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Protein

Paired immunoglobulin-like type 2 receptor beta

Gene

PILRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

GO - Molecular functioni

GO - Biological processi

  • activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT
Gene namesi
Name:PILRB
Synonyms:FDFACT
ORF Names:PP1551
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18297. PILRB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 191ExtracellularSequence analysisAdd BLAST172
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 227CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121716.
PharmGKBiPA134906700.

Polymorphism and mutation databases

DMDMi74761987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000022682220 – 227Paired immunoglobulin-like type 2 receptor betaAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UKJ0.
PeptideAtlasiQ9UKJ0.
PRIDEiQ9UKJ0.

PTM databases

iPTMnetiQ9UKJ0.
PhosphoSitePlusiQ9UKJ0.

Expressioni

Gene expression databases

BgeeiENSG00000121716.
CleanExiHS_PILRB.
ExpressionAtlasiQ9UKJ0. baseline and differential.
GenevisibleiQ9UKJ0. HS.

Organism-specific databases

HPAiHPA026750.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119015. 2 interactors.
IntActiQ9UKJ0. 4 interactors.
MINTiMINT-1033809.
STRINGi9606.ENSP00000311153.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 36Combined sources4
Beta strandi39 – 43Combined sources5
Beta strandi49 – 56Combined sources8
Beta strandi68 – 75Combined sources8
Beta strandi79 – 83Combined sources5
Turni84 – 87Combined sources4
Helixi91 – 93Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi106 – 112Combined sources7
Helixi117 – 119Combined sources3
Beta strandi121 – 134Combined sources14
Beta strandi136 – 140Combined sources5
Beta strandi145 – 149Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NFCX-ray2.20A/B32-150[»]
4NFDX-ray1.71A32-150[»]
ProteinModelPortaliQ9UKJ0.
SMRiQ9UKJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 143Ig-like V-typeAdd BLAST123

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW80. Eukaryota.
ENOG41114MH. LUCA.
GeneTreeiENSGT00390000008831.
HOGENOMiHOG000035130.
HOVERGENiHBG082142.
InParanoidiQ9UKJ0.
OMAiTESKGHS.
PhylomeDBiQ9UKJ0.
TreeFamiTF338478.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE
60 70 80 90 100
IPFSFYYPWE LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN
110 120 130 140 150
WTEGQESGFL RISNLRKEDQ SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT
160 170 180 190 200
QAVTTTTTWR PSSTTTIAGL RVTESKGHSE SWHLSLDTAI RVALAVAVLK
210 220
TVILGLLCLL LLWWRRRKGS RAPSSDF
Length:227
Mass (Da):25,542
Last modified:May 1, 2000 - v1
Checksum:i7FF960C60AB7EF09
GO
Isoform 2 (identifier: Q9UKJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Show »
Length:149
Mass (Da):16,355
Checksum:i6C5C5524024D1026
GO
Isoform 3 (identifier: Q9UKJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,630
Checksum:i31158B0F8F03B41F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63 – 66IVPN → TAPD in CAC19193 (Ref. 2) Curated4
Sequence conflicti212Missing in CAC19193 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05940663I → T.Corresponds to variant rs11771799dbSNPEnsembl.1
Natural variantiVAR_05940766N → D.Corresponds to variant rs11761306dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175031M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_01750423 – 227GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA. Translation: AAD52965.1.
AJ400845 mRNA. Translation: CAC19193.1.
AJ400846 mRNA. Translation: CAC19194.1.
AF217981 mRNA. Translation: AAG17224.1.
AL834317 mRNA. Translation: CAH10714.1.
AL834336 mRNA. Translation: CAH10711.1.
BC050547 mRNA. Translation: AAH50547.1.
CCDSiCCDS43622.1. [Q9UKJ0-1]
RefSeqiNP_839956.1. NM_178238.3. [Q9UKJ0-1]
UniGeneiHs.521075.
Hs.632314.

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
GeneIDi29990.
KEGGihsa:29990.
UCSCiuc003uun.4. human. [Q9UKJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA. Translation: AAD52965.1.
AJ400845 mRNA. Translation: CAC19193.1.
AJ400846 mRNA. Translation: CAC19194.1.
AF217981 mRNA. Translation: AAG17224.1.
AL834317 mRNA. Translation: CAH10714.1.
AL834336 mRNA. Translation: CAH10711.1.
BC050547 mRNA. Translation: AAH50547.1.
CCDSiCCDS43622.1. [Q9UKJ0-1]
RefSeqiNP_839956.1. NM_178238.3. [Q9UKJ0-1]
UniGeneiHs.521075.
Hs.632314.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NFCX-ray2.20A/B32-150[»]
4NFDX-ray1.71A32-150[»]
ProteinModelPortaliQ9UKJ0.
SMRiQ9UKJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119015. 2 interactors.
IntActiQ9UKJ0. 4 interactors.
MINTiMINT-1033809.
STRINGi9606.ENSP00000311153.

PTM databases

iPTMnetiQ9UKJ0.
PhosphoSitePlusiQ9UKJ0.

Polymorphism and mutation databases

DMDMi74761987.

Proteomic databases

PaxDbiQ9UKJ0.
PeptideAtlasiQ9UKJ0.
PRIDEiQ9UKJ0.

Protocols and materials databases

DNASUi29990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
GeneIDi29990.
KEGGihsa:29990.
UCSCiuc003uun.4. human. [Q9UKJ0-1]

Organism-specific databases

CTDi29990.
GeneCardsiPILRB.
HGNCiHGNC:18297. PILRB.
HPAiHPA026750.
MIMi605342. gene.
neXtProtiNX_Q9UKJ0.
OpenTargetsiENSG00000121716.
PharmGKBiPA134906700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW80. Eukaryota.
ENOG41114MH. LUCA.
GeneTreeiENSGT00390000008831.
HOGENOMiHOG000035130.
HOVERGENiHBG082142.
InParanoidiQ9UKJ0.
OMAiTESKGHS.
PhylomeDBiQ9UKJ0.
TreeFamiTF338478.

Miscellaneous databases

ChiTaRSiPILRB. human.
GeneWikiiPILRB.
GenomeRNAii29990.
PROiQ9UKJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121716.
CleanExiHS_PILRB.
ExpressionAtlasiQ9UKJ0. baseline and differential.
GenevisibleiQ9UKJ0. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPILRB_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.