Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UKJ0 (PILRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT
Gene names
Name:PILRB
Synonyms:FDFACT
ORF Names:PP1551
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKJ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKJ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER
Isoform 3 (identifier: Q9UKJ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 227208Paired immunoglobulin-like type 2 receptor beta
PRO_0000226822

Regions

Topological domain20 – 191172Extracellular Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 22715Cytoplasmic Potential
Domain21 – 143123Ig-like V-type

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence11M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3.
VSP_017503
Alternative sequence23 – 227205GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3.
VSP_017504
Natural variant631I → T.
Corresponds to variant rs11771799 [ dbSNP | Ensembl ].
VAR_059406
Natural variant661N → D.
Corresponds to variant rs11761306 [ dbSNP | Ensembl ].
VAR_059407

Experimental info

Sequence conflict63 – 664IVPN → TAPD in CAC19193. Ref.2
Sequence conflict2121Missing in CAC19193. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7FF960C60AB7EF09

FASTA22725,542
        10         20         30         40         50         60 
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE 

        70         80         90        100        110        120 
LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ 

       130        140        150        160        170        180 
SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE 

       190        200        210        220 
SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF 

« Hide

Isoform 2 [UniParc].

Checksum: 6C5C5524024D1026
Show »

FASTA14916,355
Isoform 3 [UniParc].

Checksum: 31158B0F8F03B41F
Show »

FASTA27129,630

References

« Hide 'large scale' references
[1]"PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta."
Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H.
J. Biol. Chem. 275:4467-4474(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Bates E.E.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Peripheral blood leukocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF161081 mRNA. Translation: AAD52965.1.
AJ400845 mRNA. Translation: CAC19193.1.
AJ400846 mRNA. Translation: CAC19194.1.
AF217981 mRNA. Translation: AAG17224.1.
AL834317 mRNA. Translation: CAH10714.1.
AL834336 mRNA. Translation: CAH10711.1.
BC050547 mRNA. Translation: AAH50547.1.
RefSeqNP_839956.1. NM_178238.3.
UniGeneHs.521075.
Hs.632314.

3D structure databases

ProteinModelPortalQ9UKJ0.
SMRQ9UKJ0. Positions 33-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119015. 2 interactions.
IntActQ9UKJ0. 3 interactions.
MINTMINT-1033809.
STRING9606.ENSP00000311153.

Polymorphism databases

DMDM74761987.

Proteomic databases

PaxDbQ9UKJ0.
PRIDEQ9UKJ0.

Protocols and materials databases

DNASU29990.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000444073; ENSP00000410764; ENSG00000121716. [Q9UKJ0-1]
ENST00000448382; ENSP00000415775; ENSG00000121716. [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716. [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716. [Q9UKJ0-1]
ENST00000610247; ENSP00000477415; ENSG00000121716. [Q9UKJ0-1]
GeneID29990.
KEGGhsa:29990.
UCSCuc003uun.3. human. [Q9UKJ0-1]

Organism-specific databases

CTD29990.
GeneCardsGC07P099945.
HGNCHGNC:18297. PILRB.
HPAHPA026750.
MIM605342. gene.
neXtProtNX_Q9UKJ0.
PharmGKBPA134906700.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27702.
HOGENOMHOG000035130.
HOVERGENHBG082142.
InParanoidQ9UKJ0.
OMATESKGHS.
OrthoDBEOG70GMH2.
PhylomeDBQ9UKJ0.
TreeFamTF338478.

Gene expression databases

ArrayExpressQ9UKJ0.
BgeeQ9UKJ0.
CleanExHS_PILRB.
GenevestigatorQ9UKJ0.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPILRB. human.
GeneWikiPILRB.
GenomeRNAi29990.
NextBio52768.
PROQ9UKJ0.
SOURCESearch...

Entry information

Entry namePILRB_HUMAN
AccessionPrimary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM