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Protein

G patch domain-containing protein 8

Gene

GPATCH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri136 – 16025C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 8
Gene namesi
Name:GPATCH8
Synonyms:GPATC8, KIAA0553
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29066. GPATCH8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390105.

Polymorphism and mutation databases

BioMutaiGPATCH8.
DMDMi254763309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15021502G patch domain-containing protein 8PRO_0000050761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei479 – 4791N6-acetyllysineBy similarity
Modified residuei738 – 7381PhosphoserineCombined sources
Modified residuei740 – 7401PhosphoserineCombined sources
Modified residuei758 – 7581PhosphoserineCombined sources
Modified residuei911 – 9111PhosphoserineBy similarity
Modified residuei914 – 9141PhosphoserineBy similarity
Modified residuei981 – 9811PhosphoserineCombined sources
Modified residuei1014 – 10141PhosphoserineCombined sources
Modified residuei1033 – 10331PhosphoserineCombined sources
Modified residuei1035 – 10351PhosphoserineCombined sources
Modified residuei1081 – 10811PhosphoserineCombined sources
Modified residuei1107 – 11071PhosphoserineCombined sources
Modified residuei1175 – 11751PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKJ3.
MaxQBiQ9UKJ3.
PaxDbiQ9UKJ3.
PRIDEiQ9UKJ3.

PTM databases

iPTMnetiQ9UKJ3.

Expressioni

Gene expression databases

BgeeiQ9UKJ3.
CleanExiHS_GPATCH8.
ExpressionAtlasiQ9UKJ3. baseline and differential.
GenevisibleiQ9UKJ3. HS.

Organism-specific databases

HPAiHPA044380.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542534EBI-948259,EBI-930964

Protein-protein interaction databases

BioGridi116749. 33 interactions.
IntActiQ9UKJ3. 14 interactions.
MINTiMINT-2870438.
STRINGi9606.ENSP00000467556.

Structurei

3D structure databases

ProteinModelPortaliQ9UKJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 8647G-patchPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili89 – 12436Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi665 – 72056Lys-richAdd
BLAST
Compositional biasi745 – 7495Poly-Arg
Compositional biasi772 – 7754Poly-Gly
Compositional biasi804 – 1009206Ser-richAdd
BLAST
Compositional biasi1384 – 13907Poly-Ala
Compositional biasi1472 – 14787Poly-Ala

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri136 – 16025C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000231046.
InParanoidiQ9UKJ3.
OMAiGKSHRHK.
OrthoDBiEOG73BVBS.
PhylomeDBiQ9UKJ3.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK
60 70 80 90 100
HGWKLGQGLG KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV
110 120 130 140 150
LEVEKEDTEE LRQKYKDYVD KEKAIAKALE DLRANFYCEL CDKQYQKHQE
160 170 180 190 200
FDNHINSYDH AHKQRLKDLK QREFARNVSS RSRKDEKKQE KALRRLHELA
210 220 230 240 250
EQRKQAECAP GSGPMFKPTT VAVDEEGGED DKDESATNSG TGATASCGLG
260 270 280 290 300
SEFSTDKGGP FTAVQITNTT GLAQAPGLAS QGISFGIKNN LGTPLQKLGV
310 320 330 340 350
SFSFAKKAPV KLESIASVFK DHAEEGTSED GTKPDEKSSD QGLQKVGDSD
360 370 380 390 400
GSSNLDGKKE DEDPQDGGSL ASTLSKLKRM KREEGAGATE PEYYHYIPPA
410 420 430 440 450
HCKVKPNFPF LLFMRASEQM DGDNTTHPKN APESKKGSSP KPKSCIKAAA
460 470 480 490 500
SQGAEKTVSE VSEQPKETSM TEPSEPGSKA EAKKALGGDV SDQSLESHSQ
510 520 530 540 550
KVSETQMCES NSSKETSLAT PAGKESQEGP KHPTGPFFPV LSKDESTALQ
560 570 580 590 600
WPSELLIFTK AEPSISYSCN PLYFDFKLSR NKDARTKGTE KPKDIGSSSK
610 620 630 640 650
DHLQGLDPGE PNKSKEVGGE KIVRSSGGRM DAPASGSACS GLNKQEPGGS
660 670 680 690 700
HGSETEDTGR SLPSKKERSG KSHRHKKKKK HKKSSKHKRK HKADTEEKSS
710 720 730 740 750
KAESGEKSKK RKKRKRKKNK SSAPADSERG PKPEPPGSGS PAPPRRRRRA
760 770 780 790 800
QDDSQRRSLP AEEGSSGKKD EGGGGSSSQD HGGRKHKGEL PPSSCQRRAG
810 820 830 840 850
TKRSSRSSHR SQPSSGDEDS DDASSHRLHQ KSPSQYSEEE EEEDSGSEHS
860 870 880 890 900
RSRSRSGRRH SSHRSSRRSY SSSSDASSDQ SCYSRQRSYS DDSYSDYSDR
910 920 930 940 950
SRRHSKRSHD SDDSDYASSK HRSKRHKYSS SDDDYSLSCS QSRSRSRSHT
960 970 980 990 1000
RERSRSRGRS RSSSCSRSRS KRRSRSTTAH SWQRSRSYSR DRSRSTRSPS
1010 1020 1030 1040 1050
QRSGSRKRSW GHESPEERHS GRRDFIRSKI YRSQSPHYFR SGRGEGPGKK
1060 1070 1080 1090 1100
DDGRGDDSKA TGPPSQNSNI GTGRGSEGDC SPEDKNSVTA KLLLEKIQSR
1110 1120 1130 1140 1150
KVERKPSVSE EVQATPNKAG PKLKDPPQGY FGPKLPPSLG NKPVLPLIGK
1160 1170 1180 1190 1200
LPATRKPNKK CEESGLERGE EQEQSETEEG PPGSSDALFG HQFPSEETTG
1210 1220 1230 1240 1250
PLLDPPPEES KSGEATADHP VAPLGTPAHS DCYPGDPTIS HNYLPDPSDG
1260 1270 1280 1290 1300
DTLESLDSSS QPGPVESSLL PIAPDLEHFP SYAPPSGDPS IESTDGAEDA
1310 1320 1330 1340 1350
SLAPLESQPI TFTPEEMEKY SKLQQAAQQH IQQQLLAKQV KAFPASAALA
1360 1370 1380 1390 1400
PATPALQPIH IQQPATASAT SITTVQHAIL QHHAAAAAAA IGIHPHPHPQ
1410 1420 1430 1440 1450
PLAQVHHIPQ PHLTPISLSH LTHSIIPGHP ATFLASHPIH IIPASAIHPG
1460 1470 1480 1490 1500
PFTFHPVPHA ALYPTLLAPR PAAAAATALH LHPLLHPIFS GQDLQHPPSH

GT
Length:1,502
Mass (Da):164,197
Last modified:July 28, 2009 - v2
Checksum:i9A0FA14F3FE7A85C
GO
Isoform 2 (identifier: Q9UKJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:1,424
Mass (Da):155,193
Checksum:i09AB7C64C1E43730
GO
Isoform 3 (identifier: Q9UKJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-43: DNI → PSF
     44-1502: Missing.

Show »
Length:43
Mass (Da):5,133
Checksum:iD14575754EE7AF18
GO

Sequence cautioni

The sequence AAI36630.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA25479.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931L → V in AK025600 (PubMed:14702039).Curated
Sequence conflicti620 – 6201E → K in AAF03681 (PubMed:10477733).Curated
Sequence conflicti680 – 6801K → E in AAF03681 (PubMed:10477733).Curated
Sequence conflicti691 – 6911H → P in AAF03681 (PubMed:10477733).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti979 – 9791A → P.1 Publication
VAR_067000
Natural varianti1012 – 10121H → Q.
Corresponds to variant rs3744427 [ dbSNP | Ensembl ].
VAR_067001
Natural varianti1043 – 10431R → Q.
Corresponds to variant rs741902 [ dbSNP | Ensembl ].
VAR_059658
Natural varianti1161 – 11611C → W.
Corresponds to variant rs936018 [ dbSNP | Ensembl ].
VAR_059659
Natural varianti1259 – 12591S → G.1 Publication
Corresponds to variant rs760339 [ dbSNP | Ensembl ].
VAR_067002

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878Missing in isoform 2. 1 PublicationVSP_037683Add
BLAST
Alternative sequencei41 – 433DNI → PSF in isoform 3. 1 PublicationVSP_037684
Alternative sequencei44 – 15021459Missing in isoform 3. 1 PublicationVSP_037685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011125 mRNA. Translation: BAA25479.2. Different initiation.
AC103703 Genomic DNA. No translation available.
AC007722 Genomic DNA. No translation available.
CH471178 Genomic DNA. Translation: EAW51593.1.
BC024147 mRNA. Translation: AAH24147.2.
BC136629 mRNA. Translation: AAI36630.1. Sequence problems.
AK025600 mRNA. No translation available.
AF160252 Genomic DNA. Translation: AAF03681.1.
CCDSiCCDS32666.1. [Q9UKJ3-1]
PIRiT00329.
RefSeqiNP_001002909.1. NM_001002909.3. [Q9UKJ3-1]
NP_001291868.1. NM_001304939.1.
NP_001291869.1. NM_001304940.1. [Q9UKJ3-2]
NP_001291870.1. NM_001304941.1. [Q9UKJ3-2]
NP_001291871.1. NM_001304942.1. [Q9UKJ3-2]
NP_001291872.1. NM_001304943.1. [Q9UKJ3-2]
XP_011522864.1. XM_011524562.1. [Q9UKJ3-2]
UniGeneiHs.463129.

Genome annotation databases

EnsembliENST00000587228; ENSP00000468719; ENSG00000186566. [Q9UKJ3-3]
ENST00000591680; ENSP00000467556; ENSG00000186566. [Q9UKJ3-1]
GeneIDi23131.
KEGGihsa:23131.
UCSCiuc002igw.3. human. [Q9UKJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011125 mRNA. Translation: BAA25479.2. Different initiation.
AC103703 Genomic DNA. No translation available.
AC007722 Genomic DNA. No translation available.
CH471178 Genomic DNA. Translation: EAW51593.1.
BC024147 mRNA. Translation: AAH24147.2.
BC136629 mRNA. Translation: AAI36630.1. Sequence problems.
AK025600 mRNA. No translation available.
AF160252 Genomic DNA. Translation: AAF03681.1.
CCDSiCCDS32666.1. [Q9UKJ3-1]
PIRiT00329.
RefSeqiNP_001002909.1. NM_001002909.3. [Q9UKJ3-1]
NP_001291868.1. NM_001304939.1.
NP_001291869.1. NM_001304940.1. [Q9UKJ3-2]
NP_001291870.1. NM_001304941.1. [Q9UKJ3-2]
NP_001291871.1. NM_001304942.1. [Q9UKJ3-2]
NP_001291872.1. NM_001304943.1. [Q9UKJ3-2]
XP_011522864.1. XM_011524562.1. [Q9UKJ3-2]
UniGeneiHs.463129.

3D structure databases

ProteinModelPortaliQ9UKJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116749. 33 interactions.
IntActiQ9UKJ3. 14 interactions.
MINTiMINT-2870438.
STRINGi9606.ENSP00000467556.

PTM databases

iPTMnetiQ9UKJ3.

Polymorphism and mutation databases

BioMutaiGPATCH8.
DMDMi254763309.

Proteomic databases

EPDiQ9UKJ3.
MaxQBiQ9UKJ3.
PaxDbiQ9UKJ3.
PRIDEiQ9UKJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587228; ENSP00000468719; ENSG00000186566. [Q9UKJ3-3]
ENST00000591680; ENSP00000467556; ENSG00000186566. [Q9UKJ3-1]
GeneIDi23131.
KEGGihsa:23131.
UCSCiuc002igw.3. human. [Q9UKJ3-1]

Organism-specific databases

CTDi23131.
GeneCardsiGPATCH8.
H-InvDBHIX0202385.
HGNCiHGNC:29066. GPATCH8.
HPAiHPA044380.
MIMi614396. gene.
neXtProtiNX_Q9UKJ3.
PharmGKBiPA162390105.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000231046.
InParanoidiQ9UKJ3.
OMAiGKSHRHK.
OrthoDBiEOG73BVBS.
PhylomeDBiQ9UKJ3.

Miscellaneous databases

ChiTaRSiGPATCH8. human.
GeneWikiiGPATCH8.
GenomeRNAii23131.
NextBioi44379.
PROiQ9UKJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKJ3.
CleanExiHS_GPATCH8.
ExpressionAtlasiQ9UKJ3. baseline and differential.
GenevisibleiQ9UKJ3. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 998-1502 (ISOFORMS 1/2).
    Tissue: Skin and Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-678 (ISOFORM 1).
  6. "The human platelet alphaIIb gene is not closely linked to its integrin partner beta3."
    Thornton M.A., Poncz M., Korostishevsky M., Yakobson E., Usher S., Seligsohn U., Peretz H.
    Blood 94:2039-2047(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 414-1502, VARIANT GLY-1259.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1014, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-758; SER-1033; SER-1035; SER-1081 AND SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738; SER-740; SER-981; SER-1035 AND SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-740, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. "Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8."
    Kaneko H., Kitoh H., Matsuura T., Masuda A., Ito M., Mottes M., Rauch F., Ishiguro N., Ohno K.
    Hum. Genet. 130:671-683(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-979.

Entry informationi

Entry nameiGPTC8_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ3
Secondary accession number(s): B9EGP9, O60300, Q8TB99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 28, 2009
Last modified: May 11, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.