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Q9UKJ0

- PILRB_HUMAN

UniProt

Q9UKJ0 - PILRB_HUMAN

Protein

Paired immunoglobulin-like type 2 receptor beta

Gene

PILRB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
    2. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired immunoglobulin-like type 2 receptor beta
    Alternative name(s):
    Activating receptor PILR-beta
    Cell surface receptor FDFACT
    Gene namesi
    Name:PILRB
    Synonyms:FDFACT
    ORF Names:PP1551
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18297. PILRB.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134906700.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 227208Paired immunoglobulin-like type 2 receptor betaPRO_0000226822Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UKJ0.
    PRIDEiQ9UKJ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UKJ0.
    BgeeiQ9UKJ0.
    CleanExiHS_PILRB.
    GenevestigatoriQ9UKJ0.

    Organism-specific databases

    HPAiHPA026750.

    Interactioni

    Protein-protein interaction databases

    BioGridi119015. 2 interactions.
    IntActiQ9UKJ0. 3 interactions.
    MINTiMINT-1033809.
    STRINGi9606.ENSP00000311153.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NFCX-ray2.20A/B32-150[»]
    4NFDX-ray1.71A32-150[»]
    ProteinModelPortaliQ9UKJ0.
    SMRiQ9UKJ0. Positions 34-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 191172ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 22715CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 143123Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG27702.
    HOGENOMiHOG000035130.
    HOVERGENiHBG082142.
    InParanoidiQ9UKJ0.
    OMAiTESKGHS.
    OrthoDBiEOG70GMH2.
    PhylomeDBiQ9UKJ0.
    TreeFamiTF338478.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKJ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE    50
    IPFSFYYPWE LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN 100
    WTEGQESGFL RISNLRKEDQ SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT 150
    QAVTTTTTWR PSSTTTIAGL RVTESKGHSE SWHLSLDTAI RVALAVAVLK 200
    TVILGLLCLL LLWWRRRKGS RAPSSDF 227
    Length:227
    Mass (Da):25,542
    Last modified:May 1, 2000 - v1
    Checksum:i7FF960C60AB7EF09
    GO
    Isoform 2 (identifier: Q9UKJ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

    Show »
    Length:149
    Mass (Da):16,355
    Checksum:i6C5C5524024D1026
    GO
    Isoform 3 (identifier: Q9UKJ0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGRASYGGSP...PRPLEKNKAM
         23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

    Note: No experimental confirmation available.

    Show »
    Length:271
    Mass (Da):29,630
    Checksum:i31158B0F8F03B41F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 664IVPN → TAPD in CAC19193. 1 PublicationCurated
    Sequence conflicti212 – 2121Missing in CAC19193. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631I → T.
    Corresponds to variant rs11771799 [ dbSNP | Ensembl ].
    VAR_059406
    Natural varianti66 – 661N → D.
    Corresponds to variant rs11761306 [ dbSNP | Ensembl ].
    VAR_059407

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3. 1 PublicationVSP_017503
    Alternative sequencei23 – 227205GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3. 2 PublicationsVSP_017504Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161081 mRNA. Translation: AAD52965.1.
    AJ400845 mRNA. Translation: CAC19193.1.
    AJ400846 mRNA. Translation: CAC19194.1.
    AF217981 mRNA. Translation: AAG17224.1.
    AL834317 mRNA. Translation: CAH10714.1.
    AL834336 mRNA. Translation: CAH10711.1.
    BC050547 mRNA. Translation: AAH50547.1.
    CCDSiCCDS43622.1. [Q9UKJ0-1]
    RefSeqiNP_839956.1. NM_178238.3. [Q9UKJ0-1]
    UniGeneiHs.521075.
    Hs.632314.

    Genome annotation databases

    EnsembliENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
    ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
    ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
    GeneIDi29990.
    KEGGihsa:29990.
    UCSCiuc003uun.3. human. [Q9UKJ0-1]

    Polymorphism databases

    DMDMi74761987.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161081 mRNA. Translation: AAD52965.1 .
    AJ400845 mRNA. Translation: CAC19193.1 .
    AJ400846 mRNA. Translation: CAC19194.1 .
    AF217981 mRNA. Translation: AAG17224.1 .
    AL834317 mRNA. Translation: CAH10714.1 .
    AL834336 mRNA. Translation: CAH10711.1 .
    BC050547 mRNA. Translation: AAH50547.1 .
    CCDSi CCDS43622.1. [Q9UKJ0-1 ]
    RefSeqi NP_839956.1. NM_178238.3. [Q9UKJ0-1 ]
    UniGenei Hs.521075.
    Hs.632314.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NFC X-ray 2.20 A/B 32-150 [» ]
    4NFD X-ray 1.71 A 32-150 [» ]
    ProteinModelPortali Q9UKJ0.
    SMRi Q9UKJ0. Positions 34-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119015. 2 interactions.
    IntActi Q9UKJ0. 3 interactions.
    MINTi MINT-1033809.
    STRINGi 9606.ENSP00000311153.

    Polymorphism databases

    DMDMi 74761987.

    Proteomic databases

    PaxDbi Q9UKJ0.
    PRIDEi Q9UKJ0.

    Protocols and materials databases

    DNASUi 29990.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000448382 ; ENSP00000415775 ; ENSG00000121716 . [Q9UKJ0-3 ]
    ENST00000452089 ; ENSP00000391748 ; ENSG00000121716 . [Q9UKJ0-1 ]
    ENST00000609309 ; ENSP00000477365 ; ENSG00000121716 . [Q9UKJ0-1 ]
    GeneIDi 29990.
    KEGGi hsa:29990.
    UCSCi uc003uun.3. human. [Q9UKJ0-1 ]

    Organism-specific databases

    CTDi 29990.
    GeneCardsi GC07P099945.
    HGNCi HGNC:18297. PILRB.
    HPAi HPA026750.
    MIMi 605342. gene.
    neXtProti NX_Q9UKJ0.
    PharmGKBi PA134906700.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27702.
    HOGENOMi HOG000035130.
    HOVERGENi HBG082142.
    InParanoidi Q9UKJ0.
    OMAi TESKGHS.
    OrthoDBi EOG70GMH2.
    PhylomeDBi Q9UKJ0.
    TreeFami TF338478.

    Miscellaneous databases

    ChiTaRSi PILRB. human.
    GeneWikii PILRB.
    GenomeRNAii 29990.
    NextBioi 52768.
    PROi Q9UKJ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKJ0.
    Bgeei Q9UKJ0.
    CleanExi HS_PILRB.
    Genevestigatori Q9UKJ0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta."
      Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H.
      J. Biol. Chem. 275:4467-4474(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Bates E.E.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Peripheral blood leukocyte.

    Entry informationi

    Entry nameiPILRB_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKJ0
    Secondary accession number(s): Q69YF9, Q9HBS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3