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Protein

Paired immunoglobulin-like type 2 receptor beta

Gene

PILRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

GO - Biological processi

  • activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT
Gene namesi
Name:PILRB
Synonyms:FDFACT
ORF Names:PP1551
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18297. PILRB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 191172ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 22715CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906700.

Polymorphism and mutation databases

DMDMi74761987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 227208Paired immunoglobulin-like type 2 receptor betaPRO_0000226822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UKJ0.
PRIDEiQ9UKJ0.

Expressioni

Gene expression databases

BgeeiQ9UKJ0.
CleanExiHS_PILRB.
ExpressionAtlasiQ9UKJ0. baseline.
GenevisibleiQ9UKJ0. HS.

Organism-specific databases

HPAiHPA026750.

Interactioni

Protein-protein interaction databases

BioGridi119015. 2 interactions.
IntActiQ9UKJ0. 3 interactions.
MINTiMINT-1033809.
STRINGi9606.ENSP00000311153.

Structurei

Secondary structure

1
227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 364Combined sources
Beta strandi39 – 435Combined sources
Beta strandi49 – 568Combined sources
Beta strandi68 – 758Combined sources
Beta strandi79 – 835Combined sources
Turni84 – 874Combined sources
Helixi91 – 933Combined sources
Beta strandi96 – 1005Combined sources
Beta strandi106 – 1127Combined sources
Helixi117 – 1193Combined sources
Beta strandi121 – 13414Combined sources
Beta strandi136 – 1405Combined sources
Beta strandi145 – 1495Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NFCX-ray2.20A/B32-150[»]
4NFDX-ray1.71A32-150[»]
ProteinModelPortaliQ9UKJ0.
SMRiQ9UKJ0. Positions 32-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 143123Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27702.
GeneTreeiENSGT00390000008831.
HOGENOMiHOG000035130.
HOVERGENiHBG082142.
InParanoidiQ9UKJ0.
OMAiTESKGHS.
OrthoDBiEOG70GMH2.
PhylomeDBiQ9UKJ0.
TreeFamiTF338478.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE
60 70 80 90 100
IPFSFYYPWE LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN
110 120 130 140 150
WTEGQESGFL RISNLRKEDQ SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT
160 170 180 190 200
QAVTTTTTWR PSSTTTIAGL RVTESKGHSE SWHLSLDTAI RVALAVAVLK
210 220
TVILGLLCLL LLWWRRRKGS RAPSSDF
Length:227
Mass (Da):25,542
Last modified:May 1, 2000 - v1
Checksum:i7FF960C60AB7EF09
GO
Isoform 2 (identifier: Q9UKJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Show »
Length:149
Mass (Da):16,355
Checksum:i6C5C5524024D1026
GO
Isoform 3 (identifier: Q9UKJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,630
Checksum:i31158B0F8F03B41F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 664IVPN → TAPD in CAC19193 (Ref. 2) Curated
Sequence conflicti212 – 2121Missing in CAC19193 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631I → T.
Corresponds to variant rs11771799 [ dbSNP | Ensembl ].
VAR_059406
Natural varianti66 – 661N → D.
Corresponds to variant rs11761306 [ dbSNP | Ensembl ].
VAR_059407

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3. 1 PublicationVSP_017503
Alternative sequencei23 – 227205GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3. 2 PublicationsVSP_017504Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA. Translation: AAD52965.1.
AJ400845 mRNA. Translation: CAC19193.1.
AJ400846 mRNA. Translation: CAC19194.1.
AF217981 mRNA. Translation: AAG17224.1.
AL834317 mRNA. Translation: CAH10714.1.
AL834336 mRNA. Translation: CAH10711.1.
BC050547 mRNA. Translation: AAH50547.1.
CCDSiCCDS43622.1. [Q9UKJ0-1]
RefSeqiNP_839956.1. NM_178238.3. [Q9UKJ0-1]
UniGeneiHs.521075.
Hs.632314.

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
GeneIDi29990.
KEGGihsa:29990.
UCSCiuc003uun.3. human. [Q9UKJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA. Translation: AAD52965.1.
AJ400845 mRNA. Translation: CAC19193.1.
AJ400846 mRNA. Translation: CAC19194.1.
AF217981 mRNA. Translation: AAG17224.1.
AL834317 mRNA. Translation: CAH10714.1.
AL834336 mRNA. Translation: CAH10711.1.
BC050547 mRNA. Translation: AAH50547.1.
CCDSiCCDS43622.1. [Q9UKJ0-1]
RefSeqiNP_839956.1. NM_178238.3. [Q9UKJ0-1]
UniGeneiHs.521075.
Hs.632314.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NFCX-ray2.20A/B32-150[»]
4NFDX-ray1.71A32-150[»]
ProteinModelPortaliQ9UKJ0.
SMRiQ9UKJ0. Positions 32-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119015. 2 interactions.
IntActiQ9UKJ0. 3 interactions.
MINTiMINT-1033809.
STRINGi9606.ENSP00000311153.

Polymorphism and mutation databases

DMDMi74761987.

Proteomic databases

PaxDbiQ9UKJ0.
PRIDEiQ9UKJ0.

Protocols and materials databases

DNASUi29990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
GeneIDi29990.
KEGGihsa:29990.
UCSCiuc003uun.3. human. [Q9UKJ0-1]

Organism-specific databases

CTDi29990.
GeneCardsiGC07P099945.
HGNCiHGNC:18297. PILRB.
HPAiHPA026750.
MIMi605342. gene.
neXtProtiNX_Q9UKJ0.
PharmGKBiPA134906700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG27702.
GeneTreeiENSGT00390000008831.
HOGENOMiHOG000035130.
HOVERGENiHBG082142.
InParanoidiQ9UKJ0.
OMAiTESKGHS.
OrthoDBiEOG70GMH2.
PhylomeDBiQ9UKJ0.
TreeFamiTF338478.

Miscellaneous databases

ChiTaRSiPILRB. human.
GeneWikiiPILRB.
GenomeRNAii29990.
NextBioi52768.
PROiQ9UKJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UKJ0.
CleanExiHS_PILRB.
ExpressionAtlasiQ9UKJ0. baseline.
GenevisibleiQ9UKJ0. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta."
    Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H.
    J. Biol. Chem. 275:4467-4474(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Bates E.E.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Peripheral blood leukocyte.

Entry informationi

Entry nameiPILRB_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.