinc 3PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147166-MONOMER.
SignaLinkiQ9UKP3.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-1-binding protein 2
Alternative name(s):
Melusin
Gene namesi
ORF Names:MSTP015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6154. ITGB1BP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147166.
PharmGKBiPA29954.

Polymorphism and mutation databases

BioMutaiITGB1BP2.
DMDMi20138790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842671 – 347Integrin beta-1-binding protein 2Add BLAST347

Proteomic databases

PaxDbiQ9UKP3.
PeptideAtlasiQ9UKP3.
PRIDEiQ9UKP3.

PTM databases

iPTMnetiQ9UKP3.
PhosphoSitePlusiQ9UKP3.

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscles but not in other tissues.

Gene expression databases

BgeeiENSG00000147166.
CleanExiHS_ITGB1BP2.
GenevisibleiQ9UKP3. HS.

Organism-specific databases

HPAiHPA040721.

Interactioni

Subunit structurei

Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium.

Binary interactionsi

WithEntry#Exp.IntActNotes
RARAP102762EBI-5659717,EBI-413374

Protein-protein interaction databases

BioGridi117742. 10 interactors.
IntActiQ9UKP3. 22 interactors.
STRINGi9606.ENSP00000362935.

Structurei

3D structure databases

ProteinModelPortaliQ9UKP3.
SMRiQ9UKP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini149 – 208CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini215 – 304CSPROSITE-ProRule annotationAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 31SH3-bindingSequence analysis4
Motifi70 – 78SH3-bindingSequence analysis9
Motifi158 – 161SH2-bindingSequence analysis4
Motifi172 – 175SH3-bindingSequence analysis4
Motifi234 – 237SH2-bindingSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 59Cys-richAdd BLAST55
Compositional biasi149 – 203Cys-richAdd BLAST55
Compositional biasi320 – 347Asp/Glu-rich (acidic)Add BLAST28

Domaini

The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca2+ ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein.

Sequence similaritiesi

Contains 2 CHORD domains.PROSITE-ProRule annotation
Contains 1 CS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
HOGENOMiHOG000207093.
HOVERGENiHBG052156.
InParanoidiQ9UKP3.
KOiK16735.
OMAiTIYGQIP.
OrthoDBiEOG091G0BY9.
PhylomeDBiQ9UKP3.
TreeFamiTF105394.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLCRNKGC GQHFDPNTNL PDSCCHHPGV PIFHDALKGW SCCRKRTVDF
60 70 80 90 100
SEFLNIKGCT MGPHCAEKLP EAPQPEGPAT SSSLQEQKPL NVIPKSAETL
110 120 130 140 150
RRERPKSELP LKLLPLNISQ ALEMALEQKE LDQEPGAGLD SLIRTGSSCQ
160 170 180 190 200
NPGCDAVYQG PESDATPCTY HPGAPRFHEG MKSWSCCGIQ TLDFGAFLAQ
210 220 230 240 250
PGCRVGRHDW GKQLPASCRH DWHQTDSLVV VTVYGQIPLP AFNWVKASQT
260 270 280 290 300
ELHVHIVFDG NRVFQAQMKL WGVINVEQSS VFLMPSRVEI SLVKADPGSW
310 320 330 340
AQLEHPDALA KKARAGVVLE MDEEESDDSD DDLSWTEEEE EEEAMGE
Length:347
Mass (Da):38,382
Last modified:May 1, 2000 - v1
Checksum:i1D0A94931821E74D
GO
Isoform 2 (identifier: Q9UKP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: LLCRNKGCGQHFDPNTNLP → T

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,374
Checksum:i90B4A0467B68A404
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563793 – 21LLCRN…NTNLP → T in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140690 mRNA. Translation: AAF01676.1.
AF110225 mRNA. Translation: AAL36913.1.
AL590762 Genomic DNA. No translation available.
BC108901 mRNA. Translation: AAI08902.1.
CCDSiCCDS14411.1. [Q9UKP3-1]
RefSeqiNP_001290206.1. NM_001303277.1.
NP_036410.1. NM_012278.2. [Q9UKP3-1]
UniGeneiHs.109999.

Genome annotation databases

EnsembliENST00000373829; ENSP00000362935; ENSG00000147166. [Q9UKP3-1]
ENST00000538820; ENSP00000440289; ENSG00000147166. [Q9UKP3-2]
GeneIDi26548.
KEGGihsa:26548.
UCSCiuc004dzr.2. human. [Q9UKP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140690 mRNA. Translation: AAF01676.1.
AF110225 mRNA. Translation: AAL36913.1.
AL590762 Genomic DNA. No translation available.
BC108901 mRNA. Translation: AAI08902.1.
CCDSiCCDS14411.1. [Q9UKP3-1]
RefSeqiNP_001290206.1. NM_001303277.1.
NP_036410.1. NM_012278.2. [Q9UKP3-1]
UniGeneiHs.109999.

3D structure databases

ProteinModelPortaliQ9UKP3.
SMRiQ9UKP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117742. 10 interactors.
IntActiQ9UKP3. 22 interactors.
STRINGi9606.ENSP00000362935.

PTM databases

iPTMnetiQ9UKP3.
PhosphoSitePlusiQ9UKP3.

Polymorphism and mutation databases

BioMutaiITGB1BP2.
DMDMi20138790.

Proteomic databases

PaxDbiQ9UKP3.
PeptideAtlasiQ9UKP3.
PRIDEiQ9UKP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373829; ENSP00000362935; ENSG00000147166. [Q9UKP3-1]
ENST00000538820; ENSP00000440289; ENSG00000147166. [Q9UKP3-2]
GeneIDi26548.
KEGGihsa:26548.
UCSCiuc004dzr.2. human. [Q9UKP3-1]

Organism-specific databases

CTDi26548.
GeneCardsiITGB1BP2.
HGNCiHGNC:6154. ITGB1BP2.
HPAiHPA040721.
MIMi300332. gene.
neXtProtiNX_Q9UKP3.
OpenTargetsiENSG00000147166.
PharmGKBiPA29954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
HOGENOMiHOG000207093.
HOVERGENiHBG052156.
InParanoidiQ9UKP3.
KOiK16735.
OMAiTIYGQIP.
OrthoDBiEOG091G0BY9.
PhylomeDBiQ9UKP3.
TreeFamiTF105394.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147166-MONOMER.
SignaLinkiQ9UKP3.

Miscellaneous databases

GenomeRNAii26548.
PROiQ9UKP3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147166.
CleanExiHS_ITGB1BP2.
GenevisibleiQ9UKP3. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKP3
Secondary accession number(s): Q32N04, Q549J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.