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Q9UKI3

- VPRE3_HUMAN

UniProt

Q9UKI3 - VPRE3_HUMAN

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Protein

Pre-B lymphocyte protein 3

Gene

VPREB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B lymphocyte protein 3
Alternative name(s):
N27C7-2
Protein VPreB3
Gene namesi
Name:VPREB3
ORF Names:UNQ355/PRO619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:12710. VPREB3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 123103Pre-B lymphocyte protein 3PRO_0000015003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UKI3.
PRIDEiQ9UKI3.

Expressioni

Tissue specificityi

Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.

Gene expression databases

BgeeiQ9UKI3.
CleanExiHS_VPREB3.
ExpressionAtlasiQ9UKI3. baseline and differential.
GenevestigatoriQ9UKI3.

Organism-specific databases

HPAiHPA003041.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248948.

Structurei

3D structure databases

ProteinModelPortaliQ9UKI3.
SMRiQ9UKI3. Positions 21-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 123103Ig-likeAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG39956.
GeneTreeiENSGT00770000120496.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiQ9UKI3.
KOiK06553.
OMAiVAQLSCM.
PhylomeDBiQ9UKI3.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR
60 70 80 90 100
DYGVSWYQQR AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL
110 120
TISPVQPEDD ADYYCSVGYG FSP
Length:123
Mass (Da):13,710
Last modified:May 1, 2000 - v1
Checksum:iBF09AC5196059E85
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → W.
Corresponds to variant rs34372784 [ dbSNP | Ensembl ].
VAR_049954

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163825 mRNA. Translation: AAF09451.1.
AB050772 Genomic DNA. Translation: BAB83034.1.
AY359000 mRNA. Translation: AAQ89359.1.
CR456610 mRNA. Translation: CAG30496.1.
AK312098 mRNA. Translation: BAG35034.1.
CH471095 Genomic DNA. Translation: EAW59598.1.
BC020666 mRNA. Translation: AAH20666.1.
CCDSiCCDS13813.1.
RefSeqiNP_037510.1. NM_013378.2.
UniGeneiHs.136713.

Genome annotation databases

EnsembliENST00000248948; ENSP00000248948; ENSG00000128218.
GeneIDi29802.
KEGGihsa:29802.
UCSCiuc002zxt.3. human.

Polymorphism databases

DMDMi11387357.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163825 mRNA. Translation: AAF09451.1 .
AB050772 Genomic DNA. Translation: BAB83034.1 .
AY359000 mRNA. Translation: AAQ89359.1 .
CR456610 mRNA. Translation: CAG30496.1 .
AK312098 mRNA. Translation: BAG35034.1 .
CH471095 Genomic DNA. Translation: EAW59598.1 .
BC020666 mRNA. Translation: AAH20666.1 .
CCDSi CCDS13813.1.
RefSeqi NP_037510.1. NM_013378.2.
UniGenei Hs.136713.

3D structure databases

ProteinModelPortali Q9UKI3.
SMRi Q9UKI3. Positions 21-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000248948.

Polymorphism databases

DMDMi 11387357.

Proteomic databases

PaxDbi Q9UKI3.
PRIDEi Q9UKI3.

Protocols and materials databases

DNASUi 29802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248948 ; ENSP00000248948 ; ENSG00000128218 .
GeneIDi 29802.
KEGGi hsa:29802.
UCSCi uc002zxt.3. human.

Organism-specific databases

CTDi 29802.
GeneCardsi GC22M024094.
HGNCi HGNC:12710. VPREB3.
HPAi HPA003041.
MIMi 605017. gene.
neXtProti NX_Q9UKI3.
PharmGKBi PA37325.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39956.
GeneTreei ENSGT00770000120496.
HOGENOMi HOG000059537.
HOVERGENi HBG018013.
InParanoidi Q9UKI3.
KOi K06553.
OMAi VAQLSCM.
PhylomeDBi Q9UKI3.
TreeFami TF352061.

Miscellaneous databases

ChiTaRSi VPREB3. human.
GeneWikii VPREB3.
GenomeRNAii 29802.
NextBioi 52355.
PROi Q9UKI3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKI3.
CleanExi HS_VPREB3.
ExpressionAtlasi Q9UKI3. baseline and differential.
Genevestigatori Q9UKI3.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse."
    Rosnet O., Mattei M.-G., Delattre O., Schiff C.
    Cytogenet. Cell Genet. 87:205-208(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of N27C7-2 gene."
    Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiVPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI3
Secondary accession number(s): B2R587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3