ID   PILRB_HUMAN             Reviewed;         227 AA.
AC   Q9UKJ0; Q69YF9; Q9HBS0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 161.
DE   RecName: Full=Paired immunoglobulin-like type 2 receptor beta;
DE   AltName: Full=Activating receptor PILR-beta;
DE   AltName: Full=Cell surface receptor FDFACT;
DE   Flags: Precursor;
GN   Name=PILRB; Synonyms=FDFACT; ORFNames=PP1551;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=10660620; DOI=10.1074/jbc.275.6.4467;
RA   Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H.;
RT   "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing
RT   protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with
RT   the truncated counterpart PILRbeta.";
RL   J. Biol. Chem. 275:4467-4474(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Bates E.E.;
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA   Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA   Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Peripheral blood leukocyte;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Paired receptors consist of highly related activating and
CC       inhibitory receptors and are widely involved in the regulation of the
CC       immune system. PILRB is thought to act as a cellular signaling
CC       activating receptor that associates with ITAM-bearing adapter molecules
CC       on the cell surface.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9UKJ0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UKJ0-2; Sequence=VSP_017504;
CC       Name=3;
CC         IsoId=Q9UKJ0-3; Sequence=VSP_017503, VSP_017504;
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DR   EMBL; AF161081; AAD52965.1; -; mRNA.
DR   EMBL; AJ400845; CAC19193.1; -; mRNA.
DR   EMBL; AJ400846; CAC19194.1; -; mRNA.
DR   EMBL; AF217981; AAG17224.1; -; mRNA.
DR   EMBL; AL834317; CAH10714.1; -; mRNA.
DR   EMBL; AL834336; CAH10711.1; -; mRNA.
DR   EMBL; BC050547; AAH50547.1; -; mRNA.
DR   CCDS; CCDS43622.1; -. [Q9UKJ0-1]
DR   RefSeq; NP_839956.1; NM_178238.3. [Q9UKJ0-1]
DR   PDB; 4NFC; X-ray; 2.20 A; A/B=32-150.
DR   PDB; 4NFD; X-ray; 1.71 A; A=32-150.
DR   PDBsum; 4NFC; -.
DR   PDBsum; 4NFD; -.
DR   AlphaFoldDB; Q9UKJ0; -.
DR   SMR; Q9UKJ0; -.
DR   BioGRID; 119015; 45.
DR   IntAct; Q9UKJ0; 4.
DR   STRING; 9606.ENSP00000391748; -.
DR   UniLectin; Q9UKJ0; -.
DR   GlyCosmos; Q9UKJ0; 1 site, No reported glycans.
DR   GlyGen; Q9UKJ0; 1 site.
DR   iPTMnet; Q9UKJ0; -.
DR   PhosphoSitePlus; Q9UKJ0; -.
DR   BioMuta; PILRB; -.
DR   DMDM; 74761987; -.
DR   MassIVE; Q9UKJ0; -.
DR   PaxDb; 9606-ENSP00000391748; -.
DR   PeptideAtlas; Q9UKJ0; -.
DR   Antibodypedia; 30676; 161 antibodies from 29 providers.
DR   DNASU; 29990; -.
DR   Ensembl; ENST00000448382.5; ENSP00000415775.1; ENSG00000121716.21. [Q9UKJ0-3]
DR   Ensembl; ENST00000452089.5; ENSP00000391748.1; ENSG00000121716.21. [Q9UKJ0-1]
DR   Ensembl; ENST00000609309.3; ENSP00000477365.1; ENSG00000121716.21. [Q9UKJ0-1]
DR   GeneID; 29990; -.
DR   KEGG; hsa:29990; -.
DR   MANE-Select; ENST00000609309.3; ENSP00000477365.1; NM_178238.4; NP_839956.1.
DR   UCSC; uc003uun.4; human. [Q9UKJ0-1]
DR   AGR; HGNC:18297; -.
DR   CTD; 29990; -.
DR   DisGeNET; 29990; -.
DR   GeneCards; PILRB; -.
DR   HGNC; HGNC:18297; PILRB.
DR   HPA; ENSG00000121716; Low tissue specificity.
DR   MIM; 605342; gene.
DR   neXtProt; NX_Q9UKJ0; -.
DR   OpenTargets; ENSG00000121716; -.
DR   PharmGKB; PA134906700; -.
DR   VEuPathDB; HostDB:ENSG00000121716; -.
DR   eggNOG; ENOG502SUHR; Eukaryota.
DR   GeneTree; ENSGT00940000163799; -.
DR   HOGENOM; CLU_070832_0_0_1; -.
DR   InParanoid; Q9UKJ0; -.
DR   OMA; GKWFWAT; -.
DR   OrthoDB; 5318725at2759; -.
DR   PhylomeDB; Q9UKJ0; -.
DR   TreeFam; TF338478; -.
DR   PathwayCommons; Q9UKJ0; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   SignaLink; Q9UKJ0; -.
DR   BioGRID-ORCS; 29990; 16 hits in 1148 CRISPR screens.
DR   GeneWiki; PILRB; -.
DR   GenomeRNAi; 29990; -.
DR   Pharos; Q9UKJ0; Tbio.
DR   PRO; PR:Q9UKJ0; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9UKJ0; Protein.
DR   Bgee; ENSG00000121716; Expressed in right testis and 93 other cell types or tissues.
DR   ExpressionAtlas; Q9UKJ0; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0042288; F:MHC class I protein binding; IBA:GO_Central.
DR   GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; NAS:UniProtKB.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:UniProtKB.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   PANTHER; PTHR15549; PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR; 1.
DR   PANTHER; PTHR15549:SF30; PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR ALPHA-RELATED; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   Genevisible; Q9UKJ0; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..227
FT                   /note="Paired immunoglobulin-like type 2 receptor beta"
FT                   /id="PRO_0000226822"
FT   TOPO_DOM        20..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..143
FT                   /note="Ig-like V-type"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MGRASYGGSPVGHQSSSDHPRAKTCRSPVRDGPRTLCGVPTVALSLH
FT                   FLREASSGSRTCGRRTSLCTSAKSSWTYRSGRLSWQSIKGTHLTITQALRQPLHRAPLL
FT                   PGQLCWSPRPLEKNKAM (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15498874"
FT                   /id="VSP_017503"
FT   VAR_SEQ         23..227
FT                   /note="GSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRG
FT                   HFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRR
FT                   SGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRV
FT                   ALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF -> LCEPALSELDRGSGERLPQD
FT                   LKPAEGGPVCVFLPSRAGHPEIREAAVAVHQGDQTHHHPGCHNHHHLEAQQHNHHSRPQ
FT                   GHRKQRALRIMAPKSGHCHQGCIGCRCAQNCHFGTAVPPPPVVEEKER (in
FT                   isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15498874,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_017504"
FT   VARIANT         63
FT                   /note="I -> T (in dbSNP:rs11771799)"
FT                   /id="VAR_059406"
FT   VARIANT         66
FT                   /note="N -> D (in dbSNP:rs11761306)"
FT                   /id="VAR_059407"
FT   CONFLICT        63..66
FT                   /note="IVPN -> TAPD (in Ref. 2; CAC19193)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        212
FT                   /note="Missing (in Ref. 2; CAC19193)"
FT                   /evidence="ECO:0000305"
FT   STRAND          33..36
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          39..43
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          49..56
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          68..75
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          79..83
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   TURN            84..87
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   HELIX           91..93
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          96..100
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          106..112
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   HELIX           117..119
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          121..134
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          136..140
FT                   /evidence="ECO:0007829|PDB:4NFD"
FT   STRAND          145..149
FT                   /evidence="ECO:0007829|PDB:4NFD"
SQ   SEQUENCE   227 AA;  25542 MW;  7FF960C60AB7EF09 CRC64;
     MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE
     LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ
     SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE
     SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF
//