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Q9UKN7

- MYO15_HUMAN

UniProt

Q9UKN7 - MYO15_HUMAN

Protein

Unconventional myosin-XV

Gene

MYO15A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1315 – 13228ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    GO - Biological processi

    1. inner ear morphogenesis Source: Ensembl
    2. locomotory behavior Source: Ensembl
    3. sensory perception of sound Source: ProtInc

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Biological processi

    Hearing

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-XV
    Alternative name(s):
    Unconventional myosin-15
    Gene namesi
    Name:MYO15A
    Synonyms:MYO15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7594. MYO15A.

    Subcellular locationi

    Cell projectionstereocilium By similarity. Cytoplasmcytoskeleton By similarity
    Note: Localizes to stereocilium tips in cochlear and vestibular hair cells.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. extracellular vesicular exosome Source: UniProt
    3. myosin complex Source: UniProtKB-KW
    4. stereocilium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 3 (DFNB3) [MIM:600316]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2111 – 21111N → Y in DFNB3; family from Bengkala. 1 Publication
    VAR_010303
    Natural varianti2113 – 21131I → F in DFNB3; Indian family. 1 Publication
    VAR_010304
    Natural varianti2205 – 22051T → I Associated with moderately severe sensorineural hearing loss (DFNB3) in a Smith-Magenis syndrome patient. 1 Publication
    Corresponds to variant rs121908970 [ dbSNP | Ensembl ].
    VAR_037961
    Natural varianti2716 – 27161Q → H in DFNB3. 1 Publication
    VAR_037964

    Keywords - Diseasei

    Deafness, Disease mutation, Non-syndromic deafness

    Organism-specific databases

    MIMi600316. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBiPA31395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 35303530Unconventional myosin-XVPRO_0000123474Add
    BLAST

    Proteomic databases

    MaxQBiQ9UKN7.
    PaxDbiQ9UKN7.
    PRIDEiQ9UKN7.

    PTM databases

    PhosphoSiteiQ9UKN7.

    Expressioni

    Tissue specificityi

    Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9UKN7.
    BgeeiQ9UKN7.
    CleanExiHS_MYO15A.
    GenevestigatoriQ9UKN7.

    Organism-specific databases

    HPAiHPA039770.

    Interactioni

    Subunit structurei

    Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with EPS8 By similarity. Interacts with FASLG.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi119348. 3 interactions.
    IntActiQ9UKN7. 4 interactions.
    STRINGi9606.ENSP00000205890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKN7.
    SMRiQ9UKN7. Positions 1181-1898, 2044-2291, 2685-2956, 3065-3443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1222 – 1899678Myosin motorAdd
    BLAST
    Domaini1902 – 192423IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1925 – 195430IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1955 – 197622IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2065 – 2217153MyTH4 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2867 – 295387SH3Add
    BLAST
    Domaini3050 – 3204155MyTH4 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini3209 – 3530322FERMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1792 – 17998Actin-bindingSequence Analysis
    Regioni1888 – 2029142Neck or regulatory domainAdd
    BLAST
    Regioni2030 – 35301501TailAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1323 – 135028Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 3 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 2 MyTH4 domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.Curated

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000113705.
    HOVERGENiHBG052554.
    InParanoidiQ9UKN7.
    KOiK10361.
    OMAiPSQNMLE.
    OrthoDBiEOG7XPZ4Q.
    PhylomeDBiQ9UKN7.
    TreeFamiTF316834.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00373. FERM_M. 1 hit.
    PF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00295. B41. 1 hit.
    SM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS50096. IQ. 3 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKN7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKEEDEEKK AKKGKKGKKA PEPEKPKRSL KGTSRLFMGF RDRTPKISKK     50
    GQFRSASAFF WGLHTGPQKT KRKRKARTVL KSTSKLMTQM RMGKKKRAMK 100
    GKKPSFMVIR FPGRRGYGRL RPRARSLSKA STAINWLTKK FLLKKAEESG 150
    SEQATVDAWL QRSSSRMGSR KLPFPSGAEI LRPGGRLRRF PRSRSIYASG 200
    EPLGFLPFED EAPFHHSGSR KSLYGLEGFQ DLGEYYDYHR DGDDYYDRQS 250
    LHRYEEQEPY LAGLGPYSPA WPPYGDHYYG YPPEDPYDYY HPDYYGGPFD 300
    PGYTYGYGYD DYEPPYAPPS GYSSPYSYHD GYEGEAHPYG YYLDPYAPYD 350
    APYPPYDLPY HTPYDVPYFD PYGVHYTVPY AEGVYGGGDE AIYPPEVPYF 400
    YPEESASAFV YPWVPPPIPS PHNPYAHAMD DIAELEEPED AGVERQGTSF 450
    RLPSAAFFEQ QGMDKPARSK LSLIRKFRLF PRPQVKLFGK EKLEVPLPPS 500
    LDIPLPLGDA DEEEDEEELP PVSAVPYGHP FWGFLTPRQR NLQRALSAFG 550
    AHRGLGFGPE FGRPVPRPAT SLARFLKKTL SEKKPIARLR GSQKARAGGP 600
    AVREAAYKRF GYKLAGMDPE KPGTPIVLRR AQPRARSSND ARRPPAPQPA 650
    PRTLSHWSAL LSPPVPPRPP SSGPPPAPPL SPALSGLPRP ASPYGSLRRH 700
    PPPWAAPAHV PPAPQASWWA FVEPPAVSPE VPPDLLAFPG PRPSFRGSRR 750
    RGAAFGFPGA SPRASRRRAW SPLASPQPSL RSSPGLGYCS PLAPPSPQLS 800
    LRTGPFQPPF LPPARRPRSL QESPAPRRAA GRLGPPGSPL PGSPRPPSPP 850
    LGLCHSPRRS SLNLPSRLPH TWRRLSEPPT RAVKPQVRLP FHRPPRAGAW 900
    RAPLEHRESP REPEDSETPW TVPPLAPSWD VDMPPTQRPP SPWPGGAGSR 950
    RGFSRPPPVP ENPFLQLLGP VPSPTLQPED PAADMTRVFL GRHHEPGPGQ 1000
    LTKSAGPTPE KPEEEATLGD PQLPAETKPP TPAPPKDVTP PKDITPPKDV 1050
    LPEQKTLRPS LSYPLAACDQ TRATWPPWHR WGTLPQAAAP LAPIRAPEPL 1100
    PKGGERRQAA PGRFAVVMPR VQKLSSFQRV GPATLKPQVQ PIQDPKPRAC 1150
    SLRWSCLWLR ADAYGPWPRV HTHPQSCHLG PGAACLSLRG SWEEVGPPSW 1200
    RNKMHSIRNL PSMRFREQHG EDGVEDMTQL EDLQETTVLS NLKIRFERNL 1250
    IYTYIGSILV SVNPYQMFGI YGPEQVQQYN GRALGENPPH LFAVANLAFA 1300
    KMLDAKQNQC IIISGESGSG KTEATKLILR YLAAMNQKRE VMQQIKILEA 1350
    TPLLESFGNA KTVRNDNSSR FGKFVEIFLE GGVISGAITS QYLLEKSRIV 1400
    FQAKNERNYH IFYELLAGLP AQLRQAFSLQ EAETYYYLNQ GGNCEIAGKS 1450
    DADDFRRLLA AMEVLGFSSE DQDSIFRILA SILHLGNVYF EKYETDAQEV 1500
    ASVVSAREIQ AVAELLQISP EGLQKAITFK VTETMREKIF TPLTVESAVD 1550
    ARDAIAKVLY ALLFSWLITR VNALVSPRQD TLSIAILDIY GFEDLSFNSF 1600
    EQLCINYANE NLQYLFNKIV FQEEQEEYIR EQIDWQEITF ADNQPCINLI 1650
    SLKPYGILRI LDDQCCFPQA TDHTFLQKCH YHHGANPLYS KPKMPLPEFT 1700
    IKHYAGKVTY QVHKFLDKNH DQVRQDVLDL FVRSRTRVVA HLFSSHAPQA 1750
    APQRLGKSSS VTRLYKAHTV AAKFQQSLLD LVEKMERCNP LFMRCLKPNH 1800
    KKEPGLFEPD VVMAQLRYSG VLETVRIRKE GFPVRLPFQG FIDRYCCLVA 1850
    LKHDLPANGD MCVSVLSRLC KVMPNMYRVG VSKLFLKEHL YQLLESMREH 1900
    VLNLAALTLQ RCLRGFFIKR RFRSLRHKII LLQSRARGYL ARQRYQQMRR 1950
    SLVKFRSLVH AYVSRRRYLK LRAEWRCQVE GALLWEQEEL SKREVVAVGH 2000
    LEVPAELAGL LQAVAGLGLA QVPQVAPVRT PRLQAEPRVT LPLDINNYPM 2050
    AKFVQCHFKE PAFGMLTVPL RTPLTQLPAE HHAEAVSIFK LILRFMGDPH 2100
    LHGARENIFG NYIVQKGLAV PELRDEILAQ LANQVWHNHN AHNAERGWLL 2150
    LAACLSGFAP SPCFNKYLLK FVSDYGRNGF QAVCQHRLMQ AMGRAQQQGS 2200
    GAARTLPPTQ LEWTATYEKA SMALDVGCFN GDQFSCPVHS WSTGEEVAGD 2250
    ILRHRGLADG WRGWTVAMKN GVQWAELAGH DYVLDLVSDL ELLRDFPRQK 2300
    SYFIVGTEGP AASRGGPKVV FGNSWDSDED MSTRPQPQEH MPKVLDSDGY 2350
    SSHNQDGTNG ETEAQRGTAT HQESDSLGEP AVPHKGLDCY LDSLFDPVLS 2400
    YGDADLEKPT AIAYRMKGGG QPGGGSSSGT EDTPRRPPEP KPIPGLDAST 2450
    LALQQAFIHK QAVLLAREMT LQATALQQQP LSAALRSLPA EKPPAPEAQP 2500
    TSVGTGPPAK PVLLRATPKP LAPAPLAKAP RLPIKPVAAP VLAQDQASPE 2550
    TTSPSPELVR YSTLNSEHFP QPTQQIKNIV RQYQQPFRGG RPEALRKDGG 2600
    KVFMKRPDPH EEALMILKGQ MTHLAAAPGT QVSREAVALV KPVTSAPRPS 2650
    MAPTSALPSR SLEPPEELTQ TRLHRLINPN FYGYQDAPWK IFLRKEVFYP 2700
    KDSYSHPVQL DLLFRQILHD TLSEACLRIS EDERLRMKAL FAQNQLDTQK 2750
    PLVTESVKRA VVSTARDTWE VYFSRIFPAT GSVGTGVQLL AVSHVGIKLL 2800
    RMVKGGQEAG GQLRVLRAYS FADILFVTMP SQNMLEFNLA SEKVILFSAR 2850
    AHQVKTLVDD FILELKKDSD YVVAVRNFLP EDPALLAFHK GDIIHLQPLE 2900
    PPRVGYSAGC VVRRKVVYLE ELRRRGPDFG WRFGTIHGRV GRFPSELVQP 2950
    AAAPDFLQLP TEPGRGRAAA VAAAVASAAA AQEVGRRREG PPVRARSADH 3000
    GEDALALPPY TMLEFAQKYF RDPQRRPQDG LRLKSKEPRE SRTLEDMLCF 3050
    TKTPLQESLI ELSDSSLSKM ATDMFLAVMR FMGDAPLKGQ SDLDVLCNLL 3100
    KLCGDHEVMR DECYCQVVKQ ITDNTSSKQD SCQRGWRLLY IVTAYHSCSE 3150
    VLHPHLTRFL QDVSRTPGLP FQGIAKACEQ NLQKTLRFGG RLELPSSIEL 3200
    RAMLAGRSSK RQLFLLPGGL ERHLKIKTCT VALDVVEEIC AEMALTRPEA 3250
    FNEYVIFVVT NRGQHVCPLS RRAYILDVAS EMEQVDGGYM LWFRRVLWDQ 3300
    PLKFENELYV TMHYNQVLPD YLKGLFSSVP ASRPSEQLLQ QVSKLASLQH 3350
    RAKDHFYLPS VREVQEYIPA QLYRTTAGST WLNLVSQHRQ QTQALSPHQA 3400
    RAQFLGLLSA LPMFGSSFFF IQSCSNIAVP APCILAINHN GLNFLSTETH 3450
    ELMVKFPLKE IQSTRTQRPT ANSSYPYVEI ALGDVAAQRT LQLQLEQGLE 3500
    LCRVVAVHVE NLLSAHEKRL TLPPSEITLL 3530
    Length:3,530
    Mass (Da):395,293
    Last modified:May 18, 2010 - v2
    Checksum:iDCCFBAD37BEA6309
    GO
    Isoform 2 (identifier: Q9UKN7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2736: Missing.
         3498-3530: GLELCRVVAVHVENLLSAHEKRLTLPPSEITLL → VRAGEVLDGRGLSLSPAGTGTVSCGGRARGEPAQCP

