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Protein

G patch domain-containing protein 8

Gene

GPATCH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri136 – 160C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 8
Gene namesi
Name:GPATCH8
Synonyms:GPATC8, KIAA0553
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29066. GPATCH8.

Pathology & Biotechi

Organism-specific databases

DisGeNETi23131.
OpenTargetsiENSG00000186566.
PharmGKBiPA162390105.

Polymorphism and mutation databases

BioMutaiGPATCH8.
DMDMi254763309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507611 – 1502G patch domain-containing protein 8Add BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei479N6-acetyllysineBy similarity1
Modified residuei491PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei911PhosphoserineBy similarity1
Modified residuei914PhosphoserineBy similarity1
Modified residuei981PhosphoserineCombined sources1
Modified residuei1009PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1107PhosphoserineCombined sources1
Modified residuei1175PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKJ3.
PaxDbiQ9UKJ3.
PeptideAtlasiQ9UKJ3.
PRIDEiQ9UKJ3.

PTM databases

iPTMnetiQ9UKJ3.
PhosphoSitePlusiQ9UKJ3.

Expressioni

Gene expression databases

BgeeiENSG00000186566.
CleanExiHS_GPATCH8.
ExpressionAtlasiQ9UKJ3. baseline and differential.
GenevisibleiQ9UKJ3. HS.

Organism-specific databases

HPAiHPA044380.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542534EBI-948259,EBI-930964

Protein-protein interaction databases

BioGridi116749. 35 interactors.
IntActiQ9UKJ3. 16 interactors.
MINTiMINT-2870438.
STRINGi9606.ENSP00000467556.

Structurei

3D structure databases

ProteinModelPortaliQ9UKJ3.
SMRiQ9UKJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 86G-patchPROSITE-ProRule annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili89 – 124Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi665 – 720Lys-richAdd BLAST56
Compositional biasi745 – 749Poly-Arg5
Compositional biasi772 – 775Poly-Gly4
Compositional biasi804 – 1009Ser-richAdd BLAST206
Compositional biasi1384 – 1390Poly-Ala7
Compositional biasi1472 – 1478Poly-Ala7

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri136 – 160C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000231046.
InParanoidiQ9UKJ3.
OMAiGKSHRHK.
OrthoDBiEOG091G01DY.
PhylomeDBiQ9UKJ3.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK
60 70 80 90 100
HGWKLGQGLG KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV
110 120 130 140 150
LEVEKEDTEE LRQKYKDYVD KEKAIAKALE DLRANFYCEL CDKQYQKHQE
160 170 180 190 200
FDNHINSYDH AHKQRLKDLK QREFARNVSS RSRKDEKKQE KALRRLHELA
210 220 230 240 250
EQRKQAECAP GSGPMFKPTT VAVDEEGGED DKDESATNSG TGATASCGLG
260 270 280 290 300
SEFSTDKGGP FTAVQITNTT GLAQAPGLAS QGISFGIKNN LGTPLQKLGV
310 320 330 340 350
SFSFAKKAPV KLESIASVFK DHAEEGTSED GTKPDEKSSD QGLQKVGDSD
360 370 380 390 400
GSSNLDGKKE DEDPQDGGSL ASTLSKLKRM KREEGAGATE PEYYHYIPPA
410 420 430 440 450
HCKVKPNFPF LLFMRASEQM DGDNTTHPKN APESKKGSSP KPKSCIKAAA
460 470 480 490 500
SQGAEKTVSE VSEQPKETSM TEPSEPGSKA EAKKALGGDV SDQSLESHSQ
510 520 530 540 550
KVSETQMCES NSSKETSLAT PAGKESQEGP KHPTGPFFPV LSKDESTALQ
560 570 580 590 600
WPSELLIFTK AEPSISYSCN PLYFDFKLSR NKDARTKGTE KPKDIGSSSK
610 620 630 640 650
DHLQGLDPGE PNKSKEVGGE KIVRSSGGRM DAPASGSACS GLNKQEPGGS
660 670 680 690 700
HGSETEDTGR SLPSKKERSG KSHRHKKKKK HKKSSKHKRK HKADTEEKSS
710 720 730 740 750
KAESGEKSKK RKKRKRKKNK SSAPADSERG PKPEPPGSGS PAPPRRRRRA
760 770 780 790 800
QDDSQRRSLP AEEGSSGKKD EGGGGSSSQD HGGRKHKGEL PPSSCQRRAG
810 820 830 840 850
TKRSSRSSHR SQPSSGDEDS DDASSHRLHQ KSPSQYSEEE EEEDSGSEHS
860 870 880 890 900
RSRSRSGRRH SSHRSSRRSY SSSSDASSDQ SCYSRQRSYS DDSYSDYSDR
910 920 930 940 950
SRRHSKRSHD SDDSDYASSK HRSKRHKYSS SDDDYSLSCS QSRSRSRSHT
960 970 980 990 1000
RERSRSRGRS RSSSCSRSRS KRRSRSTTAH SWQRSRSYSR DRSRSTRSPS
1010 1020 1030 1040 1050
QRSGSRKRSW GHESPEERHS GRRDFIRSKI YRSQSPHYFR SGRGEGPGKK
1060 1070 1080 1090 1100
DDGRGDDSKA TGPPSQNSNI GTGRGSEGDC SPEDKNSVTA KLLLEKIQSR
1110 1120 1130 1140 1150
KVERKPSVSE EVQATPNKAG PKLKDPPQGY FGPKLPPSLG NKPVLPLIGK
1160 1170 1180 1190 1200
LPATRKPNKK CEESGLERGE EQEQSETEEG PPGSSDALFG HQFPSEETTG
1210 1220 1230 1240 1250
PLLDPPPEES KSGEATADHP VAPLGTPAHS DCYPGDPTIS HNYLPDPSDG
1260 1270 1280 1290 1300
DTLESLDSSS QPGPVESSLL PIAPDLEHFP SYAPPSGDPS IESTDGAEDA
1310 1320 1330 1340 1350
SLAPLESQPI TFTPEEMEKY SKLQQAAQQH IQQQLLAKQV KAFPASAALA
1360 1370 1380 1390 1400
PATPALQPIH IQQPATASAT SITTVQHAIL QHHAAAAAAA IGIHPHPHPQ
1410 1420 1430 1440 1450
PLAQVHHIPQ PHLTPISLSH LTHSIIPGHP ATFLASHPIH IIPASAIHPG
1460 1470 1480 1490 1500
PFTFHPVPHA ALYPTLLAPR PAAAAATALH LHPLLHPIFS GQDLQHPPSH

