Reviewed, UniProtKB/Swiss-Prot Q9UKJ0 (PILRB_HUMAN)

Names and origin

Protein names

Recommended name:
    Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
    Activating receptor PILR-beta
    Cell surface receptor FDFACT

Gene names

Name:	PILRB
Synonyms:	FDFACT
ORF Names:	PP1551

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	activation of transmembrane receptor protein tyrosine kinase activity Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT5	O95870	1	EBI-347958,EBI-348517

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKJ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKJ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Isoform 3 (identifier: Q9UKJ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 227	208	Paired immunoglobulin-like type 2 receptor beta		PRO_0000226822
Regions
	Topological domain	20 – 191	172	Extracellular Potential
	Transmembrane	192 – 212	21	Potential
	Topological domain	213 – 227	15	Cytoplasmic Potential
	Domain	21 – 143	123	Ig-like V-type
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3.		VSP_017503
	Alternative sequence	23 – 227	205	GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3.		VSP_017504
	Natural variant	63	1	I → T: dbSNP rs11771799.		VAR_059406
	Natural variant	66	1	N → D: dbSNP rs11761306.		VAR_059407
Experimental info
	Sequence conflict	63 – 66	4	IVPN → TAPD in CAC19193. Ref.2
	Sequence conflict	212	1	Missing in CAC19193. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7FF960C60AB7EF09	FASTA	227	25,542
	10 20 30 40 50 60 MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE 70 80 90 100 110 120 LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ 130 140 150 160 170 180 SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE 190 200 210 220 SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF
	Isoform 2. Checksum: 6C5C5524024D1026	FASTA	149	16,355
	10 20 30 40 50 60 MGRPLLLPLL LLLQPPAFLQ PGLCEPALSE LDRGSGERLP QDLKPAEGGP VCVFLPSRAG 70 80 90 100 110 120 HPEIREAAVA VHQGDQTHHH PGCHNHHHLE AQQHNHHSRP QGHRKQRALR IMAPKSGHCH 130 140 QGCIGCRCAQ NCHFGTAVPP PPVVEEKER
	Isoform 3. Checksum: 31158B0F8F03B41F	FASTA	271	29,630
	10 20 30 40 50 60 MGRASYGGSP VGHQSSSDHP RAKTCRSPVR DGPRTLCGVP TVALSLHFLR EASSGSRTCG 70 80 90 100 110 120 RRTSLCTSAK SSWTYRSGRL SWQSIKGTHL TITQALRQPL HRAPLLPGQL CWSPRPLEKN 130 140 150 160 170 180 KAMGRPLLLP LLLLLQPPAF LQPGLCEPAL SELDRGSGER LPQDLKPAEG GPVCVFLPSR 190 200 210 220 230 240 AGHPEIREAA VAVHQGDQTH HHPGCHNHHH LEAQQHNHHS RPQGHRKQRA LRIMAPKSGH 250 260 270 CHQGCIGCRC AQNCHFGTAV PPPPVVEEKE R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta." Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H. J. Biol. Chem. 275:4467-4474(2000) [PubMed: 10660620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Bates E.E. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Peripheral blood leukocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF161081 mRNA. Translation: AAD52965.1. AJ400845 mRNA. Translation: CAC19193.1. AJ400846 mRNA. Translation: CAC19194.1. AF217981 mRNA. Translation: AAG17224.1. AL834317 mRNA. Translation: CAH10714.1. AL834336 mRNA. Translation: CAH10711.1. BC050547 mRNA. Translation: AAH50547.1.
IPI	IPI00032366. IPI00186781. IPI00738353.
RefSeq	NP_038468.3. NP_778212.2. NP_839956.1.
UniGene	Hs.632314
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKJ0. 1 interaction.
STRING	Q9UKJ0.
Proteomic databases
PRIDE	Q9UKJ0.
Genome annotation databases
Ensembl	ENST00000310771; ENSP00000311153; ENSG00000121716; Homo sapiens. [Genome view] ENST00000413850; ENSP00000388860; ENSG00000121716; Homo sapiens. [Genome view] ENST00000420688; ENSP00000391378; ENSG00000121716; Homo sapiens. [Genome view] ENST00000422752; ENSP00000394467; ENSG00000121716; Homo sapiens. [Genome view] ENST00000427221; ENSP00000399678; ENSG00000121716; Homo sapiens. [Genome view] ENST00000444073; ENSP00000410764; ENSG00000121716; Homo sapiens. [Genome view] ENST00000452089; ENSP00000391748; ENSG00000121716; Homo sapiens. [Genome view]
GeneID	29990.
KEGG	hsa:29990.
UCSC	uc003uuk.1. human. uc003uul.1. human.
Organism-specific databases
CTD	29990.
GeneCards	GC07P099771.
H-InvDB	HIX0006917.
HGNC	HGNC:18297. PILRB.
MIM	605342. gene.
PharmGKB	PA134906700.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UKJ0.
OrthoDB	EOG92NMJZ
Gene expression databases
ArrayExpress	Q9UKJ0.
Bgee	Q9UKJ0.
CleanEx	HS_PILRB.
Genevestigator	Q9UKJ0.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52768.
SOURCE	Search...

Entry information

Entry name

PILRB_HUMAN

Accession

Primary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.