Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NTF2-related export protein 1

Gene

NXT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Names & Taxonomyi

Protein namesi
Recommended name:
NTF2-related export protein 1
Alternative name(s):
Protein p15
Gene namesi
Name:NXT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132661.3.
HGNCiHGNC:15913. NXT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi114I → R: 70% reduction in mRNA export activity. 1 Publication1
Mutagenesisi134R → D: 57% reduction in mRNA export activity and loss of nuclear rim staining. 1 Publication1

Organism-specific databases

DisGeNETi29107.
OpenTargetsiENSG00000132661.
PharmGKBiPA31867.

Polymorphism and mutation databases

BioMutaiNXT1.
DMDMi18203504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001947932 – 140NTF2-related export protein 1Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UKK6.
MaxQBiQ9UKK6.
PaxDbiQ9UKK6.
PeptideAtlasiQ9UKK6.
PRIDEiQ9UKK6.
TopDownProteomicsiQ9UKK6.

PTM databases

iPTMnetiQ9UKK6.
PhosphoSitePlusiQ9UKK6.

Expressioni

Gene expression databases

BgeeiENSG00000132661.
CleanExiHS_NXT1.
GenevisibleiQ9UKK6. HS.

Organism-specific databases

HPAiHPA047471.

Interactioni

Subunit structurei

Heterodimer with NXF1. Interacts (via NTF2 domain) with NXF1. Stabilizes the NTF2 domain of NXF1 by heterodimerization. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118875. 12 interactors.
DIPiDIP-33075N.
IntActiQ9UKK6. 16 interactors.
MINTiMINT-216208.
STRINGi9606.ENSP00000254998.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 30Combined sources25
Helixi32 – 38Combined sources7
Beta strandi39 – 47Combined sources9
Beta strandi50 – 54Combined sources5
Helixi55 – 64Combined sources10
Beta strandi68 – 79Combined sources12
Turni82 – 84Combined sources3
Beta strandi90 – 101Combined sources12
Beta strandi107 – 118Combined sources12
Beta strandi121 – 123Combined sources3
Beta strandi125 – 135Combined sources11
Turni136 – 139Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JKGX-ray1.90A1-140[»]
1JN5X-ray2.80A1-140[»]
4WYKX-ray3.40B/D2-140[»]
ProteinModelPortaliQ9UKK6.
SMRiQ9UKK6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKK6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 135NTF2PROSITE-ProRule annotationAdd BLAST120

Phylogenomic databases

eggNOGiKOG4353. Eukaryota.
ENOG4111TWR. LUCA.
GeneTreeiENSGT00510000046494.
HOGENOMiHOG000231890.
HOVERGENiHBG018207.
InParanoidiQ9UKK6.
KOiK14285.
OMAiYYSTMDK.
OrthoDBiEOG091G0SMX.
PhylomeDBiQ9UKK6.
TreeFamiTF318944.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
InterProiView protein in InterPro
IPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
PfamiView protein in Pfam
PF02136. NTF2. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiView protein in PROSITE
PS50177. NTF2_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN
60 70 80 90 100
AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK
110 120 130 140
FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS
Length:140
Mass (Da):15,847
Last modified:May 1, 2000 - v1
Checksum:i358FA86AC3944594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156957 mRNA. Translation: AAD54942.1.
AL096677 Genomic DNA. No translation available.
BC000759 mRNA. Translation: AAH00759.1.
BC002687 mRNA. Translation: AAH02687.1.
BC003029 mRNA. Translation: AAH03029.1.
BC003410 mRNA. Translation: AAH03410.1.
CCDSiCCDS13150.1.
RefSeqiNP_037380.1. NM_013248.2.
XP_011527532.1. XM_011529230.2.
UniGeneiHs.516933.

Genome annotation databases

EnsembliENST00000254998; ENSP00000254998; ENSG00000132661.
GeneIDi29107.
KEGGihsa:29107.
UCSCiuc002wsx.2. human.

Similar proteinsi

Entry informationi

Entry nameiNXT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references