GT
Length:1,502
Mass (Da):164,197
Last modified:July 28, 2009 - v2
Checksum:i9A0FA14F3FE7A85C
GO
Isoform 2 (identifier: Q9UKJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:1,424
Mass (Da):155,193
Checksum:i09AB7C64C1E43730
GO
Isoform 3 (identifier: Q9UKJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-43: DNI → PSF
     44-1502: Missing.

Show »
Length:43
Mass (Da):5,133
Checksum:iD14575754EE7AF18
GO

Sequence cautioni

The sequence AAI36630 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA25479 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193L → V in AK025600 (PubMed:14702039).Curated1
Sequence conflicti620E → K in AAF03681 (PubMed:10477733).Curated1
Sequence conflicti680K → E in AAF03681 (PubMed:10477733).Curated1
Sequence conflicti691H → P in AAF03681 (PubMed:10477733).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067000979A → P.1 PublicationCorresponds to variant rs727502862dbSNPEnsembl.1
Natural variantiVAR_0670011012H → Q.Corresponds to variant rs3744427dbSNPEnsembl.1
Natural variantiVAR_0596581043R → Q.Corresponds to variant rs741902dbSNPEnsembl.1
Natural variantiVAR_0596591161C → W.Corresponds to variant rs936018dbSNPEnsembl.1
Natural variantiVAR_0670021259S → G.1 PublicationCorresponds to variant rs760339dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376831 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_03768441 – 43DNI → PSF in isoform 3. 1 Publication3
Alternative sequenceiVSP_03768544 – 1502Missing in isoform 3. 1 PublicationAdd BLAST1459

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011125 mRNA. Translation: BAA25479.2. Different initiation.
AC103703 Genomic DNA. No translation available.
AC007722 Genomic DNA. No translation available.
CH471178 Genomic DNA. Translation: EAW51593.1.
BC024147 mRNA. Translation: AAH24147.2.
BC136629 mRNA. Translation: AAI36630.1. Sequence problems.
AK025600 mRNA. No translation available.
AF160252 Genomic DNA. Translation: AAF03681.1.
CCDSiCCDS32666.1. [Q9UKJ3-1]
PIRiT00329.
RefSeqiNP_001002909.1. NM_001002909.3. [Q9UKJ3-1]
NP_001291868.1. NM_001304939.1.
NP_001291869.1. NM_001304940.1. [Q9UKJ3-2]
NP_001291870.1. NM_001304941.1. [Q9UKJ3-2]
NP_001291871.1. NM_001304942.1. [Q9UKJ3-2]
NP_001291872.1. NM_001304943.1. [Q9UKJ3-2]
XP_016879864.1. XM_017024375.1. [Q9UKJ3-2]
XP_016879865.1. XM_017024376.1. [Q9UKJ3-2]
XP_016879866.1. XM_017024377.1. [Q9UKJ3-2]
XP_016879867.1. XM_017024378.1. [Q9UKJ3-2]
XP_016879868.1. XM_017024379.1. [Q9UKJ3-2]
UniGeneiHs.463129.

