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Protein

Olfactory receptor 52A1

Gene

OR52A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. sensory perception of smell Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A1
Alternative name(s):
HPFH1OR
Odorant receptor HOR3'beta4
Olfactory receptor OR11-319
Gene namesi
Name:OR52A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8318. OR52A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 31215CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 52A1PRO_0000150765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9UKL2.

Expressioni

Gene expression databases

BgeeiQ9UKL2.
CleanExiHS_OR52A1.
GenevestigatoriQ9UKL2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369725.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86443.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9UKL2.
KOiK04257.
OMAiCAIYLIA.
OrthoDBiEOG754HPV.
PhylomeDBiQ9UKL2.
TreeFamiTF352744.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI
60 70 80 90 100
IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL
110 120 130 140 150
LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV
160 170 180 190 200
VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI
210 220 230 240 250
YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
310
QIRIHVVKMF CS
Length:312
Mass (Da):35,322
Last modified:May 17, 2010 - v2
Checksum:iB05AFD46352D513C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721S → P in AAD51279 (PubMed:10512676).Curated
Sequence conflicti272 – 2721S → P in AAG42367 (PubMed:11121057).Curated
Sequence conflicti272 – 2721S → P in AAI11723 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
CCDSiCCDS31374.1.
RefSeqiNP_036507.2. NM_012375.2.
UniGeneiHs.553520.

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneIDi23538.
KEGGihsa:23538.
UCSCiuc010qyy.2. human.

Polymorphism databases

DMDMi296439247.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154673 Genomic DNA. Translation: AAD51279.1.
AF289204 Genomic DNA. Translation: AAG42367.1.
AC129505 Genomic DNA. No translation available.
BC111722 mRNA. Translation: AAI11723.1.
BK004431 Genomic DNA. Translation: DAA04829.1.
CCDSiCCDS31374.1.
RefSeqiNP_036507.2. NM_012375.2.
UniGeneiHs.553520.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369725.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi296439247.

Proteomic databases

PRIDEiQ9UKL2.

Protocols and materials databases

DNASUi23538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328942; ENSP00000333684; ENSG00000182070.
ENST00000380367; ENSP00000369725; ENSG00000182070.
GeneIDi23538.
KEGGihsa:23538.
UCSCiuc010qyy.2. human.

Organism-specific databases

CTDi23538.
GeneCardsiGC11M005172.
H-InvDBHIX0201752.
HGNCiHGNC:8318. OR52A1.
neXtProtiNX_Q9UKL2.
PharmGKBiPA32392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86443.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9UKL2.
KOiK04257.
OMAiCAIYLIA.
OrthoDBiEOG754HPV.
PhylomeDBiQ9UKL2.
TreeFamiTF352744.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52A1.
GenomeRNAii23538.
NextBioi46038.
PROiQ9UKL2.

Gene expression databases

BgeeiQ9UKL2.
CleanExiHS_OR52A1.
GenevestigatoriQ9UKL2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells."
    Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.
    Genomics 61:15-23(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO52A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKL2
Secondary accession number(s): Q6IF31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 19, 2001
Last sequence update: May 17, 2010
Last modified: March 31, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.