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Protein

Pre-B lymphocyte protein 3

Gene

VPREB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B lymphocyte protein 3
Alternative name(s):
N27C7-2
Protein VPreB3
Gene namesi
Name:VPREB3
ORF Names:UNQ355/PRO619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:12710. VPREB3.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central

Pathology & Biotechi

Organism-specific databases

DisGeNETi29802.
OpenTargetsiENSG00000128218.
PharmGKBiPA37325.

Polymorphism and mutation databases

BioMutaiVPREB3.
DMDMi11387357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001500321 – 123Pre-B lymphocyte protein 3Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UKI3.
PeptideAtlasiQ9UKI3.
PRIDEiQ9UKI3.

Expressioni

Tissue specificityi

Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.

Gene expression databases

BgeeiENSG00000128218.
CleanExiHS_VPREB3.
ExpressionAtlasiQ9UKI3. baseline and differential.
GenevisibleiQ9UKI3. HS.

Organism-specific databases

HPAiHPA003041.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248948.

Structurei

3D structure databases

ProteinModelPortaliQ9UKI3.
SMRiQ9UKI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 123Ig-likeAdd BLAST103

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IZWB. Eukaryota.
ENOG41118MJ. LUCA.
GeneTreeiENSGT00780000121842.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiQ9UKI3.
KOiK06553.
OMAiYYRSEED.
OrthoDBiEOG091G0TNT.
PhylomeDBiQ9UKI3.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR
60 70 80 90 100
DYGVSWYQQR AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL
110 120
TISPVQPEDD ADYYCSVGYG FSP
Length:123
Mass (Da):13,710
Last modified:May 1, 2000 - v1
Checksum:iBF09AC5196059E85
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0499544R → W. Corresponds to variant dbSNP:rs34372784Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163825 mRNA. Translation: AAF09451.1.
AB050772 Genomic DNA. Translation: BAB83034.1.
AY359000 mRNA. Translation: AAQ89359.1.
CR456610 mRNA. Translation: CAG30496.1.
AK312098 mRNA. Translation: BAG35034.1.
CH471095 Genomic DNA. Translation: EAW59598.1.
BC020666 mRNA. Translation: AAH20666.1.
CCDSiCCDS13813.1.
RefSeqiNP_037510.1. NM_013378.2.
UniGeneiHs.136713.

Genome annotation databases

EnsembliENST00000248948; ENSP00000248948; ENSG00000128218.
GeneIDi29802.
KEGGihsa:29802.
UCSCiuc002zxt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI3
Secondary accession number(s): B2R587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families