    Note: No experimental confirmation available.

    Show »
    Length:797
    Mass (Da):88,988
    Checksum:i4B5A442322774C73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti595 – 5951A → T in AAF05903. (PubMed:10552926)Curated
    Sequence conflicti595 – 5951A → T in AF051976. (PubMed:10552926)Curated
    Sequence conflicti718 – 7181W → G in AAF05903. (PubMed:10552926)Curated
    Sequence conflicti718 – 7181W → G in AF051976. (PubMed:10552926)Curated
    Sequence conflicti1646 – 16461C → R in AAF05903. (PubMed:10552926)Curated
    Sequence conflicti2468 – 24681E → G in AAF05903. (PubMed:10552926)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1977 – 19771C → R.
    Corresponds to variant rs854777 [ dbSNP | Ensembl ].
    VAR_037959
    Natural varianti2018 – 20181G → R.
    Corresponds to variant rs2272571 [ dbSNP | Ensembl ].
    VAR_037960
    Natural varianti2111 – 21111N → Y in DFNB3; family from Bengkala. 1 Publication
    VAR_010303
    Natural varianti2113 – 21131I → F in DFNB3; Indian family. 1 Publication
    VAR_010304
    Natural varianti2205 – 22051T → I Associated with moderately severe sensorineural hearing loss (DFNB3) in a Smith-Magenis syndrome patient. 1 Publication
    Corresponds to variant rs121908970 [ dbSNP | Ensembl ].
    VAR_037961
    Natural varianti2490 – 24901A → T.
    Corresponds to variant rs16960959 [ dbSNP | Ensembl ].
    VAR_037962
    Natural varianti2682 – 26821Y → F.
    Corresponds to variant rs712270 [ dbSNP | Ensembl ].
    VAR_037963
    Natural varianti2716 – 27161Q → H in DFNB3. 1 Publication
    VAR_037964

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 27362736Missing in isoform 2. 1 PublicationVSP_056655Add
    BLAST
    Alternative sequencei3498 – 353033GLELC…EITLL → VRAGEVLDGRGLSLSPAGTG TVSCGGRARGEPAQCP in isoform 2. 1 PublicationVSP_056656Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051976 Genomic DNA. No translation available.
    AF144094 mRNA. Translation: AAF05903.1.
    AK294036 mRNA. Translation: BAG57388.1.
    AC087164 Genomic DNA. No translation available.
    CCDSiCCDS42271.1.
    PIRiA59266.
    RefSeqiNP_057323.3. NM_016239.3.
    UniGeneiHs.462390.

