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Q9UKL2

- O52A1_HUMAN

UniProt

Q9UKL2 - O52A1_HUMAN

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Protein
Olfactory receptor 52A1
Gene
OR52A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. sensory perception of smell Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A1
Alternative name(s):
HPFH1OR
Odorant receptor HOR3'beta4
Olfactory receptor OR11-319
Gene namesi
Name:OR52A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8318. OR52A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini78 – 10124Extracellular Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini123 – 14119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini163 – 19937Extracellular Reviewed prediction
Add
BLAST
Transmembranei200 – 22021Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini221 – 24020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini262 – 27615Extracellular Reviewed prediction
Add
BLAST
Transmembranei277 – 29721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini298 – 31215Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 52A1
PRO_0000150765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 182 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9UKL2.

Expressioni

Gene expression databases

BgeeiQ9UKL2.
CleanExiHS_OR52A1.
GenevestigatoriQ9UKL2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369725.

Structurei

3D structure databases

ProteinModelPortaliQ9UKL2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86443.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9UKL2.
KOiK04257.
OMAiCAIYLIA.
OrthoDBiEOG754HPV.
PhylomeDBiQ9UKL2.
TreeFamiTF352744.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKL2-1 [UniParc]FASTAAdd to Basket

« Hide

MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI    50
IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL 100
LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV 150
VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI 200
YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV 250
FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT 300
QIRIHVVKMF CS 312
Length:312
Mass (Da):35,322
Last modified:May 18, 2010 - v2
Checksum:iB05AFD46352D513C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721S → P in AAD51279. 1 Publication
Sequence conflicti272 – 2721S → P in AAG42367. 1 Publication
Sequence conflicti272 – 2721S → P in AAI11723. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
CCDSiCCDS31374.1.
RefSeqiNP_036507.2. NM_012375.2.
UniGeneiHs.553520.

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneIDi23538.
KEGGihsa:23538.
UCSCiuc010qyy.2. human.

Polymorphism databases

DMDMi296439247.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1 .
AF289204 Genomic DNA. Translation: AAG42367.1 .
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1 .
BK004431 Genomic DNA. Translation: DAA04829.1 .
CCDSi CCDS31374.1.
RefSeqi NP_036507.2. NM_012375.2.
UniGenei Hs.553520.

3D structure databases

ProteinModelPortali Q9UKL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369725.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296439247.

Proteomic databases

PRIDEi Q9UKL2.

Protocols and materials databases

DNASUi 23538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328942 ; ENSP00000333684 ; ENSG00000182070 .
ENST00000380367 ; ENSP00000369725 ; ENSG00000182070 .
GeneIDi 23538.
KEGGi hsa:23538.
UCSCi uc010qyy.2. human.

Organism-specific databases

CTDi 23538.
GeneCardsi GC11M005172.
H-InvDB HIX0201752.
HGNCi HGNC:8318. OR52A1.
neXtProti NX_Q9UKL2.
PharmGKBi PA32392.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86443.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q9UKL2.
KOi K04257.
OMAi CAIYLIA.
OrthoDBi EOG754HPV.
PhylomeDBi Q9UKL2.
TreeFami TF352744.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR52A1.
GenomeRNAii 23538.
NextBioi 46038.
PROi Q9UKL2.

Gene expression databases

Bgeei Q9UKL2.
CleanExi HS_OR52A1.
Genevestigatori Q9UKL2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells."
    Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.
    Genomics 61:15-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKL2
Secondary accession number(s): Q6IF31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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