Reviewed, UniProtKB/Swiss-Prot Q9UKI3 (VPRE3_HUMAN)

Names and origin

Protein names

Recommended name:
    Pre-B lymphocyte protein 3
Alternative name(s):
    VpreB3 protein
    N27C7-2

Gene names

Name:	VPREB3
ORF Names:	UNQ355/PRO619

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Tissue specificity	Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Ref.1 Non-traceable author statement. Source: ProtInc nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 123	103	Pre-B lymphocyte protein 3		PRO_0000015003
Regions
	Domain	21 – 123	103	Ig-like
Amino acid modifications
	Disulfide bond	40 ↔ 115		By similarity
Natural variations
	Natural variant	4	1	R → W: dbSNP rs34372784.		VAR_049954

Sequences

	Sequence		Length	Mass (Da)
	Q9UKI3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BF09AC5196059E85	FASTA	123	13,710
	10 20 30 40 50 60 MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR DYGVSWYQQR 70 80 90 100 110 120 AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL TISPVQPEDD ADYYCSVGYG FSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse." Rosnet O., Mattei M.-G., Delattre O., Schiff C. Cytogenet. Cell Genet. 87:205-208(1999) [PubMed: 10702669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of N27C7-2 gene." Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF163825 mRNA. Translation: AAF09451.1. AB050772 Genomic DNA. Translation: BAB83034.1. AY359000 mRNA. Translation: AAQ89359.1. CR456610 mRNA. Translation: CAG30496.1. BC020666 mRNA. Translation: AAH20666.1.
IPI	IPI00007573.
RefSeq	NP_037510.1.
UniGene	Hs.136713
3D structure databases
HSSP	HSSP built from PDB template 2MCG based on UniProtKB P01709.
ModBase	Search...
Proteomic databases
PRIDE	Q9UKI3.
Genome annotation databases
Ensembl	ENSG00000128218. Homo sapiens. [Contig view]
GeneID	29802.
KEGG	hsa:29802.
Organism-specific databases
GeneCards	GC22M022419.
H-InvDB	HIX0021114.
HGNC	HGNC:12710. VPREB3.
HPA	HPA003041.
MIM	605017. gene.
PharmGKB	PA37325.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UKI3.
HOVERGEN	Q9UKI3.
Gene expression databases
ArrayExpress	Q9UKI3.
Bgee	Q9UKI3.
CleanEx	HS_VPREB3.
GermOnline	ENSG00000128218. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52355.
SOURCE	Search...

Entry information

Entry name

VPRE3_HUMAN

Accession

Primary (citable) accession number: Q9UKI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)