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Q9UKI3

- VPRE3_HUMAN

UniProt

Q9UKI3 - VPRE3_HUMAN

Protein

Pre-B lymphocyte protein 3

Gene

VPREB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-B lymphocyte protein 3
    Alternative name(s):
    N27C7-2
    Protein VPreB3
    Gene namesi
    Name:VPREB3
    ORF Names:UNQ355/PRO619
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:12710. VPREB3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37325.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 123103Pre-B lymphocyte protein 3PRO_0000015003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 115PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9UKI3.
    PRIDEiQ9UKI3.

    Expressioni

    Tissue specificityi

    Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.

    Gene expression databases

    ArrayExpressiQ9UKI3.
    BgeeiQ9UKI3.
    CleanExiHS_VPREB3.
    GenevestigatoriQ9UKI3.

    Organism-specific databases

    HPAiHPA003041.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000248948.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKI3.
    SMRiQ9UKI3. Positions 21-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 123103Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG39956.
    HOGENOMiHOG000059537.
    HOVERGENiHBG018013.
    KOiK06553.
    OMAiVAQLSCM.
    PhylomeDBiQ9UKI3.
    TreeFamiTF352061.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UKI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR    50
    DYGVSWYQQR AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL 100
    TISPVQPEDD ADYYCSVGYG FSP 123
    Length:123
    Mass (Da):13,710
    Last modified:May 1, 2000 - v1
    Checksum:iBF09AC5196059E85
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41R → W.
    Corresponds to variant rs34372784 [ dbSNP | Ensembl ].
    VAR_049954

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163825 mRNA. Translation: AAF09451.1.
    AB050772 Genomic DNA. Translation: BAB83034.1.
    AY359000 mRNA. Translation: AAQ89359.1.
    CR456610 mRNA. Translation: CAG30496.1.
    AK312098 mRNA. Translation: BAG35034.1.
    CH471095 Genomic DNA. Translation: EAW59598.1.
    BC020666 mRNA. Translation: AAH20666.1.
    CCDSiCCDS13813.1.
    RefSeqiNP_037510.1. NM_013378.2.
    UniGeneiHs.136713.

    Genome annotation databases

    EnsembliENST00000248948; ENSP00000248948; ENSG00000128218.
    GeneIDi29802.
    KEGGihsa:29802.
    UCSCiuc002zxt.3. human.

    Polymorphism databases

    DMDMi11387357.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163825 mRNA. Translation: AAF09451.1 .
    AB050772 Genomic DNA. Translation: BAB83034.1 .
    AY359000 mRNA. Translation: AAQ89359.1 .
    CR456610 mRNA. Translation: CAG30496.1 .
    AK312098 mRNA. Translation: BAG35034.1 .
    CH471095 Genomic DNA. Translation: EAW59598.1 .
    BC020666 mRNA. Translation: AAH20666.1 .
    CCDSi CCDS13813.1.
    RefSeqi NP_037510.1. NM_013378.2.
    UniGenei Hs.136713.

    3D structure databases

    ProteinModelPortali Q9UKI3.
    SMRi Q9UKI3. Positions 21-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000248948.

    Polymorphism databases

    DMDMi 11387357.

    Proteomic databases

    PaxDbi Q9UKI3.
    PRIDEi Q9UKI3.

    Protocols and materials databases

    DNASUi 29802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248948 ; ENSP00000248948 ; ENSG00000128218 .
    GeneIDi 29802.
    KEGGi hsa:29802.
    UCSCi uc002zxt.3. human.

    Organism-specific databases

    CTDi 29802.
    GeneCardsi GC22M024094.
    HGNCi HGNC:12710. VPREB3.
    HPAi HPA003041.
    MIMi 605017. gene.
    neXtProti NX_Q9UKI3.
    PharmGKBi PA37325.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39956.
    HOGENOMi HOG000059537.
    HOVERGENi HBG018013.
    KOi K06553.
    OMAi VAQLSCM.
    PhylomeDBi Q9UKI3.
    TreeFami TF352061.

    Miscellaneous databases

    ChiTaRSi VPREB3. human.
    GeneWikii VPREB3.
    GenomeRNAii 29802.
    NextBioi 52355.
    PROi Q9UKI3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKI3.
    Bgeei Q9UKI3.
    CleanExi HS_VPREB3.
    Genevestigatori Q9UKI3.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse."
      Rosnet O., Mattei M.-G., Delattre O., Schiff C.
      Cytogenet. Cell Genet. 87:205-208(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of N27C7-2 gene."
      Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiVPRE3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKI3
    Secondary accession number(s): B2R587
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3