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Q9UKI2

- BORG2_HUMAN

UniProt

Q9UKI2 - BORG2_HUMAN

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Protein

Cdc42 effector protein 3

Gene

CDC42EP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.2 Publications

GO - Molecular functioni

  1. cytoskeletal regulatory protein binding Source: ProtInc

GO - Biological processi

  1. regulation of cell shape Source: UniProtKB-KW
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

SignaLinkiQ9UKI2.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 3
Alternative name(s):
Binder of Rho GTPases 2
MSE55-related Cdc42-binding protein
Gene namesi
Name:CDC42EP3
Synonyms:BORG2, CEP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16943. CDC42EP3.

Subcellular locationi

Endomembrane system 1 Publication; Peripheral membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: LIFEdb
  2. cytoplasm Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Cdc42 effector protein 3PRO_0000212651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphotyrosineBy similarity
Modified residuei108 – 1081PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UKI2.
PaxDbiQ9UKI2.
PRIDEiQ9UKI2.

PTM databases

PhosphoSiteiQ9UKI2.

Expressioni

Tissue specificityi

Highly expressed in the heart and weakly in the brain.1 Publication

Gene expression databases

BgeeiQ9UKI2.
CleanExiHS_CDC42EP3.
ExpressionAtlasiQ9UKI2. baseline and differential.
GenevestigatoriQ9UKI2.

Organism-specific databases

HPAiHPA034986.

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.2 Publications

Protein-protein interaction databases

BioGridi115849. 9 interactions.
IntActiQ9UKI2. 6 interactions.
MINTiMINT-1397043.
STRINGi9606.ENSP00000295324.

Structurei

3D structure databases

ProteinModelPortaliQ9UKI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 4515CRIBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG46217.
GeneTreeiENSGT00730000110928.
HOGENOMiHOG000233908.
HOVERGENiHBG052803.
InParanoidiQ9UKI2.
OMAiSMFTETP.
OrthoDBiEOG7V1FSH.
PhylomeDBiQ9UKI2.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH
60 70 80 90 100
DVFGDISFLQ GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS
110 120 130 140 150
PVLKNAISLP TIGGSQALML PLLSPVTFNS KQESFGPAKL PRLSCEPVME
160 170 180 190 200
EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ SSQGRDSHSS SLSEQYPDWP
210 220 230 240 250
AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP SLLDEVLNVM

DKNK
Length:254
Mass (Da):27,678
Last modified:May 1, 2000 - v1
Checksum:iC31CDBE151C161ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561I → N in AAD16888. (PubMed:11035016)Curated
Sequence conflicti233 – 2331S → F in AAC71773. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164118 mRNA. Translation: AAD48815.1.
AF104857 mRNA. Translation: AAD16888.1.
AF094521 mRNA. Translation: AAC71773.1.
AL136842 mRNA. Translation: CAB66776.1.
BT007190 mRNA. Translation: AAP35854.1.
AK313483 mRNA. Translation: BAG36267.1.
AC006369 Genomic DNA. Translation: AAX93072.1.
CH471053 Genomic DNA. Translation: EAX00390.1.
BC019270 mRNA. Translation: AAH19270.1.
CCDSiCCDS1791.1.
PIRiT46465.
RefSeqiNP_001257365.1. NM_001270436.1.
NP_001257366.1. NM_001270437.1.
NP_001257367.1. NM_001270438.1.
NP_006440.2. NM_006449.4.
UniGeneiHs.369574.

Genome annotation databases

EnsembliENST00000295324; ENSP00000295324; ENSG00000163171.
ENST00000611976; ENSP00000480549; ENSG00000163171.
GeneIDi10602.
KEGGihsa:10602.
UCSCiuc002rqi.2. human.

Polymorphism databases

DMDMi71152340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164118 mRNA. Translation: AAD48815.1 .
AF104857 mRNA. Translation: AAD16888.1 .
AF094521 mRNA. Translation: AAC71773.1 .
AL136842 mRNA. Translation: CAB66776.1 .
BT007190 mRNA. Translation: AAP35854.1 .
AK313483 mRNA. Translation: BAG36267.1 .
AC006369 Genomic DNA. Translation: AAX93072.1 .
CH471053 Genomic DNA. Translation: EAX00390.1 .
BC019270 mRNA. Translation: AAH19270.1 .
CCDSi CCDS1791.1.
PIRi T46465.
RefSeqi NP_001257365.1. NM_001270436.1.
NP_001257366.1. NM_001270437.1.
NP_001257367.1. NM_001270438.1.
NP_006440.2. NM_006449.4.
UniGenei Hs.369574.

3D structure databases

ProteinModelPortali Q9UKI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115849. 9 interactions.
IntActi Q9UKI2. 6 interactions.
MINTi MINT-1397043.
STRINGi 9606.ENSP00000295324.

PTM databases

PhosphoSitei Q9UKI2.

Polymorphism databases

DMDMi 71152340.

Proteomic databases

MaxQBi Q9UKI2.
PaxDbi Q9UKI2.
PRIDEi Q9UKI2.

Protocols and materials databases

DNASUi 10602.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295324 ; ENSP00000295324 ; ENSG00000163171 .
ENST00000611976 ; ENSP00000480549 ; ENSG00000163171 .
GeneIDi 10602.
KEGGi hsa:10602.
UCSCi uc002rqi.2. human.

Organism-specific databases

CTDi 10602.
GeneCardsi GC02M037878.
HGNCi HGNC:16943. CDC42EP3.
HPAi HPA034986.
MIMi 606133. gene.
neXtProti NX_Q9UKI2.
PharmGKBi PA38429.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46217.
GeneTreei ENSGT00730000110928.
HOGENOMi HOG000233908.
HOVERGENi HBG052803.
InParanoidi Q9UKI2.
OMAi SMFTETP.
OrthoDBi EOG7V1FSH.
PhylomeDBi Q9UKI2.
TreeFami TF331725.

Enzyme and pathway databases

SignaLinki Q9UKI2.

Miscellaneous databases

ChiTaRSi CDC42EP3. human.
GeneWikii CDC42EP3.
GenomeRNAii 10602.
NextBioi 40262.
PROi Q9UKI2.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKI2.
CleanExi HS_CDC42EP3.
ExpressionAtlasi Q9UKI2. baseline and differential.
Genevestigatori Q9UKI2.

Family and domain databases

InterProi IPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view ]
Pfami PF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view ]
SMARTi SM00285. PBD. 1 hit.
[Graphical view ]
PROSITEi PS50108. CRIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."
    Joberty G., Perlungher R.R., Macara I.G.
    Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RHOQ AND CDC42.
    Tissue: Heart.
  2. "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."
    Hirsch D.S., Pirone D.M., Burbelo P.D.
    J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Uterus.
  3. "MSE55-related Cdc42-binding protein."
    Alberts A.S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  10. "Borg proteins control septin organization and are negatively regulated by Cdc42."
    Joberty G., Perlungher R.R., Sheffield P.J., Kinoshita M., Noda M., Haystead T., Macara I.G.
    Nat. Cell Biol. 3:861-866(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEPT7.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBORG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI2
Secondary accession number(s): B2R8S0, O95353, Q9UQJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3