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Q9UKL2

- O52A1_HUMAN

UniProt

Q9UKL2 - O52A1_HUMAN

Protein

Olfactory receptor 52A1

Gene

OR52A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro
    3. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. sensory perception of smell Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52A1
    Alternative name(s):
    HPFH1OR
    Odorant receptor HOR3'beta4
    Olfactory receptor OR11-319
    Gene namesi
    Name:OR52A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8318. OR52A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 52A1PRO_0000150765Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9UKL2.

    Expressioni

    Gene expression databases

    BgeeiQ9UKL2.
    CleanExiHS_OR52A1.
    GenevestigatoriQ9UKL2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369725.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31215CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86443.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ9UKL2.
    KOiK04257.
    OMAiCAIYLIA.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ9UKL2.
    TreeFamiTF352744.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UKL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI    50
    IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL 100
    LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV 150
    VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI 200
    YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV 250
    FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT 300
    QIRIHVVKMF CS 312
    Length:312
    Mass (Da):35,322
    Last modified:May 18, 2010 - v2
    Checksum:iB05AFD46352D513C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721S → P in AAD51279. (PubMed:10512676)Curated
    Sequence conflicti272 – 2721S → P in AAG42367. (PubMed:11121057)Curated
    Sequence conflicti272 – 2721S → P in AAI11723. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154673 Genomic DNA. Translation: AAD51279.1.
    AF289204 Genomic DNA. Translation: AAG42367.1.
    AC129505 Genomic DNA. No translation available.
    BC111722 mRNA. Translation: AAI11723.1.
    BK004431 Genomic DNA. Translation: DAA04829.1.
    CCDSiCCDS31374.1.
    RefSeqiNP_036507.2. NM_012375.2.
    UniGeneiHs.553520.

    Genome annotation databases

    EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
    ENST00000380367; ENSP00000369725; ENSG00000182070.
    GeneIDi23538.
    KEGGihsa:23538.
    UCSCiuc010qyy.2. human.

    Polymorphism databases

    DMDMi296439247.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154673 Genomic DNA. Translation: AAD51279.1 .
    AF289204 Genomic DNA. Translation: AAG42367.1 .
    AC129505 Genomic DNA. No translation available.
    BC111722 mRNA. Translation: AAI11723.1 .
    BK004431 Genomic DNA. Translation: DAA04829.1 .
    CCDSi CCDS31374.1.
    RefSeqi NP_036507.2. NM_012375.2.
    UniGenei Hs.553520.

    3D structure databases

    ProteinModelPortali Q9UKL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369725.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296439247.

    Proteomic databases

    PRIDEi Q9UKL2.

    Protocols and materials databases

    DNASUi 23538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328942 ; ENSP00000333684 ; ENSG00000182070 .
    ENST00000380367 ; ENSP00000369725 ; ENSG00000182070 .
    GeneIDi 23538.
    KEGGi hsa:23538.
    UCSCi uc010qyy.2. human.

    Organism-specific databases

    CTDi 23538.
    GeneCardsi GC11M005172.
    H-InvDB HIX0201752.
    HGNCi HGNC:8318. OR52A1.
    neXtProti NX_Q9UKL2.
    PharmGKBi PA32392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86443.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q9UKL2.
    KOi K04257.
    OMAi CAIYLIA.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q9UKL2.
    TreeFami TF352744.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52A1.
    GenomeRNAii 23538.
    NextBioi 46038.
    PROi Q9UKL2.

    Gene expression databases

    Bgeei Q9UKL2.
    CleanExi HS_OR52A1.
    Genevestigatori Q9UKL2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells."
      Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.
      Genomics 61:15-23(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
      Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
      Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKL2
    Secondary accession number(s): Q6IF31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3