ID   O52A1_HUMAN             Reviewed;         312 AA.
AC   Q9UKL2; Q6IF31;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 175.
DE   RecName: Full=Olfactory receptor 52A1;
DE   AltName: Full=HPFH1OR;
DE   AltName: Full=Odorant receptor HOR3'beta4;
DE   AltName: Full=Olfactory receptor OR11-319;
GN   Name=OR52A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10512676; DOI=10.1006/geno.1999.5935;
RA   Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.;
RT   "An olfactory receptor gene is located in the extended human beta-globin
RT   gene cluster and is expressed in erythroid cells.";
RL   Genomics 61:15-23(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52A1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF154673; AAD51279.1; -; Genomic_DNA.
DR   EMBL; AF289204; AAG42367.1; -; Genomic_DNA.
DR   EMBL; AC129505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC111722; AAI11723.1; -; mRNA.
DR   EMBL; BK004431; DAA04829.1; -; Genomic_DNA.
DR   CCDS; CCDS31374.1; -.
DR   RefSeq; NP_036507.2; NM_012375.2.
DR   AlphaFoldDB; Q9UKL2; -.
DR   SMR; Q9UKL2; -.
DR   STRING; 9606.ENSP00000369725; -.
DR   GlyCosmos; Q9UKL2; 1 site, No reported glycans.
DR   GlyGen; Q9UKL2; 1 site.
DR   BioMuta; OR52A1; -.
DR   DMDM; 296439247; -.
DR   PaxDb; 9606-ENSP00000369725; -.
DR   PeptideAtlas; Q9UKL2; -.
DR   Antibodypedia; 55354; 117 antibodies from 21 providers.
DR   DNASU; 23538; -.
DR   Ensembl; ENST00000380367.3; ENSP00000369725.1; ENSG00000182070.7.
DR   GeneID; 23538; -.
DR   KEGG; hsa:23538; -.
DR   MANE-Select; ENST00000380367.3; ENSP00000369725.1; NM_012375.3; NP_036507.2.
DR   UCSC; uc010qyy.2; human.
DR   AGR; HGNC:8318; -.
DR   CTD; 23538; -.
DR   GeneCards; OR52A1; -.
DR   HGNC; HGNC:8318; OR52A1.
DR   HPA; ENSG00000182070; Not detected.
DR   neXtProt; NX_Q9UKL2; -.
DR   OpenTargets; ENSG00000182070; -.
DR   PharmGKB; PA32392; -.
DR   VEuPathDB; HostDB:ENSG00000182070; -.
DR   eggNOG; ENOG502SITM; Eukaryota.
DR   GeneTree; ENSGT01090000260013; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9UKL2; -.
DR   OMA; HTFQGME; -.
DR   OrthoDB; 4578140at2759; -.
DR   PhylomeDB; Q9UKL2; -.
DR   TreeFam; TF352744; -.
DR   PathwayCommons; Q9UKL2; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 23538; 7 hits in 751 CRISPR screens.
DR   GeneWiki; OR52A1; -.
DR   GenomeRNAi; 23538; -.
DR   Pharos; Q9UKL2; Tdark.
DR   PRO; PR:Q9UKL2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9UKL2; Protein.
DR   Bgee; ENSG00000182070; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26450:SF98; OLFACTORY RECEPTOR 52A1; 1.
DR   PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9UKL2; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 52A1"
FT                   /id="PRO_0000150765"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..182
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        272
FT                   /note="S -> P (in Ref. 1; AAD51279, 2; AAG42367 and 4;
FT                   AAI11723)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  35322 MW;  B05AFD46352D513C CRC64;
     MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI IKSERSLHEP
     LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL LQMWFIHTLQ GIESGILVAM
     ALDRYVAICY PLRHANIFTH QLVIQIGTMV VLRAAILVAP CLVLIKCRFQ FYHTTVISHS
     YCEHMAIVKL AAANVQVNKI YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA
     FNTCIAHICV FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
     QIRIHVVKMF CS
//