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Q9UKN7

- MYO15_HUMAN

UniProt

Q9UKN7 - MYO15_HUMAN

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Protein

Unconventional myosin-XV

Gene
MYO15A, MYO15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1315 – 13228ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. inner ear morphogenesis Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. sensory perception of sound Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Hearing

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
Gene namesi
Name:MYO15A
Synonyms:MYO15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7594. MYO15A.

Subcellular locationi

Cell projectionstereocilium By similarity. Cytoplasmcytoskeleton By similarity
Note: Localizes to stereocilium tips in cochlear and vestibular hair cells By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
  3. myosin complex Source: UniProtKB-KW
  4. stereocilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 3 (DFNB3) [MIM:600316]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2111 – 21111N → Y in DFNB3; family from Bengkala. 1 Publication
VAR_010303
Natural varianti2113 – 21131I → F in DFNB3; Indian family. 1 Publication
VAR_010304
Natural varianti2205 – 22051T → I Associated with moderately severe sensorineural hearing loss (DFNB3) in a Smith-Magenis syndrome patient. 1 Publication
Corresponds to variant rs121908970 [ dbSNP | Ensembl ].
VAR_037961
Natural varianti2716 – 27161Q → H in DFNB3. 1 Publication
VAR_037964

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi600316. phenotype.
Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKBiPA31395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35303530Unconventional myosin-XVPRO_0000123474Add
BLAST

Proteomic databases

MaxQBiQ9UKN7.
PaxDbiQ9UKN7.
PRIDEiQ9UKN7.

PTM databases

PhosphoSiteiQ9UKN7.

Expressioni

Tissue specificityi

Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.1 Publication

Gene expression databases

ArrayExpressiQ9UKN7.
BgeeiQ9UKN7.
CleanExiHS_MYO15A.
GenevestigatoriQ9UKN7.

Organism-specific databases

HPAiHPA039770.

Interactioni

Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with EPS8 By similarity. Interacts with FASLG.1 Publication

Protein-protein interaction databases

BioGridi119348. 3 interactions.
IntActiQ9UKN7. 3 interactions.
STRINGi9606.ENSP00000205890.

Structurei

3D structure databases

ProteinModelPortaliQ9UKN7.
SMRiQ9UKN7. Positions 1181-1898, 2044-2291, 2685-2956, 3065-3443.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1222 – 1899678Myosin motorAdd
BLAST
Domaini1902 – 192423IQ 1Add
BLAST
Domaini1925 – 195430IQ 2Add
BLAST
Domaini1955 – 197622IQ 3Add
BLAST
Domaini2065 – 2217153MyTH4 1Add
BLAST
Domaini2867 – 295387SH3Add
BLAST
Domaini3050 – 3204155MyTH4 2Add
BLAST
Domaini3209 – 3530322FERMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1792 – 17998Actin-binding Reviewed prediction
Regioni1888 – 2029142Neck or regulatory domainAdd
BLAST
Regioni2030 – 35301501TailAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1323 – 135028 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.
Contains 3 IQ domains.
Contains 2 MyTH4 domains.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000113705.
HOVERGENiHBG052554.
InParanoidiQ9UKN7.
KOiK10361.
OMAiPSQNMLE.
OrthoDBiEOG7XPZ4Q.
PhylomeDBiQ9UKN7.
TreeFamiTF316834.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 1 hit.
SM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKN7-1 [UniParc]FASTAAdd to Basket

