Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UKI9

- PO2F3_HUMAN

UniProt

Q9UKI9 - PO2F3_HUMAN

Protein

POU domain, class 2, transcription factor 3

Gene

POU2F3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. epidermis development Source: ProtInc
    2. keratinocyte differentiation Source: Ensembl
    3. negative regulation by host of viral transcription Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    6. wound healing Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 3
    Alternative name(s):
    Octamer-binding protein 11
    Short name:
    Oct-11
    Octamer-binding transcription factor 11
    Short name:
    OTF-11
    Transcription factor PLA-1
    Transcription factor Skn-1
    Gene namesi
    Name:POU2F3
    Synonyms:OTF11, PLA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19864. POU2F3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134963258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436POU domain, class 2, transcription factor 3PRO_0000100717Add
    BLAST

    Proteomic databases

    MaxQBiQ9UKI9.
    PaxDbiQ9UKI9.
    PRIDEiQ9UKI9.

    PTM databases

    PhosphoSiteiQ9UKI9.

    Expressioni

    Tissue specificityi

    Specifically expressed in epidermis and cultured keratinocytes.

    Gene expression databases

    ArrayExpressiQ9UKI9.
    BgeeiQ9UKI9.
    CleanExiHS_POU2F3.
    GenevestigatoriQ9UKI9.

    Organism-specific databases

    HPAiHPA019652.

    Interactioni

    Protein-protein interaction databases

    BioGridi117361. 2 interactions.
    IntActiQ9UKI9. 1 interaction.
    STRINGi9606.ENSP00000260264.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKI9.
    SMRiQ9UKI9. Positions 187-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini183 – 25775POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi354 – 42572Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOVERGENiHBG052783.
    InParanoidiQ9UKI9.
    KOiK09364.
    OMAiEMFGRKR.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiQ9UKI9.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKI9-1) [UniParc]FASTAAdd to Basket

    Also known as: Skn-1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL    50
    SDSLQQTLSH RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV 100
    PGHLQSVSQF LLSQTQPGQQ GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF 150
    GHPGLPGSSL EPHLEASQHL PVPKHLPSSG GADEPSDLEE LEKFAKTFKQ 200
    RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK NMCKLKPLLE 250
    KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF 300
    QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP 350
    VYNSRLVSPS GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA 400
    SSPTASQNNS KAAVNSASSF NSSGSWYRWN HSTYLH 436
    Length:436
    Mass (Da):47,432
    Last modified:November 2, 2010 - v3
    Checksum:iCFF7F0153F0B7589
    GO
    Isoform 2 (identifier: Q9UKI9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MVNLESMHT → MESPRTAKGGR

    Note: No experimental confirmation available.

    Show »
    Length:438
    Mass (Da):47,560
    Checksum:i1630C710251D292B
    GO
    Isoform 3 (identifier: Q9UKI9-3) [UniParc]FASTAAdd to Basket

    Also known as: Skn-1n

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MVNLESMHT → MNDAK

    Note: Specifically expressed in keratinocytes, induced by high calcium concentration.

    Show »
    Length:432
    Mass (Da):46,949
    Checksum:iF8E1EFD969CF6BC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61S → P in CAB45383. 1 PublicationCurated
    Sequence conflicti37 – 371N → K in AAD55245. 1 PublicationCurated
    Sequence conflicti351 – 3511V → D in AAF00199. (PubMed:10473598)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521H → R.3 Publications
    Corresponds to variant rs7110845 [ dbSNP | Ensembl ].
    VAR_031618
    Natural varianti390 – 3901R → K.1 Publication
    Corresponds to variant rs2282537 [ dbSNP | Ensembl ].
    VAR_055906

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MVNLESMHT → MESPRTAKGGR in isoform 2. 1 PublicationVSP_043900
    Alternative sequencei1 – 99MVNLESMHT → MNDAK in isoform 3. CuratedVSP_043901

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162278 mRNA. Translation: AAF00199.1.
    AF133895 mRNA. Translation: AAD55245.1.
    AJ012214 mRNA. Translation: CAB45383.1.
    AK291993 mRNA. Translation: BAF84682.1.
    AK302212 mRNA. Translation: BAG63569.1.
    AP000679 Genomic DNA. No translation available.
    AP001150 Genomic DNA. No translation available.
    BC101649 mRNA. Translation: AAI01650.1.
    CCDSiCCDS58190.1. [Q9UKI9-2]
    CCDS8431.1. [Q9UKI9-1]
    RefSeqiNP_001231611.1. NM_001244682.1. [Q9UKI9-2]
    NP_055167.2. NM_014352.3. [Q9UKI9-1]
    UniGeneiHs.227115.

