Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UKI2

- BORG2_HUMAN

UniProt

Q9UKI2 - BORG2_HUMAN

Protein

Cdc42 effector protein 3

Gene

CDC42EP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.2 Publications

    GO - Molecular functioni

    1. cytoskeletal regulatory protein binding Source: ProtInc

    GO - Biological processi

    1. regulation of cell shape Source: UniProtKB-KW
    2. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell shape

    Enzyme and pathway databases

    SignaLinkiQ9UKI2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cdc42 effector protein 3
    Alternative name(s):
    Binder of Rho GTPases 2
    MSE55-related Cdc42-binding protein
    Gene namesi
    Name:CDC42EP3
    Synonyms:BORG2, CEP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16943. CDC42EP3.

    Subcellular locationi

    Endomembrane system 1 Publication; Peripheral membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. actin cytoskeleton Source: LIFEdb
    2. cytoplasm Source: UniProtKB-KW
    3. endomembrane system Source: UniProtKB-SubCell
    4. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38429.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Cdc42 effector protein 3PRO_0000212651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631PhosphotyrosineBy similarity
    Modified residuei108 – 1081PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UKI2.
    PaxDbiQ9UKI2.
    PRIDEiQ9UKI2.

    PTM databases

    PhosphoSiteiQ9UKI2.

    Expressioni

    Tissue specificityi

    Highly expressed in the heart and weakly in the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9UKI2.
    BgeeiQ9UKI2.
    CleanExiHS_CDC42EP3.
    GenevestigatoriQ9UKI2.

    Organism-specific databases

    HPAiHPA034986.

    Interactioni

    Subunit structurei

    Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.2 Publications

    Protein-protein interaction databases

    BioGridi115849. 9 interactions.
    IntActiQ9UKI2. 6 interactions.
    MINTiMINT-1397043.
    STRINGi9606.ENSP00000295324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 4515CRIBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BORG/CEP family.Curated
    Contains 1 CRIB domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG46217.
    HOGENOMiHOG000233908.
    HOVERGENiHBG052803.
    InParanoidiQ9UKI2.
    OMAiSMFTETP.
    OrthoDBiEOG7V1FSH.
    PhylomeDBiQ9UKI2.
    TreeFamiTF331725.

    Family and domain databases

    InterProiIPR029273. Cdc42_effect.
    IPR000095. CRIB_dom.
    [Graphical view]
    PfamiPF14957. BORG_CEP. 1 hit.
    PF00786. PBD. 1 hit.
    [Graphical view]
    SMARTiSM00285. PBD. 1 hit.
    [Graphical view]
    PROSITEiPS50108. CRIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UKI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH    50
    DVFGDISFLQ GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS 100
    PVLKNAISLP TIGGSQALML PLLSPVTFNS KQESFGPAKL PRLSCEPVME 150
    EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ SSQGRDSHSS SLSEQYPDWP 200
    AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP SLLDEVLNVM 250
    DKNK 254
    Length:254
    Mass (Da):27,678
    Last modified:May 1, 2000 - v1
    Checksum:iC31CDBE151C161ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561I → N in AAD16888. (PubMed:11035016)Curated
    Sequence conflicti233 – 2331S → F in AAC71773. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164118 mRNA. Translation: AAD48815.1.
    AF104857 mRNA. Translation: AAD16888.1.
    AF094521 mRNA. Translation: AAC71773.1.
    AL136842 mRNA. Translation: CAB66776.1.
    BT007190 mRNA. Translation: AAP35854.1.
    AK313483 mRNA. Translation: BAG36267.1.
    AC006369 Genomic DNA. Translation: AAX93072.1.
    CH471053 Genomic DNA. Translation: EAX00390.1.
    BC019270 mRNA. Translation: AAH19270.1.
    CCDSiCCDS1791.1.
    PIRiT46465.
    RefSeqiNP_001257365.1. NM_001270436.1.
    NP_001257366.1. NM_001270437.1.
    NP_001257367.1. NM_001270438.1.
    NP_006440.2. NM_006449.4.
    UniGeneiHs.369574.

    Genome annotation databases

    EnsembliENST00000295324; ENSP00000295324; ENSG00000163171.
    GeneIDi10602.
    KEGGihsa:10602.
    UCSCiuc002rqi.2. human.

    Polymorphism databases

    DMDMi71152340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164118 mRNA. Translation: AAD48815.1 .
    AF104857 mRNA. Translation: AAD16888.1 .
    AF094521 mRNA. Translation: AAC71773.1 .
    AL136842 mRNA. Translation: CAB66776.1 .
    BT007190 mRNA. Translation: AAP35854.1 .
    AK313483 mRNA. Translation: BAG36267.1 .
    AC006369 Genomic DNA. Translation: AAX93072.1 .
    CH471053 Genomic DNA. Translation: EAX00390.1 .
    BC019270 mRNA. Translation: AAH19270.1 .
    CCDSi CCDS1791.1.
    PIRi T46465.
    RefSeqi NP_001257365.1. NM_001270436.1.
    NP_001257366.1. NM_001270437.1.
    NP_001257367.1. NM_001270438.1.
    NP_006440.2. NM_006449.4.
    UniGenei Hs.369574.

    3D structure databases

    ProteinModelPortali Q9UKI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115849. 9 interactions.
    IntActi Q9UKI2. 6 interactions.
    MINTi MINT-1397043.
    STRINGi 9606.ENSP00000295324.

    PTM databases

    PhosphoSitei Q9UKI2.

    Polymorphism databases

    DMDMi 71152340.

    Proteomic databases

    MaxQBi Q9UKI2.
    PaxDbi Q9UKI2.
    PRIDEi Q9UKI2.

    Protocols and materials databases

    DNASUi 10602.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295324 ; ENSP00000295324 ; ENSG00000163171 .
    GeneIDi 10602.
    KEGGi hsa:10602.
    UCSCi uc002rqi.2. human.

    Organism-specific databases

    CTDi 10602.
    GeneCardsi GC02M037782.
    HGNCi HGNC:16943. CDC42EP3.
    HPAi HPA034986.
    MIMi 606133. gene.
    neXtProti NX_Q9UKI2.
    PharmGKBi PA38429.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46217.
    HOGENOMi HOG000233908.
    HOVERGENi HBG052803.
    InParanoidi Q9UKI2.
    OMAi SMFTETP.
    OrthoDBi EOG7V1FSH.
    PhylomeDBi Q9UKI2.
    TreeFami TF331725.

    Enzyme and pathway databases

    SignaLinki Q9UKI2.

    Miscellaneous databases

    ChiTaRSi CDC42EP3. human.
    GeneWikii CDC42EP3.
    GenomeRNAii 10602.
    NextBioi 40262.
    PROi Q9UKI2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKI2.
    Bgeei Q9UKI2.
    CleanExi HS_CDC42EP3.
    Genevestigatori Q9UKI2.

    Family and domain databases

    InterProi IPR029273. Cdc42_effect.
    IPR000095. CRIB_dom.
    [Graphical view ]
    Pfami PF14957. BORG_CEP. 1 hit.
    PF00786. PBD. 1 hit.
    [Graphical view ]
    SMARTi SM00285. PBD. 1 hit.
    [Graphical view ]
    PROSITEi PS50108. CRIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."
      Joberty G., Perlungher R.R., Macara I.G.
      Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RHOQ AND CDC42.
      Tissue: Heart.
    2. "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."
      Hirsch D.S., Pirone D.M., Burbelo P.D.
      J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Uterus.
    3. "MSE55-related Cdc42-binding protein."
      Alberts A.S.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    10. "Borg proteins control septin organization and are negatively regulated by Cdc42."
      Joberty G., Perlungher R.R., Sheffield P.J., Kinoshita M., Noda M., Haystead T., Macara I.G.
      Nat. Cell Biol. 3:861-866(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEPT7.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBORG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKI2
    Secondary accession number(s): B2R8S0, O95353, Q9UQJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3