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Protein

Olfactory receptor 52A1

Gene

OR52A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • sensory perception of smell Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32241-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A1
Alternative name(s):
HPFH1OR
Odorant receptor HOR3'beta4
Olfactory receptor OR11-319
Gene namesi
Name:OR52A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8318. OR52A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 312CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23538.
OpenTargetsiENSG00000182070.
PharmGKBiPA32392.

Polymorphism and mutation databases

BioMutaiOR52A1.
DMDMi296439247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507651 – 312Olfactory receptor 52A1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKL2.
PeptideAtlasiQ9UKL2.
PRIDEiQ9UKL2.

Expressioni

Gene expression databases

BgeeiENSG00000182070.
CleanExiHS_OR52A1.
GenevisibleiQ9UKL2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333684.

Structurei

3D structure databases

ProteinModelPortaliQ9UKL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT7. Eukaryota.
ENOG4111EGC. LUCA.
GeneTreeiENSGT00840000129788.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9UKL2.
KOiK04257.
OMAiCAIYLIA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9UKL2.
TreeFamiTF352744.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI
60 70 80 90 100
IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL
110 120 130 140 150
LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV
160 170 180 190 200
VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI
210 220 230 240 250
YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
310
QIRIHVVKMF CS
Length:312
Mass (Da):35,322
Last modified:May 18, 2010 - v2
Checksum:iB05AFD46352D513C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272S → P in AAD51279 (PubMed:10512676).Curated1
Sequence conflicti272S → P in AAG42367 (PubMed:11121057).Curated1
Sequence conflicti272S → P in AAI11723 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
CCDSiCCDS31374.1.
RefSeqiNP_036507.2. NM_012375.2.
UniGeneiHs.553520.

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneIDi23538.
KEGGihsa:23538.
UCSCiuc010qyy.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
CCDSiCCDS31374.1.
RefSeqiNP_036507.2. NM_012375.2.
UniGeneiHs.553520.

3D structure databases

ProteinModelPortaliQ9UKL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333684.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52A1.
DMDMi296439247.

Proteomic databases

PaxDbiQ9UKL2.
PeptideAtlasiQ9UKL2.
PRIDEiQ9UKL2.

Protocols and materials databases

DNASUi23538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneIDi23538.
KEGGihsa:23538.
UCSCiuc010qyy.2. human.

Organism-specific databases

CTDi23538.
DisGeNETi23538.
GeneCardsiOR52A1.
H-InvDBHIX0201752.
HGNCiHGNC:8318. OR52A1.
neXtProtiNX_Q9UKL2.
OpenTargetsiENSG00000182070.
PharmGKBiPA32392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVT7. Eukaryota.
ENOG4111EGC. LUCA.
GeneTreeiENSGT00840000129788.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9UKL2.
KOiK04257.
OMAiCAIYLIA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9UKL2.
TreeFamiTF352744.

Enzyme and pathway databases

BioCyciZFISH:G66-32241-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52A1.
GenomeRNAii23538.
PROiQ9UKL2.

Gene expression databases

BgeeiENSG00000182070.
CleanExiHS_OR52A1.
GenevisibleiQ9UKL2. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKL2
Secondary accession number(s): Q6IF31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.