Q9UKI3 (VPRE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pre-B lymphocyte protein 3

Alternative name(s):
N27C7-2
Protein VPreB3

Gene names

Name:	VPREB3
ORF Names:	UNQ355/PRO619

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Tissue specificity	Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum Non-traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 123	103	Pre-B lymphocyte protein 3		PRO_0000015003
Regions
	Domain	21 – 123	103	Ig-like
Amino acid modifications
	Disulfide bond	40 ↔ 115		By similarity
Natural variations
	Natural variant	4	1	R → W. Corresponds to variant rs34372784 [ dbSNP | Ensembl ].		VAR_049954

Sequences

	Sequence		Length	Mass (Da)
	Q9UKI3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BF09AC5196059E85	FASTA	123	13,710
	10 20 30 40 50 60 MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR DYGVSWYQQR 70 80 90 100 110 120 AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL TISPVQPEDD ADYYCSVGYG FSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse." Rosnet O., Mattei M.-G., Delattre O., Schiff C. Cytogenet. Cell Genet. 87:205-208(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of N27C7-2 gene." Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF163825 mRNA. Translation: AAF09451.1. AB050772 Genomic DNA. Translation: BAB83034.1. AY359000 mRNA. Translation: AAQ89359.1. CR456610 mRNA. Translation: CAG30496.1. AK312098 mRNA. Translation: BAG35034.1. CH471095 Genomic DNA. Translation: EAW59598.1. BC020666 mRNA. Translation: AAH20666.1.
IPI	IPI00007573.
RefSeq	NP_037510.1. NM_013378.2.
UniGene	Hs.136713.
3D structure databases
ProteinModelPortal	Q9UKI3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000248948.
Polymorphism databases
DMDM	11387357.
Proteomic databases
PaxDb	Q9UKI3.
PRIDE	Q9UKI3.
Protocols and materials databases
DNASU	29802.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248948; ENSP00000248948; ENSG00000128218.
GeneID	29802.
KEGG	hsa:29802.
UCSC	uc002zxt.3. human.
Organism-specific databases
CTD	29802.
GeneCards	GC22M024094.
HGNC	HGNC:12710. VPREB3.
HPA	HPA003041.
MIM	605017. gene.
neXtProt	NX_Q9UKI3.
PharmGKB	PA37325.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39956.
HOGENOM	HOG000059537.
HOVERGEN	HBG018013.
KO	K06553.
OMA	QVAQLSC.
OrthoDB	EOG441QCX.
PhylomeDB	Q9UKI3.
Gene expression databases
ArrayExpress	Q9UKI3.
Bgee	Q9UKI3.
CleanEx	HS_VPREB3.
Genevestigator	Q9UKI3.
GermOnline	ENSG00000128218. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VPREB3. human.
GenomeRNAi	29802.
NextBio	52355.
SOURCE	Search...

Entry information

Entry name

VPRE3_HUMAN

Accession

Primary (citable) accession number: Q9UKI3
Secondary accession number(s): B2R587

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.