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Q9UKI2 (BORG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cdc42 effector protein 3
Alternative name(s):
Binder of Rho GTPases 2
MSE55-related Cdc42-binding protein
Gene names
Name:CDC42EP3
Synonyms:BORG2, CEP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Ref.1 Ref.2

Subunit structure

Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7. Ref.1 Ref.10

Subcellular location

Endomembrane system; Peripheral membrane protein. Cytoplasmcytoskeleton Ref.2.

Tissue specificity

Highly expressed in the heart and weakly in the brain. Ref.1

Sequence similarities

Belongs to the BORG/CEP family.

Contains 1 CRIB domain.

Ontologies

Keywords
   Biological processCell shape
   Cellular componentCytoplasm
Cytoskeleton
Membrane
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell shape

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentactin cytoskeleton

Inferred from direct assay. Source: LIFEdb

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

endomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytoskeletal regulatory protein binding

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Cdc42 effector protein 3
PRO_0000212651

Regions

Domain31 – 4515CRIB

Amino acid modifications

Modified residue631Phosphotyrosine By similarity
Modified residue1081Phosphoserine By similarity

Experimental info

Sequence conflict561I → N in AAD16888. Ref.2
Sequence conflict2331S → F in AAC71773. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9UKI2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C31CDBE151C161ED

FASTA25427,678
        10         20         30         40         50         60 
MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH DVFGDISFLQ 

        70         80         90        100        110        120 
GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS PVLKNAISLP TIGGSQALML 

       130        140        150        160        170        180 
PLLSPVTFNS KQESFGPAKL PRLSCEPVME EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ 

       190        200        210        220        230        240 
SSQGRDSHSS SLSEQYPDWP AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP 

       250 
SLLDEVLNVM DKNK 

« Hide

References

« Hide 'large scale' references
[1]"The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."
Joberty G., Perlungher R.R., Macara I.G.
Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RHOQ AND CDC42.
Tissue: Heart.
[2]"A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."
Hirsch D.S., Pirone D.M., Burbelo P.D.
J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Tissue: Uterus.
[3]"MSE55-related Cdc42-binding protein."
Alberts A.S.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[7]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[10]"Borg proteins control septin organization and are negatively regulated by Cdc42."
Joberty G., Perlungher R.R., Sheffield P.J., Kinoshita M., Noda M., Haystead T., Macara I.G.
Nat. Cell Biol. 3:861-866(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SEPT7.
[11]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF164118 mRNA. Translation: AAD48815.1.
AF104857 mRNA. Translation: AAD16888.1.
AF094521 mRNA. Translation: AAC71773.1.
AL136842 mRNA. Translation: CAB66776.1.
BT007190 mRNA. Translation: AAP35854.1.
AK313483 mRNA. Translation: BAG36267.1.
AC006369 Genomic DNA. Translation: AAX93072.1.
CH471053 Genomic DNA. Translation: EAX00390.1.
BC019270 mRNA. Translation: AAH19270.1.
CCDSCCDS1791.1.
PIRT46465.
RefSeqNP_001257365.1. NM_001270436.1.
NP_001257366.1. NM_001270437.1.
NP_001257367.1. NM_001270438.1.
NP_006440.2. NM_006449.4.
UniGeneHs.369574.

3D structure databases

ProteinModelPortalQ9UKI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115849. 9 interactions.
IntActQ9UKI2. 4 interactions.
MINTMINT-1397043.
STRING9606.ENSP00000295324.

PTM databases

PhosphoSiteQ9UKI2.

Polymorphism databases

DMDM71152340.

Proteomic databases

MaxQBQ9UKI2.
PaxDbQ9UKI2.
PRIDEQ9UKI2.

Protocols and materials databases

DNASU10602.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295324; ENSP00000295324; ENSG00000163171.
GeneID10602.
KEGGhsa:10602.
UCSCuc002rqi.2. human.

Organism-specific databases

CTD10602.
GeneCardsGC02M037782.
HGNCHGNC:16943. CDC42EP3.
HPAHPA034986.
MIM606133. gene.
neXtProtNX_Q9UKI2.
PharmGKBPA38429.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46217.
HOGENOMHOG000233908.
HOVERGENHBG052803.
InParanoidQ9UKI2.
OMASMFTETP.
OrthoDBEOG7V1FSH.
PhylomeDBQ9UKI2.
TreeFamTF331725.

Enzyme and pathway databases

SignaLinkQ9UKI2.

Gene expression databases

ArrayExpressQ9UKI2.
BgeeQ9UKI2.
CleanExHS_CDC42EP3.
GenevestigatorQ9UKI2.

Family and domain databases

InterProIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTSM00285. PBD. 1 hit.
[Graphical view]
PROSITEPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDC42EP3. human.
GeneWikiCDC42EP3.
GenomeRNAi10602.
NextBio40262.
PROQ9UKI2.
SOURCESearch...

Entry information

Entry nameBORG2_HUMAN
AccessionPrimary (citable) accession number: Q9UKI2
Secondary accession number(s): B2R8S0, O95353, Q9UQJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM