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Q9UKI9 (PO2F3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Octamer-binding protein 11
Short name=Oct-11
Octamer-binding transcription factor 11
Short name=OTF-11
Transcription factor PLA-1
Transcription factor Skn-1
Gene names
Name:POU2F3
Synonyms:OTF11, PLA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Subcellular location

Nucleus.

Tissue specificity

Specifically expressed in epidermis and cultured keratinocytes.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKI9-1)

Also known as: Skn-1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKI9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MESPRTAKGGR
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UKI9-3)

Also known as: Skn-1n;

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MNDAK
Note: Specifically expressed in keratinocytes, induced by high calcium concentration.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436POU domain, class 2, transcription factor 3
PRO_0000100717

Regions

Domain183 – 25775POU-specific
DNA binding281 – 34060Homeobox
Compositional bias354 – 42572Ser-rich

Natural variations

Alternative sequence1 – 99MVNLESMHT → MESPRTAKGGR in isoform 2.
VSP_043900
Alternative sequence1 – 99MVNLESMHT → MNDAK in isoform 3.
VSP_043901
Natural variant1521H → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs7110845 [ dbSNP | Ensembl ].
VAR_031618
Natural variant3901R → K. Ref.4
Corresponds to variant rs2282537 [ dbSNP | Ensembl ].
VAR_055906

Experimental info

Sequence conflict61S → P in CAB45383. Ref.3
Sequence conflict371N → K in AAD55245. Ref.2
Sequence conflict3511V → D in AAF00199. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Skn-1a) [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: CFF7F0153F0B7589

FASTA43647,432
        10         20         30         40         50         60 
MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL SDSLQQTLSH 

        70         80         90        100        110        120 
RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV PGHLQSVSQF LLSQTQPGQQ 

       130        140        150        160        170        180 
GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF GHPGLPGSSL EPHLEASQHL PVPKHLPSSG 

       190        200        210        220        230        240 
GADEPSDLEE LEKFAKTFKQ RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK 

       250        260        270        280        290        300 
NMCKLKPLLE KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF 

       310        320        330        340        350        360 
QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP VYNSRLVSPS 

       370        380        390        400        410        420 
GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA SSPTASQNNS KAAVNSASSF 

       430 
NSSGSWYRWN HSTYLH 

« Hide

Isoform 2 [UniParc].

Checksum: 1630C710251D292B
Show »

FASTA43847,560
Isoform 3 (Skn-1n) [UniParc].

Checksum: F8E1EFD969CF6BC1
Show »

FASTA43246,949

References

« Hide 'large scale' references
[1]"Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor."
Hildesheim J., Foster R.A., Chamberlin M.E., Vogel J.C.
J. Biol. Chem. 274:26399-26406(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
[2]"Characterisation of the human transcription factor Oct-11: involvement in the regulation of the SPRR2A gene."
Fischer D.F., Hemelaar J., Backendorf C.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
[3]"PLA-1, a novel human POU transcription factor, regulates the placental lactogen-3 gene expression."
Jimenez-Mateo O., Castrillo J.-L.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-152 AND LYS-390.
Tissue: Small intestine and Testis.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF162278 mRNA. Translation: AAF00199.1.
AF133895 mRNA. Translation: AAD55245.1.
AJ012214 mRNA. Translation: CAB45383.1.
AK291993 mRNA. Translation: BAF84682.1.
AK302212 mRNA. Translation: BAG63569.1.
AP000679 Genomic DNA. No translation available.
AP001150 Genomic DNA. No translation available.
BC101649 mRNA. Translation: AAI01650.1.
RefSeqNP_001231611.1. NM_001244682.1.
NP_055167.2. NM_014352.3.
UniGeneHs.227115.

3D structure databases

ProteinModelPortalQ9UKI9.
SMRQ9UKI9. Positions 187-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117361. 2 interactions.
IntActQ9UKI9. 1 interaction.
STRING9606.ENSP00000260264.

PTM databases

PhosphoSiteQ9UKI9.

Polymorphism databases

DMDM311033416.

Proteomic databases

PaxDbQ9UKI9.
PRIDEQ9UKI9.

Protocols and materials databases

DNASU25833.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260264; ENSP00000260264; ENSG00000137709. [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709. [Q9UKI9-1]
GeneID25833.
KEGGhsa:25833.
UCSCuc001pxc.3. human. [Q9UKI9-1]
uc021qrk.1. human. [Q9UKI9-2]

Organism-specific databases

CTD25833.
GeneCardsGC11P120144.
H-InvDBHIX0010200.
HGNCHGNC:19864. POU2F3.
HPAHPA019652.
MIM607394. gene.
neXtProtNX_Q9UKI9.
PharmGKBPA134963258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267922.
HOVERGENHBG052783.
InParanoidQ9UKI9.
KOK09364.
OMADIKMSGD.
OrthoDBEOG7DJSMG.
PhylomeDBQ9UKI9.
TreeFamTF316413.

Gene expression databases

ArrayExpressQ9UKI9.
BgeeQ9UKI9.
CleanExHS_POU2F3.
GenevestigatorQ9UKI9.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPOU2F3.
GenomeRNAi25833.
NextBio47133.
PROQ9UKI9.
SOURCESearch...

Entry information

Entry namePO2F3_HUMAN
AccessionPrimary (citable) accession number: Q9UKI9
Secondary accession number(s): A8K7H8 expand/collapse secondary AC list , B4DY07, F5GWW6, Q3MIY3, Q9UKR7, Q9Y504
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 2, 2010
Last modified: March 19, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM