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Q9UKL6 (PPCT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylcholine transfer protein

Short name=PC-TP
Alternative name(s):
START domain-containing protein 2
Short name=StARD2
StAR-related lipid transfer protein 2
Gene names
Name:PCTP
Synonyms:STARD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule. Ref.7

Subunit structure

Interacts with ACOT13/THEM2 By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus. Ref.1

Sequence similarities

Contains 1 START domain.

Sequence caution

The sequence AAH05112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKL6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKL6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Phosphatidylcholine transfer protein
PRO_0000220658

Regions

Domain1 – 212212START

Sites

Binding site721Phosphatidylcholine
Binding site781Phosphatidylcholine
Binding site1571Phosphatidylcholine

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Natural variations

Alternative sequence1 – 7272Missing in isoform 2.
VSP_041363
Natural variant101E → A.
Corresponds to variant rs12941739 [ dbSNP | Ensembl ].
VAR_052070

Experimental info

Mutagenesis631C → A: Reduces activity by 20%. Ref.7
Sequence conflict521Y → H in AAF08347. Ref.1

Secondary structure

......................................... 214
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E40204B7C0A9AF83

FASTA21424,843
        10         20         30         40         50         60 
MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG LYEYKVFGVL 

        70         80         90        100        110        120 
EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY WEVKYPFPMS NRDYVYLRQR 

       130        140        150        160        170        180 
RDLDMEGRKI HVILARSTSM PQLGERSGVI RVKQYKQSLA IESDGKKGSK VFMYYFDNPG 

       190        200        210 
GQIPSWLINW AAKNGVPNFL KDMARACQNY LKKT 

« Hide

Isoform 2 [UniParc].

Checksum: 1BA1CE03358BAB59
Show »

FASTA14216,824

References

« Hide 'large scale' references
[1]"Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein."
Cohen D.E., Green R.M., Wu M.K., Beier D.R.
Biochim. Biophys. Acta 1447:265-270(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"Mice without phosphatidylcholine transfer protein have no defects in the secretion of PC into bile or into the lung airspaces."
van Helvoort A., de Brouwer A., Ottenhoff R., Brouwers J.F.H.M., Wijnholds J., Beijnen J.H., Rijneveld A., van der Poll T., van der Valk M.A., Majoor D., Voorhout W., Wirtz K.W.A., Oude Elferink R.P.J., Borst P.
Proc. Natl. Acad. Sci. U.S.A. 96:11501-11506(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Uterus.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: B-cell.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data."
Chan W.W., Roderick S.L., Cohen D.E.
Biochim. Biophys. Acta 1596:1-5(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
[7]"Structure of human phosphatidylcholine transfer protein in complex with its ligand."
Roderick S.L., Chan W.W., Agate D.S., Olsen L.R., Vetting M.W., Rajashankar K.R., Cohen D.E.
Nat. Struct. Biol. 9:507-511(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEXES WITH PHOSPHATIDYLCHOLINE, FUNCTION, MUTAGENESIS OF CYS-63.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF114436 expand/collapse EMBL AC list , AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA. Translation: AAF08347.1.
AF114430 mRNA. Translation: AAF08345.1.
AF151638 mRNA. Translation: AAF02536.1.
AC009837 Genomic DNA. No translation available.
AC091155 Genomic DNA. No translation available.
BC005112 mRNA. Translation: AAH05112.1. Different initiation.
BC012084 mRNA. Translation: AAH12084.1.
RefSeqNP_001095872.1. NM_001102402.2.
NP_067036.2. NM_021213.3.
UniGeneHs.285218.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LN1X-ray2.40A1-214[»]
1LN2X-ray2.90A/B1-214[»]
1LN3X-ray2.90A/B1-214[»]
ProteinModelPortalQ9UKL6.
SMRQ9UKL6. Positions 8-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121818. 2 interactions.
STRING9606.ENSP00000268896.

PTM databases

PhosphoSiteQ9UKL6.

Polymorphism databases

DMDM15214192.

Proteomic databases

PaxDbQ9UKL6.
PRIDEQ9UKL6.

Protocols and materials databases

DNASU58488.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268896; ENSP00000268896; ENSG00000141179. [Q9UKL6-1]
ENST00000325214; ENSP00000325181; ENSG00000141179. [Q9UKL6-2]
GeneID58488.
KEGGhsa:58488.
UCSCuc002iul.4. human. [Q9UKL6-1]

Organism-specific databases

CTD58488.
GeneCardsGC17P053828.
HGNCHGNC:8752. PCTP.
HPAHPA022979.
MIM606055. gene.
neXtProtNX_Q9UKL6.
PharmGKBPA33098.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264966.
HOGENOMHOG000261644.
HOVERGENHBG008237.
InParanoidQ9UKL6.
OMACADVYMD.
OrthoDBEOG70KGQK.
PhylomeDBQ9UKL6.
TreeFamTF320705.

Gene expression databases

ArrayExpressQ9UKL6.
BgeeQ9UKL6.
CleanExHS_PCTP.
GenevestigatorQ9UKL6.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF01852. START. 1 hit.
[Graphical view]
SMARTSM00234. START. 1 hit.
[Graphical view]
PROSITEPS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9UKL6.
GeneWikiPhosphatidylcholine_transfer_protein.
GenomeRNAi58488.
NextBio64950.
PROQ9UKL6.
SOURCESearch...

Entry information

Entry namePPCT_HUMAN
AccessionPrimary (citable) accession number: Q9UKL6
Secondary accession number(s): Q9BSC9, Q9UIT3, Q9UKW7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM