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Q9UKI9

- PO2F3_HUMAN

UniProt

Q9UKI9 - PO2F3_HUMAN

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Protein

POU domain, class 2, transcription factor 3

Gene

POU2F3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. epidermis development Source: ProtInc
  2. keratinocyte differentiation Source: Ensembl
  3. negative regulation by host of viral transcription Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  6. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Transcription factor PLA-1
Transcription factor Skn-1
Gene namesi
Name:POU2F3
Synonyms:OTF11, PLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19864. POU2F3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436POU domain, class 2, transcription factor 3PRO_0000100717Add
BLAST

Proteomic databases

MaxQBiQ9UKI9.
PaxDbiQ9UKI9.
PRIDEiQ9UKI9.

PTM databases

PhosphoSiteiQ9UKI9.

Expressioni

Tissue specificityi

Specifically expressed in epidermis and cultured keratinocytes.

Gene expression databases

BgeeiQ9UKI9.
CleanExiHS_POU2F3.
ExpressionAtlasiQ9UKI9. baseline and differential.
GenevestigatoriQ9UKI9.

Organism-specific databases

HPAiHPA019652.

Interactioni

Protein-protein interaction databases

BioGridi117361. 2 interactions.
IntActiQ9UKI9. 1 interaction.
STRINGi9606.ENSP00000260264.

Structurei

3D structure databases

ProteinModelPortaliQ9UKI9.
SMRiQ9UKI9. Positions 187-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 25775POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi354 – 42572Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG052783.
InParanoidiQ9UKI9.
KOiK09364.
OMAiEMFGRKR.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ9UKI9.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKI9-1) [UniParc]FASTAAdd to Basket

Also known as: Skn-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
SDSLQQTLSH RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV
110 120 130 140 150
PGHLQSVSQF LLSQTQPGQQ GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF
160 170 180 190 200
GHPGLPGSSL EPHLEASQHL PVPKHLPSSG GADEPSDLEE LEKFAKTFKQ
210 220 230 240 250
RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK NMCKLKPLLE
260 270 280 290 300
KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF
310 320 330 340 350
QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP
360 370 380 390 400
VYNSRLVSPS GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA
410 420 430
SSPTASQNNS KAAVNSASSF NSSGSWYRWN HSTYLH
Length:436
Mass (Da):47,432
Last modified:November 2, 2010 - v3
Checksum:iCFF7F0153F0B7589
GO
Isoform 2 (identifier: Q9UKI9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MESPRTAKGGR

Note: No experimental confirmation available.

Show »
Length:438
Mass (Da):47,560
Checksum:i1630C710251D292B
GO
Isoform 3 (identifier: Q9UKI9-3) [UniParc]FASTAAdd to Basket

Also known as: Skn-1n

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MNDAK

Note: Specifically expressed in keratinocytes, induced by high calcium concentration.

Show »
Length:432
Mass (Da):46,949
Checksum:iF8E1EFD969CF6BC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61S → P in CAB45383. 1 PublicationCurated
Sequence conflicti37 – 371N → K in AAD55245. 1 PublicationCurated
Sequence conflicti351 – 3511V → D in AAF00199. (PubMed:10473598)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521H → R.3 Publications
Corresponds to variant rs7110845 [ dbSNP | Ensembl ].
VAR_031618
Natural varianti390 – 3901R → K.1 Publication
Corresponds to variant rs2282537 [ dbSNP | Ensembl ].
VAR_055906

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MVNLESMHT → MESPRTAKGGR in isoform 2. 1 PublicationVSP_043900
Alternative sequencei1 – 99MVNLESMHT → MNDAK in isoform 3. CuratedVSP_043901

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162278 mRNA. Translation: AAF00199.1.
AF133895 mRNA. Translation: AAD55245.1.
AJ012214 mRNA. Translation: CAB45383.1.
AK291993 mRNA. Translation: BAF84682.1.
AK302212 mRNA. Translation: BAG63569.1.
AP000679 Genomic DNA. No translation available.
AP001150 Genomic DNA. No translation available.
BC101649 mRNA. Translation: AAI01650.1.
CCDSiCCDS58190.1. [Q9UKI9-2]
CCDS8431.1. [Q9UKI9-1]
RefSeqiNP_001231611.1. NM_001244682.1. [Q9UKI9-2]
NP_055167.2. NM_014352.3. [Q9UKI9-1]
UniGeneiHs.227115.

Genome annotation databases

EnsembliENST00000260264; ENSP00000260264; ENSG00000137709. [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709. [Q9UKI9-1]
GeneIDi25833.
KEGGihsa:25833.
UCSCiuc001pxc.3. human. [Q9UKI9-1]
uc021qrk.1. human. [Q9UKI9-2]

Polymorphism databases

DMDMi311033416.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162278 mRNA. Translation: AAF00199.1 .
AF133895 mRNA. Translation: AAD55245.1 .
AJ012214 mRNA. Translation: CAB45383.1 .
AK291993 mRNA. Translation: BAF84682.1 .
AK302212 mRNA. Translation: BAG63569.1 .
AP000679 Genomic DNA. No translation available.
AP001150 Genomic DNA. No translation available.
BC101649 mRNA. Translation: AAI01650.1 .
CCDSi CCDS58190.1. [Q9UKI9-2 ]
CCDS8431.1. [Q9UKI9-1 ]
RefSeqi NP_001231611.1. NM_001244682.1. [Q9UKI9-2 ]
NP_055167.2. NM_014352.3. [Q9UKI9-1 ]
UniGenei Hs.227115.

3D structure databases

ProteinModelPortali Q9UKI9.
SMRi Q9UKI9. Positions 187-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117361. 2 interactions.
IntActi Q9UKI9. 1 interaction.
STRINGi 9606.ENSP00000260264.

PTM databases

PhosphoSitei Q9UKI9.

Polymorphism databases

DMDMi 311033416.

Proteomic databases

MaxQBi Q9UKI9.
PaxDbi Q9UKI9.
PRIDEi Q9UKI9.

Protocols and materials databases

DNASUi 25833.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260264 ; ENSP00000260264 ; ENSG00000137709 . [Q9UKI9-2 ]
ENST00000543440 ; ENSP00000441687 ; ENSG00000137709 . [Q9UKI9-1 ]
GeneIDi 25833.
KEGGi hsa:25833.
UCSCi uc001pxc.3. human. [Q9UKI9-1 ]
uc021qrk.1. human. [Q9UKI9-2 ]

Organism-specific databases

CTDi 25833.
GeneCardsi GC11P120144.
H-InvDB HIX0010200.
HGNCi HGNC:19864. POU2F3.
HPAi HPA019652.
MIMi 607394. gene.
neXtProti NX_Q9UKI9.
PharmGKBi PA134963258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267922.
GeneTreei ENSGT00760000118935.
HOVERGENi HBG052783.
InParanoidi Q9UKI9.
KOi K09364.
OMAi EMFGRKR.
OrthoDBi EOG7DJSMG.
PhylomeDBi Q9UKI9.
TreeFami TF316413.

Miscellaneous databases

GeneWikii POU2F3.
GenomeRNAii 25833.
NextBioi 47133.
PROi Q9UKI9.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKI9.
CleanExi HS_POU2F3.
ExpressionAtlasi Q9UKI9. baseline and differential.
Genevestigatori Q9UKI9.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor."
    Hildesheim J., Foster R.A., Chamberlin M.E., Vogel J.C.
    J. Biol. Chem. 274:26399-26406(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
  2. "Characterisation of the human transcription factor Oct-11: involvement in the regulation of the SPRR2A gene."
    Fischer D.F., Hemelaar J., Backendorf C.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-152.
  3. "PLA-1, a novel human POU transcription factor, regulates the placental lactogen-3 gene expression."
    Jimenez-Mateo O., Castrillo J.-L.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-152 AND LYS-390.
    Tissue: Small intestine and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiPO2F3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI9
Secondary accession number(s): A8K7H8
, B4DY07, F5GWW6, Q3MIY3, Q9UKR7, Q9Y504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3