    Genome annotation databases

    EnsembliENST00000205890; ENSP00000205890; ENSG00000091536.
    ENST00000418233; ENSP00000408800; ENSG00000091536.
    GeneIDi51168.
    KEGGihsa:51168.
    UCSCiuc021trl.1. human.

    Polymorphism databases

    DMDMi296439233.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051976 Genomic DNA. No translation available.
    AF144094 mRNA. Translation: AAF05903.1 .
    AK294036 mRNA. Translation: BAG57388.1 .
    AC087164 Genomic DNA. No translation available.
    CCDSi CCDS42271.1.
    PIRi A59266.
    RefSeqi NP_057323.3. NM_016239.3.
    UniGenei Hs.462390.

    3D structure databases

    ProteinModelPortali Q9UKN7.
    SMRi Q9UKN7. Positions 1181-1898, 2044-2291, 2685-2956, 3065-3443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119348. 3 interactions.
    IntActi Q9UKN7. 4 interactions.
    STRINGi 9606.ENSP00000205890.

    PTM databases

    PhosphoSitei Q9UKN7.

    Polymorphism databases

    DMDMi 296439233.

    Proteomic databases

    MaxQBi Q9UKN7.
    PaxDbi Q9UKN7.
    PRIDEi Q9UKN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000205890 ; ENSP00000205890 ; ENSG00000091536 .
    ENST00000418233 ; ENSP00000408800 ; ENSG00000091536 .
    GeneIDi 51168.
    KEGGi hsa:51168.
    UCSCi uc021trl.1. human.

    Organism-specific databases

    CTDi 51168.
    GeneCardsi GC17P018012.
    GeneReviewsi MYO15A.
    H-InvDB HIX0013595.
    HGNCi HGNC:7594. MYO15A.
    HPAi HPA039770.
    MIMi 600316. phenotype.
    602666. gene.
    neXtProti NX_Q9UKN7.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBi PA31395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000113705.
    HOVERGENi HBG052554.
    InParanoidi Q9UKN7.
    KOi K10361.
    OMAi PSQNMLE.
    OrthoDBi EOG7XPZ4Q.
    PhylomeDBi Q9UKN7.
    TreeFami TF316834.

    Miscellaneous databases

    GeneWikii MYO15A.
    GenomeRNAii 51168.
    NextBioi 54107.
    PROi Q9UKN7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKN7.
    Bgeei Q9UKN7.
    CleanExi HS_MYO15A.
    Genevestigatori Q9UKN7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00373. FERM_M. 1 hit.
    PF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00295. B41. 1 hit.
    SM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS50096. IQ. 3 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3."
      Wang A., Liang Y., Fridell R.A., Probst F.J., Wilcox E.R., Touchman J.W., Morton C.C., Morell R.J., Noben-Trauth K., Camper S.A., Friedman T.B.
      Science 280:1447-1451(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS DFNB3 TYR-2111 AND PHE-2113.
    2. "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2."
      Liang Y., Wang A., Belyantseva I.A., Anderson D.W., Probst F.J., Barber T.D., Miller W., Touchman J.W., Jin L., Sullivan S.L., Sellers J.R., Camper S.A., Lloyd R.V., Kachar B., Friedman T.B., Fridell R.A.
      Genomics 61:243-258(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    6. "Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome."
      Liburd N., Ghosh M., Riazuddin S., Naz S., Khan S., Ahmed Z., Riazuddin S., Liang Y., Menon P.S.N., Smith T., Smith A.C.M., Chen K.-S., Lupski J.R., Wilcox E.R., Potocki L., Friedman T.B.
      Hum. Genet. 109:535-541(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DFNB3 HIS-2716, VARIANT ILE-2205.

    Entry informationi

    Entry nameiMYO15_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKN7
    Secondary accession number(s): B4DFC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3