Q9UKJ0 (PILRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Paired immunoglobulin-like type 2 receptor beta

Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT

Gene names

Name:	PILRB
Synonyms:	FDFACT
ORF Names:	PP1551

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of transmembrane receptor protein tyrosine kinase activity Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKJ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKJ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Isoform 3 (identifier: Q9UKJ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 227	208	Paired immunoglobulin-like type 2 receptor beta		PRO_0000226822
Regions
	Topological domain	20 – 191	172	Extracellular Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Topological domain	213 – 227	15	Cytoplasmic Potential
	Domain	21 – 143	123	Ig-like V-type
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3.		VSP_017503
	Alternative sequence	23 – 227	205	GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3.		VSP_017504
	Natural variant	63	1	I → T. Corresponds to variant rs11771799 [ dbSNP | Ensembl ].		VAR_059406
	Natural variant	66	1	N → D. Corresponds to variant rs11761306 [ dbSNP | Ensembl ].		VAR_059407
Experimental info
	Sequence conflict	63 – 66	4	IVPN → TAPD in CAC19193. Ref.2
	Sequence conflict	212	1	Missing in CAC19193. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7FF960C60AB7EF09	FASTA	227	25,542
	10 20 30 40 50 60 MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE 70 80 90 100 110 120 LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ 130 140 150 160 170 180 SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE 190 200 210 220 SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF
	Isoform 2 [UniParc]. Checksum: 6C5C5524024D1026	FASTA	149	16,355
	10 20 30 40 50 60 MGRPLLLPLL LLLQPPAFLQ PGLCEPALSE LDRGSGERLP QDLKPAEGGP VCVFLPSRAG 70 80 90 100 110 120 HPEIREAAVA VHQGDQTHHH PGCHNHHHLE AQQHNHHSRP QGHRKQRALR IMAPKSGHCH 130 140 QGCIGCRCAQ NCHFGTAVPP PPVVEEKER
	Isoform 3 [UniParc]. Checksum: 31158B0F8F03B41F	FASTA	271	29,630
	10 20 30 40 50 60 MGRASYGGSP VGHQSSSDHP RAKTCRSPVR DGPRTLCGVP TVALSLHFLR EASSGSRTCG 70 80 90 100 110 120 RRTSLCTSAK SSWTYRSGRL SWQSIKGTHL TITQALRQPL HRAPLLPGQL CWSPRPLEKN 130 140 150 160 170 180 KAMGRPLLLP LLLLLQPPAF LQPGLCEPAL SELDRGSGER LPQDLKPAEG GPVCVFLPSR 190 200 210 220 230 240 AGHPEIREAA VAVHQGDQTH HHPGCHNHHH LEAQQHNHHS RPQGHRKQRA LRIMAPKSGH 250 260 270 CHQGCIGCRC AQNCHFGTAV PPPPVVEEKE R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta." Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H. J. Biol. Chem. 275:4467-4474(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Bates E.E. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Peripheral blood leukocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF161081 mRNA. Translation: AAD52965.1. AJ400845 mRNA. Translation: CAC19193.1. AJ400846 mRNA. Translation: CAC19194.1. AF217981 mRNA. Translation: AAG17224.1. AL834317 mRNA. Translation: CAH10714.1. AL834336 mRNA. Translation: CAH10711.1. BC050547 mRNA. Translation: AAH50547.1.
IPI	IPI00032366. IPI00186781. IPI00738353.
RefSeq	NP_839956.1. NM_178238.2.
UniGene	Hs.521075. Hs.632314.
3D structure databases
ProteinModelPortal	Q9UKJ0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKJ0. 3 interactions.
MINT	MINT-1033809.
STRING	9606.ENSP00000311153.
Polymorphism databases
DMDM	74761987.
Proteomic databases
PaxDb	Q9UKJ0.
PRIDE	Q9UKJ0.
Protocols and materials databases
DNASU	29990.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310771; ENSP00000311153; ENSG00000121716. ENST00000420688; ENSP00000391378; ENSG00000121716. ENST00000444073; ENSP00000410764; ENSG00000121716. ENST00000444874; ENSP00000406563; ENSG00000121716. ENST00000448382; ENSP00000415775; ENSG00000121716. ENST00000452089; ENSP00000391748; ENSG00000121716.
GeneID	29990.
KEGG	hsa:29990.
UCSC	uc003uun.3. human.
Organism-specific databases
CTD	29990.
GeneCards	GC07P099945.
HGNC	HGNC:18297. PILRB.
HPA	HPA026750.
MIM	605342. gene.
neXtProt	NX_Q9UKJ0.
PharmGKB	PA134906700.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG27702.
HOGENOM	HOG000035130.
HOVERGEN	HBG082142.
InParanoid	Q9UKJ0.
OrthoDB	EOG4MKNHF.
Gene expression databases
ArrayExpress	Q9UKJ0.
Bgee	Q9UKJ0.
CleanEx	HS_PILRB.
Genevestigator	Q9UKJ0.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PILRB. human.
GenomeRNAi	29990.
NextBio	52768.
SOURCE	Search...

Entry information

Entry name

PILRB_HUMAN

Accession

Primary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.