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Protein

Phosphatidylcholine transfer protein

Gene

PCTP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72Phosphatidylcholine1
Binding sitei78Phosphatidylcholine1
Binding sitei157Phosphatidylcholine1

GO - Molecular functioni

  • phosphatidylcholine binding Source: UniProtKB
  • phosphatidylcholine transporter activity Source: UniProtKB

GO - Biological processi

  • lipid transport Source: UniProtKB
  • phospholipid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141179-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Chemistry databases

SwissLipidsiSLP:000001541.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine transfer protein
Short name:
PC-TP
Alternative name(s):
START domain-containing protein 2
Short name:
StARD2
StAR-related lipid transfer protein 2
Gene namesi
Name:PCTP
Synonyms:STARD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8752. PCTP.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63C → A: Reduces activity by 20%. 1 Publication1

Organism-specific databases

DisGeNETi58488.
OpenTargetsiENSG00000141179.
PharmGKBiPA33098.

Polymorphism and mutation databases

BioMutaiPCTP.
DMDMi15214192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206581 – 214Phosphatidylcholine transfer proteinAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei139PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKL6.
PaxDbiQ9UKL6.
PeptideAtlasiQ9UKL6.
PRIDEiQ9UKL6.

PTM databases

iPTMnetiQ9UKL6.
PhosphoSitePlusiQ9UKL6.

Expressioni

Tissue specificityi

Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus.1 Publication

Gene expression databases

BgeeiENSG00000141179.
CleanExiHS_PCTP.
ExpressionAtlasiQ9UKL6. baseline and differential.
GenevisibleiQ9UKL6. HS.

Organism-specific databases

HPAiHPA022979.

Interactioni

Subunit structurei

Interacts with ACOT13/THEM2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-4402391,EBI-741181

Protein-protein interaction databases

BioGridi121818. 4 interactors.
IntActiQ9UKL6. 1 interactor.
STRINGi9606.ENSP00000268896.

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 15Combined sources6
Helixi18 – 21Combined sources4
Turni26 – 29Combined sources4
Beta strandi31 – 36Combined sources6
Beta strandi39 – 45Combined sources7
Turni47 – 49Combined sources3
Beta strandi52 – 60Combined sources9
Helixi65 – 73Combined sources9
Helixi75 – 81Combined sources7
Beta strandi85 – 93Combined sources9
Beta strandi96 – 103Combined sources8
Beta strandi107 – 109Combined sources3
Beta strandi112 – 123Combined sources12
Helixi125 – 127Combined sources3
Beta strandi130 – 137Combined sources8
Beta strandi149 – 152Combined sources4
Beta strandi155 – 163Combined sources9
Beta strandi165 – 177Combined sources13
Helixi185 – 193Combined sources9
Helixi195 – 208Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LN1X-ray2.40A1-214[»]
1LN2X-ray2.90A/B1-214[»]
1LN3X-ray2.90A/B1-214[»]
ProteinModelPortaliQ9UKL6.
SMRiQ9UKL6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKL6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 212STARTPROSITE-ProRule annotationAdd BLAST212

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2761. Eukaryota.
ENOG4111HC0. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiQ9UKL6.
OMAiCADVYMD.
PhylomeDBiQ9UKL6.
TreeFamiTF320705.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG
60 70 80 90 100
LYEYKVFGVL EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY
110 120 130 140 150
WEVKYPFPMS NRDYVYLRQR RDLDMEGRKI HVILARSTSM PQLGERSGVI
160 170 180 190 200
RVKQYKQSLA IESDGKKGSK VFMYYFDNPG GQIPSWLINW AAKNGVPNFL
210
KDMARACQNY LKKT
Length:214
Mass (Da):24,843
Last modified:May 1, 2000 - v1
Checksum:iE40204B7C0A9AF83
GO
Isoform 2 (identifier: Q9UKL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:142
Mass (Da):16,824
Checksum:i1BA1CE03358BAB59
GO

