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Q9UKL2 (O52A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52A1
Alternative name(s):
HPFH1OR
Odorant receptor HOR3'beta4
Olfactory receptor OR11-319
Gene names
Name:OR52A1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 52A1
PRO_0000150765

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19937Extracellular Potential
Transmembrane200 – 22021Helical; Name=5; Potential
Topological domain221 – 24020Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27615Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 31215Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 182 By similarity

Experimental info

Sequence conflict2721S → P in AAD51279. Ref.1
Sequence conflict2721S → P in AAG42367. Ref.2
Sequence conflict2721S → P in AAI11723. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9UKL2 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: B05AFD46352D513C

FASTA31235,322
        10         20         30         40         50         60 
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI IKSERSLHEP 

        70         80         90        100        110        120 
LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL LQMWFIHTLQ GIESGILVAM 

       130        140        150        160        170        180 
ALDRYVAICY PLRHANIFTH QLVIQIGTMV VLRAAILVAP CLVLIKCRFQ FYHTTVISHS 

       190        200        210        220        230        240 
YCEHMAIVKL AAANVQVNKI YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA 

       250        260        270        280        290        300 
FNTCIAHICV FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT 

       310 
QIRIHVVKMF CS 

« Hide

References

« Hide 'large scale' references
[1]"An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells."
Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.
Genomics 61:15-23(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
RefSeqNP_036507.2. NM_012375.2.
UniGeneHs.553520.

3D structure databases

ProteinModelPortalQ9UKL2.
SMRQ9UKL2. Positions 111-142, 279-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369725.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM296439247.

Proteomic databases

PRIDEQ9UKL2.

Protocols and materials databases

DNASU23538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneID23538.
KEGGhsa:23538.
UCSCuc010qyy.2. human.

Organism-specific databases

CTD23538.
GeneCardsGC11M005172.
H-InvDBHIX0201752.
HGNCHGNC:8318. OR52A1.
neXtProtNX_Q9UKL2.
PharmGKBPA32392.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86443.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ9UKL2.
KOK04257.
OMACAIYLIA.
OrthoDBEOG754HPV.
PhylomeDBQ9UKL2.
TreeFamTF352744.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9UKL2.
CleanExHS_OR52A1.
GenevestigatorQ9UKL2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52A1.
GenomeRNAi23538.
NextBio46038.
PROQ9UKL2.

Entry information

Entry nameO52A1_HUMAN
AccessionPrimary (citable) accession number: Q9UKL2
Secondary accession number(s): Q6IF31
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries