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Protein

Olfactory receptor 52A1

Gene

OR52A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • sensory perception of smell Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A1
Alternative name(s):
HPFH1OR
Odorant receptor HOR3'beta4
Olfactory receptor OR11-319
Gene namesi
Name:OR52A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000182070.4
HGNCiHGNC:8318 OR52A1
neXtProtiNX_Q9UKL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 312CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23538
OpenTargetsiENSG00000182070
PharmGKBiPA32392

Polymorphism and mutation databases

BioMutaiOR52A1
DMDMi296439247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507651 – 312Olfactory receptor 52A1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKL2
PRIDEiQ9UKL2

Expressioni

Gene expression databases

BgeeiENSG00000182070
CleanExiHS_OR52A1
GenevisibleiQ9UKL2 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333684

Structurei

3D structure databases

ProteinModelPortaliQ9UKL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT7 Eukaryota
ENOG4111EGC LUCA
GeneTreeiENSGT00840000129788
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9UKL2
KOiK04257
OMAiCAIYLIA
OrthoDBiEOG091G0AZH
PhylomeDBiQ9UKL2
TreeFamiTF352744

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI
60 70 80 90 100
IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL
110 120 130 140 150
LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV
160 170 180 190 200
VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI
210 220 230 240 250
YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
310
QIRIHVVKMF CS
Length:312
Mass (Da):35,322
Last modified:May 18, 2010 - v2
Checksum:iB05AFD46352D513C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272S → P in AAD51279 (PubMed:10512676).Curated1
Sequence conflicti272S → P in AAG42367 (PubMed:11121057).Curated1
Sequence conflicti272S → P in AAI11723 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154673 Genomic DNA Translation: AAD51279.1
AF289204 Genomic DNA Translation: AAG42367.1
AC129505 Genomic DNA No translation available.
BC111722 mRNA Translation: AAI11723.1
BK004431 Genomic DNA Translation: DAA04829.1
CCDSiCCDS31374.1
RefSeqiNP_036507.2, NM_012375.2
UniGeneiHs.553520

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070
ENST00000380367; ENSP00000369725; ENSG00000182070
GeneIDi23538
KEGGihsa:23538
UCSCiuc010qyy.2 human

Entry informationi

Entry nameiO52A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKL2
Secondary accession number(s): Q6IF31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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