Genome annotation databases

EnsembliENST00000587228; ENSP00000468719; ENSG00000186566. [Q9UKJ3-3]
ENST00000591680; ENSP00000467556; ENSG00000186566. [Q9UKJ3-1]
GeneIDi23131.
KEGGihsa:23131.
UCSCiuc002igw.3. human. [Q9UKJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011125 mRNA. Translation: BAA25479.2. Different initiation.
AC103703 Genomic DNA. No translation available.
AC007722 Genomic DNA. No translation available.
CH471178 Genomic DNA. Translation: EAW51593.1.
BC024147 mRNA. Translation: AAH24147.2.
BC136629 mRNA. Translation: AAI36630.1. Sequence problems.
AK025600 mRNA. No translation available.
AF160252 Genomic DNA. Translation: AAF03681.1.
CCDSiCCDS32666.1. [Q9UKJ3-1]
PIRiT00329.
RefSeqiNP_001002909.1. NM_001002909.3. [Q9UKJ3-1]
NP_001291868.1. NM_001304939.1.
NP_001291869.1. NM_001304940.1. [Q9UKJ3-2]
NP_001291870.1. NM_001304941.1. [Q9UKJ3-2]
NP_001291871.1. NM_001304942.1. [Q9UKJ3-2]
NP_001291872.1. NM_001304943.1. [Q9UKJ3-2]
XP_016879864.1. XM_017024375.1. [Q9UKJ3-2]
XP_016879865.1. XM_017024376.1. [Q9UKJ3-2]
XP_016879866.1. XM_017024377.1. [Q9UKJ3-2]
XP_016879867.1. XM_017024378.1. [Q9UKJ3-2]
XP_016879868.1. XM_017024379.1. [Q9UKJ3-2]
UniGeneiHs.463129.

3D structure databases

ProteinModelPortaliQ9UKJ3.
SMRiQ9UKJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116749. 35 interactors.
IntActiQ9UKJ3. 16 interactors.
MINTiMINT-2870438.
STRINGi9606.ENSP00000467556.

PTM databases

iPTMnetiQ9UKJ3.
PhosphoSitePlusiQ9UKJ3.

Polymorphism and mutation databases

BioMutaiGPATCH8.
DMDMi254763309.

Proteomic databases

EPDiQ9UKJ3.
PaxDbiQ9UKJ3.
PeptideAtlasiQ9UKJ3.
PRIDEiQ9UKJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587228; ENSP00000468719; ENSG00000186566. [Q9UKJ3-3]
ENST00000591680; ENSP00000467556; ENSG00000186566. [Q9UKJ3-1]
GeneIDi23131.
KEGGihsa:23131.
UCSCiuc002igw.3. human. [Q9UKJ3-1]

Organism-specific databases

CTDi23131.
DisGeNETi23131.
GeneCardsiGPATCH8.
H-InvDBHIX0202385.
HGNCiHGNC:29066. GPATCH8.
HPAiHPA044380.
MIMi614396. gene.
neXtProtiNX_Q9UKJ3.
OpenTargetsiENSG00000186566.
PharmGKBiPA162390105.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000231046.
InParanoidiQ9UKJ3.
OMAiGKSHRHK.
OrthoDBiEOG091G01DY.
PhylomeDBiQ9UKJ3.

Enzyme and pathway databases

BioCyciZFISH:G66-31674-MONOMER.

Miscellaneous databases

ChiTaRSiGPATCH8. human.
GeneWikiiGPATCH8.
GenomeRNAii23131.
PROiQ9UKJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186566.
CleanExiHS_GPATCH8.
ExpressionAtlasiQ9UKJ3. baseline and differential.
GenevisibleiQ9UKJ3. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPTC8_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ3
Secondary accession number(s): B9EGP9, O60300, Q8TB99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.