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Q9UKL6

- PPCT_HUMAN

UniProt

Q9UKL6 - PPCT_HUMAN

Protein

Phosphatidylcholine transfer protein

Gene

PCTP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721Phosphatidylcholine
    Binding sitei78 – 781Phosphatidylcholine
    Binding sitei157 – 1571Phosphatidylcholine

    GO - Molecular functioni

    1. phosphatidylcholine binding Source: UniProtKB
    2. phosphatidylcholine transporter activity Source: UniProtKB

    GO - Biological processi

    1. cholesterol metabolic process Source: Ensembl
    2. lipid transport Source: UniProtKB
    3. phospholipid transport Source: UniProtKB

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylcholine transfer protein
    Short name:
    PC-TP
    Alternative name(s):
    START domain-containing protein 2
    Short name:
    StARD2
    StAR-related lipid transfer protein 2
    Gene namesi
    Name:PCTP
    Synonyms:STARD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8752. PCTP.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi63 – 631C → A: Reduces activity by 20%. 1 Publication

    Organism-specific databases

    PharmGKBiPA33098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Phosphatidylcholine transfer proteinPRO_0000220658Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9UKL6.
    PaxDbiQ9UKL6.
    PRIDEiQ9UKL6.

    PTM databases

    PhosphoSiteiQ9UKL6.

    Expressioni

    Tissue specificityi

    Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus.1 Publication

    Gene expression databases

    ArrayExpressiQ9UKL6.
    BgeeiQ9UKL6.
    CleanExiHS_PCTP.
    GenevestigatoriQ9UKL6.

    Organism-specific databases

    HPAiHPA022979.

    Interactioni

    Subunit structurei

    Interacts with ACOT13/THEM2.By similarity

    Protein-protein interaction databases

    BioGridi121818. 3 interactions.
    STRINGi9606.ENSP00000268896.

    Structurei

    Secondary structure

    1
    214
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 156
    Helixi18 – 214
    Turni26 – 294
    Beta strandi31 – 366
    Beta strandi39 – 457
    Turni47 – 493
    Beta strandi52 – 609
    Helixi65 – 739
    Helixi75 – 817
    Beta strandi85 – 939
    Beta strandi96 – 1038
    Beta strandi107 – 1093
    Beta strandi112 – 12312
    Helixi125 – 1273
    Beta strandi130 – 1378
    Beta strandi149 – 1524
    Beta strandi155 – 1639
    Beta strandi165 – 17713
    Helixi185 – 1939
    Helixi195 – 20814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LN1X-ray2.40A1-214[»]
    1LN2X-ray2.90A/B1-214[»]
    1LN3X-ray2.90A/B1-214[»]
    ProteinModelPortaliQ9UKL6.
    SMRiQ9UKL6. Positions 8-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UKL6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 212212STARTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 START domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG264966.
    HOGENOMiHOG000261644.
    HOVERGENiHBG008237.
    InParanoidiQ9UKL6.
    OMAiCADVYMD.
    OrthoDBiEOG70KGQK.
    PhylomeDBiQ9UKL6.
    TreeFamiTF320705.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PfamiPF01852. START. 1 hit.
    [Graphical view]
    SMARTiSM00234. START. 1 hit.
    [Graphical view]
    PROSITEiPS50848. START. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKL6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG    50
    LYEYKVFGVL EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY 100
    WEVKYPFPMS NRDYVYLRQR RDLDMEGRKI HVILARSTSM PQLGERSGVI 150
    RVKQYKQSLA IESDGKKGSK VFMYYFDNPG GQIPSWLINW AAKNGVPNFL 200
    KDMARACQNY LKKT 214
    Length:214
    Mass (Da):24,843
    Last modified:May 1, 2000 - v1
    Checksum:iE40204B7C0A9AF83
    GO
    Isoform 2 (identifier: Q9UKL6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: Missing.

    Show »
    Length:142
    Mass (Da):16,824
    Checksum:i1BA1CE03358BAB59
    GO

    Sequence cautioni

    The sequence AAH05112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521Y → H in AAF08347. (PubMed:10542325)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101E → A.
    Corresponds to variant rs12941739 [ dbSNP | Ensembl ].
    VAR_052070

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_041363Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF114436
    , AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA. Translation: AAF08347.1.
    AF114430 mRNA. Translation: AAF08345.1.
    AF151638 mRNA. Translation: AAF02536.1.
    AC009837 Genomic DNA. No translation available.
    AC091155 Genomic DNA. No translation available.
    BC005112 mRNA. Translation: AAH05112.1. Different initiation.
    BC012084 mRNA. Translation: AAH12084.1.
    CCDSiCCDS11588.1. [Q9UKL6-1]
    CCDS45741.1. [Q9UKL6-2]
    RefSeqiNP_001095872.1. NM_001102402.2. [Q9UKL6-2]
    NP_067036.2. NM_021213.3. [Q9UKL6-1]
    UniGeneiHs.285218.

    Genome annotation databases

    EnsembliENST00000268896; ENSP00000268896; ENSG00000141179. [Q9UKL6-1]
    ENST00000325214; ENSP00000325181; ENSG00000141179. [Q9UKL6-2]
    GeneIDi58488.
    KEGGihsa:58488.
    UCSCiuc002iul.4. human. [Q9UKL6-1]

    Polymorphism databases

    DMDMi15214192.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF114436
    , AF114431 , AF114432 , AF114433 , AF114434 , AF114435 Genomic DNA. Translation: AAF08347.1 .
    AF114430 mRNA. Translation: AAF08345.1 .
    AF151638 mRNA. Translation: AAF02536.1 .
    AC009837 Genomic DNA. No translation available.
    AC091155 Genomic DNA. No translation available.
    BC005112 mRNA. Translation: AAH05112.1 . Different initiation.
    BC012084 mRNA. Translation: AAH12084.1 .
    CCDSi CCDS11588.1. [Q9UKL6-1 ]
    CCDS45741.1. [Q9UKL6-2 ]
    RefSeqi NP_001095872.1. NM_001102402.2. [Q9UKL6-2 ]
    NP_067036.2. NM_021213.3. [Q9UKL6-1 ]
    UniGenei Hs.285218.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LN1 X-ray 2.40 A 1-214 [» ]
    1LN2 X-ray 2.90 A/B 1-214 [» ]
    1LN3 X-ray 2.90 A/B 1-214 [» ]
    ProteinModelPortali Q9UKL6.
    SMRi Q9UKL6. Positions 8-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121818. 3 interactions.
    STRINGi 9606.ENSP00000268896.

    PTM databases

    PhosphoSitei Q9UKL6.

    Polymorphism databases

    DMDMi 15214192.

    Proteomic databases

    MaxQBi Q9UKL6.
    PaxDbi Q9UKL6.
    PRIDEi Q9UKL6.

    Protocols and materials databases

    DNASUi 58488.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268896 ; ENSP00000268896 ; ENSG00000141179 . [Q9UKL6-1 ]
    ENST00000325214 ; ENSP00000325181 ; ENSG00000141179 . [Q9UKL6-2 ]
    GeneIDi 58488.
    KEGGi hsa:58488.
    UCSCi uc002iul.4. human. [Q9UKL6-1 ]

    Organism-specific databases

    CTDi 58488.
    GeneCardsi GC17P053828.
    HGNCi HGNC:8752. PCTP.
    HPAi HPA022979.
    MIMi 606055. gene.
    neXtProti NX_Q9UKL6.
    PharmGKBi PA33098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264966.
    HOGENOMi HOG000261644.
    HOVERGENi HBG008237.
    InParanoidi Q9UKL6.
    OMAi CADVYMD.
    OrthoDBi EOG70KGQK.
    PhylomeDBi Q9UKL6.
    TreeFami TF320705.

    Miscellaneous databases

    EvolutionaryTracei Q9UKL6.
    GeneWikii Phosphatidylcholine_transfer_protein.
    GenomeRNAii 58488.
    NextBioi 64950.
    PROi Q9UKL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKL6.
    Bgeei Q9UKL6.
    CleanExi HS_PCTP.
    Genevestigatori Q9UKL6.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    Pfami PF01852. START. 1 hit.
    [Graphical view ]
    SMARTi SM00234. START. 1 hit.
    [Graphical view ]
    PROSITEi PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein."
      Cohen D.E., Green R.M., Wu M.K., Beier D.R.
      Biochim. Biophys. Acta 1447:265-270(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Uterus.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: B-cell.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data."
      Chan W.W., Roderick S.L., Cohen D.E.
      Biochim. Biophys. Acta 1596:1-5(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    7. "Structure of human phosphatidylcholine transfer protein in complex with its ligand."
      Roderick S.L., Chan W.W., Agate D.S., Olsen L.R., Vetting M.W., Rajashankar K.R., Cohen D.E.
      Nat. Struct. Biol. 9:507-511(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEXES WITH PHOSPHATIDYLCHOLINE, FUNCTION, MUTAGENESIS OF CYS-63.

    Entry informationi

    Entry nameiPPCT_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKL6
    Secondary accession number(s): Q9BSC9, Q9UIT3, Q9UKW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3