    Genome annotation databases

    EnsembliENST00000260264; ENSP00000260264; ENSG00000137709. [Q9UKI9-2]
    ENST00000543440; ENSP00000441687; ENSG00000137709. [Q9UKI9-1]
    GeneIDi25833.
    KEGGihsa:25833.
    UCSCiuc001pxc.3. human. [Q9UKI9-1]
    uc021qrk.1. human. [Q9UKI9-2]

    Polymorphism databases

    DMDMi311033416.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162278 mRNA. Translation: AAF00199.1 .
    AF133895 mRNA. Translation: AAD55245.1 .
    AJ012214 mRNA. Translation: CAB45383.1 .
    AK291993 mRNA. Translation: BAF84682.1 .
    AK302212 mRNA. Translation: BAG63569.1 .
    AP000679 Genomic DNA. No translation available.
    AP001150 Genomic DNA. No translation available.
    BC101649 mRNA. Translation: AAI01650.1 .
    CCDSi CCDS58190.1. [Q9UKI9-2 ]
    CCDS8431.1. [Q9UKI9-1 ]
    RefSeqi NP_001231611.1. NM_001244682.1. [Q9UKI9-2 ]
    NP_055167.2. NM_014352.3. [Q9UKI9-1 ]
    UniGenei Hs.227115.

    3D structure databases

    ProteinModelPortali Q9UKI9.
    SMRi Q9UKI9. Positions 187-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117361. 2 interactions.
    IntActi Q9UKI9. 1 interaction.
    STRINGi 9606.ENSP00000260264.

    PTM databases

    PhosphoSitei Q9UKI9.

    Polymorphism databases

    DMDMi 311033416.

    Proteomic databases

    MaxQBi Q9UKI9.
    PaxDbi Q9UKI9.
    PRIDEi Q9UKI9.

    Protocols and materials databases

    DNASUi 25833.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260264 ; ENSP00000260264 ; ENSG00000137709 . [Q9UKI9-2 ]
    ENST00000543440 ; ENSP00000441687 ; ENSG00000137709 . [Q9UKI9-1 ]
    GeneIDi 25833.
    KEGGi hsa:25833.
    UCSCi uc001pxc.3. human. [Q9UKI9-1 ]
    uc021qrk.1. human. [Q9UKI9-2 ]

    Organism-specific databases

    CTDi 25833.
    GeneCardsi GC11P120144.
    H-InvDB HIX0010200.
    HGNCi HGNC:19864. POU2F3.
    HPAi HPA019652.
    MIMi 607394. gene.
    neXtProti NX_Q9UKI9.
    PharmGKBi PA134963258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267922.
    HOVERGENi HBG052783.
    InParanoidi Q9UKI9.
    KOi K09364.
    OMAi EMFGRKR.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi Q9UKI9.
    TreeFami TF316413.

    Miscellaneous databases

    GeneWikii POU2F3.
    GenomeRNAii 25833.
    NextBioi 47133.
    PROi Q9UKI9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKI9.
    Bgeei Q9UKI9.
    CleanExi HS_POU2F3.
    Genevestigatori Q9UKI9.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor."
      Hildesheim J., Foster R.A., Chamberlin M.E., Vogel J.C.
      J. Biol. Chem. 274:26399-26406(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
    2. "Characterisation of the human transcription factor Oct-11: involvement in the regulation of the SPRR2A gene."
      Fischer D.F., Hemelaar J., Backendorf C.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
    3. "PLA-1, a novel human POU transcription factor, regulates the placental lactogen-3 gene expression."
      Jimenez-Mateo O., Castrillo J.-L.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-152 AND LYS-390.
      Tissue: Small intestine and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiPO2F3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKI9
    Secondary accession number(s): A8K7H8
    , B4DY07, F5GWW6, Q3MIY3, Q9UKR7, Q9Y504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3