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MAKEEDEEKK AKKGKKGKKA PEPEKPKRSL KGTSRLFMGF RDRTPKISKK     50
GQFRSASAFF WGLHTGPQKT KRKRKARTVL KSTSKLMTQM RMGKKKRAMK 100
GKKPSFMVIR FPGRRGYGRL RPRARSLSKA STAINWLTKK FLLKKAEESG 150
SEQATVDAWL QRSSSRMGSR KLPFPSGAEI LRPGGRLRRF PRSRSIYASG 200
EPLGFLPFED EAPFHHSGSR KSLYGLEGFQ DLGEYYDYHR DGDDYYDRQS 250
LHRYEEQEPY LAGLGPYSPA WPPYGDHYYG YPPEDPYDYY HPDYYGGPFD 300
PGYTYGYGYD DYEPPYAPPS GYSSPYSYHD GYEGEAHPYG YYLDPYAPYD 350
APYPPYDLPY HTPYDVPYFD PYGVHYTVPY AEGVYGGGDE AIYPPEVPYF 400
YPEESASAFV YPWVPPPIPS PHNPYAHAMD DIAELEEPED AGVERQGTSF 450
RLPSAAFFEQ QGMDKPARSK LSLIRKFRLF PRPQVKLFGK EKLEVPLPPS 500
LDIPLPLGDA DEEEDEEELP PVSAVPYGHP FWGFLTPRQR NLQRALSAFG 550
AHRGLGFGPE FGRPVPRPAT SLARFLKKTL SEKKPIARLR GSQKARAGGP 600
AVREAAYKRF GYKLAGMDPE KPGTPIVLRR AQPRARSSND ARRPPAPQPA 650
PRTLSHWSAL LSPPVPPRPP SSGPPPAPPL SPALSGLPRP ASPYGSLRRH 700
PPPWAAPAHV PPAPQASWWA FVEPPAVSPE VPPDLLAFPG PRPSFRGSRR 750
RGAAFGFPGA SPRASRRRAW SPLASPQPSL RSSPGLGYCS PLAPPSPQLS 800
LRTGPFQPPF LPPARRPRSL QESPAPRRAA GRLGPPGSPL PGSPRPPSPP 850
LGLCHSPRRS SLNLPSRLPH TWRRLSEPPT RAVKPQVRLP FHRPPRAGAW 900
RAPLEHRESP REPEDSETPW TVPPLAPSWD VDMPPTQRPP SPWPGGAGSR 950
RGFSRPPPVP ENPFLQLLGP VPSPTLQPED PAADMTRVFL GRHHEPGPGQ 1000
LTKSAGPTPE KPEEEATLGD PQLPAETKPP TPAPPKDVTP PKDITPPKDV 1050
LPEQKTLRPS LSYPLAACDQ TRATWPPWHR WGTLPQAAAP LAPIRAPEPL 1100
PKGGERRQAA PGRFAVVMPR VQKLSSFQRV GPATLKPQVQ PIQDPKPRAC 1150
SLRWSCLWLR ADAYGPWPRV HTHPQSCHLG PGAACLSLRG SWEEVGPPSW 1200
RNKMHSIRNL PSMRFREQHG EDGVEDMTQL EDLQETTVLS NLKIRFERNL 1250
IYTYIGSILV SVNPYQMFGI YGPEQVQQYN GRALGENPPH LFAVANLAFA 1300
KMLDAKQNQC IIISGESGSG KTEATKLILR YLAAMNQKRE VMQQIKILEA 1350
TPLLESFGNA KTVRNDNSSR FGKFVEIFLE GGVISGAITS QYLLEKSRIV 1400
FQAKNERNYH IFYELLAGLP AQLRQAFSLQ EAETYYYLNQ GGNCEIAGKS 1450
DADDFRRLLA AMEVLGFSSE DQDSIFRILA SILHLGNVYF EKYETDAQEV 1500
ASVVSAREIQ AVAELLQISP EGLQKAITFK VTETMREKIF TPLTVESAVD 1550
ARDAIAKVLY ALLFSWLITR VNALVSPRQD TLSIAILDIY GFEDLSFNSF 1600
EQLCINYANE NLQYLFNKIV FQEEQEEYIR EQIDWQEITF ADNQPCINLI 1650
SLKPYGILRI LDDQCCFPQA TDHTFLQKCH YHHGANPLYS KPKMPLPEFT 1700
IKHYAGKVTY QVHKFLDKNH DQVRQDVLDL FVRSRTRVVA HLFSSHAPQA 1750
APQRLGKSSS VTRLYKAHTV AAKFQQSLLD LVEKMERCNP LFMRCLKPNH 1800
KKEPGLFEPD VVMAQLRYSG VLETVRIRKE GFPVRLPFQG FIDRYCCLVA 1850
LKHDLPANGD MCVSVLSRLC KVMPNMYRVG VSKLFLKEHL YQLLESMREH 1900
VLNLAALTLQ RCLRGFFIKR RFRSLRHKII LLQSRARGYL ARQRYQQMRR 1950
SLVKFRSLVH AYVSRRRYLK LRAEWRCQVE GALLWEQEEL SKREVVAVGH 2000
LEVPAELAGL LQAVAGLGLA QVPQVAPVRT PRLQAEPRVT LPLDINNYPM 2050
AKFVQCHFKE PAFGMLTVPL RTPLTQLPAE HHAEAVSIFK LILRFMGDPH 2100
LHGARENIFG NYIVQKGLAV PELRDEILAQ LANQVWHNHN AHNAERGWLL 2150
LAACLSGFAP SPCFNKYLLK FVSDYGRNGF QAVCQHRLMQ AMGRAQQQGS 2200
GAARTLPPTQ LEWTATYEKA SMALDVGCFN GDQFSCPVHS WSTGEEVAGD 2250
ILRHRGLADG WRGWTVAMKN GVQWAELAGH DYVLDLVSDL ELLRDFPRQK 2300
SYFIVGTEGP AASRGGPKVV FGNSWDSDED MSTRPQPQEH MPKVLDSDGY 2350
SSHNQDGTNG ETEAQRGTAT HQESDSLGEP AVPHKGLDCY LDSLFDPVLS 2400
YGDADLEKPT AIAYRMKGGG QPGGGSSSGT EDTPRRPPEP KPIPGLDAST 2450
LALQQAFIHK QAVLLAREMT LQATALQQQP LSAALRSLPA EKPPAPEAQP 2500
TSVGTGPPAK PVLLRATPKP LAPAPLAKAP RLPIKPVAAP VLAQDQASPE 2550
TTSPSPELVR YSTLNSEHFP QPTQQIKNIV RQYQQPFRGG RPEALRKDGG 2600
KVFMKRPDPH EEALMILKGQ MTHLAAAPGT QVSREAVALV KPVTSAPRPS 2650
MAPTSALPSR SLEPPEELTQ TRLHRLINPN FYGYQDAPWK IFLRKEVFYP 2700
KDSYSHPVQL DLLFRQILHD TLSEACLRIS EDERLRMKAL FAQNQLDTQK 2750
PLVTESVKRA VVSTARDTWE VYFSRIFPAT GSVGTGVQLL AVSHVGIKLL 2800
RMVKGGQEAG GQLRVLRAYS FADILFVTMP SQNMLEFNLA SEKVILFSAR 2850
AHQVKTLVDD FILELKKDSD YVVAVRNFLP EDPALLAFHK GDIIHLQPLE 2900
PPRVGYSAGC VVRRKVVYLE ELRRRGPDFG WRFGTIHGRV GRFPSELVQP 2950
AAAPDFLQLP TEPGRGRAAA VAAAVASAAA AQEVGRRREG PPVRARSADH 3000
GEDALALPPY TMLEFAQKYF RDPQRRPQDG LRLKSKEPRE SRTLEDMLCF 3050
TKTPLQESLI ELSDSSLSKM ATDMFLAVMR FMGDAPLKGQ SDLDVLCNLL 3100
KLCGDHEVMR DECYCQVVKQ ITDNTSSKQD SCQRGWRLLY IVTAYHSCSE 3150
VLHPHLTRFL QDVSRTPGLP FQGIAKACEQ NLQKTLRFGG RLELPSSIEL 3200
RAMLAGRSSK RQLFLLPGGL ERHLKIKTCT VALDVVEEIC AEMALTRPEA 3250
FNEYVIFVVT NRGQHVCPLS RRAYILDVAS EMEQVDGGYM LWFRRVLWDQ 3300
PLKFENELYV TMHYNQVLPD YLKGLFSSVP ASRPSEQLLQ QVSKLASLQH 3350
RAKDHFYLPS VREVQEYIPA QLYRTTAGST WLNLVSQHRQ QTQALSPHQA 3400
RAQFLGLLSA LPMFGSSFFF IQSCSNIAVP APCILAINHN GLNFLSTETH 3450
ELMVKFPLKE IQSTRTQRPT ANSSYPYVEI ALGDVAAQRT LQLQLEQGLE 3500
LCRVVAVHVE NLLSAHEKRL TLPPSEITLL 3530
Length:3,530
Mass (Da):395,293
Last modified:May 18, 2010 - v2
Checksum:iDCCFBAD37BEA6309
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1977 – 19771C → R.
Corresponds to variant rs854777 [ dbSNP | Ensembl ].
VAR_037959
Natural varianti2018 – 20181G → R.
Corresponds to variant rs2272571 [ dbSNP | Ensembl ].
VAR_037960
Natural varianti2111 – 21111N → Y in DFNB3; family from Bengkala. 1 Publication
VAR_010303
Natural varianti2113 – 21131I → F in DFNB3; Indian family. 1 Publication
VAR_010304
Natural varianti2205 – 22051T → I Associated with moderately severe sensorineural hearing loss (DFNB3) in a Smith-Magenis syndrome patient. 1 Publication
Corresponds to variant rs121908970 [ dbSNP | Ensembl ].
VAR_037961
Natural varianti2490 – 24901A → T.
Corresponds to variant rs16960959 [ dbSNP | Ensembl ].
VAR_037962
Natural varianti2682 – 26821Y → F.
Corresponds to variant rs712270 [ dbSNP | Ensembl ].
VAR_037963
Natural varianti2716 – 27161Q → H in DFNB3. 1 Publication
VAR_037964

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti595 – 5951A → T in AAF05903. 1 Publication
Sequence conflicti595 – 5951A → T in AF051976. 1 Publication
Sequence conflicti718 – 7181W → G in AAF05903. 1 Publication
Sequence conflicti718 – 7181W → G in AF051976. 1 Publication
Sequence conflicti1646 – 16461C → R in AAF05903. 1 Publication
Sequence conflicti2468 – 24681E → G in AAF05903. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051976 Genomic DNA. No translation available.
AF144094 mRNA. Translation: AAF05903.1.
AC087164 Genomic DNA. No translation available.
CCDSiCCDS42271.1.
PIRiA59266.
RefSeqiNP_057323.3. NM_016239.3.
UniGeneiHs.462390.

Genome annotation databases

EnsembliENST00000205890; ENSP00000205890; ENSG00000091536.
GeneIDi51168.
KEGGihsa:51168.
UCSCiuc021trl.1. human.

Polymorphism databases

DMDMi296439233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051976 Genomic DNA. No translation available.
AF144094 mRNA. Translation: AAF05903.1 .
AC087164 Genomic DNA. No translation available.
CCDSi CCDS42271.1.
PIRi A59266.
RefSeqi NP_057323.3. NM_016239.3.
UniGenei Hs.462390.

3D structure databases

ProteinModelPortali Q9UKN7.
SMRi Q9UKN7. Positions 1181-1898, 2044-2291, 2685-2956, 3065-3443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119348. 3 interactions.
IntActi Q9UKN7. 3 interactions.
STRINGi 9606.ENSP00000205890.

PTM databases

PhosphoSitei Q9UKN7.

Polymorphism databases

DMDMi 296439233.

Proteomic databases

MaxQBi Q9UKN7.
PaxDbi Q9UKN7.
PRIDEi Q9UKN7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000205890 ; ENSP00000205890 ; ENSG00000091536 .
GeneIDi 51168.
KEGGi hsa:51168.
UCSCi uc021trl.1. human.

Organism-specific databases

CTDi 51168.
GeneCardsi GC17P018012.
GeneReviewsi MYO15A.
H-InvDB HIX0013595.
HGNCi HGNC:7594. MYO15A.
HPAi HPA039770.
MIMi 600316. phenotype.
602666. gene.
neXtProti NX_Q9UKN7.
Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKBi PA31395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000113705.
HOVERGENi HBG052554.
InParanoidi Q9UKN7.
KOi K10361.
OMAi PSQNMLE.
OrthoDBi EOG7XPZ4Q.
PhylomeDBi Q9UKN7.
TreeFami TF316834.

Miscellaneous databases

GeneWikii MYO15A.
GenomeRNAii 51168.
NextBioi 54107.
PROi Q9UKN7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKN7.
Bgeei Q9UKN7.
CleanExi HS_MYO15A.
Genevestigatori Q9UKN7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00373. FERM_M. 1 hit.
PF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00295. B41. 1 hit.
SM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50057. FERM_3. 1 hit.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3."
    Wang A., Liang Y., Fridell R.A., Probst F.J., Wilcox E.R., Touchman J.W., Morton C.C., Morell R.J., Noben-Trauth K., Camper S.A., Friedman T.B.
    Science 280:1447-1451(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS DFNB3 TYR-2111 AND PHE-2113.
  2. "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2."
    Liang Y., Wang A., Belyantseva I.A., Anderson D.W., Probst F.J., Barber T.D., Miller W., Touchman J.W., Jin L., Sullivan S.L., Sellers J.R., Camper S.A., Lloyd R.V., Kachar B., Friedman T.B., Fridell R.A.
    Genomics 61:243-258(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  5. "Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome."
    Liburd N., Ghosh M., Riazuddin S., Naz S., Khan S., Ahmed Z., Riazuddin S., Liang Y., Menon P.S.N., Smith T., Smith A.C.M., Chen K.-S., Lupski J.R., Wilcox E.R., Potocki L., Friedman T.B.
    Hum. Genet. 109:535-541(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DFNB3 HIS-2716, VARIANT ILE-2205.

Entry informationi

Entry nameiMYO15_HUMAN
AccessioniPrimary (citable) accession number: Q9UKN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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