Sequence cautioni

The sequence AAH05112 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52Y → H in AAF08347 (PubMed:10542325).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05207010E → A.Corresponds to variant rs12941739dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413631 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114436
, AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA. Translation: AAF08347.1.
AF114430 mRNA. Translation: AAF08345.1.
AF151638 mRNA. Translation: AAF02536.1.
AC009837 Genomic DNA. No translation available.
AC091155 Genomic DNA. No translation available.
BC005112 mRNA. Translation: AAH05112.1. Different initiation.
BC012084 mRNA. Translation: AAH12084.1.
CCDSiCCDS11588.1. [Q9UKL6-1]
CCDS45741.1. [Q9UKL6-2]
RefSeqiNP_001095872.1. NM_001102402.2. [Q9UKL6-2]
NP_001317307.1. NM_001330378.1.
NP_067036.2. NM_021213.3. [Q9UKL6-1]
UniGeneiHs.285218.

Genome annotation databases

EnsembliENST00000268896; ENSP00000268896; ENSG00000141179. [Q9UKL6-1]
ENST00000325214; ENSP00000325181; ENSG00000141179. [Q9UKL6-2]
GeneIDi58488.
KEGGihsa:58488.
UCSCiuc002iul.5. human. [Q9UKL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114436
, AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA. Translation: AAF08347.1.
AF114430 mRNA. Translation: AAF08345.1.
AF151638 mRNA. Translation: AAF02536.1.
AC009837 Genomic DNA. No translation available.
AC091155 Genomic DNA. No translation available.
BC005112 mRNA. Translation: AAH05112.1. Different initiation.
BC012084 mRNA. Translation: AAH12084.1.
CCDSiCCDS11588.1. [Q9UKL6-1]
CCDS45741.1. [Q9UKL6-2]
RefSeqiNP_001095872.1. NM_001102402.2. [Q9UKL6-2]
NP_001317307.1. NM_001330378.1.
NP_067036.2. NM_021213.3. [Q9UKL6-1]
UniGeneiHs.285218.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LN1X-ray2.40A1-214[»]
1LN2X-ray2.90A/B1-214[»]
1LN3X-ray2.90A/B1-214[»]
ProteinModelPortaliQ9UKL6.
SMRiQ9UKL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121818. 4 interactors.
IntActiQ9UKL6. 1 interactor.
STRINGi9606.ENSP00000268896.

Chemistry databases

SwissLipidsiSLP:000001541.

PTM databases

iPTMnetiQ9UKL6.
PhosphoSitePlusiQ9UKL6.

Polymorphism and mutation databases

BioMutaiPCTP.
DMDMi15214192.

Proteomic databases

EPDiQ9UKL6.
PaxDbiQ9UKL6.
PeptideAtlasiQ9UKL6.
PRIDEiQ9UKL6.

Protocols and materials databases

DNASUi58488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268896; ENSP00000268896; ENSG00000141179. [Q9UKL6-1]
ENST00000325214; ENSP00000325181; ENSG00000141179. [Q9UKL6-2]
GeneIDi58488.
KEGGihsa:58488.
UCSCiuc002iul.5. human. [Q9UKL6-1]

Organism-specific databases

CTDi58488.
DisGeNETi58488.
GeneCardsiPCTP.
HGNCiHGNC:8752. PCTP.
HPAiHPA022979.
MIMi606055. gene.
neXtProtiNX_Q9UKL6.
OpenTargetsiENSG00000141179.
PharmGKBiPA33098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2761. Eukaryota.
ENOG4111HC0. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiQ9UKL6.
OMAiCADVYMD.
PhylomeDBiQ9UKL6.
TreeFamiTF320705.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141179-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

EvolutionaryTraceiQ9UKL6.
GeneWikiiPhosphatidylcholine_transfer_protein.
GenomeRNAii58488.
PROiQ9UKL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141179.
CleanExiHS_PCTP.
ExpressionAtlasiQ9UKL6. baseline and differential.
GenevisibleiQ9UKL6. HS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UKL6
Secondary accession number(s): Q9BSC9, Q9UIT3, Q9UKW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.